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Maternal death

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https://www.readbyqxmd.com/read/29793136/effects-of-gestational-hypertension-and-pre-eclampsia-in-mrna-expression-of-fibrinolysis-genes-in-primary-cultured-human-umbilical-vein-endothelial-cells
#1
Irais Poblete-Naredo, Yury Rodríguez-Yáñez, Rogelio O Corona-Núñez, Stuart González-Monroy, Juan E Salinas, Arnulfo Albores
Hypertension disorders (HD) and pre-eclampsia (PRE) are leading causes of maternal deaths worldwide. PRE is associated with vascular endothelial dysfunction and with deregulation of the fibrinolysis pathway genes. Fibrinolysis is the fibrin clot hydrolysis process catalyzed by plasmin, a proteolytic enzyme formed from plasminogen. Plasminogen is cleaved by tissue-type (tPA) and urokinase-type (uPA) activators and inhibited by the plasminogen activator inhibitors type-1 (PAI-1) and type-2 (PAI-2). The whole process maintains blood hemostasis...
May 17, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29792103/prolonged-use-of-antibiotics-after-birth-is-associated-with-increased-morbidity-in-preterm-infants-with-negative-cultures
#2
C Fajardo, B Alshaikh, A Harabor
BACKGROUND: Most preterm infants are exposed to a variable duration of antibiotic therapy after birth despite negative cultures. Data is emerging about the risks of prolonged antibiotics. We sought to assess the association between length of initial antibiotic course and neonatal outcomes in a cohort from a single large perinatal centre. METHODS: Retrospective cohort study of prospectively collected data on all infants with a birth weight of less than 1250 g hospitalized in our NICU in a 4-year window and who had negative blood and CSF cultures in the first 2 days of life...
May 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29792056/placenta-in-intrauterine-fetal-demise-iufd-a-comprehensive-study-from-a-tertiary-care-hospital
#3
Anisha Manocha, Gayatri Ravikumar, Julian Crasta
BACKGROUND: Intrauterine fetal demise (IUFD) is an unpredictable and challenging obstetric complication. Its etiology is multifactorial with more than 60% attributed to the placental cause. The present study was done with a primary objective of understanding the placental lesions underlying IUFD. METHODS: In this retrospective observational study, IUFD cases (> 22 weeks) between January 2012-September 2015 were collected from pathology database. The clinical details with ultrasound findings were collected from mother's charts...
May 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29789058/prevention-and-treatment-of-respiratory-distress-syndrome-in-preterm-neonates
#4
Christopher McPherson, Jennifer A Wambach
Respiratory distress syndrome (RDS) impacts a high proportion of preterm neonates, resulting in significant morbidity and mortality. Advances in pharmacotherapy, specifically antenatal corticosteroids and postnatal surfactant therapy, have significantly reduced the incidence and impact of neonatal RDS. Antenatal corticosteroids accelerate fetal lung maturation by increasing the activity of enzymes responsible for surfactant biosynthesis, resulting in improved lung compliance. Maternal antenatal corticosteroid treatment has improved survival of preterm neonates and lowered the incidence of brain injury...
May 1, 2018: Neonatal Network: NN
https://www.readbyqxmd.com/read/29783963/he-tamariki-kokoti-tau-tackling-preterm-a-data-linkage-methodology-to-explore-the-clinical-care-pathway-in-preterm-deliveries
#5
Sara Filoche, Fiona Cram, Angela Beard, Dalice Sim, Stacie Geller, Liza Edmonds, Bridget Robson, Beverley Lawton
BACKGROUND: Significant health inequities exist around maternal and infant health for Māori, the indigenous people of Aotearoa New Zealand - and in particular around a premature (preterm) delivery. Māori babies are more likely to be born preterm (8.1%, compared to an overall rate of 7.4%) and they are more likely to have a preterm death. An essential part of redressing these disparities is to examine the clinical care pathway and outcomes associated with preterm deliveries. This paper describes a protocol utilising national and local health collections to enable such a study...
