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https://www.readbyqxmd.com/read/29775773/trimeprazine-is-enantioselectively-degraded-by-an-activated-sludge-in-ready-biodegradability-test-conditions
#1
Laura Escuder-Gilabert, Yolanda Martín-Biosca, Mireia Perez-Baeza, Salvador Sagrado, María José Medina-Hernández
A great number of available pharmaceuticals are chiral compounds. Although they are usually manufactured as racemic mixtures, they can be enantioselectively biodegraded as a result of microbial processes. In this paper, a biodegradability assay in similar conditions to those recommended in OECD tests of enantiomers of trimeprazine (a phenothiazine employed as a racemate) is carried out. Experiments were performed in batch mode using a minimal salts medium inoculated with an activated sludge (collected from a Valencian Waste Water Treatment Plant, WWTP) and supplemented with the racemate...
May 9, 2018: Water Research
https://www.readbyqxmd.com/read/29775440/crystalline-multiwall-carbon-nanotube-and-its-application-as-field-emission-electron-source
#2
Peng Liu, Duanliang Zhou, Chunhai Zhang, Haoming Wei, Xinhe Yang, Yang Wu, Qingwei Li, Changhong Liu, Bingchu Du, Liang Liu, Kaili Jiang, Shoushan Fan
With the super aligned carbon nanotube (SACNT) film, we have fabricated crystalline multiwall CNT (MWCNT) by adopting a high pressure and high temperature processing. The CNTs keep parallel to each other and distributed uniformly. XRD characterization shows peaks at small angle range, which can be assigned to the spacing of MWCNT crystal. The mechanical, electrical and thermal properties are all greatly improved compared with the original CNT film. The field emission properties of crystalline MWCNT are tested and it shows a better surface morphology stability at large emission current...
May 18, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29774516/periodic-variation-of-aak1-in-an-a%C3%AE-1-42-induced-mouse-model-of-alzheimer-s-disease
#3
Xue Fu, Meiling Ke, Weihua Yu, Xia Wang, Qian Xiao, Min Gu, Yang Lü
Inhibition of endocytosis in an Alzheimer's disease (AD) model has been shown to be able to prevent amyloid β (Aβ)-induced damage and to exert a beneficial effect in treating AD. Adaptor-associated kinase 1 (AAK1), which binds to the adaptor protein complex 2 (AP-2), regulates the process of clathrin-mediated endocytosis. However, how AAK1 expression varies over the course of AD is unknown. In this study, we investigated AAK1 levels in AD model mice over time. Aβ1-42 was used to establish a mouse AD model, and the Morris water maze test was used to characterize the time course of Aβ1-42 -induced cognition changes...
May 17, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29772789/downregulation-of-the-s1p-transporter-spinster-homology-protein-2-spns2-exerts-an-anti-fibrotic-and-anti-inflammatory-effect-in-human-renal-proximal-tubular-epithelial-cells
#4
Olivier Blanchard, Bisera Stepanovska, Manuel Starck, Martin Erhardt, Isolde Römer, Dagmar Meyer Zu Heringdorf, Josef Pfeilschifter, Uwe Zangemeister-Wittke, Andrea Huwiler
Sphingosine kinase (SK) catalyses the formation of sphingosine 1-phosphate (S1P), which acts as a key regulator of inflammatory and fibrotic reactions, mainly via S1P receptor activation. Here, we show that in the human renal proximal tubular epithelial cell line HK2, the profibrotic mediator transforming growth factor β (TGFβ) induces SK-1 mRNA and protein expression, and in parallel, it also upregulates the expression of the fibrotic markers connective tissue growth factor (CTGF) and fibronectin. Stable downregulation of SK-1 by RNAi resulted in the increased expression of CTGF, suggesting a suppressive effect of SK-1-derived intracellular S1P in the fibrotic process, which is lost when SK-1 is downregulated...
