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vitamin A and osteoporosis

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https://www.readbyqxmd.com/read/28205055/effectiveness-of-calcifediol-in-improving-muscle-function-in-post-menopausal-women-a-prospective-cohort-study
#1
Giovanni Iolascon, Antimo Moretti, Alessandro de Sire, Dario Calafiore, Francesca Gimigliano
INTRODUCTION: The role of vitamin D supplementation on muscle function and physical performance is still debated. Calcifediol is an available treatment for hypovitaminosis D, particularly for extra-skeletal effects. Aim of this prospective cohort study was to evaluate the effectiveness of calcifediol on serum levels of 25(OH)D3, appendicular muscle strength, physical performance, and prevention of falls in post-menopausal women. METHODS: We recruited post-menopausal women aged ≥50 years, referring to an outpatient service for the management of osteoporosis over a 18-month period...
February 15, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28201922/diagnosis-of-osteoporosis-in-rural-arctic-greenland-a-clinical-case-using-plain-chest-radiography-for-secondary-prevention-and-consideration-of-tools-for-primary-prevention-in-remote-areas
#2
Inuuteq Fleischer, Louise K Schæbel, Nadja Albertsen, Vibeke N Sørensen, Stig Andersen
CONTEXT: Osteoporosis is a frequent disease in many populations. The hallmark is fragility fractures, which are harbingers of future fractures, disability, mortality and cost on society. The occurrence increases with age, low vitamin D level and smoking. Smoking rates are high, vitamin D is low and life expectancy is rising steeply in Greenland, as is the need for focus on osteoporosis. We report a case that uses a simple and readily available tool to diagnose osteoporosis at the hospital in Sisimiut, a town of 5000 inhabitants on the west coast of Greenland...
January 2017: Rural and Remote Health
https://www.readbyqxmd.com/read/28179094/pediatric-onset-inflammatory-bowel-disease-poses-risk-for-low-bone-mineral-density-at-early-adulthood
#3
Anat Guz-Mark, Firas Rinawi, Oxana Egotubov, Ilan Shimon, Raanan Shamir, Amit Assa
BACKGROUND: Inflammatory bowel disease (IBD) is known to pose a risk for low bone mineral density (BMD) in children and adults. We aimed to evaluate the impact of pediatric-onset IBD on BMD in adulthood. METHODS: Records of pediatric-IBD patients were retrospectively reviewed for documentation of dual-energy X-ray absorptiometry (DXA) scans in adulthood. BMD was expressed as z-score. RESULTS: Sixty one patients were included. Mean (±SD) age at diagnosis was 14...
January 20, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28178628/25-hydroxyvitamin-d-1-%C3%AE-hydroxylase-in-apoliporotein-e-knockout-mice-the-role-of-protecting-vascular-smooth-muscle-cell-from-calcification
#4
Wei Xiang, Wang Liao, Zhuwen Yi, Xiaojie He, Yan Ding
Previous publications widely reported that 25-hydroxyvitamin D-1-α-hydroxylase (CYP27B1) regulated the metabolism of 25-hydroxyvitamin D3, which has a close association between altered activity of vitamin D and vascular calcification has been reported in various human diseases, including chronic kidney disease, osteoporosis and atherosclerosis. Vascular calcification is a clinically significant component of atherosclerosis and may be promoted by ROS associated inflammatory. In this study, we evaluated the effect of 25-hydroxyvitamin D-1-α-hydroxylase on the atherosclerosis disease both in apolipoprotein (apo) E-/- mice and wild-type mice...
February 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28177161/vdr-in-osteoblast-lineage-cells-primarily-mediates-vitamin-d-treatment-induced-increase-in-bone-mass-by-suppressing-bone-resorption
#5
Yuko Nakamichi, Nobuyuki Udagawa, Kanji Horibe, Toshihide Mizoguchi, Yoko Yamamoto, Takashi Nakamura, Akihiro Hosoya, Shigeaki Kato, Tatsuo Suda, Naoyuki Takahashi
Long-term treatment with active vitamin D [1α,25(OH)2 D3 ] and its derivatives is effective for increasing bone mass in patients with primary and secondary osteoporosis. Derivatives of 1α,25(OH)2 D3 , including eldecalcitol (ELD), exert their actions through the vitamin D receptor (VDR). ELD is more resistant to metabolic degradation than 1α,25(OH)2 D3 . It is reported that ELD treatment causes a net increase in bone mass by suppressing bone resorption rather than by increasing bone formation in animals and humans...
