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sentinel lymph node, DCIS

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https://www.readbyqxmd.com/read/27779988/is-sentinel-lymph-node-dissection-necessary-in-all-patients-with-ductal-carcinoma-in-situ-undergoing-total-mastectomy
#1
Valentina Bonev, Carlos Chavez De Paz Villanueva, Naveenraj Solomon, Maheswari Senthil, Mark E Reeves, Carlos Garberoglio, Sharon S Lum
When ductal carcinoma in situ (DCIS) is found on core needle biopsy, rates of upgrade to invasive cancer of 25 per cent and nodal positivity of 10 per cent have been reported. Sentinel lymph node dissection (SLND) is recommended when mastectomy is performed for DCIS. We investigated the role of SLND in DCIS patients undergoing partial and total mastectomy (TM). During the study period 2004 to 2013, 170 patients with DCIS were identified with a median age of 60 years (range 26-84 years). Of these, 58.2 per cent had partial mastectomy (PM) alone, 10...
October 2016: American Surgeon
https://www.readbyqxmd.com/read/27773373/is-sentinel-lymph-node-biopsy-indicated-in-patients-with-a-diagnosis-of-ductal-carcinoma-in%C3%A2-situ-a-systematic-literature-review-and-meta-analysis
#2
Hiba El Hage Chehade, Hannah Headon, Umar Wazir, Houssam Abtar, Abdul Kasem, Kefah Mokbel
BACKGROUND: Recent discussion has suggested that some cases of ductal carcinoma in situ (DCIS) with high risk of invasive disease may require sentinel lymph node biopsy (SLNB). METHODS: Systematic literature review identified 48 studies (9,803 DCIS patients who underwent SLNB). Separate analyses for patients diagnosed preoperatively by core sampling and patients diagnosed postoperatively by specimen pathology were conducted to determine the percentage of patients with axillary nodal involvement...
September 6, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27365080/axillary-evaluation-and-lymphedema-in-women-with-ductal-carcinoma-in-situ
#3
Ellie J Coromilas, Jason D Wright, Yongmei Huang, Sheldon Feldman, Alfred I Neugut, Grace Clarke Hillyer, Ling Chen, Dawn L Hershman
Axillary evaluation in women with ductal carcinoma in situ (DCIS) is increasing; however, this may introduce additional morbidity with unclear benefit. Our objective was to examine the morbidity and mortality associated with axillary evaluation in DCIS. We conducted a retrospective cohort study of 10,504 women aged 65-90 years with DCIS who underwent breast conserving surgery between 2002 and 2012 using SEER-Medicare database. Patients were categorized by receipt of axillary evaluation with either sentinel lymph node biopsy (SLNB) or axillary node dissection (ALND)...
July 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27334212/utilization-of-axillary-surgery-for-patients-with-ductal-carcinoma-in-situ-a-report-from-the-national-cancer-data-base
#4
Megan E Miller, Alexandra Kyrillos, Katharine Yao, Olga Kantor, Jennifer Tseng, David J Winchester, Lawrence N Shulman
BACKGROUND: This study evaluated the use of axillary surgery (AS), including sentinel lymph node biopsy (SLNB), for patients with ductal carcinoma in situ (DCIS) and the factors associated with its use. To determine whether utilization of SLNB is appropriate, predictors of SLNB performance were compared with factors predictive of tumor upstaging. METHODS: The National Cancer Data Base was utilized to identify patients with American Joint Committee on Cancer (AJCC) clinical stage 0 breast cancer treated from 2004 to 2013...
October 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27212695/ductal-carcinoma-in-situ-diagnosed-by-breast-needle-biopsy-predictors-of-invasion-in-the-excision-specimen
#5
S C Doebar, C de Monyé, H Stoop, J Rothbarth, S P Willemsen, C H M van Deurzen
BACKGROUND: A substantial proportion of women with a pre-operative diagnosis of pure ductal carcinoma in situ (DCIS) has a final diagnosis of invasive breast cancer (IBC) after surgical excision and, consequently, a potential indication for lymph node staging. The aim of our study was to identify novel predictors of invasion in patients with a needle-biopsy diagnosis of DCIS that would help us to select patients that may benefit from a sentinel node biopsy (SNB). PATIENTS AND METHODS: We included 153 patients with a needle-biopsy diagnosis of DCIS between 2000 and 2014, which was followed by surgical excision...
