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https://www.readbyqxmd.com/read/27890407/postoperative-tachycardia-clinically-meaningful-or-benign-consequence-of-orthopedic-surgery
#1
Alana E Sigmund, Yixin Fang, Matthew Chin, Harmony R Reynolds, Leora I Horwitz, Ezra Dweck, Eduardo Iturrate
OBJECTIVE: To determine the clinical significance of tachycardia in the postoperative period. PATIENTS AND METHODS: Individuals 18 years or older undergoing hip and knee arthroplasty were included in the study. Two data sets were collected from different time periods: development data set from January 1, 2011, through December 31, 2011, and validation data set from December 1, 2012, through September 1, 2014. We used the development data set to identify the optimal definition of tachycardia with the strongest association with the vascular composite outcome (pulmonary embolism and myocardial necrosis and infarction)...
November 24, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27499691/the-neutrophil-to-lymphocyte-ratio-on-admission-and-short-term-outcomes-in-orthogeriatric-patients
#2
Alexander Fisher, Wichat Srikusalanukul, Leon Fisher, Paul Smith
AIM: To investigate the association of the neutrophil to lymphocyte ratio (NLR) at admission with presence of fracture, comorbid conditions, and its prognostic value for short-term outcomes in orthogeriatric patients. METHODS: On 415 consecutive patients (mean age 78.8 ±8.7[SD] years, 281 women, 255 with a non-vertebral bone fracture, including 167 with a hip fracture, HF) admitted to the Department of Orthopaedic Surgery at the Canberra hospital (2010 - 2011) data on clinical and laboratory characteristics were collected prospectively...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27497658/obesity-and-novel-cardiovascular-markers-in-a-population-without-diabetes-and-cardiovascular-disease-in-china
#3
Qiang Zeng, Sheng-Yong Dong, Man-Liu Wang, Jin-Ming Li, Chong-Lei Ren, Chang-Qing Gao
OBJECTIVE: To investigate associations of novel cardiovascular markers with obesity in a general population. METHODS: A total of 9361 individuals without diabetes or cardiovascular disease were studied between 2009 and 2012 in China. High-sensitivity cardiac troponin T (hs-cTnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), brachial-ankle pulse wave velocity (baPWV), pulse pressure, and central systolic blood pressure (cSBP) were assessed according to body mass index (BMI) levels and different BMI/metabolic syndrome (MetS) combinations...
October 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27217733/correlation-between-vitamin-d-levels-and-muscle-fatigue-risk-factors-based-on-physical-activity-in-healthy-older-adults
#4
Einas S Al-Eisa, Ahmad H Alghadir, Sami A Gabr
PURPOSE: The purpose of this study was to investigate the relationship of serum vitamin D levels with physical activity, obesity, muscle fatigue biomarkers, and total antioxidant capacity (TAC) in healthy older adults. METHODS: A total of 85 healthy older subjects aged 64-96 years were recruited in this study. Based on estimated energy expenditure scores, the participants were classified into three groups: inactive (n=25), moderate (n=20), and physically active (n=35)...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/26911583/predicting-the-outcome-of-hip-fracture-patients-by-using-n-terminal-fragment-of-pro-b-type-natriuretic-peptide
#5
Pauliina Nordling, Tuomas Kiviniemi, Marjatta Strandberg, Niko Strandberg, Juhani Airaksinen
OBJECTIVE: To examine the prognostic value of perioperative N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) in hip fracture patients. DESIGN: Blinded prospective cohort study. SETTING: Single centre trial at Turku University Hospital in Finland. PARTICIPANTS: Inclusion criterion was admittance to the study hospital due to hip fracture during the trial period of October 2009--May 2010. Exclusion criteria were the patient's refusal and inadequate laboratory tests...
