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https://www.readbyqxmd.com/read/27904960/active-and-passive-involvement-of-claudins-in-the-pathophysiology-of-intestinal-inflammatory-diseases
#1
REVIEW
Christian Barmeyer, Michael Fromm, Jörg-Dieter Schulzke
Intestinal inflammatory diseases, four of which are discussed here, are associated with alterations of claudins. In ulcerative colitis, diarrhea and antigen entry into the mucosa occurs. Claudin-2 is upregulated but data on other claudins are still limited or vary (e.g., claudin-1 and -4). Apart from that, tight junction changes contribute to diarrhea via a leak flux mechanism, while protection against antigen entry disappears behind epithelial gross lesions (erosions) and apoptotic foci. Crohn's disease is additionally characterized by a claudin-5 and claudin-8 reduction which plays an active role in antigen uptake already before gross lesions appear...
November 30, 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27492679/celiac-disease-presenting-as-profound-diarrhea-and-weight-loss-a-celiac-crisis
#2
Vadim Bul, Brett Sleesman, Brian Boulay
BACKGROUND Celiac disease is a hypersensitivity enteropathy that can have various presentations in adults. Rarely, patients can present with severe lab abnormalities, dehydration and weight loss caused by celiac disease - a celiac crisis. CASE REPORT A 46-year-old male with a past medical history significant for diabetes mellitus, type 2 (DM2) and recently treated Bell's Palsy presented to the emergency room complaining of weakness, diarrhea and lightheadedness. On presentation, the patient had a systolic blood pressure (SBP) of 60 mm Hg and a lactic acidosis with pH of 7...
August 5, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27489467/celiac-disease-in-children-and-adolescents-with-hashimoto-thyroiditis
#3
Hale Tuhan, Sakine Işık, Ayhan Abacı, Erdem Şimşek, Ahmet Anık, Özden Anal, Ece Böber
AIM: The aim of this study was to evaluate clinical and laboratory findings and determine the prevalence of celiac disease (CD) in children with Hashimoto thyroiditis (HT). MATERIAL AND METHODS: The data of a total of 80 patients with positive anti-thyroid antibodies who were aged between 6 and 17.9 years were retrospectively studied. Age, gender, complaints at the time of presentation, family history of thyroid disorders, clinical and laboratory findings were recorded...
June 2016: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/27367991/the-role-of-soluble-tumor-necrosis-factor-like-weak-inducer-of-apoptosis-and-interleukin-17a-in-the-etiopathogenesis-of-celiac-disease-a-cross-sectional-study
#4
Mahmut Yuksel, Mustafa Kaplan, Ihsan Ates, Zeki Mesut Yaln Kilic, Hasan Kilic, Nuretdin Suna, Hale Ates, Ertugrul Kayacetin
Our aim in this study was to determine soluble tumor necrosis factor (TNF)-like weak inducer of apoptosis (sTWEAK) and interleukin-17A (IL-17A) levels in celiac disease, and their association with the gluten diet and autoantibodies. Eighty patients with celiac diagnosis and 80 healthy control individuals with similar age, gender and body mass index to the patient group were included in the study. Serum sTWEAK and IL-17A levels were measured by the serum enzyme-linked immunosorbent assay kit. The median IL-17A (117...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27052281/pattern-of-thyroid-celiac-and-anti-cyclic-citrullinated-peptide-autoantibodies-coexistence-with-type-1-diabetes-mellitus-in-patients-from-southwestern-saudi-arabia
#5
Ahmed M Al-Hakami
OBJECTIVES: To investigate the seroprevalence of coexisting autoantibodies among type 1 diabetes mellitus (T1DM) patients, and to look for possible correlations with age at diagnosis, diabetes duration, and glycemic control. METHODS: This is a cross-sectional study conducted at Aseer Central Hospital, Abha, Kingdom of Saudi Arabia from March 2013 to June 2014. A total of 202 T1DM patients were screened for serum anti-thyroglobulin (TG), anti-thyroid peroxidase (TPO), anti-tissue transglutaminase (aTTG), anti-endomysial (EMA), and anti-cyclic citrullinated peptide (anti-CCP) antibodies along with glycated hemoglobin, and biometric data...
April 2016: Saudi Medical Journal
https://www.readbyqxmd.com/read/27030188/-seronegative-celiac-disease-a-case-report
#6
L M Krums, A I Parfenov, E A Sabelnikova, N I Poleva, S V Bykova, E A Dubtsova, R B Gudkova, S G Khomeriki, D L Rotin, M V Pavlov, N S Starostina
The paper describes a rare case of celiac disease in the absence of serum anti-tissue transglutaminase (anti-tTG) antibodies. A 51-year-old patient has been suffering from diarrheas for 20 years. He has lost 15 kg gradually; weakness progressed; muscle cramps, leg edemas, and signs of dynamic pseudoobstruction appeared. Morphological examination revealed small intestinal mucosal (SIM) villous atrophy (Marsh IIIC stage). IgA anti-tTG and IgG anti-tTG antibodies were 0.086 and 0.178, respectively. The patient was prescribed a gluten-free diet, water electrolyte solutions to correct metabolic disturbances, and prednisolone...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/26753888/in-the-intestinal-mucosa-of-children-with-potential-celiac-disease-il-21-and-il-17a-are-less-expressed-than-in-the-active-disease
#7
Melissa Borrelli, Carmen Gianfrani, Giuliana Lania, Rosita Aitoro, Katia Ferrara, Merlin Nanayakkara, Domenico Ponticelli, Delia Zanzi, Valentina Discepolo, Serena Vitale, Maria Vittoria Barone, Riccardo Troncone, Renata Auricchio, Mariantonia Maglio
OBJECTIVES: Potential celiac disease (CD) patients are at an increased risk to developing CD as indicated by positive CD-associated serology. We investigated in duodenal mucosa of such patients the presence of both IL-21 and IL-17A and the role of gliadin peptides and IL-15 in their expression. METHODS: Duodenal biopsies from 76 active CD, 90 potential CD, and 58 control patients were analyzed for IL-21 and/or IL-17A production by quantitative real-time PCR, immunohistochemistry, flow cytometry, and ELISA...
