keyword
https://read.qxmd.com/read/38534956/paraneoplastic-syndromes-in-neuroendocrine-prostate-cancer-a-systematic-review
#1
REVIEW
Mohammad Abufaraj, Raghad Ramadan, Amro Alkhatib
Neuroendocrine prostate cancer (NEPC) is a rare subtype of prostate cancer (PCa) that usually results in poor clinical outcomes and may be accompanied by paraneoplastic syndromes (PNS). NEPC is becoming more frequent. It can initially manifest as PNS, complicating diagnosis. Therefore, we reviewed the literature on the different PNS associated with NEPC. We systematically reviewed English-language articles from January 2017 to September 2023, identifying 17 studies meeting PRISMA guidelines for NEPC and associated PNS...
March 21, 2024: Current Oncology
https://read.qxmd.com/read/38532986/a-theory-of-the-neural-mechanisms-underlying-negative-cognitive-bias-in-major-depression
#2
JOURNAL ARTICLE
Yuyue Jiang
The widely acknowledged cognitive theory of depression, developed by Aaron Beck, focused on biased information processing that emphasizes the negative aspects of affective and conceptual information. Current attempts to discover the neurological mechanism underlying such cognitive and affective bias have successfully identified various brain regions associated with severally biased functions such as emotion, attention, rumination, and inhibition control. However, the neurobiological mechanisms of how individuals in depression develop this selective processing toward negative is still under question...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38526373/dysconnectivity-of-the-nucleus-accumbens-and-amygdala-in-youths-with-thought-problems-a-dimensional-approach
#3
JOURNAL ARTICLE
Chen-Fang Chung, Jules R Dugré, Stéphane Potvin
BACKGROUND: Youths with thought problems (TP) are at risk to develop psychosis and obsessive-compulsive disorder (OCD). Yet, the pathophysiological mechanisms underpinning TP is still unclear. Functional magnetic resonance imaging (fMRI) studies have shown that striatal and limbic alterations are associated with psychosis-like and obsessive-like symptoms in individuals at clinical risk for psychosis, schizophrenia, and OCD patients. More specifically, Nucleus accumbens (NAcc) and amygdala are mainly involved in these associations...
March 25, 2024: Brain Connectivity
https://read.qxmd.com/read/38520489/disentangling-and-quantifying-the-relative-cognitive-impact-of-concurrent-mixed-neurodegenerative-pathologies
#4
JOURNAL ARTICLE
Carolina Maldonado-Díaz, Satomi Hiya, Raquel T Yokoda, Kurt Farrell, Gabriel A Marx, Justin Kauffman, Elena V Daoud, Mitzi M Gonzales, Alicia S Parker, Leyla Canbeldek, Lakshmi Shree Kulumani Mahadevan, John F Crary, Charles L White, Jamie M Walker, Timothy E Richardson
Neurodegenerative pathologies such as Alzheimer disease neuropathologic change (ADNC), Lewy body disease (LBD), limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC), and cerebrovascular disease (CVD) frequently coexist, but little is known about the exact contribution of each pathology to cognitive decline and dementia in subjects with mixed pathologies. We explored the relative cognitive impact of concurrent common and rare neurodegenerative pathologies employing multivariate logistic regression analysis adjusted for age, gender, and level of education...
March 23, 2024: Acta Neuropathologica
https://read.qxmd.com/read/38520362/electroencephalography-connectome-changes-in-chronic-insomnia-disorder-are-correlated-with-neurochemical-signatures
#5
JOURNAL ARTICLE
Liyong Yu, Wei Peng, Wenting Lin, Yucai Luo, Daijie Hu, Guangli Zhao, Hao Xu, Zeyang Dou, Qi Zhang, Xiaojuan Hong, Siyi Yu
STUDY OBJECTIVES: This study aimed to investigate the alterations in resting-state electroencephalography (EEG) global brain connectivity (GBC) in patients with chronic insomnia disorder (CID) and to explore the correlation between macroscale connectomic variances and microscale neurotransmitter distributions. METHODS: We acquired 64-channel EEG from 35 female CID patients and 34 healthy females. EEG signals were source-localized using individual brain anatomy and orthogonalized to mitigate volume conduction...