2016: BMJ Open
https://www.readbyqxmd.com/read/26592377/transfusion-strategy-in-hematological-intensive-care-unit-study-protocol-for-a-randomized-controlled-trial
#6
RANDOMIZED CONTROLLED TRIAL
Sylvain P Chantepie, Jean-Baptiste Mear, Lydia Guittet, Benoît Dervaux, Jean-Pierre Marolleau, Fabrice Jardin, Jean-Jacques Dutheil, Jean-Jacques Parienti, Jean-Pierre Vilque, Oumedaly Reman
BACKGROUND: Packed red blood cell (PRBC) transfusion is required in hematology patients treated with chemotherapy for acute leukemia, autologous (auto) or allogeneic (allo) hematopoietic stem cell transplantation (HSCT). In certain situations like septic shock, hip surgery, coronary disease or gastrointestinal hemorrhage, a restrictive transfusion strategy is associated with a reduction of infection and death. A transfusion strategy using a single PRBC unit has been retrospectively investigated and showed a safe reduction of PRBC consumption and costs...
2015: Trials
https://www.readbyqxmd.com/read/26563767/acute-coronary-syndromes-with-significant-troponin-increase-in-patients-with-hip-fracture-prior-to-surgical-repair-differential-diagnosis-and-clinical-implications
#7
Carlo Rostagno, Alessandra Cammilli, Annalaura Di Cristo, Gian Luca Polidori, Claudia Ranalli, Alessandro Cartei, Roberto Buzzi, Domenico Prisco
Myocardial infarction after hip fracture but before surgical repair is associated with a 30-day mortality as high as 30 % at 1 month. In Florence, since 2011, hip fractures are referred to a multidisciplinary hip fracture team including internal medicine specialists, anesthesiologists, and orthopaedic surgeons. The aim of the present investigation was to evaluate the clinical characteristics of patients with hip fracture who had at hospital admission a significant increase of troponin (>10 times reference levels), the diagnostic and therapeutic strategies adopted, and overall 1-year survival...
March 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/26537815/the-opvi-trial-perioperative-hemodynamic-optimization-using-the-plethysmographic-variability-index-in-orthopedic-surgery-study-protocol-for-a-multicenter-randomized-controlled-trial
#8
RANDOMIZED CONTROLLED TRIAL
Marc-Olivier Fischer, Georges Daccache, Sandrine Lemoine, Benoît Tavernier, Vincent Compère, Christophe Hulet, Chems Eddine Bouchakour, Christophe Canevet, Jean-Louis Gérard, Lydia Guittet, Emmanuel Lorne, Jean-Luc Hanouz, Jean-Jacques Parienti
BACKGROUND: Hemodynamic optimization during surgery is of major importance to decrease postoperative morbidity and length of hospital stay. However, conventional cardiac output monitoring is rarely used at the bedside. Recently, the plethysmographic variability index (PVI) was described as a simplified alternative, using plug-and-play noninvasive technology, but its clinical utility remains to be established. METHODS/DESIGN: The hemodynamic optimization using the PVI (OPVI) trial is a multicenter randomized controlled two-arm trial, randomizing 440 patients at intermediate risk of postoperative complications after orthopedic surgery...
2015: Trials
https://www.readbyqxmd.com/read/26156715/myocardial-ischaemia-after-hip-and-knee-arthroplasty-incidence-and-risk-factors
#9
Anne Ruth Bass, Tomás Rodriguez, Gina Hyun, Francisco Gerardo Santiago, Jacqueline Ilji Kim, Scott Christopher Woller, Brian Foster Gage
PURPOSE: Because the occurrence of postoperative myocardial ischaemia (MI) predicts subsequent cardiac morbidity and mortality, we determined the prevalence of and risk factors for MI in hip and knee arthroplasty patients. METHODS: High-sensitivity cardiac troponin T (hs-cTnT) was measured on stored samples from postoperative day two in 394 hip and knee arthroplasty patients ≥ 65 years of age enrolled in the Genetics-InFormatics Trial (GIFT). RESULTS: Fifty-three (13...
October 2015: International Orthopaedics
https://www.readbyqxmd.com/read/26100650/pharmacologic-options-for-the-treatment-of-sarcopenia
#10
REVIEW
John E Morley
Sarcopenia is now clinically defined as a loss of muscle mass coupled with functional deterioration (either walking speed or distance or grip strength). Based on the FRAX studies suggesting that the questions without bone mineral density can be used to screen for osteoporosis, there is now a valid simple questionnaire to screen for sarcopenia, i.e., the SARC-F. Numerous factors have been implicated in the pathophysiology of sarcopenia. These include genetic factors, mitochondrial defects, decreased anabolic hormones (e...