May 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29772731/energy-efficient-gnss-signal-acquisition-using-singular-value-decomposition-svd
#5
Juan Carlos Bermúdez Ordoñez, Rosa María Arnaldo Valdés, Fernando Gómez Comendador
A significant challenge in global navigation satellite system (GNSS) signal processing is a requirement for a very high sampling rate. The recently-emerging compressed sensing (CS) theory makes processing GNSS signals at a low sampling rate possible if the signal has a sparse representation in a certain space. Based on CS and SVD theories, an algorithm for sampling GNSS signals at a rate much lower than the Nyquist rate and reconstructing the compressed signal is proposed in this research, which is validated after the output from that process still performs signal detection using the standard fast Fourier transform (FFT) parallel frequency space search acquisition...
May 16, 2018: Sensors
https://www.readbyqxmd.com/read/29772255/the-gist-and-details-of-sex-differences-in-cognition-and-the-brain-how-parallels-in-sex-differences-across-domains-are-shaped-by-the-locus-coeruleus-and-catecholamine-systems
#6
REVIEW
Alexandra Ycaza Herrera, Jiaxi Wang, Mara Mather
Across three different domains, there are similar sex differences in how men and women process information. There tends to be a male advantage in attending to and remembering the gist (essential central information of a scene or situation), but a female advantage in attending to and remembering the details (non-essential peripheral information of a scene or situation). This is seen in emotional memory, where emotion enhances gist memory more for males than for females, but enhances detail memory more for females than for males...
May 14, 2018: Progress in Neurobiology
https://www.readbyqxmd.com/read/29771503/internal-electric-field-modulation-in-molecular-electronic-devices-by-atmosphere-and-mobile-ions
#7
Prakash Chandra Mondal, Ushula M Tefashe, Richard L McCreery
The internal potential profile and electric field are major factors controlling the electronic behavior of molecular electronic junctions consisting of ~1-10 nm thick layers of molecules oriented in parallel between conducting contacts. The potential profile is assumed linear in the simplest cases, but can be affected by internal dipoles, charge polarization, and electronic coupling between the contacts and the molecular layer. Electrochemical processes in solutions or solid state are entirely dependent on modification of the electric field by electrolyte ions, which screen the electrodes and form the ionic double layers which are fundamental to electrode kinetics and widespread applications...
May 17, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29770351/a-microfluidic-device-for-massively-parallel-whole-lifespan-imaging-of-single-fission-yeast-cells
#8
Stephen K Jones, Eric C Spivey, James R Rybarski, Ilya J Finkelstein
Whole-lifespan single-cell analysis has greatly increased our understanding of fundamental cellular processes such as cellular aging. To observe individual cells across their entire lifespan, all progeny must be removed from the growth medium, typically via manual microdissection. However, manual microdissection is laborious, low-throughput, and incompatible with fluorescence microscopy. Here, we describe assembly and operation of the multiplexed-Fission Yeast Lifespan Microdissector (multFYLM), a high-throughput microfluidic device for rapidly acquiring single-cell whole-lifespan imaging...