May 21, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29781250/low-level-aflatoxin-exposure-associated-with-greater-linear-growth-in-southern-mexico-a-longitudinal-study
#6
Jef L Leroy, Celeste Sununtnasuk, Armando García-Guerra, Jia-Sheng Wang
Aflatoxins are a group of naturally occurring mycotoxins, which can lead to death and are a known cause of hepatocellular carcinoma. AF exposure has been hypothesised to lead to stunted growth in children, but separating the AF effect from other determinants of linear growth retardation is difficult. The study used secondary data from an efficacy trial conducted in young children in southern Mexico to test the comparative efficacy of a milk-based multiple micronutrient-fortified food, a multiple micronutrient syrup, or a multiple micronutrient powder...
May 21, 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29777093/estimating-child-mortality-rate-and-its-trend-in-hamadan-province-western-iran-from-1990-to-2016-implications-for-sustainable-development-goal
#7
Younes Mohammadi, Rashid Heidarimoghadam, Bistoon Hosseini, Mohammad Babamiri, Azita Nikravesh, Masoumeh Javaheri, Babak Moeini
BACKGROUND: Child mortality is one of the major health indices and the main targets in sustainable development goals. This study aimed to estimate child mortality rate and assess the progress toward sustainable development goals in Hamadan Province, western Iran and its districts from 1990 to 2016. STUDY DESIGN: A cross-sectional study. METHODS: We used two data sources including death registration system (DRS) and summary birth history data (SBH) of 2010 census for estimating child mortality rate...
March 7, 2018: Journal of Research in Health Sciences
https://www.readbyqxmd.com/read/29775476/maternal-asthma-is-associated-with-increased-risk-of-perinatal-mortality
#8
Mari Kemppainen, Anna-Maria Lahesmaa-Korpinen, Paula Kauppi, Martti Virtanen, Suvi M Virtanen, Riitta Karikoski, Mika Gissler, Turkka Kirjavainen
BACKGROUND: Asthma is the most common chronic disease during pregnancy and it may have influence on pregnancy outcome. OBJECTIVES: Our goal was to assess the association between maternal asthma and the perinatal risks as well as possible effects of asthma medication. METHODS: The study was based on a nationwide Finnish register-based cohort between the years 1996 and 2012 in the Drug and Pregnancy Database. The register data comprised 962 405 singleton live and stillbirths, 898 333 (93...
2018: PloS One
https://www.readbyqxmd.com/read/29772076/victims-and-victimisation
#9
Matthew Cauldwell, Susan Bewley
We congratulate McNamara et al. on their work examining the impact that intrapartum stillbirth has on obstetricians (1). The findings from their qualitative study highlight and reinforce themes others have identified. We conducted a similar study interviewing maternity staff (consultant obstetricians, trainees and midwives) about the impact of their involvement in rarer maternal death cases (2). We reported similar themes particularly around the fear of blame. This was perceived as coming not only from the media but also from professional colleagues...
May 17, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29771574/is-adding-maternal-vaccination-to-prevent-whooping-cough-cost-effective-in-australia
#10
Laure-Anne Van Bellinghen, Alex Dimitroff, Michael Haberl, Xiao Li, Andrew Manton, Karen Moeremans, Nadia Demarteau
Pertussis or whooping cough, a highly infectious respiratory infection, causes significant morbidity and mortality in infants. In adolescents and adults, pertussis presents with atypical symptoms often resulting in under-diagnosis and under-reporting, increasing the risk of transmission to more vulnerable groups. Maternal vaccination against pertussis protects mothers and newborns. This evaluation assessed the cost-effectiveness of adding maternal dTpa (reduced antigen diphtheria, Tetanus, acellular pertussis) vaccination to the 2016 nationally-funded pertussis program (DTPa [Diphtheria, Tetanus, acellular Pertussis] at 2, 4, 6, 18 months, 4 years and dTpa at 12-13 years) in Australia...