June 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27083179/sentinel-lymph-node-biopsy-can-be-omitted-in-dcis-patients-treated-with-breast-conserving-therapy
#6
L M van Roozendaal, B Goorts, M Klinkert, K B M I Keymeulen, B De Vries, L J A Strobbe, C A P Wauters, Y E van Riet, E Degreef, E J T Rutgers, J Wesseling, M L Smidt
Breast cancer guidelines advise sentinel lymph node biopsy (SLNB) in patients with ductal carcinoma in situ (DCIS) on core biopsy at high risk of invasive cancer or in case of mastectomy. This study investigates the incidence of SLNB and SLN metastases and the relevance of indications in guidelines and literature to perform SLNB in order to validate whether SLNB is justified in patients with DCIS on core biopsy in current era. Clinically node negative patients diagnosed from 2004 to 2013 with only DCIS on core needle biopsy were selected from a national database...
April 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27081649/sentinel-lymph-node-biopsy-in-clinically-detected-ductal-carcinoma-in-situ
#7
Ahmed Yahia Al-Ameer, Sahar Al Nefaie, Badria Al Johani, Ihab Anwar, Taher Al Tweigeri, Asma Tulbah, Mohmmed Alshabanah, Osama Al Malik
AIM: To study the indications for sentinel lymph node biopsy (SLNB) in clinically-detected ductal carcinoma in situ (CD-DCIS). METHODS: A retrospective analysis of 20 patients with an initial diagnosis of pure DCIS by an image-guided core needle biopsy (CNB) between June 2006 and June 2012 was conducted at King Faisal Specialist Hospital. The accuracy of performing SLNB in CD-DCIS, the rate of sentinel and non-sentinel nodal metastasis, and the histologic underestimation rate of invasive cancer at initial diagnosis were analyzed...
April 10, 2016: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/26960927/is-sentinel-lymph-node-biopsy-indicated-at-completion-mastectomy-for-ductal-carcinoma-in-situ
#8
Melissa Pilewskie, Maria Karsten, Julia Radosa, Anne Eaton, Tari A King
BACKGROUND: Sentinel lymph node biopsy (SLNB) is recommended when mastectomy is performed for ductal carcinoma in situ (DCIS). The role of SLNB for women with DCIS who undergo mastectomy following one or more attempts at breast-conserving surgery (BCS) is uncertain. We examined the upgrade rate and SLNB yield in women who converted to mastectomy after one or more attempts at BCS for DCIS. METHODS: All patients who underwent one or more attempts at BCS prior to conversion to mastectomy with SLNB for DCIS were identified...
July 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26622778/sentinel-lymph-node-biopsy-in-patients-with-breast-ductal-carcinoma-in-situ-chinese-experiences
#9
Xiao Sun, Hao Li, Yan-Bing Liu, Zheng-Bo Zhou, Peng Chen, Tong Zhao, Chun-Jian Wang, Zhao-Peng Zhang, Peng-Fei Qiu, Yong-Sheng Wang
The axillary treatment of patients with ductal carcinoma in situ (DCIS) remains controversial. The aim of the present study was to evaluate the roles of sentinel lymph node biopsy (SLNB) in patients with breast DCIS. A database containing the data from 262 patients diagnosed with breast DCIS and 100 patients diagnosed with DCIS with microinvasion (DCISM) who received SLNB between January 2002 and July 2014 was retrospectively analyzed. Of the 262 patients with DCIS, 9 presented with SLN metastases (3 macrometastases and 6 micrometastases)...
September 2015: Oncology Letters
https://www.readbyqxmd.com/read/26550818/male-ductal-carcinoma-in-situ-dcis-treatment-strategies-in-this-rare-entity
#10
M S Aznan, R Razrim, C A Affirul, M Rohaizak
Ductal carcinoma in situ (DCIS) in females is a recognized premalignant disease. However, its occurrence in males is rare. Articles describing this disease are scarce with documented occurrence is less than 7% worldwide. We report a case of 52 year-old gentleman presented with 6 months history of left breast lump. It was painless with no nipple discharge. Despite an inconclusive biopsy, lumpectomy was performed in view of the suspicion of malignant disease. Histopathology confirms DCIS. He underwent mastectomy and sentinel lymph nodes...