April 5, 2018: Bio-protocol
https://www.readbyqxmd.com/read/29769664/parallel-odor-processing-by-mitral-and-middle-tufted-cells-in-the-olfactory-bulb
#9
Francesco Cavarretta, Shawn D Burton, Kei M Igarashi, Gordon M Shepherd, Michael L Hines, Michele Migliore
The olfactory bulb (OB) transforms sensory input into spatially and temporally organized patterns of activity in principal mitral (MC) and middle tufted (mTC) cells. Thus far, the mechanisms underlying odor representations in the OB have been mainly investigated in MCs. However, experimental findings suggest that MC and mTC may encode parallel and complementary odor representations. We have analyzed the functional roles of these pathways by using a morphologically and physiologically realistic three-dimensional model to explore the MC and mTC microcircuits in the glomerular layer and deeper plexiform layer...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769616/magnetic-field-induced-rotation-of-magnetosome-chains-in-silicified-magnetotactic-bacteria
#10
Marine Blondeau, Yohan Guyodo, François Guyot, Christophe Gatel, Nicolas Menguy, Imène Chebbi, Bernard Haye, Mickaël Durand-Dubief, Edouard Alphandery, Roberta Brayner, Thibaud Coradin
Understanding the biological processes enabling magnetotactic bacteria to maintain oriented chains of magnetic iron-bearing nanoparticles called magnetosomes is a major challenge. The study aimed to constrain the role of an external applied magnetic field on the alignment of magnetosome chains in Magnetospirillum magneticum AMB-1 magnetotactic bacteria immobilized within a hydrated silica matrix. A deviation of the chain orientation was evidenced, without significant impact on cell viability, which was preserved after the field was turned-off...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768404/tissue-specific-activities-of-the-fat1-cadherin-cooperate-to-control-neuromuscular-morphogenesis
#11
Françoise Helmbacher
Muscle morphogenesis is tightly coupled with that of motor neurons (MNs). Both MNs and muscle progenitors simultaneously explore the surrounding tissues while exchanging reciprocal signals to tune their behaviors. We previously identified the Fat1 cadherin as a regulator of muscle morphogenesis and showed that it is required in the myogenic lineage to control the polarity of progenitor migration. To expand our knowledge on how Fat1 exerts its tissue-morphogenesis regulator activity, we dissected its functions by tissue-specific genetic ablation...
May 16, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29768234/improved-experimental-time-of-ultra-large-bioassays-using-a-parallelised-microfluidic-biochip-architecture-scheduling
#12
Maryam Taajobian, Ali Jahanian
Digital microfluidic is an emerging technology to reduce the cost and time of experiments and improve the flexibility, automate-ability and correctness of biochemical assays. In many of applications such as drug discovery and DNA profiling, a large number of bio-operations (e.g. the chemical operations used in biology applications) must be done. In these applications, parallelising the operations will be critical in accuracy and cost of the process and digital microfluidic biochips can be considered as a reasonable platform...
June 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29766588/synthesis-of-chlorotrifluoromethylated-pyrrolidines-via-electrocatalytic-radical-ene-yne-cyclization
#13
Ke-Yin Ye, Zhidong Song, Gregory Sauer, Johannes Harenberg, Niankai Fu, Song Lin
The stereoselective synthesis of chlorotrifluoromethylated pyrrolidines was achieved using anodically coupled electrolysis, an electrochemical process that combines two parallel oxidative events in a convergent and productive manner. The bench-stable and commercially available solids CF3SO2Na and MgCl2 were used as the functional group sources to generate CF3· and Cl·, respectively, via electrochemical oxidation, and the subsequent reaction of these radicals with the 1,6-enyne substrate was controlled with an earth-abundant Mn catalyst...
May 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29766324/a-general-lc-ms-ms-method-for-monitoring-potential-%C3%AE-lactam-contamination-in-drugs-and-drug-manufacturing-surfaces
#14
Chen Qiu, Hongbin Zhu, Connie Ruzicka, David Keire, Hongping Ye
Penicillins and some non-penicillin β-lactams may cause potentially life-threatening allergic reactions. Thus, possible cross contamination of β-lactams in food or drugs can put people at risk. Therefore, when there is a reasonable possibility that a non-penicillin product could be contaminated by penicillin, the drug products are tested for penicillin contamination. Here, a sensitive and rapid method for simultaneous determination of multiple β-lactam antibiotics using high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated...
May 15, 2018: AAPS Journal
https://www.readbyqxmd.com/read/29766175/bismuth-as-a-versatile-cation-for-luminescence-in-coordination-polymers-from-bix-3-4-4-bipy-understanding-of-photophysics-by-quantum-chemical-calculations-and-structural-parallels-to-lanthanides
#15
Jens R Sorg, Tobias Wehner, Philipp R Matthes, Rebecca Sure, Stefan Grimme, Johanna Heine, Klaus Müller-Buschbaum
Coordination polymers (CPs) with bismuth(iii) as a connectivity centre have been prepared from BiX3 (X = Cl-I) and 4,4'-bipyridine (bipy) in order to implement Bi-based luminescence. The products were obtained via different synthetic routes such as solution chemistry, melt syntheses or mechanochemical reactions. Five neutral and anionic 1D-CPs are presented that show a chemical parallel to trivalent lanthanides forming isostructural or closely related 1D-CPs, of which five additional compounds are described...