May 17, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29768662/immersion-in-water-during-labour-and-birth
#11
REVIEW
Elizabeth R Cluett, Ethel Burns, Anna Cuthbert
BACKGROUND: Water immersion during labour and birth is increasingly popular and is becoming widely accepted across many countries, and particularly in midwifery-led care settings. However, there are concerns around neonatal water inhalation, increased requirement for admission to neonatal intensive care unit (NICU), maternal and/or neonatal infection, and obstetric anal sphincter injuries (OASIS). This is an update of a review last published in 2011. OBJECTIVES: To assess the effects of water immersion during labour and/or birth (first, second and third stage of labour) on women and their infants...
May 16, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29768611/deaths-of-women-hospitalized-for-childbirth-and-abortion-and-of-their-concept-in-maternity-wards-of-brazilian-public-hospitals
#12
Pauline Lorena Kale, Maria Helena Prado de Mello Jorge, Sandra Costa Fonseca, Angela Maria Cascão, Kátia Silveira da Silva, Ana Cristina Reis, Mauro Tomoyuki Taniguchi
The aim of this cross-sectional hospital-based study of 7,845 pregnancies was to analyze deaths of women hospitalized for childbirth and abortion, and fetal and neonatal deaths, in public hospitals in the cities of São Paulo, Rio de Janeiro and Niteroi (RJ), Brazil, in 2011. Outcomes of the pregnancies were: one maternal death, 498 abortions, 65 fetal deaths, 44 neonatal deaths and 7,291 infant survivors. Data were collected through interviews, medical records and the women's pregnancy records, and from the Mortality Information System (SIM)...
May 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29768579/-cost-effectiveness-analysis-of-spontaneous-vaginal-delivery-and-elective-cesarean-for-normal-risk-pregnant-women-in-the-brazilian-unified-national-health-system
#13
Aline Piovezan Entringer, Márcia Pinto, Marcos Augusto Bastos Dias, Maria Auxiliadora de Souza Mendes Gomes
The purpose of this study was to conduct a cost-effectiveness analysis of spontaneous vaginal delivery and elective cesarean (with no clinical indication) for normal risk pregnant women, from the perspective of the Brazilian Unified National Health System. An analytical decision model was developed and included the choice of delivery mode and clinical consequences for mothers and newborns, from admission for delivery to hospital discharge. The reference population consisted of normal risk pregnant women with singleton, at-term gestations in cephalic position, subdivided into primiparas and multiparas with prior uterine scar...
May 10, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29764806/temporal-efficacy-of-a-sulforaphane-based-broccoli-sprout-diet-in-prevention-of-breast-cancer-through-modulation-of-epigenetic-mechanisms
#14
Yuanyuan Li, Phillip Buckhaults, Shizhao Li, Trygve O Tollefsbol
Breast cancer is the most common cancer and the second leading cause of cancer death among women. An important risk factor for breast cancer is individual genetic background which is initially generated early in human life; for example, during the processes of embryogenesis and fetal development in utero. Bioactive dietary components such as sulforaphane (SFN), an isothiocyanate from cruciferous vegetables including broccoli sprouts (BSp), cabbage and kale, has been shown to reduce the risk of developing many common cancers through regulation of epigenetic mechanisms...
May 15, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29764572/-a-single-center-study-on-the-incidence-and-mortality-of-preterm-infants-from-2006-to-2016
#15
Jun-Mei Yan, Hui Huang, Qian-Qian Li, Xiao-Yi Deng
OBJECTIVE: To investigate the incidence and mortality rates of preterm infants and the main causes of death. METHODS: The basic information of preterm infants was collected from their medical records and admission/discharge records to analyze the incidence and mortality rates of preterm infants and the causes of their death. RESULTS: There were 76 812 neonates born in the Xuzhou Maternal and Child Health Hospital from January 2006 to December 2016, among whom 5 585 (7...
