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Late preterm antenatal steroids

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https://www.readbyqxmd.com/read/27733360/antenatal-corticosteroids-for-maturity-of-term-or-near-term-fetuses-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#1
Gabriele Saccone, Vincenzo Berghella
OBJECTIVE:  To evaluate the effectiveness of antenatal corticosteroids given at ≥34 weeks' gestation. DESIGN:  Systematic review with meta-analysis. DATA SOURCES:  Electronic databases were searched from their inception to February 2016. ELIGIBILITY CRITERIA FOR STUDY SELECTION:  Randomized clinical trials comparing antenatal corticosteroids with placebo or no treatment in women with a singleton pregnancy at ≥34 weeks' gestation...
October 12, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27651621/respiratory-morbidity-in-late-preterm-births-a-prospective-observational-study-at-a-tertiary-care-hospital
#2
Nazia Shaikh, Shaweez Faizi, Lavanya Rai
OBJECTIVES: To study the neonatal respiratory morbidity in late-preterm neonates. MATERIALS AND METHODS: This study was done over a period of 6 months (November 2014-April 2015) including 120 late-preterm births at a tertiary referral center. RESULTS: Among the 120 late-preterm babies, 42 (35 %) developed respiratory morbidity. Respiratory distress syndrome (RDS) developed in 43 % of the babies who had not received steroid prophylaxis against 25...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27613336/modeling-the-impact-of-growth-and-leptin-deficits-on-the-neuronal-regulation-of-blood-pressure
#3
Baiba Steinbrekera, Robert D Roghair
The risk of hypertension is increased by intrauterine growth restriction (IUGR) and preterm birth. In the search for modifiable etiologies for this life-threatening cardiovascular morbidity, a number of pathways have been investigated, including excessive glucocorticoid exposure, nutritional deficiency, and aberration in sex hormone levels. As a neurotrophic hormone intimately involved in cardiovascular regulation whose levels are influenced by glucocorticoids, nutritional status and sex hormones, leptin has emerged as a putative etiologic and thus therapeutic agent...
September 9, 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27577326/area-based-study-identifies-risk-factors-associated-with-missed-antenatal-corticosteroid-prophylaxis-in-women-delivering-preterm-infants
#4
Luigi Gagliardi, Carolina Amador, Monia Puglia, Federico Mecacci, Simone Pratesi, Emilio Sigali, Barbara Tomasini, Franca Rusconi
AIM: All women delivering a preterm infant should receive antenatal corticosteroid prophylaxis, but many miss this opportunity. We determined the risk factors associated with missed prophylaxis in a geographically defined area of Italy. METHODS: We prospectively studied all mothers who delivered babies between 24 and 31 completed weeks of gestation, from 2009 to 2013, in all maternity units in Tuscany. RESULTS: Of 1,232 mothers, 186 (15.1%) did not receive prophylaxis...
August 31, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27518672/antenatal-betamethasone-for-women-at-risk-for-late-preterm-delivery
#5
LETTER
Gordon C S Smith
No abstract text is available yet for this article.
August 4, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27518671/antenatal-betamethasone-for-women-at-risk-for-late-preterm-delivery
#6
LETTER
Anke Redlich, Ralf Böttger, Serban D Costa
No abstract text is available yet for this article.
August 4, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27518670/antenatal-betamethasone-for-women-at-risk-for-late-preterm-delivery
#7
LETTER
Peter R Stutchfield, Sailesh Kotecha, Iolo J M Doull
No abstract text is available yet for this article.
August 4, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27518669/antenatal-betamethasone-for-women-at-risk-for-late-preterm-delivery
#8
LETTER
Cynthia Gyamfi-Bannerman, Elizabeth A Thom
No abstract text is available yet for this article.
August 4, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27411106/antenatal-steroid-exposure-in-the-late-preterm-period-is-associated-with-reduced-cord-blood-neurotrophin-3
#9
Nicolette A Hodyl, Tara M Crawford, Lorna McKerracher, Andrew Lawrence, Julia B Pitcher, Michael J Stark
BACKGROUND: Neurotrophins are proteins critically involved in neural growth, survival and differentiation, and therefore important for fetal brain development. Reduced cord blood neurotrophins have been observed in very preterm infants (<32weeks gestation) who subsequently develop brain injury. Antenatal steroid exposure can alter neurotrophin concentrations, yet studies to date have not examined whether this occurs in the late preterm infant (33-36weeks gestation), despite increasing recognition of subtle neurodevelopmental deficits in this population...