2015: La Clinica Terapeutica
https://www.readbyqxmd.com/read/26424780/addressing-overtreatment-in-dcis-what-should-physicians-do-now
#11
EDITORIAL
Monica Morrow, Steven J Katz
No abstract text is available yet for this article.
December 2015: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/26424776/trends-in-treatment-patterns-and-outcomes-for-ductal-carcinoma-in-situ
#12
COMPARATIVE STUDY
Mathias Worni, Igor Akushevich, Rachel Greenup, Deba Sarma, Marc D Ryser, Evan R Myers, E Shelley Hwang
BACKGROUND: Impact of contemporary treatment of pre-invasive breast cancer (ductal carcinoma in situ [DCIS]) on long-term outcomes remains poorly defined. We aimed to evaluate national treatment trends for DCIS and to determine their impact on disease-specific (DSS) and overall survival (OS). METHODS: The Surveillance, Epidemiology, and End Results (SEER) registry was queried for patients diagnosed with DCIS from 1991 to 2010. Treatment pattern trends were analyzed using Cochran-Armitage trend test...
December 2015: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/26380805/adenomyoepithelioma-of-the-breast-coexisting-with-ductal-carcinoma-in-situ-a-case-report-and-review-of-the-literature
#13
Mirei Kamei, Tsutomu Daa, Michiyo Miyawaki, Shuji Suehiro, Kenji Sugio
We herein report a case of adenomyoepithelioma (AME) of the breast with ductal carcinoma in situ (DCIS) involving a 71-year-old Japanese woman. She presented with bloody discharge from the left nipple. Mammography and ultrasonography showed a well-defined polygonal tumor. Fine-needle aspiration cytology of the mass and stamp cytology of the bloody nipple discharge showed malignancy. Mastectomy and a sentinel lymph node biopsy were performed. The final diagnosis was AME of the breast with DCIS. There are no reports of AME of the breast presenting with bloody nipple discharge; upon a diagnosis of AME of the breast with bloody nipple discharge, the possibility of the coexistence of breast cancer should thus be considered when encountering such cases...
December 2015: Surgical Case Reports
https://www.readbyqxmd.com/read/26346047/a-model-to-predict-upstaging-to-invasive-carcinoma-in-patients-preoperatively-diagnosed-with-ductal-carcinoma-in-situ-of-the-breast
#14
Takafumi Kondo, Naoki Hayashi, Sachiko Ohde, Koyu Suzuki, Atsushi Yoshida, Hiroshi Yagata, Naoki Niikura, Takayuki Iwamoto, Kumiko Kida, Michiko Murai, Yuko Takahashi, Hiroko Tsunoda, Seigo Nakamura, Hideko Yamauchi
BACKGROUND: The aims of this study were to determine clinicopathological factors associated with postoperative upstaging to invasive carcinoma in patients preoperatively diagnosed with ductal carcinoma in situ (DCIS) and to develop a model to predict the risk of upstaging. METHODS: Pre- and post-operative pathological diagnoses and radiological findings were assessed for 1,187 consecutive patients. RESULTS: Of the patients, 306 (25.8%) were upstaged on the surgical specimen...
October 2015: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26324758/sonographic-features-of-ductal-carcinoma-in-situ-of-the-breast-with-microinvasion-correlation-with-clinicopathologic-findings-and-biomarkers
#15
COMPARATIVE STUDY
Jie-Jie Yao, Wei-Wei Zhan, Man Chen, Xiao-Xiao Zhang, Ying Zhu, Xiao-Chun Fei, Xiao-Song Chen
OBJECTIVES: To compare the sonographic results, clinicopathologic characteristics, and biomarkers in pure ductal carcinoma in situ (DCIS) of the breast and DCIS with microinvasion. METHODS: A total of 218 patients with pathologically proven DCIS based on sonography in our hospital (2009-2013) were retrospectively enrolled. Clinicopathologic characteristics and biomarkers were examined. Grayscale sonographic results were investigated according to the American College of Radiology Breast Imaging Reporting and Data System lexicon, and color Doppler sonography was used to assess the vascularization distribution and degree...