May 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29765629/reliability-modelling-and-analysis-of-a-multi-state-element-based-on-a-dynamic-bayesian-network
#16
Zhiqiang Li, Tingxue Xu, Junyuan Gu, Qi Dong, Linyu Fu
This paper presents a quantitative reliability modelling and analysis method for multi-state elements based on a combination of the Markov process and a dynamic Bayesian network (DBN), taking perfect repair, imperfect repair and condition-based maintenance (CBM) into consideration. The Markov models of elements without repair and under CBM are established, and an absorbing set is introduced to determine the reliability of the repairable element. According to the state-transition relations between the states determined by the Markov process, a DBN model is built...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29765358/get_phylomarkers-a-software-package-to-select-optimal-orthologous-clusters-for-phylogenomics-and-inferring-pan-genome-phylogenies-used-for-a-critical-geno-taxonomic-revision-of-the-genus-stenotrophomonas
#17
Pablo Vinuesa, Luz E Ochoa-Sánchez, Bruno Contreras-Moreira
The massive accumulation of genome-sequences in public databases promoted the proliferation of genome-level phylogenetic analyses in many areas of biological research. However, due to diverse evolutionary and genetic processes, many loci have undesirable properties for phylogenetic reconstruction. These, if undetected, can result in erroneous or biased estimates, particularly when estimating species trees from concatenated datasets. To deal with these problems, we developed GET_PHYLOMARKERS, a pipeline designed to identify high-quality markers to estimate robust genome phylogenies from the orthologous clusters, or the pan-genome matrix (PGM), computed by GET_HOMOLOGUES...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29765347/how-deep-is-your-snarc-interactions-between-numerical-magnitude-response-hands-and-reachability-in-peripersonal-space
#18
Johannes Lohmann, Philipp A Schroeder, Hans-Christoph Nuerk, Christian Plewnia, Martin V Butz
Spatial, physical, and semantic magnitude dimensions can influence action decisions in human cognitive processing and interact with each other. For example, in the spatial-numerical associations of response code (SNARC) effect, semantic numerical magnitude facilitates left-hand or right-hand responding dependent on the small or large magnitude of number symbols. SNARC-like interactions of numerical magnitudes with the radial spatial dimension (depth) were postulated from early on. Usually, the SNARC effect in any direction is investigated using fronto-parallel computer monitors for presentation of stimuli...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29765051/concurrent-and-orthogonal-gold-i-and-ruthenium-ii-catalysis-inside-living-cells
#19
Cristian Vidal, María Tomás-Gamasa, Paolo Destito, Fernando López, José L Mascareñas
The viability of building artificial metabolic pathways within a cell will depend on our ability to design biocompatible and orthogonal catalysts capable of achieving non-natural transformations. In this context, transition metal complexes offer unique possibilities to develop catalytic reactions that do not occur in nature. However, translating the potential of metal catalysts to living cells poses numerous challenges associated to their biocompatibility, and their stability and reactivity in crowded aqueous environments...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29764378/grim-filter-fast-seed-location-filtering-in-dna-read-mapping-using-processing-in-memory-technologies
#20
Jeremie S Kim, Damla Senol Cali, Hongyi Xin, Donghyuk Lee, Saugata Ghose, Mohammed Alser, Hasan Hassan, Oguz Ergin, Can Alkan, Onur Mutlu
BACKGROUND: Seed location filtering is critical in DNA read mapping, a process where billions of DNA fragments (reads) sampled from a donor are mapped onto a reference genome to identify genomic variants of the donor. State-of-the-art read mappers 1) quickly generate possible mapping locations for seeds (i.e., smaller segments) within each read, 2) extract reference sequences at each of the mapping locations, and 3) check similarity between each read and its associated reference sequences with a computationally-expensive algorithm (i...
May 9, 2018: BMC Genomics
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