keyword
https://read.qxmd.com/read/35907315/tolerance-of-hydrocortisone-prophylaxis-administration-in-extreme-preterm-neonates-experience-of-a-single-uk-level-iii-neonatal-unit
#21
JOURNAL ARTICLE
Alexandra Briscoe, Chinthika Piyasena, Virginie Meau-Petit
OBJECTIVE: To assess the safety of the routine use of low-dose prophylactic hydrocortisone to improve survival without bronchopulmonary dysplasia (BPD) in infants born <28 weeks' gestation. DESIGN: A single-centre retrospective cohort study of infants born <28 weeks, before and after hydrocortisone implementation. Data was collected from electronic patient records and compared between both groups. MAIN OUTCOME MEASURES: The incidence of serious adverse events associated with hydrocortisone use was measured in each group...
August 2022: Early Human Development
https://read.qxmd.com/read/35820608/latency-of-late-preterm-steroid-administration-to-delivery-and-risk-of-neonatal-hypoglycemia
#22
JOURNAL ARTICLE
Eliza R McElwee, Kyla Wilkinson, Rebecca Crowe, K Thomas Hardy, Jill C Newman, Alison Chapman, Rebecca Wineland, Matthew M Finneran
BACKGROUND: Late preterm antenatal corticosteroid administration has been associated with an increased risk of neonatal hypoglycemia. The mechanism is thought to be secondary to transient fetal hyperinsulinemia, which may be more likely if delivery occurs during peak antenatal corticosteroid levels. OBJECTIVE: This study aimed to investigate whether there is a latency interval between antenatal corticosteroid administration and delivery that places neonates at the greatest risk of hypoglycemia...
September 2022: American journal of obstetrics & gynecology MFM
https://read.qxmd.com/read/35618748/the-effects-of-betamethasone-on-the-amplitude-integrated-eeg-of-infants-born-at-34-or-35-weeks-gestation
#23
RANDOMIZED CONTROLLED TRIAL
Abbot R Laptook, Lina Chalak, Athina Pappas, Alexis Davis, Pablo J Sanchez, Krisa P Van Meurs, William Oh, Ross Sommers, Seetha Shankaran, Angelita M Hensman, Dwight J Rouse, Scott McDonald, Abhik Das, Ronald N Goldberg, Namasivayam Ambalavanan, Cynthia Gyamfi-Bannerman, Elizabeth A Thom, Rosemary D Higgins
OBJECTIVE: Assess if maternal betamethasone administration at 34-35 weeks accelerated neonatal amplitude integrated EEG (aEEG) maturation. STUDY DESIGN: Nested, observational cohort in 7 centers participating in the Antenatal Late Preterm Steroid randomized trial. Up to 2 aEEGs were obtained in neonates born from 340 -356 weeks gestation before 72 h (aEEG 1) and at 5-7 days (aEEG 2) if hospitalized. Personnel and aEEG central readers were masked to the intervention...
December 2022: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/35583868/us-incidence-of-late-preterm-steroid-use-and-associated-neonatal-respiratory-morbidity-after-publication-of-the-antenatal-late-preterm-steroids-trial-2015-2017
#24
JOURNAL ARTICLE
Mark A Clapp, Alexander Melamed, Taylor S Freret, Kaitlyn E James, Cynthia Gyamfi-Bannerman, Anjali J Kaimal
IMPORTANCE: The Antenatal Late Preterm Steroids (ALPS) trial demonstrated a 20% reduction in the risk of respiratory complications in neonates at risk for a late-preterm birth who were exposed to antenatal corticosteroids compared with those who were not. OBJECTIVE: To assess whether new evidence of steroid administration for neonatal respiratory benefit in the late-preterm period is associated with changes in obstetric practice and the use of assisted ventilation for the neonate after delivery...
May 2, 2022: JAMA Network Open
https://read.qxmd.com/read/35402112/incidence-of-hyponatremia-and-associated-factors-in-preterm-infants-in-saudi-arabia
#25
JOURNAL ARTICLE
Maha Bamehrez
OBJECTIVE: To investigate the incidence of hyponatremia in preterm infants. The secondary aim was to determine the risk factors of late-onset of hyponatremia (LOH) and their influence on neonatal outcomes. STUDY DESIGN: The present study is a retrospective cohort study of 71 preterm infants born before 32 weeks of gestation at King Abdulaziz University Hospital and admitted to the neonatal intensive care unit, level 3, from January to December 2019. Hyponatremia was defined as a sodium level ≤ 132 mEq/L...