February 8, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28167238/serum-from-postmenopausal-women-treated-with-a-by-product-of-olive-oil-extraction-process-stimulates-osteoblastogenesis-and-inhibits-adipogenesis-in-human-mesenchymal-stem-cells-msc
#6
Antonio Casado-Díaz, Isaac Túnez-Fiñana, José María Mata-Granados, María Victoria Ruiz-Méndez, Gabriel Dorado, María Concepción Romero-Sánchez, Cristina Navarro-Valverde, José Manuel Quesada-Gómez
Aging may enhance both oxidative stress and bone-marrow mesenchymal stem-cell (MSC) differentiation into adipocytes. That reduces osteoblastogenesis, thus favoring bone-mass loss and fracture, representing an important worldwide health-issue, mainly in countries with aging populations. Intake of antioxidant products may help to retain bone-mass density. Interestingly, a novel olive-pomace physical treatment to generate olive oil also yields by-products rich in functional antioxidants. Thus, diet of postmenopausal women was supplemented for two months with one of such by-products (distillate 6; D6), being rich in squalene...
February 3, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28164599/evaluation-of-an-automated-competitive-protein-binding-assay-for-25-hydroxyvitamin-d
#7
Stephan H Scharla, Uta G Lempert
BACKGROUND: The measurement of 25-hydroxyvitamin D is of increasing importance in the management of patients with mineral disorders. However, there are a great variety of test results for 25-hyroxyvitamin D depending on the method used. In this report a new automated method provided by Roche diagnostics (Elecsys Vitamin D Total assay) and the previously marketed method are compared to a reference method (Immundiagnostik ELISA). Further, we tested the new Roche method for its ability to monitor vitamin D supplementation...
September 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28161839/osteoprotegerin-and-uremic-osteoporosis-in-chronic-hemodialysis-patients
#8
Diana Moldovan, Crina Rusu, Alina Potra, Ioan Moldovan, Ioan Mihai Patiu, Mirela Gherman-Caprioara, Ina Maria Kacso
INTRODUCTION: Osteoprotegerin (OPG) is a powerful inhibitor of osteoclast activity, and it plays an important role in bone metabolism. In hemodialysis (HD) patients, the relationship between OPG and bone mineral density (BMD) is important, but remains unclear yet. The study objective was to assess the OPG role related to uremic osteoporosis in HD patients. METHODS: This cross-sectional study has been realized on a cohort of 63 chronic HD patients. INCLUSION CRITERIA: elderly prevalent HD patients with an age over 55 years old...
February 4, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28161223/genetic-polymorphisms-in-the-esr1-and-vdr-genes-do-not-correlate-with-osteoporosis-in-patients-with-familial-dysautonomia
#9
David Cheishvili, Channa Maayan, Daniel M Sapozhnikov, Elad Lax, Rivka Dresner-Pollak
One of the major clinical manifestations of familial dysautonomia (FD)-a rare, neurodegenerative, autosomal-recessive disorder-is a high incidence and early onset of osteoporotic bone fractures. Early diagnosis is essential to initiate preventative therapy in at-risk patients and thus improve quality of life. However, the current lack of understanding of the complex relationship between FD and osteoporosis etiology precludes early diagnosis, and as such, accurate predictors of osteoporosis development in FD patients remain to be determined...
February 1, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28160246/hypogonadotropic-hypogonadism-in-males-with-glycogen-storage-disease-type-1
#10
Evelyn M Wong, Anna Lehman, Philip Acott, Jane Gillis, Daniel L Metzger, Sandra Sirrs
BACKGROUND: Glycogen storage disease type 1 is an autosomal recessive disorder with an incidence of 1 in 100,000. Long-term complications include chronic blood glucose lability, lactic academia, short stature, osteoporosis, delayed puberty, gout, progressive renal insufficiency, systemic or pulmonary hypertension, hepatic adenomas at risk for malignant transformation, anemia, vitamin D deficiency, hyperuricemic nephrocalcinosis, inflammatory bowel syndrome (type 1b), hypertriglyceridemia, and irregular menstrual cycles...
February 4, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28155836/fracture-liaison-services-polish-experience-methods-of-secondary-prevention-of-osteoporotic-fractures
#11
Jarosław Amarowicz, Edward Czerwiński, Katarzyna Zając, Anna Kumorek
BACKGROUND: Fragility fractures are a major challenge to health systems around the world. The risk of a subsequent fracture may increase even 11-fold after one's first fracture event. A coordinator-based system (Fracture Liaison Services) was established in Poland in order to fill the gap in the care of patients with osteoporotic fractures. In the past years, the FLS has become a crucial part of orthopaedic facilities worldwide, bringing benefits to patients and savings to health systems' budgets...
November 30, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28155141/compliance-to-the-joint-commission-proposed-core-measure-set-on-osteoporosis-associated-fracture-review-of-different-secondary-fracture-prevention-programs-in-an-open-medical-system-from-2010-to-2015
#12
Ma Conchitina Fojas, Lauren T Southerland, Laura S Phieffer, Julie A Stephens, Tanya Srivastava, Steven W Ing
: There are care gaps in the evaluation and treatment of osteoporosis after a fragility fracture. The Joint Commission is considering adoption of core measures. We compared compliance between two secondary fracture prevention programs in our institution. Incorporating strengths of both may provide the best outcomes for secondary fracture prevention. PURPOSE: There are significant care gaps in the evaluation and treatment of osteoporosis after occurrence of fragility fracture...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28154943/validity-of-height-loss-as-a-predictor-for-prevalent-vertebral-fractures-low-bone-mineral-density-and-vitamin-d-deficiency
#13
A L Mikula, S J Hetzel, N Binkley, P A Anderson
: Many osteoporosis-related vertebral fractures are unappreciated but their detection is important as their presence increases future fracture risk. We found height loss is a useful tool in detecting patients with vertebral fractures, low bone mineral density, and vitamin D deficiency which may lead to improvements in patient care. INTRODUCTION: This study aimed to determine if/how height loss can be used to identify patients with vertebral fractures, low bone mineral density, and vitamin D deficiency...
February 3, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28144165/osteosarcopenic-obesity-in-women-impact-prevalence-and-management-challenges
#14
REVIEW
Pegah JafariNasabian, Julia E Inglis, Owen J Kelly, Jasminka Z Ilich
Osteosarcopenic obesity syndrome (OSO) has recently been identified as a condition encompassing osteopenia/osteoporosis, sarcopenia and obesity. OSO is especially deleterious in older adults (even if they are not obese by conventional measures), due to age-related redistribution of fat and its infiltration into bone and muscle. Osteoporosis and bone fractures in elderly increase the risk of sarcopenia, which, through decreased mobility, increases the risk of more falls and fractures, creating a vicious cycle...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28138903/the-treatment-of-giant-cell-arteritis
#15
REVIEW
Imran Jivraj, Madhura Tamhankar
Giant cell arteritis (GCA) is a systemic inflammatory vasculitis affecting medium and large vessels with potentially sight and life-threatening complications. Early diagnosis and prompt treatment are imperative in order to prevent vision loss and progression of the disease. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are inflammatory markers which are elevated in the majority of patients and support the diagnosis of GCA among patients who present with typical symptoms. GCA is confirmed with superficial temporal artery biopsy which demonstrates characteristic pathological findings...