January 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/26665656/-benefits-of-gluten-free-diet-myth-or-reality
#8
Yann Coattrenec, Thomas Harr, Claude Pichard, Mathieu Nendaz
Non celiac gluten sensitivity may explain digestive and general symptoms in patients without celiac disease but this recently described entity is controversial. The role of gluten in comparison to other nutriments such as saccharides and polyols (FODMAPs) remains debated. If a gluten-free diet is clearly indicated in celiac disease and wheat allergy, it remains debatable in non-celiac gluten sensitivity given weak and contradictory evidence. There is no strong evidence for a strict indication to a gluten-free diet in endocrinological, psychiatric, and rheumatologic diseases, or to improve performance in elite sports...
October 14, 2015: Revue Médicale Suisse
https://www.readbyqxmd.com/read/26505973/despite-sequence-homologies-to-gluten-salivary-proline-rich-proteins-do-not-elicit-immune-responses-central-to-the-pathogenesis-of-celiac-disease
#9
Na Tian, Daniel A Leffler, Ciaran P Kelly, Joshua Hansen, Eric V Marietta, Joseph A Murray, Detlef Schuppan, Eva J Helmerhorst
Celiac disease (CD) is an inflammatory disorder triggered by ingested gluten, causing immune-mediated damage to the small-intestinal mucosa. Gluten proteins are strikingly similar in amino acid composition and sequence to proline-rich proteins (PRPs) in human saliva. On the basis of this feature and their shared destination in the gastrointestinal tract, we hypothesized that salivary PRPs may modulate gluten-mediated immune responses in CD. Parotid salivary secretions were collected from CD patients, refractory CD patients, non-CD patients with functional gastrointestinal complaints, and healthy controls...
December 1, 2015: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/26328039/h-pylori%C3%A2-associated-with-iron-deficiency-anemia-even-in-celiac-disease-patients-strongly-evidence-based-but-weakly-reflected-in-practice
#10
REVIEW
Mohammad Rostami-Nejad, David Aldulaimi, Helen Livett, Kamran Rostami
Inflammation can lead to malabsorption of important micronutrients such as iron. Malabsorption and nutritional deficiency can be caused by a variety of pathological and environmental factors causing a range of other symptoms commonly caused by both H. pylori infection and coeliac disease (CD). National guidelines suggest the routine taking of duodenal biopsies to exclude CD when investigating patients for iron deficiency anemia (IDA). Studies suggest that in absence of positive antibodies, IDA is rarely caused by CD...
2015: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/26310636/proximal-muscle-weakness-as-a-result-of-osteomalacia-associated-with-celiac-disease-a-case-report
#11
B Oz, O Akan, H Kocyigit, H A Gürgan
UNLABELLED: A 24-year-old woman suffering from back and hip pain with difficulty in walking was reported. She had proximal muscle weakness. Laboratory findings led to the diagnosis of osteomalacia. Positivity of antibodies strengthened suspicion of celiac disease. In patients with proximal muscle weakness, osteomalacia should be considered in differential diagnosis even in a young woman. INTRODUCTION: A 24-year-old woman suffering from back pain, bilateral hip pain, and difficulty in walking was reported...
February 2016: Osteoporosis International
https://www.readbyqxmd.com/read/26265523/bilateral-femoral-neck-fatigue-fracture-due-to-osteomalacia-secondary-to-celiac-disease-report-of-three-cases
#12
Ozgur Selek, Kaya Memisoglu, Alev Selek
Bilateral non traumatic femoral neck fatigue fracture is a rare condition usually occurring secondary to medical conditions such as pregnancy, pelvic irradiation, corticosteroid exposure, chronic renal failure and osteomalacia. In this report, we present three young female patients with bilateral femoral neck fracture secondary to osteomalacia. The underlying cause of osteomalacia was Celiac disease in all patients. The patients were treated with closed reduction and internal fixation with cannulated lag screws...
August 2015: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/26140001/evolution-of-nonspecific-duodenal-lymphocytosis-over-2-years-of-follow-up
#13
Giuseppe Losurdo, Domenico Piscitelli, Antonio Giangaspero, Mariabeatrice Principi, Francesca Buffelli, Floriana Giorgio, Lucia Montenegro, Claudia Sorrentino, Annacinzia Amoruso, Enzo Ierardi, