keyword
https://read.qxmd.com/read/33562838/repeated-measurements-of-cardiac-troponin-t-and-n-terminal-pro-b-type-natriuretic-peptide-to-assess-long-term-mortality-risk-in-subjects-with-osteoarthritis
#21
JOURNAL ARTICLE
Martin Rehm, Gisela Büchele, Rolf Erwin Brenner, Klaus-Peter Günther, Hermann Brenner, Wolfgang Koenig, Dietrich Rothenbacher
Osteoarthritis (OA) is associated with higher cardiovascular mortality risk. High-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are well-characterized prognostic cardiac markers. We aimed to describe the changes in biomarkers measured one year apart in a cohort of 347 subjects with OA who underwent hip or knee replacement surgery in 1995/1996 and to analyze the prognostic value of repeated measurements for long-term mortality. During a median follow-up of 19 years, 209 (60...
February 5, 2021: Biomolecules
https://read.qxmd.com/read/33377924/individualized-fluid-management-using-the-pleth-variability-index
#22
JOURNAL ARTICLE
Marc-Olivier Fischer, Sandrine Lemoine, Benoît Tavernier, Chems-Eddine Bouchakour, Vincent Colas, Marion Houard, William Greub, Georges Daccache, Christophe Hulet, Vincent Compère, Diane Taing, Emmanuel Lorne, Jean-Jacques Parienti, Jean-Luc Hanouz
BACKGROUND: The present trial was designed to assess whether individualized strategies of fluid administration using a noninvasive plethysmographic variability index could reduce the postoperative hospital length of stay and morbidity after intermediate-risk surgery. METHODS: This was a multicenter, randomized, nonblinded parallel-group clinical trial conducted in five hospitals. Adult patients in sinus rhythm having elective orthopedic surgery (knee or hip arthroplasty) under general anesthesia were enrolled...
July 1, 2020: Anesthesiology
https://read.qxmd.com/read/33327599/perioperative-myocardial-infarction-myocardial-injury-is-associated-with-high-hospital-mortality-in-elderly-patients-undergoing-hip-fracture-surgery
#23
JOURNAL ARTICLE
Carlo Rostagno, Alessandro Cartei, Gaia Rubbieri, Alice Ceccofiglio, Agnese Magni, Silvia Forni, Roberto Civinini, Alberto Boccaccini
Cardiovascular complications in patients undergoing non-cardiac surgery are associated with longer hospital stays and higher in-hospital mortality. The aim of this study was to assess the incidence of in-hospital myocardial infarction and/or myocardial injury in patients undergoing hip fracture surgery and their association with mortality. Moreover, we evaluated the prognostic value of troponin increase stratified on the basis of peak troponin value. The electronic records of 1970 consecutive hip fracture patients were reviewed...
December 14, 2020: Journal of Clinical Medicine
https://read.qxmd.com/read/33287316/impact-of-pulse-wave-velocity-and-parameters-reflecting-android-type-fat-distribution-on-left-ventricular-diastolic-dysfunction-in-patients-with-chronic-coronary-syndromes
#24
JOURNAL ARTICLE
Marlena Paniczko, Małgorzata Chlabicz, Jacek Jamiołkowski, Paweł Sowa, Małgorzata Szpakowicz, Magda Łapińska, Marcin Kondraciuk, Katarzyna Ptaszyńska-Kopczyńska, Andrzej Raczkowski, Anna Szpakowicz, Karol Adam Kamiński
BACKGROUND: Left ventricular diastolic dysfunction (LVDD) is caused by a decreased left ventricle relaxation and is associated with an increased risk of symptomatic heart failure (HF) and excessive mortality. AIM: To evaluate the frequency and factors related to LVDD in the population with chronic coronary syndromes (CCS). METHODS: 200 patients (mean age 63.18 ± 8.12 years, 75.5% male) with CCS were included. LVDD was diagnosed based on the recent echocardiography guidelines...
December 3, 2020: Journal of Clinical Medicine
https://read.qxmd.com/read/33264342/relationship-between-cardiac-biomarker-concentrations-and-long-term-mortality-in-subjects-with-osteoarthritis
#25
JOURNAL ARTICLE
Martin Rehm, Gisela Büchele, Raphael Simon Peter, Rolf Erwin Brenner, Klaus-Peter Günther, Hermann Brenner, Wolfgang Koenig, Dietrich Rothenbacher
Osteoarthritis (OA) is associated with adverse cardio-metabolic features. N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponins T and I (hs-cTnT and hs-cTnI) are well-characterized cardiac markers and provide prognostic information. The objective was to assess the association of cardiac biomarker concentrations with long-term mortality in subjects with OA. In a cohort of 679 OA subjects, undergoing hip or knee replacement during 1995/1996, cardiac biomarkers were measured and subjects were followed over 20 years...
2020: PloS One
https://read.qxmd.com/read/32864459/takotsubo-syndrome-is-this-a-common-occurrence-in-elderly-females-after-hip-fracture
#26
JOURNAL ARTICLE
Carlo Rostagno, Gianluca Polidori, Alice Ceccofiglio, Alessandro Cartei, Alberto Boccaccini, Adriano Peris, Gaia Rubbieri, Roberto Civinini, Massimo Innocenti
Background: The prevalence of Takotsubo syndrome in hip fracture is not known. Methods: Hip fracture patients were evaluated in a multidisciplinary unit. Patients with ECG abnormalities and increased troponin I values at the time of hospital admission were included in the study Follow-up was clinical at 30 days and by telephonic interview at one year. Results: Between October 1st 2011 to September 30th 2016, 51 of 1506 patients had preoperative evidence of myocardial damage...
July 2020: Journal of Critical Care Medicine
https://read.qxmd.com/read/32703548/a-restrictive-versus-liberal-transfusion-strategy-to-prevent-myocardial-injury-in-patients-undergoing-surgery-for-fractured-neck-of-femur-a-feasibility-randomised-trial-result-nof
#27
RANDOMIZED CONTROLLED TRIAL
Michael A Gillies, Sadia Ghaffar, Iain K Moppett, Annemarie B Docherty, Sarah Clarke, Nicola Rea, Jacqueline Stephen, Catriona Keerie, David C Ray, Timothy O White, Alasdair M J MacLullich, Nicholas M Mills, Megan R Rowley, Krishna Murthy, Rupert M Pearse, Simon J Stanworth, Timothy S Walsh
BACKGROUND: The optimum transfusion strategy in patients with fractured neck of femur is uncertain, particularly if there is coexisting cardiovascular disease. METHODS: We conducted a prospective, single-centre, randomised feasibility trial of two transfusion strategies. We randomly assigned patients undergoing surgery for fractured neck of femur to a restrictive (haemoglobin, 70-90 g L-1 ) or liberal (haemoglobin, 90-110 g L-1 ) transfusion strategy throughout their hospitalisation...
January 2021: British Journal of Anaesthesia
https://read.qxmd.com/read/32657745/prevalence-of-a-postoperative-troponin-leak-in-patients-with-cardiac-risk-factors-undergoing-knee-and-hip-arthroplasty-in-a-south-african-population
#28
JOURNAL ARTICLE
R D Van Zyl, M C Burger, J D Jordaan
BACKGROUND: Patients undergoing arthroplasty may have comorbidities that put them at risk of myocardial injury after non-cardiac surgery (MINS). MINS, a new clinical concept that has a different pathophysiology from conventional myocardial infarction, is related to a supply-demand mismatch ischaemia in the perioperative setting. MINS is often a silent event, and the diagnosis relies on cardiac biomarker testing such as troponin T. The incidence is estimated at 40%, with a fourfold increase in morbidity and mortality risk 1 year post surgery...
March 30, 2020: South African Medical Journal
https://read.qxmd.com/read/32466360/effects-of-anesthesia-techniques-on-outcomes-after-hip-fracture-surgery-in-elderly-patients-a-prospective-randomized-controlled-trial
#29
JOURNAL ARTICLE
Seokyung Shin, Seung Hyun Kim, Kwan Kyu Park, Seon Ju Kim, Jae Chan Bae, Yong Seon Choi
The superiority of distinct anesthesia methods for geriatric hip fracture surgery remains unclear. We evaluated high mobility group box-1 (HMGB1) and interleukin-6 (IL-6) with three different anesthesia methods in elderly patients undergoing hip fracture surgery. Routine blood test findings, postoperative morbidity, and mortality were assessed as secondary outcome. In total, 176 patients were randomized into desflurane ( n = 60), propofol ( n = 58), or spinal groups ( n = 58) that received desflurane-based balanced anesthesia, propofol-based total intravenous anesthesia (TIVA), or spinal anesthesia, respectively...
May 26, 2020: Journal of Clinical Medicine
https://read.qxmd.com/read/32360086/risk-factors-for-major-adverse-cardiovascular-events-after-osteoporotic-hip-fracture-repair-surgery
#30
JOURNAL ARTICLE
M A Araguas, A Herrera, I Garrido, J Mateo, A P Mayoral, M Muñoz
Osteoporotic hip fracture (OHF) is an increasingly frequent age-related pathology, which results in high rates of functional loss and mortality within the first year after surgery. This study assessed whether preoperative levels of brain natriuretic peptide (NT-proBNP) and troponin I were related to early occurrence (30d) of major adverse cardio-vascular events (MACE) after OHF repair surgery. During a 6-month period, perioperative clinical and analytical data from consecutive patients, without known history of cardiovascular disease and undergoing surgery for OHF repair at a single centre, were prospectively collected...
April 2020: Injury
https://read.qxmd.com/read/32253610/perioperative-myocardial-injury-risk-after-elective-knee-and-hip-arthroplasty-in-patients-with-a-high-risk-of-obstructive-sleep-apnea
#31
JOURNAL ARTICLE
Steven Lee, A J Hirsch Allen, Erin Morley, Petrus Swart, William Henderson, Rachel Jen, Najib Ayas
BACKGROUND: Myocardial injury after non-cardiac surgery (MINS) occurs in approximately 8-13% of patients and has significant 30-day mortality. Patients with obstructive sleep apnea (OSA) suffer recurrent hypoxemia during sleep and surgical patients with OSA are known to have increased risk of cardiorespiratory complications. We hypothesized that patients at high risk for OSA may have an increased risk of MINS. As a secondary analysis, we assessed rates of postoperative cardiopulmonary complications...
April 7, 2020: Sleep & Breathing
https://read.qxmd.com/read/32205547/individualized-fluid-management-using-the-pleth-variability-index-a-randomized-clinical-trial
#32
RANDOMIZED CONTROLLED TRIAL
Marc-Olivier Fischer, Sandrine Lemoine, Benoît Tavernier, Chems-Eddine Bouchakour, Vincent Colas, Marion Houard, William Greub, Georges Daccache, Christophe Hulet, Vincent Compère, Diane Taing, Emmanuel Lorne, Jean-Jacques Parienti, Jean-Luc Hanouz
BACKGROUND: The present trial was designed to assess whether individualized strategies of fluid administration using a noninvasive plethysmographic variability index could reduce the postoperative hospital length of stay and morbidity after intermediate-risk surgery. METHODS: This was a multicenter, randomized, nonblinded parallel-group clinical trial conducted in five hospitals. Adult patients in sinus rhythm having elective orthopedic surgery (knee or hip arthroplasty) under general anesthesia were enrolled...
July 2020: Anesthesiology
https://read.qxmd.com/read/31801725/the-effect-of-remote-ischaemic-preconditioning-on-myocardial-injury-in-emergency-hip-fracture-surgery-pixie-trial-phase-ii-randomised-clinical-trial
#33
RANDOMIZED CONTROLLED TRIAL
Sarah Ekeloef, Morten Homilius, Maiken Stilling, Peter Ekeloef, Seda Koyuncu, Anna-Marie Bloch Münster, Christian S Meyhoff, Ossian Gundel, Julie Holst-Knudsen, Ole Mathiesen, Ismail Gögenur
OBJECTIVE: To investigate whether remote ischaemic preconditioning (RIPC) prevents myocardial injury in patients undergoing hip fracture surgery. DESIGN: Phase II, multicentre, randomised, observer blinded, clinical trial. SETTING: Three Danish university hospitals, 2015-17. PARTICIPANTS: 648 patients with cardiovascular risk factors undergoing hip fracture surgery. 286 patients were assigned to RIPC and 287 were assigned to standard practice (control group)...
December 4, 2019: BMJ: British Medical Journal
https://read.qxmd.com/read/30958967/serum-irisin-level-in-myocardial-infarction-patients-with-or-without-heart-failure
#34
JOURNAL ARTICLE
Nashwa A Abd El-Mottaleb, Heba M Galal, Khaled M El Maghraby, Aml I Gadallah
This study aimed to assess serum irisin level in myocardial infarction (MI) with or without heart failure (HF) and the possible relation between irisin and cardiac markers, tumor necrosis factor-α (TNF-α) and lipid profile. Eighty-six subjects were included (33 patients had MI, 33 patients had MI with HF, and 20 controls). Body mass index (BMI), waist/hip ratio (WHR), systolic and diastolic blood pressure (SBP and DBP), heart rate, and left ventricular ejection fraction (LVEF) were measured. Blood samples were withdrawn on admission for measuring irisin, cardiac markers, TNF-α, total cholesterol (TC), triglycerides (TGs), low-density lipoprotein-cholesterol concentration (LDL-C), and high-density lipoprotein-cholesterol concentration (HDL-C)...