March 23, 2024: Sleep
https://read.qxmd.com/read/38514032/microsurgical-resection-for-cavernous-malformation-of-the-uncus-3d-operative-video
#6
Talita Helena Martins Sarti, Rodrigo Akira Watanabe, Glaucia Suzanna Jong-A-Liem, Juan Carlos Ahumada-Vizcaíno, Pedro José Ramiro Muiños, Felipe Magalhães, Feres Chaddad-Neto
Cavernous malformations (CMs) are rare and often oligosymptomatic vascular lesions. The main symptoms include seizure and focal neurological deficits.1-3 Depending on the symptomatology, the location, the size, and the risk factors for bleeding, like the presence of a developmental venous anomaly, it can be highly morbid. Thus, surgical resection may be considered. Deep-seated and eloquent CMs, like those in the uncus, can be challenging.4,5 In this operative video, we present a 23-year-old male adult who developed focal seizures (i...
March 19, 2024: World Neurosurgery
https://read.qxmd.com/read/38509778/large-nesting-expression-in-deer-mice-remains-stable-under-conditions-of-visual-deprivation-despite-heightened-limbic-involvement-perspectives-on-compulsive-like-behavior
#7
JOURNAL ARTICLE
Harry Marx, Thomas E Krahe, De Wet Wolmarans
Visual stimuli and limbic activation varyingly influence obsessive-compulsive symptom expression and so impact treatment outcomes. Some symptom phenotypes, for example, covert repugnant thoughts, are likely less sensitive to sensory stimuli compared to symptoms with an extrinsic focus, that is, symptoms related to contamination, safety, and "just-right-perceptions." Toward an improved understanding of the neurocognitive underpinnings of obsessive-compulsive psychobiology, work in naturalistic animal model systems is useful...
March 2024: Journal of Neuroscience Research
https://read.qxmd.com/read/38502960/functional-brain-network-controllability-dysfunction-in-alzheimer-s-disease-and-its-relationship-with-cognition-and-gene-expression-profiling
#8
JOURNAL ARTICLE
Chuchu Zheng, Xiaoxia Xiao, Wei Zhao, Zeyu Yang, Shuixia Guo
In recent studies, network control theory has been applied to clarify transitions between brain states, emphasizing the significance of assessing the controllability of brain networks in facilitating transitions from one state to another. Despite these advancements, the potential alterations in functional network controllability associated with Alzheimer's disease (AD), along with the underlying genetic mechanisms responsible for these alterations, remain unclear. We conducted a comparative analysis of functional network controllability measures between patients with AD (n=64) and matched normal controls (NCs, n=64)...
March 19, 2024: Journal of Neural Engineering
https://read.qxmd.com/read/38496216/autoimmune-encephalitis-with-antibodies-against-a-amino-3hydroxy-5-methyl-4-isoxazolepropionic-acid-receptor-and-%C3%AE-aminobutyric-acid-beta-receptor-case-report
#9
Faruk Uğur Doğan, Bedia Samanci, Vuslat Yilmaz, Haşmet Ayhan Hanağasi, İbrahim Hakan Gürvit, Erdem Tüzün, Başar Bilgiç
INTRODUCTION: Limbic encephalitis is a rapidly progressing disease that presents with seizures, psychiatric symptoms, and recent memory loss. Detection of more than one autoantibody is a rare condition in this disease where an underlying autoantibody is frequently detected. Although different autoantibodies have been reported in the literature, no case has been reported regarding the association of anti-γ-aminobutyric acid-beta-receptor (anti-GABAB R) and anti-α-amino-3 hydroxy-5-methyl-4-isoxazolepropionic acid (anti-AMPAR)...
2024: Noro Psikiyatri Arsivi
https://read.qxmd.com/read/38494747/rapid-eye-movement-sleep-behavior-disorder-and-its-relation-to-parkinson-s-disease-the-potential-of-graph-measures-as-brain-biomarkers-to-identify-the-underlying-physiopathology-of-the-disorder
#10
REVIEW
Milad Najafzadeh, Fatemeh Mohammadian, Sara Mirabian, Zohre Ganji, Hossein Akbari, Masoud Rezaie, Esmaeil Ranjbar, Hoda Zare, Shahrokh Nasseri, Luigi Ferini-Strambi
Rapid eye movement behavior disorder (RBD) is a parasomnia characterized by the loss of skeletal muscle atonia during the rapid eye movement (REM) sleep phase. On the other hand, idiopathic RDB (iRBD) is considered the prelude of the various α-synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy. Consequently, over 40% of patients eventually develop PD. Recent neuroimaging studies utilizing structural magnetic resonance imaging (s-MRI), diffusion-weighted imaging (DWI), and functional magnetic resonance imaging (fMRI) with graph theoretical analysis have demonstrated that patients with iRBD and Parkinson's disease have extensive brain abnormalities...