January 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28138749/the-relationship-between-postmenopausal-women-s-sclerostin-levels-and-their-bone-density-age-body-mass-index-hormonal-status-and-smoking-and-consumption-of-coffee-and-dairy-products
#16
Muberra Namlı Kalem, Ziya Kalem, Nilufer Akgun, Batuhan Bakırarar
PURPOSE: To investigate the relationship between postmenopausal women's sclerostin levels and bone density and the factors that may affect this relationship. MATERIALS AND METHODS: 135 postmenopausal patients' ages, BMIs, hormonal statuses, BMD values, and smoking, and consumption of coffee and dairy products were compared with their sclerostin levels. RESULTS: No statistical relationship was found between sclerostin level and age in the group with osteoporosis (p = 0...
January 31, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28130552/melatonin-micronutrients-osteopenia-treatment-study-mots-a-translational-study-assessing-melatonin-strontium-citrate-vitamin-d3-and-vitamin-k2-mk7-on-bone-density-bone-marker-turnover-and-health-related-quality-of-life-in-postmenopausal-osteopenic-women-following
#17
Sifat Maria, Mark H Swanson, Larry T Enderby, Frank D'Amico, Brianna Enderby, Rebekah M Samsonraj, Amel Dudakovic, Andre J van Wijnen, Paula A Witt-Enderby
This one-year double blind randomized control trial assessed the effects of nightly melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7; MSDK) on bone mineral density (BMD) and quality of life (QOL) in postmenopausal osteopenic women (ages 49-75). Compared to placebo, MSDK treatment increased BMD in lumbar spine (4.3%) and left femoral neck (2.2%), with an upward trend for total left hip (p=0.069). MSDK increased serum P1NP levels and reduced bone turnover (CTx:P1NP). Psychometric analyses indicated that mood and sleep quality improved for the MSDK group...
January 26, 2017: Aging
https://www.readbyqxmd.com/read/28130180/optimal-vitamin-d-status-and-its-relationship-with-bone-and-mineral-metabolism-in-hong-kong-chinese
#18
Raymond Yh Leung, Bernard My Cheung, Uyen-Sa Nguyen, Annie Wc Kung, Kathryn Cb Tan, Ching-Lung Cheung
BACKGROUND: Although 25-hydroxyvitamin D (25[OH]D) is commonly used to define vitamin D status, there is no consensus on the cutoff levels for vitamin D deficiency and insufficiency. In this study, we aimed to identify the 25(OH)D threshold that maximally suppressed parathyroid hormone (PTH) in Hong Kong Chinese population. METHODS: The study included 5276 participants (70% female) of the Hong Kong Osteoporosis Study aged 20 or above who had total 25(OH)D measured...
January 24, 2017: Bone
https://www.readbyqxmd.com/read/28125404/bone-mineral-density-and-bone-metabolic-markers-status-in-children-with-neurofibromatosis-type-1
#19
Hatice Gamze Poyrazoğlu, Veysel Nijat Baş, Alev Arslan, Funda Bastug, Mehmet Canpolat, Hüseyin Per, Hakan Gümüs, Sefer Kumandas
BACKGROUND: Neurofibromatosis type 1 (NF1) is a multisystem disorder characterized by progressive manifestations, which is inherited in an autosomal dominant manner. The majority of patients with NF1 experience a diffuse, significant reduction in bone mass over time, with osteoporosis, osteopenia in the absence of severe scoliosis, or gross bone deformities. This study aimed to determine the bone mineral density (BMD) status, evaluate bone metabolism, and to determine the relevant factors in children with NF1...
February 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28124221/serum-25-hydroxyvitamin-d-and-bone-turnover-markers-in-palestinian-postmenopausal-osteoporosis-and-normal-women
#20
Akram Kharroubi, Elias Saba, Riham Smoom, Khaldoun Bader, Hisham Darwish
: This study evaluated the association of vitamin D and bone markers with the development osteoporosis in Palestinian postmenopausal women. Even though vitamin D deficiency was very high for the recruited subjects, it was not associated with osteoporosis except for bones of the hip. Age and obesity were the strongest determining factors of the disease. PURPOSE: The purpose of this study was to investigate the association of bone mineral density (BMD) with serum vitamin D levels, parathyroid hormone (PTH), calcium, obesity, and bone turnover markers in Palestinian postmenopausal women...
December 2017: Archives of Osteoporosis
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