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Deep Brain Stimulation

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https://www.readbyqxmd.com/read/28089264/development-and-validation-of-the-deep-brain-stimulation-impairment-scale-dbs-is
#1
Franziska Maier, Catharine J Lewis, Carsten Eggers, Andrea A Kühn, Henriette Krug, Jens Volkmann, Anna D Kirsch, Lars Wojtecki, Alfons Schnitzler, Günther Deuschl, Joachim K Krauss, Christiane Woopen, Lars Timmermann
BACKGROUND: Bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS) has considerable influence on motor and non-motor symptoms in Parkinson's disease (PD). While improvements in motor functioning can be easily assessed with general quality of life questionnaires, the measurement of specific STN-DBS-associated impairments often remains insufficient. Hence, we aimed to develop a questionnaire that measures STN-DBS-related impairments. METHODS: The development of the (STN-)DBS Impairment Scale (DBS-IS) consisted of four steps...
January 6, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28088795/influence-of-intracranial-air-on-electrode-position-and-clinical-outcomes-following-deep-brain-stimulation-for-parkinson-s-disease
#2
J Nicole Bentley, Zhe Guan, Karen S Cummings, Kelvin L Chou, Parag G Patil
BACKGROUND: The introduction of intracranial air during deep brain stimulation (DBS) surgery is believed to negatively impact targeting accuracy and clinical outcomes. OBJECTIVE: To quantify the relationship between intracranial air (ICA) volumes, targeting accuracy, and clinical outcomes in patients undergoing subthalamic nucleus (STN) DBS for Parkinson's disease. METHODS: ICA in 73 consecutive STN DBS cases (146 leads) was measured by high-resolution CT and correlated with proximal lead bowing, electrode displacement, targeting accuracy, and clinical outcomes at 6 and 12 months...
January 14, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28088666/vocal-emotion-decoding-in-the-subthalamic-nucleus-an-intracranial-erp-study-in-parkinson-s-disease
#3
Julie Péron, Olivier Renaud, Claire Haegelen, Lucas Tamarit, Valérie Milesi, Jean-François Houvenaghel, Thibaut Dondaine, Marc Vérin, Paul Sauleau, Didier Grandjean
Using intracranial local field potential (LFP) recordings in patients with Parkinson's disease (PD) undergoing deep brain stimulation (DBS), we explored the electrophysiological activity of the subthalamic nucleus (STN) in response to emotional stimuli in the auditory modality. Previous studies focused on the influence of visual stimuli. To this end, we recorded LFPs within the STN in response to angry, happy, and neutral prosodies in 13 patients with PD who had just undergone implantation of DBS electrodes...
January 12, 2017: Brain and Language
https://www.readbyqxmd.com/read/28081139/long-latency-somatosensory-evoked-potentials-of-the-subthalamic-nucleus-in-patients-with-parkinson-s-disease
#4
Carlos Trenado, Saskia Elben, Lena Friggemann, Sonja Gruhn, Stefan Jun Groiss, Jan Vesper, Alfons Schnitzler, Lars Wojtecki
Somatosensory evoked potentials (SSEPs) are a viable way to measure processing of somatosensory information. SSEPs have been described at the scalp and the cortical level by electroencephalographic, magnetoencephalographic and intracranial cortical recordings focusing on short-latency (SL; latency<40 ms) and long-latency (LL; latency>40 ms) SSEPs as well as by deep brain stimulation (DBS) electrode studies targeting SL-SSEPs. Unfortunately, LL-SSEPs have not been addressed at the subcortical level aside from the fact that studies targeting the characteristics and generators of SSEPs have been neglected for the last ten years...