April 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/26033978/coronary-high-intensity-plaque-on-t1-weighted-magnetic-resonance-imaging-and-its-association-with-myocardial-injury-after-percutaneous-coronary-intervention
#11
Tomoya Hoshi, Akira Sato, Daiki Akiyama, Daigo Hiraya, Shunsuke Sakai, Masashi Shindo, Kensaku Mori, Manabu Minami, Kazutaka Aonuma
AIMS: Non-contrast T1-weighted imaging (T1WI) has emerged as a novel non-invasive imaging for vulnerable coronary plaque showing a high-intensity plaque (HIP). However, the association between HIP and percutaneous coronary intervention (PCI) has not been evaluated. We investigated the association between the presence of HIP and the incidence of myocardial injury after PCI. METHODS AND RESULTS: A total of 77 patients with stable angina were imaged with non-contrast T1WI by using a 1...
August 1, 2015: European Heart Journal
https://www.readbyqxmd.com/read/25890628/relation-of-perioperative-elevation-of-troponin-to-long-term-mortality-after-orthopedic-surgery
#12
Brandon S Oberweis, Nathaniel R Smilowitz, Swetha Nukala, Andrew Rosenberg, Jinfeng Xu, Steven Stuchin, Richard Iorio, Thomas Errico, Martha J Radford, Jeffrey S Berger
Myocardial necrosis in the perioperative period of noncardiac surgery is associated with short-term mortality, but long-term outcomes have not been characterized. We investigated the association between perioperative troponin elevation and long-term mortality in a retrospective study of consecutive subjects who underwent hip, knee, and spine surgery. Perioperative myocardial necrosis and International Classification of Disease, Ninth Revision-coded myocardial infarction (MI) were recorded. Long-term survival was assessed using the Social Security Death Index database...
June 15, 2015: American Journal of Cardiology
https://www.readbyqxmd.com/read/25841593/structural-and-functional-screening-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-accurately-identifies-cardiotoxicity-of-multiple-drug-types
#13
Kimberly R Doherty, Dominique R Talbert, Patricia B Trusk, Diarmuid M Moran, Scott A Shell, Sarah Bacus
Safety pharmacology studies that evaluate new drug entities for potential cardiac liability remain a critical component of drug development. Current studies have shown that in vitro tests utilizing human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM) may be beneficial for preclinical risk evaluation. We recently demonstrated that an in vitro multi-parameter test panel assessing overall cardiac health and function could accurately reflect the associated clinical cardiotoxicity of 4 FDA-approved targeted oncology agents using hiPS-CM...
May 15, 2015: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/25589886/liver-function-parameters-in-hip-fracture-patients-relations-to-age-adipokines-comorbidities-and-outcomes
#14
Leon Fisher, Wichat Srikusalanukul, Alexander Fisher, Paul Smith
AIM: To asses liver markers in older patients with hip fracture (HF) in relation to age, comorbidities, metabolic characteristics and short-term outcomes. METHODS: In 294 patients with HF (mean age 82.0±7.9 years, 72.1% women) serum alanine aminotransferase (ALT), gammaglutamyltransferase (GGT), alkaline phosphatase (ALP), albumin, bilirubin, 25(OH)vitaminD, PTH, calcium, phosphate, magnesium, adiponectin, leptin, resistin, thyroid function and cardiac troponin I were measured...
2015: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/25478387/varicose-vein-trauma-a-risk-for-pulmonary-embolism
#15
Parijat S Joy, Creticus P Marak, Anna M Ponea, Achuta K Guddati
Pulmonary embolism (PE) is a deceptive condition which is often incorrectly diagnosed leading to high morbidity and mortality. We present a case where symptoms were localised to different areas of the body starting with post-traumatic pain over lower extremity varicosities that migrated sequentially over a month to the knee, hip, back, abdomen and chest finally presenting as syncope. Despite a low pre-test clinical probability, a very high index of suspicion led to a timely diagnosis of a massive bilateral PE that eventually caused a troponin leak...