March 2024: Brain and Behavior
https://read.qxmd.com/read/38488854/comparative-neuroimaging-of-sex-differences-in-human-and-mouse-brain-anatomy
#11
JOURNAL ARTICLE
Elisa Guma, Antoine Beauchamp, Siyuan Liu, Elizabeth Levitis, Jacob Ellegood, Linh Pham, Rogier B Mars, Armin Raznahan, Jason P Lerch
In vivo neuroimaging studies have established several reproducible volumetric sex differences in the human brain, but the causes of such differences are hard to parse. While mouse models are useful for understanding the cellular and mechanistic bases of sex-specific brain development, there have been no attempts to formally compare human and mouse neuroanatomical sex differences to ascertain how well they translate. Addressing this question would shed critical light on the use of the mouse as a translational model for sex differences in the human brain and provide insights into the degree to which sex differences in brain volume are conserved across mammals...
March 15, 2024: ELife
https://read.qxmd.com/read/38486709/visualizing-the-trans-synaptic-arrangement-of-synaptic-proteins-by-expansion-microscopy
#12
JOURNAL ARTICLE
Stefan Sachs, Sebastian Reinhard, Janna Eilts, Markus Sauer, Christian Werner
High fidelity synaptic neurotransmission in the millisecond range is provided by a defined structural arrangement of synaptic proteins. At the presynapse multi-epitope scaffolding proteins are organized spatially at release sites to guarantee optimal binding of neurotransmitters at receptor clusters. The organization of pre- and postsynaptic proteins in trans-synaptic nanocolumns would thus intuitively support efficient information transfer at the synapse. Visualization of these protein-dense regions as well as the minute size of protein-packed synaptic clefts remains, however, challenging...
2024: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/38476931/unraveling-the-relations-between-post-traumatic-stress-symptoms-neurocognitive-functioning-and-limbic-white-matter-in-pediatric-brain-tumor-patients
#13
JOURNAL ARTICLE
Anne E M Leenders, Eva Kremer-Hooft van Huijsduijnen, Bruno Robalo, Rosa van Male, Alberto De Luca, Rachèl Kemps, Eelco Hoving, Maarten H Lequin, Martha A Grootenhuis, Marita Partanen
BACKGROUND: Pediatric brain tumor patients are at risk of developing neurocognitive impairments and associated white matter alterations. In other populations, post-traumatic stress symptoms (PTSS) impact cognition and white matter. This study aims to investigate the effect of PTSS on neurocognitive functioning and limbic white matter in pediatric brain tumor patients. METHODS: Sixty-six patients (6-16 years) completed neuropsychological assessment and brain MRI (1-year post-diagnosis) and parents completed PTSS proxy questionnaires (CRIES-13; 1-3 months and 1-year post-diagnosis)...
2024: Neuro-oncology advances
https://read.qxmd.com/read/38476183/video-polysomnographic-analysis-of-elevated-emg-activity-and-rapid-eye-movements-before-abnormal-behaviors-in-rem-sleep-behavior-disorder
#14
JOURNAL ARTICLE
Mondo Yoshizawa, Yoshiyuki Tamura, Asami Yasuda-Ohata, Shinsuke Yoshihara, Hideki Takasaki, Sadayuki Hashioka
The pathogenesis of rapid eye movement (REM) sleep behavior disorder (RBD) is unclear. According to the cortical hypothesis, severe RBD episode (RBDE) occurs when spinal motoneurons are less inhibited and cortical and limbic systems are more active. We made this study to prove the hypothesis for the development of RBDE using video-polysomnography (VPSG). VPSG records of 35 patients with RBD were analyzed. According to severity, RBDEs were classified into three motor events (MEs): ME 1; small movements or jerks, ME 2; proximal movements including violent behavior, and ME 3; axial movements including bed falls...
October 2023: Sleep and Biological Rhythms
https://read.qxmd.com/read/38476042/sex-specific-distributed-white-matter-microarchitectural-alterations-in-preadolescent-youths-with-anxiety-disorders-a-mega-analytic-study
#15
JOURNAL ARTICLE
Nakul Aggarwal, Do P M Tromp, Jennifer U Blackford, Daniel S Pine, Patrick H Roseboom, Lisa E Williams, Ned H Kalin
OBJECTIVE: Anxiety disorders are among the most common psychiatric disorders in youths and emerge during childhood. This is also a period of rapid white matter (WM) development, which is critical for efficient neuronal communication. Previous work in preadolescent children with anxiety disorders demonstrated anxiety disorder-related reductions in WM microstructural integrity (fractional anisotropy [FA]) in the uncinate fasciculus (UF), the major WM tract facilitating prefrontal cortical-limbic structural connectivity...
