Thomas L Kremer, Junfang Chen, Anais Buhl, Oksana Berhe, Edda Bilek, Lena Geiger-Primo, Ren Ma, Carolin Moessnang, Markus Reichert, Iris Reinhard, Kristina Schwarz, Janina I Schweiger, Fabian Streit, Stephanie H Witt, Zhenxiang Zang, Xiaolong Zhang, Markus M Noethen, Marcella Rietschel, Ulrich W Ebner-Priemer, Emanuel Schwarz, Andreas Meyer-Lindenberg, Urs Braun, Heike Tost
BACKGROUND: Understanding the biological processes underlying individual differences in emotion regulation and stress responsivity is a key challenge for translational neuroscience. The gene FKBP5 is a core regulator in molecular stress signaling that is implicated in the development of psychiatric disorders. Yet it remains unclear how FKBP5 DNA methylation (DNAm) in peripheral blood relates to individual differences in measures of neural structure and function, and their relevance to daily-life stress responsivity...
March 7, 2024: Biological Psychiatry