May 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29764416/safety-of-a-condom-uterine-balloon-tamponade-esm-ubt-device-for-uncontrolled-primary-postpartum-hemorrhage-among-facilities-in-kenya-and-sierra-leone
#16
Aparna Ramanathan, Melody J Eckardt, Brett D Nelson, Moytrayee Guha, Monica Oguttu, Zaid Altawil, Thomas Burke
BACKGROUND: Postpartum hemorrhage is the leading cause of maternal mortality in low- and middle-income countries. While evidence on uterine balloon tamponade efficacy for severe hemorrhage is encouraging, little is known about safety of this intervention. The objective of this study was to evaluate the safety of an ultra-low-cost uterine balloon tamponade package (named ESM-UBT) for facility-based management of uncontrolled postpartum hemorrhage (PPH) in Kenya and Sierra Leone. METHODS: Data were collected on complications/adverse events in all women who had an ESM-UBT device placed among 92 facilities in Sierra Leone and Kenya, between September 2012 and December 2015, as part of a multi-country study...
May 15, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29763608/early-prognostic-factors-of-outcomes-in-monochorionic-twin-pregnancy-systematic-review-and-meta-analysis
#17
REVIEW
Fiona L Mackie, Matthew J Hall, R Katie Morris, Mark D Kilby
OBJECTIVE: Assess ability of first trimester pregnancy related factors (ultrasound measurements, maternal characteristics, biomarkers) to predict complications in monochorionic twin pregnancies DATA SOURCES: MEDLINE, EMBASE, ISI Web of Science, CINAHL, the Cochrane Central Registration of Controlled Trials and Research Registers, and Google Scholar, from inception to 12 May 2017. Grey literature and bibliographies of articles were checked. STUDY ELIGIBILITY CRITERIA: Studies that reported ultrasound measurements, maternal characteristics, or potential biomarkers, measured in the first trimester in monochorionic diamniotic twin pregnancies, where the potential prognostic ability between the variable and twin-twin transfusion syndrome, growth restriction, or intrauterine fetal death could be assessed...
May 12, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29758065/the-genetic-component-of-preeclampsia-a-whole-exome-sequencing-study
#18
Anette Tarp Hansen, Jens Magnus Bernth Jensen, Anne-Mette Hvas, Mette Christiansen
Preeclampsia is a major cause of maternal and perinatal deaths. The aetiology of preeclampsia is largely unknown but a polygenetic component is assumed. To explore this hypothesis, we performed an in-depth whole-exome sequencing study in women with (cases, N = 50) and without (controls, N = 50) preeclampsia. The women were identified in an unselected cohort of 2,545 pregnant women based on data from the Danish National Patient Registry and the Medical Birth Registry. Matching DNA was obtained from a biobank containing excess blood from routine antenatal care visits...
2018: PloS One
https://www.readbyqxmd.com/read/29757782/newborn-apgar-score-and-prediction-of-maternal-death
#19
Alyssa F Kahane, Alison L Park, Joel G Ray
No abstract text is available yet for this article.
May 11, 2018: Epidemiology
https://www.readbyqxmd.com/read/29757778/a-contemporary-analysis-of-medicolegal-issues-in-obstetric-anesthesia-between-2005-and-2015
#20
Vesela P Kovacheva, Ethan Y Brovman, Penny Greenberg, Ellen Song, Arvind Palanisamy, Richard D Urman
BACKGROUND: Detailed reviews of closed malpractice claims have provided insights into the most common events resulting in litigation and helped improve anesthesia care. In the past 10 years, there have been multiple safety advancements in the practice of obstetric anesthesia. We investigated the relationship among contributing factors, patient injuries, and legal outcome by analyzing a contemporary cohort of closed malpractice claims where obstetric anesthesiology was the principal defendant...
May 10, 2018: Anesthesia and Analgesia
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