October 2014: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/25132247/does-dexmedetomidine-have-a-cardiac-protective-effect-during-non-cardiac-surgery-a-randomised-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Lili Xu, Zhiyong Hu, Jianjun Shen, Patrick M McQuillan
This study was designed to determine the effects of dexmedetomidine on perioperative myocardial injury by observing peripheral circulatory changes in response to tracheal intubation and extubation, myocardial enzyme levels, myocardial ischaemia improvements, cardiovascular adverse events and cytokines in patients with coronary heart disease (CHD) undergoing non-cardiac surgery. This study was a prospective, randomized, double-blind trial. Eighty patients having CHD were scheduled for elective hip-replacement surgery and randomly allocated to receive a loading dose of 1 μg/kg dexmedetomidine followed by a 0...
November 2014: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/24856320/usefulness-of-troponin-t-to-predict-short-term-and-long-term-mortality-in-patients-after-hip-fracture
#17
Pauliina Hietala, Marjatta Strandberg, Tuomas Kiviniemi, Niko Strandberg, K E Juhani Airaksinen
The purpose was to evaluate the short-term (30-day) and long-term (1,000-day) prognostic values of perioperative troponin T (TnT) and electrocardiographic (ECG) findings in hip fracture patients. A consecutive cohort of 200 patients (68 men) was enrolled. Blinded TnT levels and ECG were assessed on admission, before operation, and on first and second postoperative days. Median (interquartile range) follow-up time was 3.1 (0.3) years. TnT elevation was observed in 71 patients (35.5%): already before the operation in 36 patients (51%) and only after surgery in 35 patients (49%)...
July 15, 2014: American Journal of Cardiology
https://www.readbyqxmd.com/read/24745719/unprovoked-proximal-venous-thrombosis-is-associated-with-an-increased-risk-of-asymptomatic-pulmonary-embolism
#18
Anja Boc, Nina Vene, Monika Stalc, Katarina Košmelj, Alenka Mavri
INTRODUCTION: Pulmonary embolism (PE) is common in patients with deep venous thrombosis (DVT). The outcome of DVT with concomitant symptomatic PE is worse than the outcome of isolated DVT. The risk factors for DVT and simultaneous asymptomatic PE have not been systematically studied yet. AIM: To evaluate the frequency and risk factors for asymptomatic PE in patients with DVT. PATIENTS/METHODS: In 155 consecutive patients with a first episode of DVT and no PE symptoms, a ventilation-perfusion lung scan was performed...
June 2014: Thrombosis Research
https://www.readbyqxmd.com/read/24030425/enhanced-survival-of-transplanted-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-by-the-combination-of-cell-sheets-with-the-pedicled-omental-flap-technique-in-a-porcine-heart
#19
Masashi Kawamura, Shigeru Miyagawa, Satsuki Fukushima, Atsuhiro Saito, Kenji Miki, Emiko Ito, Nagako Sougawa, Takuji Kawamura, Takashi Daimon, Tatsuya Shimizu, Teruo Okano, Koichi Toda, Yoshiki Sawa
BACKGROUND: Transplantation of cardiomyocytes that are derived from human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) shows promise in generating new functional myocardium in situ, whereas the survival and functionality of the transplanted cells are critical in considering this therapeutic impact. Cell-sheet method has been used to transplant many functional cells; however, potential ischemia might limit cell survival. The omentum, which is known to have rich vasculature, is expected to be a source of blood supply...
September 10, 2013: Circulation
https://www.readbyqxmd.com/read/23592605/hypobaric-spinal-anesthesia-with-ropivacaine-plus-sufentanil-for-traumatic-femoral-neck-surgery-in-the-elderly-a-dose-response-study
#20
RANDOMIZED CONTROLLED TRIAL
Marc Lilot, Pascal Meuret, Lionel Bouvet, Liana Caruso, Rabia Dabouz, Robert Deléat-Besson, Bernard Rousselet, Bruno Thouverez, Abbès Zadam, Bernard Allaouchiche, Emmanuel Boselli
BACKGROUND: In this randomized, prospective trial, we sought to determine the effective dose of hypobaric ropivacaine with sufentanil providing 95% success (ED95) in spinal anesthesia for traumatic femoral neck surgery in the elderly. METHODS: Sixty-eight elderly patients with unilateral hip fracture randomly received 6, 8, 10, or 12 mg spinal hypobaric ropivacaine combined with 5 µg sufentanil. Patients remained in a lateral position for 15 minutes after spinal injection...
July 2013: Anesthesia and Analgesia
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