2017: PloS One
https://www.readbyqxmd.com/read/28074898/the-curved-lead-pathway-method-to-enable-a-single-lead-to-reach-any-two-intracranial-targets
#5
Chen-Yu Ding, Liang-Hong Yu, Yuan-Xiang Lin, Fan Chen, Zhang-Ya Lin, De-Zhi Kang
Deep brain stimulation is an effective way to treat movement disorders, and a powerful research tool for exploring brain functions. This report proposes a "curved lead pathway" method for lead implantation, such that a single lead can reach in sequence to any two intracranial targets. A new type of stereotaxic system for implanting a curved lead to the brain of human/primates was designed, the auxiliary device needed for this method to be used in rat/mouse was fabricated and verified in rat, and the Excel algorithm used for automatically calculating the necessary parameters was implemented...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28068428/a-network-model-of-local-field-potential-activity-in-essential-tremor-and-the-impact-of-deep-brain-stimulation
#6
Nada Yousif, Michael Mace, Nicola Pavese, Roman Borisyuk, Dipankar Nandi, Peter Bain
Essential tremor (ET), a movement disorder characterised by an uncontrollable shaking of the affected body part, is often professed to be the most common movement disorder, affecting up to one percent of adults over 40 years of age. The precise cause of ET is unknown, however pathological oscillations of a network of a number of brain regions are implicated in leading to the disorder. Deep brain stimulation (DBS) is a clinical therapy used to alleviate the symptoms of a number of movement disorders. DBS involves the surgical implantation of electrodes into specific nuclei in the brain...
January 9, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28068296/orientation-selective-deep-brain-stimulation
#7
Lauri J Lehto, Julia P Slopsema, Matthew D Johnson, Artem Shatillo, Benjamin A Teplitzky, Lynn Utecht, Gregor Adriany, Silvia Mangia, Alejandra Sierra, Walter C Low, Olli Gröhn, Shalom Michaeli
OBJECTIVE: Target selectivity of deep brain stimulation (DBS) therapy is critical, as the precise locus and pattern of the stimulation dictates the degree to which desired treatment responses are achieved and adverse side effects are avoided. There is a clear clinical need to improve DBS technology beyond currently available stimulation steering and shaping approaches. We introduce orientation selective neural stimulation as a concept to increase the specificity of target selection in DBS...
February 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28068291/particle-swarm-optimization-for-programming-deep-brain-stimulation-arrays
#8
Edgar Peña, Simeng Zhang, Steve Deyo, YiZi Xiao, Matthew D Johnson
OBJECTIVE: Deep brain stimulation (DBS) therapy relies on both precise neurosurgical targeting and systematic optimization of stimulation settings to achieve beneficial clinical outcomes. One recent advance to improve targeting is the development of DBS arrays (DBSAs) with electrodes segmented both along and around the DBS lead. However, increasing the number of independent electrodes creates the logistical challenge of optimizing stimulation parameters efficiently. APPROACH: Solving such complex problems with multiple solutions and objectives is well known to occur in biology, in which complex collective behaviors emerge out of swarms of individual organisms engaged in learning through social interactions...
February 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28065487/the-effect-of-unilateral-subthalamic-nucleus-deep-brain-stimulation-on-depression-in-parkinson-s-disease
#9
Elizabeth L Birchall, Harrison C Walker, Gary Cutter, Stephanie Guthrie, Allen Joop, Raima A Memon, Ray L Watts, David G Standaert, Amy W Amara
BACKGROUND: Depression is common in Parkinson's disease (PD) and adversely affects quality of life. Both unilateral and bilateral subthalamic (STN) deep brain stimulation (DBS) effectively treat the motor symptoms of PD, but questions remain regarding the impact of unilateral STN DBS on non-motor symptoms, such as depression. METHODS: We report changes in depression, as measured by the Hamilton Depression Rating Scale (HAMD-17), in 50 consecutive PD patients who underwent unilateral STN DBS...