October 2016: Early Human Development
https://www.readbyqxmd.com/read/27405904/morbidity-and-mortality-of-preterm-infants-less-than-26-weeks-of-gestational-age
#10
Maria I Durães, Filipa Flor-DE-Lima, Gustavo Rocha, Henrique Soares, Hercília Guimarães
BACKGROUND: Extreme preterm infants have a high risk of morbidity and mortality. Newborns delivered between 23+0 and 25+6 weeks, are considered to be in the "gray zone" and have uncertain prognosis. For these children medical decision-making becomes complex and controversial. The present study intends to evaluate the neonatal morbidity and mortality of preterm infants born between 23 weeks and 25+6 weeks of gestational age. METHODS: A retrospective study was conducted including all inborn preterm infants, with a gestational age between 23+0 and 25+6 weeks, admitted to a level IIIC NICU, between 1st January, 1996 and 31th December, 2014...
July 13, 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/27342043/antenatal-corticosteroids-beyond-34-weeks-gestation-what%C3%A2-do%C3%A2-we%C3%A2-do%C3%A2-now
#11
REVIEW
Beena D Kamath-Rayne, Paul J Rozance, Robert L Goldenberg, Alan H Jobe
The practice of antenatal corticosteroid administration in pregnancies of 24-34 weeks of gestation that are at risk of preterm delivery was adopted over 20 years after the first randomized clinical trial in humans. It is biologically plausible that antenatal corticosteroid in pregnancies beyond 34 weeks of gestation would reduce rates of respiratory morbidity and neonatal intensive care admission. Mostly guided by the results of a large multicenter randomized trial of antenatal corticosteroid in late preterm infants, the Antenatal Late Preterm Steroids Trial, the American Congress of Obstetricians and Gynecologists has released a practice advisory that the "administration of betamethasone may be considered in women with a singleton pregnancy between 34 0/7 and 36 6/7 weeks of gestation at imminent risk of preterm birth within 7 days...
October 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27004981/preterm-cranial-ultrasound-scanning-is-both-feasible-and-effective-in-a-middle-income-country
#12
Pavel A Mazmanyan, Knarik V Nikoghosyan, Varsenik V Kerobyan, Kathy J Mellor, Jesus Diez-Sebastian, Miriam Martinez-Biarge, Frances M Cowan
AIM: Cranial ultrasound is seldom used in middle-income countries, and the burden of preterm brain injury and its relationship to perinatal data is unknown. We assessed cranial ultrasound abnormalities in very low-birthweight (VLBW) infants and correlated the findings with perinatal data. METHODS: VLBW Armenian infants receiving neonatal intensive care in 2012 were scanned from birth to term-equivalent age (TEA). Clinical data were collected prospectively. RESULTS: We studied 100 VLBW infants with a median gestation of 30 weeks...
July 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/26677882/neonatal-morbidities-and-need-for-intervention-in-twins-and-singletons-born-at-34-35-weeks-of-gestation
#13
Michal J Simchen, Avital L Okrent Smolar, Mordechai Dulitzky, Eyal Sivan, Iris Morag
OBJECTIVE: To compare indications for delivery and neonatal morbidities between twins and singletons born between 34 and 35 weeks of gestation. STUDY DESIGN: A prospective observational study was performed in which all infants born between January and August 2008, at Sheba Medical Center at 34 0/7-35 6/7 weeks of gestational age were included. Indications for delivery, infants' morbidities and medical interventions were documented. Twins and singletons were compared for antenatal maternal characteristics, risks of short-term neonatal complications and interventions...
October 1, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/26590298/the-clinical-use-of-corticosteroids-in-pregnancy
#14
REVIEW
M W Kemp, J P Newnham, J G Challis, A H Jobe, S J Stock
BACKGROUND: The use of antenatal steroid therapy is common in pregnancy. In early pregnancy, steroids may be used in women for the treatment of recurrent miscarriage or fetal abnormalities such as congenital adrenal hyperplasia. In mid-late pregnancy, the antenatal administration of corticosteroids to expectant mothers in anticipation of preterm birth is one of the most important advances in perinatal medicine; antenatal corticosteroids are now standard care for pregnancies at risk of premature delivery in high- and middle-income countries...
March 2016: Human Reproduction Update
https://www.readbyqxmd.com/read/26483220/-clinical-features-prevention-and-treatment-of-respiratory-distress-syndrome-in-neonates-of-different-gestational-ages-in-tertiary-hospitals-in-northwest-china
#15
Hui-Ling Fu, Li Liu, Juan Zhang, Quan-Li Wang
OBJECTIVE: To investigate the clinical features, prevention and treatment of respiratory distress syndrome (RDS) in neonates of different gestational ages (GA) in the tertiary hospitals in Northwest China. METHODS: A total of 440 neonates diagnosed with RDS between January and December, 2011 in 12 tertiary hospitals in Northwest China were enrolled and classified into three groups: early preterm (GA<34 weeks; n=247), late preterm (GA 34-36(+6) weeks; n=131) and full-term (GA≥37 weeks; n=62)...