October 2019: Canadian Journal of Physiology and Pharmacology
https://read.qxmd.com/read/30928924/comparison-of-combined-lumbar-and-sacral-plexus-block-with-sedation-versus-general-anaesthesia-on-postoperative-outcomes-in-elderly-patients-undergoing-hip-fracture-surgery-clsb-hipeld-study-protocol-for-a-prospective-multicentre-randomised-controlled-trial
#35
COMPARATIVE STUDY
Junfeng Zhang, Xiaofeng Wang, Hui Zhang, Zhuolin Shu, Wei Jiang
INTRODUCTION: Hip fracture in elderly people is a global public health problem, with substantial associated mortality and disability. Nearly all patients with hip fracture undergo surgical treatment, but optimal anaesthesia for hip fracture surgery in elderly patients is still inconclusive. Ultrasound-guided combined lumbar and sacral plexus block has been widely used in hip fracture surgery in recent years, especially for some high-risk patients. However, it is not clear whether it can improve the postoperative outcomes of elderly patients with hip fracture...
March 30, 2019: BMJ Open
https://read.qxmd.com/read/30719421/perioperative-cardiac-troponin-i-levels-in-patients-undergoing-total-hip-and-total-knee-arthroplasty-a-single-center-study
#36
JOURNAL ARTICLE
Mir Mohammad Taghi Mortazavi, Jafar Ganjpour Sales, Masoud Nouri-Vaskeh, Masoud Parish, Salar Abdolhosseynzadeh
Background: Cardiac injury is one of the significant perioperative complications in major orthopedic surgeries and its early diagnosis is useful in the reduction of postoperative comorbidity. The cardiac troponin is a sensitive and specific biomarker for detecting this damage. Objectives: The aim of this study was to evaluate the levels of perioperative cardiac troponin I (cTnI) before and after arthroplasty in patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA)...
December 2018: Anesthesiology and Pain Medicine
https://read.qxmd.com/read/30508032/2018-update-on-medical-overuse
#37
REVIEW
Daniel J Morgan, Sanket S Dhruva, Eric R Coon, Scott M Wright, Deborah Korenstein
Importance: Overuse of medical care is a well-recognized problem in health care, associated with patient harm and costs. We sought to identify and highlight original research articles published in 2017 that are most relevant to understanding medical overuse. Observations: A structured review of English-language articles published in 2017 was performed, coupled with examination of tables of contents of high-impact journals to identify articles related to medical overuse in adult care...
February 1, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/30371649/takotsubo-syndrome-triggered-by-emotional-and-physical-stress-due-to-coincidental-immobilization-resembling-the-experimental-model-of-the-disease-a-case-report
#38
JOURNAL ARTICLE
Waldemar Elikowski, Małgorzata Małek-Elikowska, Natalia Fertała, Magdalena Zawodna, Alina Baszko, Zofia Trypuć
The term takotsubo syndrome (TTS) is derived from a comparison of left ventricular (LV) appearance in its apical form to the shape of the pot which is a trap used for octopus catching. In the classical animal model on rats, its occurrence can be triggered by experimental immobilization (IMO). Former observations of capture myopathy, seen in animals after extreme exertion, showed coexistence of rhabdomyolysis related to skeletal muscle injury and myocardial damage. The authors describe a case of a 66-year-old obese female in whom TTS was triggered by an uncommonly stressful event when she had been trapped in the bathtub for several hours...
October 29, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/30017140/-perioperative-lumbar-plexus-block-and-cardiac-ischemia-in-patients-with-hip-fracture-randomized-clinical-trial
#39
JOURNAL ARTICLE
Fernando R Altermatt, Ghislaine C Echevarría, René F de la Fuente, Ricardo Baeza, Marcela Ferrada, Juan C de la Cuadra, Marcia A Corvetto
BACKGROUND: Perioperative myocardial ischemia is common among patients undergoing hip fracture surgery. Our aim is to evaluate the efficacy of perioperative continuous lumbar plexus block in reducing the risk of cardiac ischemic events of elderly patients undergoing surgery for hip fractures, expressed as a reduction of ischemic events per subject. METHODS: Patients older than 60 years, ASA II-III, with risk factors for or known coronary artery disease were enrolled in this randomized controlled study...
September 2018: Revista Brasileira de Anestesiologia
https://read.qxmd.com/read/29931346/tnnt1-nemaline-myopathy-natural-history-and-therapeutic-frontier
#40
JOURNAL ARTICLE
Michael D Fox, Vincent J Carson, Han-Zhong Feng, Michael W Lawlor, John T Gray, Karlla W Brigatti, J-P Jin, Kevin A Strauss
We describe the natural history of 'Amish' nemaline myopathy (ANM), an infantile-onset, lethal disease linked to a pathogenic c.505G>T nonsense mutation of TNNT1, which encodes the slow fiber isoform of troponin T (TNNT1; a.k.a. TnT). The TNNT1 c.505G>T allele has a carrier frequency of 6.5% within Old Order Amish settlements of North America. We collected natural history data for 106 ANM patients born between 1923 and 2017. Over the last two decades, mean age of molecular diagnosis was 16 ± 27 days...
September 15, 2018: Human Molecular Genetics
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