December 27, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/28062949/can-cyclic-nucleotide-phosphodiesterase-inhibitors-be-drugs-for-parkinson-s-disease
#10
REVIEW
Dominic Ngima Nthenge-Ngumbau, Kochupurackal P Mohanakumar
Parkinson's disease (PD) has no known cure; available therapies are only capable of offering temporary, symptomatic relief to the patients. Varied therapeutic strategies that are clinically used for PD are pharmacological therapies including dopamine replacement therapies (with or without adjuvant), postsynaptic dopamine receptor stimulation, dopamine catabolism inhibitors and also anticholinergics. Surgical therapies like deep brain stimulation and ablative surgical techniques are also employed. Phosphodiesterases (PDEs) are enzymes that degrade the phosphodiester bond in the second messenger molecules, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)...
January 6, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28061431/effect-of-subthalamic-nucleus-deep-brain-stimulation-on-balance-in-parkinson-s-disease-a-static-posturographic-analysis
#11
Beatriz De la Casa-Fages, Fernando Alonso-Frech, Francisco Grandas
BACKGROUND: The effect of subthalamic deep brain stimulation on balance in Parkinson's disease remains unclear. OBJECTIVE: To evaluate the effect of subthalamic nucleus stimulation on balance in Parkinson's disease using posturography. METHODS: 16 patients (9 women) who underwent subthalamic deep brain stimulation [mean age 59.6 years (46-70); mean disease duration 15.6 years (7-25); mean duration of subthalamic stimulation 32.1 months (3...
December 29, 2016: Gait & Posture
https://www.readbyqxmd.com/read/28061418/memory-and-mood-outcomes-after-anterior-thalamic-stimulation-for-refractory-partial-epilepsy
#12
Alexander I Tröster, Kimford J Meador, Christopher P Irwin, Robert S Fisher
PURPOSE: Bilateral deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) reduces seizures and is relatively safe but may be accompanied by complaints of memory problems and depression. This study examined incidence of memory and depression adverse events (AE) in the SANTE study blinded phase and their relationship to objective neurobehavioral measures, baseline characteristics, quality of life and long-term neurobehavioral outcome. METHOD: The neurobehavioral AE and neuropsychological data from a previously reported prospective randomized trial (SANTE) were analyzed...
December 23, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28059945/airway-management-with-a-stereotactic-headframe-in-situ-a-mannequin-study
#13
Melissa Brockerville, Zoe Unger, Nathan C Rowland, Francesco Sammartino, Pirjo H Manninen, Lashmi Venkatraghavan
BACKGROUND: Stereotactic headframe-based imaging is often needed for target localization during surgery for insertion of deep brain stimulators. A major concern during this surgery is the need for emergency airway management while an awake or sedated patient is in the stereotactic headframe. The aim of our study was to determine the ease of emergency airway management with a stereotactic headframe in situ. MATERIALS AND METHODS: We conducted an observational study using a mannequin...
January 4, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28058727/exppning-how-acetylcholine-improves-gait-in-parkinson-s-disease-an-editorial-highlight-for-deletion-of-the-vesicular-acetylcholine-transporter-from-pedunculopontine-laterodorsal-tegmental-neurons-modifies-gait
#14
EDITORIAL
Björn Falkenburger
Gait impairment is one of the most intractable symptoms of Parkinson's disease, responding poorly to dopaminergic medication. Promising therapeutic strategies include deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) and enhancing cholinergic neurotransmission by acetylcholine esterase inhibitors. This Editorial discusses an elegant study by Janickova and coworkers in the current issue of the Journal of Neurochemistry, in which the authors engineered mice lacking cholinergic transmission selectively in the PPN and demonstrate that cholinergic neurons of the PPN are critical for gait...
January 6, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28055131/subthalamic-nuclei-stimulation-in-patients-with-pantothenate-kinase-associated-neurodegeneration-pkan
#15
Ziyuan Liu, Yang Liu, Yingmai Yang, Lin Wang, Wanchen Dou, Jinzhu Guo, Yu Wang, Yi Guo, Xinhua Wan, Wenbin Ma, Renzhi Wang
INTRODUCTION: Pantothenate kinase-associated neurodegeneration (PKAN) is a rare autosomal recessive genetic disease that leads to extrapyramidal symptoms, such as dystonia, ataxia, dysarthria, and involuntary movements. Treatment of PKAN with deep brain stimulation (DBS) has been reported, but mainly focuses on targeting the globus pallidus internus (GPi). Subthalamic nuclei (STN) may also be a potential target for treatment of PKAN. METHODS: In this study, we reviewed three patients with PKAN (two with typical PKAN and one with atypical PKAN) treated by bilateral STN stimulation and present a review of the literature...