April 2022: Curēus
https://read.qxmd.com/read/35346889/euglycemia-after-antenatal-late-preterm-steroids-a-multicenter-randomized-controlled-trial
#26
RANDOMIZED CONTROLLED TRIAL
Ashley N Battarbee, Yuanfan Ye, Jeff M Szychowski, Brian M Casey, Alan T Tita, Kim A Boggess
BACKGROUND: Late preterm steroid administration can induce transient maternal and thus fetal hyperglycemia, which can increase production of fetal insulin and C-peptide. Infants delivered in this setting are subsequently at increased risk for hypoglycemia. Although maternal glycemic control before delivery is a key component of care for parturients with diabetes, this intervention has not been studied in the setting of late preterm steroid administration. OBJECTIVE: This study aimed to determine the effect of maternal screening for and treatment of hyperglycemia after late preterm steroid administration on fetal C-peptide levels and other metabolic markers...
July 2022: American journal of obstetrics & gynecology MFM
https://read.qxmd.com/read/35341727/the-impact-of-the-antenatal-late-preterm-steroids-trial-on-the-administration-of-antenatal-corticosteroids
#27
JOURNAL ARTICLE
Elise O R Kearsey, Jasper V Been, Vivienne L Souter, Sarah J Stock
BACKGROUND: In 2016 the Antenatal Late Preterm Steroids study was published, demonstrating that antenatal corticosteroid therapy given to women at risk of late preterm delivery reduces respiratory morbidity in infants. However, the administration of antenatal corticosteroid therapy in late-preterm infants remains controversial. Late-preterm infants do not suffer from the same rates of morbidity as early-preterm infants, and the short-term benefits of antenatal corticosteroid therapy are less pronounced; consequently, the risk of possible harm is more difficult to balance...
August 2022: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/35146694/antenatal-steroids-and-cord-blood-t-cell-glucocorticoid-receptor-dna-methylation-and-exon-1-splicing
#28
JOURNAL ARTICLE
Jeanette R Carpenter, Kathleen A Jablonski, Jordan Koncinsky, Michael W Varner, Cynthia Gyamfi-Bannerman, Lisa A Joss-Moore
Antenatal administration of glucocorticoids such as betamethasone (BMZ) during the late preterm period improves neonatal respiratory outcomes. However, glucocorticoids may elicit programming effects on immune function and gene regulation. Here, we test the hypothesis that exposure to antenatal BMZ alters cord blood immune cell composition in association with altered DNA methylation and alternatively expressed Exon 1 transcripts of the glucocorticoid receptor (GR) gene in cord blood CD4+ T-cells. Cord blood was collected from 51 subjects in the Antenatal Late Preterm Steroids Trial: 27 BMZ, 24 placebo...
February 10, 2022: Reproductive Sciences
https://read.qxmd.com/read/34981851/improving-the-external-validity-of-antenatal-late-preterm-steroids-trial-findings
#29
JOURNAL ARTICLE
Jennifer A Hutcheon, Jessica Liauw
BACKGROUND: The external validity of randomised trials can be compromised when trial participants differ from real-world populations. In the Antenatal Late Preterm Steroids (ALPS) trial of antenatal corticosteroids at late preterm ages, participants had systematically younger gestational ages than those outside the trial setting. As risk of respiratory morbidity (the primary trial outcome) is higher at younger gestations, absolute benefits of corticosteroids calculated in the trial population may overestimate real-world treatment benefits...
January 2023: Paediatric and Perinatal Epidemiology
https://read.qxmd.com/read/34949936/a-comparative-study-of-the-respiratory-neonatal-outcomes-utilizing-dexamethasone-sodium-phosphate-versus-a-mixture-of-betamethasone-dipropionate-and-betamethasone-sodium-phosphate-as-an-antenatal-corticosteroid-therapy
#30
JOURNAL ARTICLE
Omar F Altal, Ahmed H Al Sharie, Yazan O Al Zu'bi, Saif Aldin Rawabdeh, Wasim Khasawneh, Tamara Dawaymeh, Haneen Tashtoush, Rawan Obeidat, Omar M Halalsheh
OBJECTIVE: The aim of this study is to compare the respiratory neonatal outcomes utilizing antenatal dexamethasone sodium phosphate (DSP) versus a mixture of betamethasone dipropionate and betamethasone sodium phosphate (B-DP/SP) for preterm births. PATIENTS AND METHODS: All neonatal intensive care unit (NICU) admissions for prematurity were retrospectively identified at our center in the period between September 2016 and September 2018. Pregnant women expected to give preterm birth and received steroid injections whether it is DSP or B-DP/SP were included in the study...