March 13, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38472413/flanagan-s-condensed-protocol-for-neurodegenerative-diseases-implementation-in-a-clinical-autopsy-setting-with-partial-supervision-of-a-neuropathologist
#16
JOURNAL ARTICLE
Aitana López, Samuel López-Muñoz, Gabriela Caballero, Natalia Castrejon, Leonardo Rojo, Nuria Vidal-Robau, Abel Muñoz, Estrella Ortiz, Maite Rodrigo, Adriana García, Miriam Cuatrecasas, Teresa Ribalta, Iban Aldecoa
The Condensed Protocol (CP) was originally developed for the evaluation of Alzheimer's Disease (AD) and other neurodegenerative diseases as a workable alternative to the complex and costly established autopsy guidelines. The study objective is to examine the degree of implementation of the CP in the pathology department of a third level university hospital in a period of 5 years. Clinical autopsies performed between 2016 and 2021 on patients aged 65 years or over and did not require a specific neuropathological examination were reviewed...
March 12, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38470418/reconfiguration-of-structural-and-functional-connectivity-coupling-in-patient-subgroups-with-adolescent-depression
#17
JOURNAL ARTICLE
Ming Xu, Xuemei Li, Teng Teng, Yang Huang, Mengqi Liu, Yicheng Long, Fajin Lv, Dongmei Zhi, Xiang Li, Aichen Feng, Shan Yu, Vince Calhoun, Xinyu Zhou, Jing Sui
IMPORTANCE: Adolescent major depressive disorder (MDD) is associated with serious adverse implications for brain development and higher rates of self-injury and suicide, raising concerns about its neurobiological mechanisms in clinical neuroscience. However, most previous studies regarding the brain alterations in adolescent MDD focused on single-modal images or analyzed images of different modalities separately, ignoring the potential role of aberrant interactions between brain structure and function in the psychopathology...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38460581/multimodal-associations-of-fkbp5-methylation-with-emotion-regulatory-brain-circuits
#18
JOURNAL ARTICLE
Thomas L Kremer, Junfang Chen, Anais Buhl, Oksana Berhe, Edda Bilek, Lena Geiger-Primo, Ren Ma, Carolin Moessnang, Markus Reichert, Iris Reinhard, Kristina Schwarz, Janina I Schweiger, Fabian Streit, Stephanie H Witt, Zhenxiang Zang, Xiaolong Zhang, Markus M Noethen, Marcella Rietschel, Ulrich W Ebner-Priemer, Emanuel Schwarz, Andreas Meyer-Lindenberg, Urs Braun, Heike Tost
BACKGROUND: Understanding the biological processes underlying individual differences in emotion regulation and stress responsivity is a key challenge for translational neuroscience. The gene FKBP5 is a core regulator in molecular stress signaling that is implicated in the development of psychiatric disorders. Yet it remains unclear how FKBP5 DNA methylation (DNAm) in peripheral blood relates to individual differences in measures of neural structure and function, and their relevance to daily-life stress responsivity...
March 7, 2024: Biological Psychiatry
https://read.qxmd.com/read/38453896/association-between-resting-state-connectivity-patterns-in-the-defensive-system-network-and-treatment-response-in-spider-phobia-a-replication-approach
#19
JOURNAL ARTICLE
Elisabeth J Leehr, Fabian R Seeger, Joscha Böhnlein, Bettina Gathmann, Thomas Straube, Kati Roesmann, Markus Junghöfer, Hanna Schwarzmeier, Niklas Siminski, Martin J Herrmann, Till Langhammer, Janik Goltermann, Dominik Grotegerd, Susanne Meinert, Nils R Winter, Udo Dannlowski, Ulrike Lueken
Although highly effective on average, exposure-based treatments do not work equally well for all patients with anxiety disorders. The identification of pre-treatment response-predicting patient characteristics may enable patient stratification. Preliminary research highlights the relevance of inhibitory fronto-limbic networks as such. We aimed to identify pre-treatment neural signatures differing between exposure treatment responders and non-responders in spider phobia and to validate results through rigorous replication...
March 7, 2024: Translational Psychiatry
https://read.qxmd.com/read/38449334/developmental-programming-by-prenatal-sounds-insights-into-possible-mechanisms
#20
JOURNAL ARTICLE
Mylene M Mariette
In recent years, the impact of prenatal sound on development, notably for programming individual phenotypes for postnatal conditions, has increasingly been revealed. However, the mechanisms through which sound affects physiology and development remain mostly unexplored. Here, I gather evidence from neurobiology, developmental biology, cellular biology and bioacoustics to identify the most plausible modes of action of sound on developing embryos. First, revealing often-unsuspected plasticity, I discuss how prenatal sound may shape auditory system development and determine individuals' later capacity to receive acoustic information...
March 7, 2024: Journal of Experimental Biology
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