January 5, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28055126/neuromodulation-therapies-for-alcohol-addiction-a-literature-review
#16
REVIEW
Celeste A Azevedo, Antonios Mammis
OBJECTIVES: The goal of this review is to explore alternative neurological therapies in the treatment of alcohol use disorder; including transcranial direct current stimulation (tDCS), transcranial magnetic stimulation, deep brain stimulation (DBS), electroconvulsive therapy (ECT), and the off-label use of the GABAB receptor agonist baclofen. METHODS: A comprehensive literature search was conducted through EBSCOhost regarding the neurological therapies in the treatment of alcoholism discussed in this paper...
January 5, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28054129/the-relevance-of-gender-in-parkinson-s-disease-a-review
#17
REVIEW
Marina Picillo, Alessandra Nicoletti, Vincenza Fetoni, Barbara Garavaglia, Paolo Barone, Maria Teresa Pellecchia
Since the official and systematic inclusion of sex and gender in biomedical research, gender differences have been acknowledged as important determinants of both the susceptibility to develop neurodegenerative diseases in general population and the clinical and therapeutic management of neurodegenerative patients. In this review, we gathered the available evidence on gender differences in Parkinson's disease (PD) regarding clinical phenotype (including motor and non-motor symptoms), biomarkers, genetics and therapeutic management (including pharmacological and surgical treatment)...
January 4, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28053151/optimized-temporal-pattern-of-brain-stimulation-designed-by-computational-evolution
#18
David T Brocker, Brandon D Swan, Rosa Q So, Dennis A Turner, Robert E Gross, Warren M Grill
Brain stimulation is a promising therapy for several neurological disorders, including Parkinson's disease. Stimulation parameters are selected empirically and are limited to the frequency and intensity of stimulation. We varied the temporal pattern of deep brain stimulation to ameliorate symptoms in a parkinsonian animal model and in humans with Parkinson's disease. We used model-based computational evolution to optimize the stimulation pattern. The optimized pattern produced symptom relief comparable to that from standard high-frequency stimulation (a constant rate of 130 or 185 Hz) and outperformed frequency-matched standard stimulation in a parkinsonian rat model and in patients...
January 4, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28049077/computational-models-of-bitemporal-bifrontal-and-right-unilateral-ect-predict-differential-stimulation-of-brain-regions-associated-with-efficacy-and-cognitive-side-effects
#19
S Bai, V Gálvez, S Dokos, D Martin, M Bikson, C Loo
BACKGROUND: Extensive clinical research has shown that the efficacy and cognitive outcomes of electroconvulsive therapy (ECT) are determined, in part, by the type of electrode placement used. Bitemporal ECT (BT, stimulating electrodes placed bilaterally in the frontotemporal region) is the form of ECT with relatively potent clinical and cognitive side effects. However, the reasons for this are poorly understood. OBJECTIVE: This study used computational modelling to examine regional differences in brain excitation between BT, Bifrontal (BF) and Right Unilateral (RUL) ECT, currently the most clinically-used ECT placements...
December 29, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28044019/resolving-the-neural-dynamics-of-visual-and-auditory-scene-processing-in-the-human-brain-a-methodological-approach
#20
REVIEW
Radoslaw Martin Cichy, Santani Teng
In natural environments, visual and auditory stimulation elicit responses across a large set of brain regions in a fraction of a second, yielding representations of the multimodal scene and its properties. The rapid and complex neural dynamics underlying visual and auditory information processing pose major challenges to human cognitive neuroscience. Brain signals measured non-invasively are inherently noisy, the format of neural representations is unknown, and transformations between representations are complex and often nonlinear...
February 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
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