2021: International Journal of General Medicine
https://read.qxmd.com/read/34787903/comparison-of-neonatal-outcomes-with-and-without-the-administration-of-betamethasone-in-late-preterm-births
#31
JOURNAL ARTICLE
Ayca N Bulut, Cevat R Cundubey, Venhar Ceyhan, Emine Aydin
OBJECTIVE: To evaluate the effects of antenatal steroid administration on neonatal outcomes in late preterm births. METHODS: Demographic and neonatal data from women who gave birth between May 2018 and March 2021 at 34+0 -36+6  weeks of gestation were screened from the information system of the hospital. The patients were assigned to two groups: those who were and those who were not given steroids. All parameters were compared between the two groups. RESULTS: The 1-minute (9 versus 8) and 5-minute (10 versus 9) Apgar scores, need for a neonatal intensive care unit (NICU) stay (23...
February 2022: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/34775487/neonatal-hypoglycemia-after-antenatal-late-preterm-steroids-in-individuals-with-diabetes
#32
JOURNAL ARTICLE
Annie M Dude, Lynn M Yee, Andrea Henricks, Patrick Eucalitto, Nevert Badreldin
OBJECTIVE: To establish whether administration of antenatal late preterm steroids to pregnant people with diabetes resulted in higher risk of neonatal hypoglycemia. STUDY DESIGN: This is a retrospective cohort study of individuals with pre-gestational or gestational diabetes admitted between 34 0/7-36 6/7 weeks' gestation before and after introduction of an antenatal late preterm steroids protocol. The primary outcome was any neonatal blood glucose ≤ 60 mg/dL in the first 24 h of life...
December 2021: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/34595358/ten-year-trend-of-care-practices-morbidities-and-survival-of-very-preterm-neonates-in-the-malaysian-national-neonatal-registry-a-retrospective-cohort-study
#33
JOURNAL ARTICLE
Nem Yun Boo, Seok Chiong Chee, Siew Hong Neoh, Eric Boon-Kuang Ang, Ee Lee Ang, Pauline Choo, Azanna Ahmad Kamar, Farah Inaz Syed-Abdullah, Ann Cheng Wong
Objectives: To determine a 10-year trend of survival, morbidities and care practices, and predictors of in-hospital mortality in very preterm neonates (VPTN, gestation 22 to <32 weeks) in the Malaysian National Neonatal Registry. Design: Retrospective cohort study. Setting: 43 Malaysian neonatal intensive care units. Patients: 29 010 VPTN (without major malformations) admitted between 1 January 2009 and 31 December 2018...
2021: BMJ Paediatrics Open
https://read.qxmd.com/read/34537463/risk-factors-for-periventricular-leukomalacia-in-preterm-infants-a-systematic-review-meta-analysis-and-grade-based-assessment-of-certainty-of-evidence
#34
JOURNAL ARTICLE
Thangaraj Abiramalatha, Tapas Bandyopadhyay, Viraraghavan Vadakkencherry Ramaswamy, Nasreen Banu Shaik, Sivam Thanigainathan, Abdul Kareem Pullattayil, Prakash Amboiram
BACKGROUND: We analyzed the certainty of evidence (CoE) for risk factors of periventricular leukomalacia (PVL) in preterm neonates, a common morbidity of prematurity. METHODS: Medline, CENTRAL, Embase, and CINAHL were searched. Cohort and case-control studies and randomised randomized controlled trials were included. Data extraction was performed in duplicate. A random random-effects meta-analysis was utilizedused. CoE was evaluated as per Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines...
November 2021: Pediatric Neurology
https://read.qxmd.com/read/34520057/figo-good-practice-recommendations-on-the-use-of-prenatal-corticosteroids-to-improve-outcomes-and-minimize-harm-in-babies-born-preterm
#35
JOURNAL ARTICLE
Jane Norman, Andrew Shennan, Bo Jacobsson, Sarah J Stock
For women with a singleton or a multiple pregnancy in situations where active neonatal care is appropriate, and for whom preterm birth is anticipated between 24 and 34 weeks of gestation, one course of prenatal corticosteroids should ideally be offered 18 to 72 h before preterm birth is expected to improve outcomes for the baby. However, if preterm birth is expected within 18 h, prenatal corticosteroids should still be administered. One course of corticosteroids includes two doses of betamethasone acetate/phosphate 12 mg IM 24 h apart, or two doses of dexamethasone phosphate 12 mg IM 24 h apart...