October 2015: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/26324092/preoperatively-diagnosed-ductal-carcinoma-in-situ-risk-prediction-of-invasion-and-effects-on-axillary-management
#16
Yuya Sato, Takayuki Kinoshita, Junko Suzuki, Kenjiro Jimbo, Sota Asaga, Takashi Hojo, Masayuki Yoshida, Hitoshi Tsuda
BACKGROUND: Preoperatively diagnosed ductal carcinoma in situ (DCIS) has the potential to have occult invasion. The predictors of invasive carcinoma underestimation in patients with DCIS diagnosed by preoperative percutaneous biopsy were identified and the effects of underestimation on axillary management were evaluated. METHODS: Medical records of 280 patients preoperatively diagnosed as DCIS who underwent surgery were retrospectively analyzed. The patients were divided into non-invasive and invasive carcinoma groups according to the final pathological diagnosis...
September 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/26277546/the-locoregional-recurrence-post-mastectomy-for-ductal-carcinoma-in-situ-incidence-and-risk-factors
#17
Sahar Bannani, Sophie Rouquette, Cecile Bendavid-Athias, Patrick Tas, Jean Levêque
BACKGROUND: The objective of this retrospective study was to determine the incidence of recurrence of breast cancer after mastectomy for ductal carcinoma in situ (DCIS) in our institution, and to evaluate the associated risk factors while comparing them to those proposed in the literature. METHODS: The files of 218 patients who had undergone mastectomy for pure DCIS or DCIS with micro-invasion at Centre Eugène Marquis between January 2003 and November 2013 were compared for: age at diagnosis, type of mastectomy and immediate reconstruction, tumor characteristics, and the evaluation of the sentinel axillary lymph node...
October 2015: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/26202552/modern-trends-in-the-surgical-management-of-paget-s-disease
#18
Stephanie M Wong, Rachel A Freedman, Emily Stamell, Yasuaki Sagara, Jane E Brock, Stephen D Desantis, Mehra Golshan
PURPOSE: We examined the incidence and modern national trends in the management of Paget's disease (PD), including the use of breast-conserving surgery (BCS), mastectomy, axillary surgery, and receipt of radiotherapy. METHODS: Using surveillance, epidemiology and end results (SEER) data, we identified 2631 patients diagnosed with PD during 2000-2011. Of these patients, 185 (7%) had PD of the nipple only, 953 (36.2%) had PD with ductal carcinoma in situ (PD-DCIS), and 1493 (56...
October 2015: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26181180/the-influence-of-hospital-and-surgeon-factors-on-the-prevalence-of-axillary-lymph-node-evaluation-in-ductal-carcinoma-in-situ
#19
Ellie J Coromilas, Jason D Wright, Yongmei Huang, Sheldon Feldman, Alfred I Neugut, Ling Chen, Dawn L Hershman
IMPORTANCE: Although axillary lymph node evaluation is standard of care in the surgical management of invasive breast cancer, a benefit has not been demonstrated in ductal carcinoma in situ (DCIS). Despite uncertainty regarding the efficacy, axillary evaluation is often performed in women with DCIS. OBJECTIVE: To determine the incidence of axillary evaluation in women with DCIS and identify clinical, hospital, and surgeon-related factors associated with axillary evaluation...
June 2015: JAMA Oncology
https://www.readbyqxmd.com/read/26089220/acr-appropriateness-criteria%C3%A2-ductal-carcinoma-in-situ
#20
REVIEW
Seth A Kaufman, Eleanor E R Harris, Lisa Bailey, Manjeet Chadha, Sharon C Dutton, Gary M Freedman, Sharad Goyal, Michele Y Halyard, Kathleen C Horst, Kristina L M Novick, Catherine C Park, W Warren Suh, Deborah Toppmeyer, Jennifer Zook, Bruce G Haffty
Ductal carcinoma in situ (DCIS) is a breast neoplasm with potential for progression to invasive cancer. Management commonly involves excision, radiotherapy, and hormonal therapy. Surgical assessment of regional lymph nodes is rarely indicated except in cases of microinvasion or mastectomy. Radiotherapy is employed for local control in breast conservation, although it may be omitted for select low-risk situations. Several radiotherapy techniques exist beyond standard whole-breast irradiation (ie, partial-breast irradiation [PBI], hypofractionated whole-breast radiation); evidence for these is evolving...
June 2015: Oncology (Williston Park, NY)
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