October 2015: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/26403130/late-preterm-infants-impact-of-perinatal-factors-on-neonatal-results-a-clinical-study
#16
Grzegorz Jakiel, Maria Wilińska, Małgorzata Bińkowska, Anna Kowal, Sylwia Rumowska, Michał Ciebiera
INTRODUCTION: Infants born between the 34(th) - 36(th) week of pregnancy account for 75% of all preterm infants. Their seemingly slight immaturity is related to serious health problems. OBJECTIVE: The aim of the study was to analyse perinatal factors that influence the occurrence in infants of such problems as respiratory failure, metabolic problems and early onset sepsis (EOS). MATERIALS AND METHOD: The material for the study included all mothers and their late preterm infants: 34+0 - 36+6 born in our hospital (a tertiary referral academic centre) in 2010 and 2011...
2015: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/26390401/duration-of-cord-clamping-and-neonatal-outcomes-in-very-preterm-infants
#17
Dongli Song, Priya Jegatheesan, Glenn DeSandre, Balaji Govindaswami
BACKGROUND: Delayed cord clamping (DCC, ≥30 s) increases blood volume in newborns and is associated with fewer blood transfusions and short-term neonatal complications. The optimal timing of cord clamping for very preterm infants should maximize placental transfusion without interfering with stabilization and resuscitation. AIM: We compared the effect of different durations of DCC, 30-45 s vs. 60-75 s, on delivery room (DR) and neonatal outcomes in preterm infants <32 weeks gestational age (GA)...
2015: PloS One
https://www.readbyqxmd.com/read/26348753/trends-in-care-practices-morbidity-and-mortality-of-extremely-preterm-neonates-1993-2012
#18
Barbara J Stoll, Nellie I Hansen, Edward F Bell, Michele C Walsh, Waldemar A Carlo, Seetha Shankaran, Abbot R Laptook, Pablo J Sánchez, Krisa P Van Meurs, Myra Wyckoff, Abhik Das, Ellen C Hale, M Bethany Ball, Nancy S Newman, Kurt Schibler, Brenda B Poindexter, Kathleen A Kennedy, C Michael Cotten, Kristi L Watterberg, Carl T D'Angio, Sara B DeMauro, William E Truog, Uday Devaskar, Rosemary D Higgins
IMPORTANCE: Extremely preterm infants contribute disproportionately to neonatal morbidity and mortality. OBJECTIVE: To review 20-year trends in maternal/neonatal care, complications, and mortality among extremely preterm infants born at Neonatal Research Network centers. DESIGN, SETTING, PARTICIPANTS: Prospective registry of 34,636 infants, 22 to 28 weeks' gestation, birth weight of 401 to 1500 g, and born at 26 network centers between 1993 and 2012...
September 8, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/25988638/outcomes-for-extremely-premature-infants
#19
REVIEW
Hannah C Glass, Andrew T Costarino, Stephen A Stayer, Claire M Brett, Franklyn Cladis, Peter J Davis
Premature birth is a significant cause of infant and child morbidity and mortality. In the United States, the premature birth rate, which had steadily increased during the 1990s and early 2000s, has decreased annually for 7 years and is now approximately 11.39%. Human viability, defined as gestational age at which the chance of survival is 50%, is currently approximately 23 to 24 weeks in developed countries. Infant girls, on average, have better outcomes than infant boys. A relatively uncomplicated course in the intensive care nursery for an extremely premature infant results in a discharge date close to the prenatal estimated date of confinement...
June 2015: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/25812674/death-or-survival-with-major-morbidity-in-vlbw-infants-born-at-brazilian-neonatal-research-network-centers
#20
Ruth Guinsburg, Maria Fernanda Branco de Almeida, Junia Sampel de Castro, Rita C Silveira, Jamil Pedro de Siqueira Caldas, Humberto Holmer Fiori, Marynéa Silva do Vale, Vânia Olivetti Steffen Abdallah, Laura Emilia Monteiro Bigélli Cardoso, Navantino Alves Filho, Maria Elisabeth Moreira, Ana Lucia Acquesta, Lígia S Lopes Ferrari, Maria Regina Bentlin, Paulyne Stadler Venzon, Walusa Assad Gonçalves Ferri, Jucille do Amaral Meneses, Edna Maria De Albuquerque Diniz, Dulce Maria Toledo Zanardi, Cristina Nunes Dos Santos, José Luiz Bandeira Duarte, Maria Albertina Santiago Rego
OBJECTIVE: To analyze unfavorable outcomes at hospital discharge of preterm infants born at Brazilian public university centers. METHODS: Prospective cohort of 2646 inborn infants with gestational age 23-33 weeks and birth weight 400-1499 g, without malformations, born at 20 centers in 2012-2013. Unfavorable outcome was defined as in-hospital death or survival at hospital discharge with ≥1 major morbidities: bronchopulmonary dysplasia (BPD) at 36 corrected weeks, intraventricular hemorrhage (IVH) grades 3-4, periventricular leukomalacia (PVL) or surgically treated retinopathy of prematurity (ROP)...
March 2016: Journal of Maternal-fetal & Neonatal Medicine
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