October 2021: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/34505639/glucocorticoids-regulate-mitochondrial-fatty-acid-oxidation-in-fetal-cardiomyocytes
#36
JOURNAL ARTICLE
Jessica R Ivy, Roderic N Carter, Jin-Feng Zhao, Charlotte Buckley, Helena Urquijo, Eva A Rog-Zielinska, Emma Panting, Lenka Hrabalkova, Cara Nicholson, Emma J Agnew, Matthew W Kemp, Nicholson N Morton, Sarah J Stock, Caitlin Wyrwoll, Ian G Ganley, Karen E Chapman
KEY POINTS: Glucocorticoids are steroid hormones that play a vital role in late pregnancy in maturing fetal organs, including the heart. In fetal cardiomyocytes in culture, glucocorticoids promote mitochondrial fatty acids oxidation, suggesting they facilitate the perinatal switch from carbohydrates to fatty acids as the predominant energy substrate. Administration of a synthetic glucocorticoid in late pregnancy in mice down-regulates the glucocorticoid receptor and interferes with the normal increase in genes involved in fatty acid metabolism in the heart...
September 10, 2021: Journal of Physiology
https://read.qxmd.com/read/34363784/society-for-maternal-fetal-medicine-consult-series-58-use-of-antenatal-corticosteroids-for-individuals-at-risk-for-late-preterm-delivery-replaces-smfm-statement-4-implementation-of-the-use-of-antenatal-corticosteroids-in-the-late-preterm-birth-period-in-women
#37
REVIEW
Uma M Reddy, Uma Deshmukh, Annie Dude, Lorie Harper, Sarah S Osmundson
The administration of antenatal corticosteroids has been widely adopted as the standard of care in the management of pregnancies at risk for preterm delivery before 37 weeks of gestation, with the primary goal of reducing neonatal morbidity. However, the long-term risks associated with antenatal corticosteroid use remain uncertain. The purpose of this Consult is to review the current literature on the benefits and risks of antenatal corticosteroid use in the late preterm period and to provide recommendations based on the available evidence...
November 2021: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/34058419/race-and-neonatal-respiratory-morbidity-in-the-late-preterm-period-race-and-late-term-respiratory-morbidity
#38
JOURNAL ARTICLE
Maria Andrikopoulou, Ukachi N Emeruwa, Elizabeth Ludwig, Eve Overton, Cynthia Gyamfi-Bannerman
BACKGROUND: Prematurity is one of the leading causes of perinatal morbidity and mortality. Some studies suggest that respiratory disease may differ by race in early preterm infants. However, the role of race in late term neonatal morbidity is not yet established. OBJECTIVE: The objective of our study was to determine whether neonatal respiratory morbidity differs by race in neonates born late preterm. STUDY DESIGN: This is a secondary analysis of a randomized trial of women at high risk for late preterm delivery (Antenatal Late Preterm Steroids, ALPS)...
May 28, 2021: American journal of obstetrics & gynecology MFM
https://read.qxmd.com/read/34044454/evaluation-of-hypoglycemia-in-neonates-of-women-at-risk-for-late-preterm-delivery-an-antenatal-late-preterm-steroids-trial-cohort-study
#39
JOURNAL ARTICLE
Cynthia Gyamfi-Bannerman, Kathleen A Jablonski, Sean C Blackwell, Alan T N Tita, Uma M Reddy, Lucky Jain, George R Saade, Dwight J Rouse, Erin A S Clark, John M Thorp, Edward K Chien, Alan M Peaceman, Ronald S Gibbs, Geeta K Swamy, Mary E Norton, Brian M Casey, Steve N Caritis, Jorge E Tolosa, Yoram Sorokin, J Peter VanDorsten
OBJECTIVE:  In the antenatal late preterm steroids (ALPS) trial betamethasone significantly decreased short-term neonatal respiratory morbidity but increased the risk of neonatal hypoglycemia, diagnosed only categorically (<40 mg/dL). We sought to better characterize the nature, duration, and treatment for hypoglycemia. STUDY DESIGN:  Secondary analysis of infants from ALPS, a multicenter trial randomizing women at risk for late preterm delivery to betamethasone or placebo...
May 27, 2021: American Journal of Perinatology
https://read.qxmd.com/read/33895731/morbidity-in-late-preterm-birth-a-retrospective-cohort-study-assessing-the-role-of-immaturity-versus-antecedent-factors
#40
JOURNAL ARTICLE
Melissa Lorenzo, Megan Laupacis, Wilma M Hopman, Imtiaz Ahmad, Faiza Khurshid
INTRODUCTION: Late preterm infants (LPIs) are infants born between 340/7 and 366/7 weeks gestation. Morbidities in these infants are commonly considered a result of prematurity; however, some research has suggested immaturity may not be the sole cause of morbidities. We hypothesize that antecedents leading to late preterm birth are associated with different patterns of morbidities and that morbidities are the result of gestational age superimposed by the underlying etiologies of preterm delivery...
2021: Neonatology
keyword
keyword
94202
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.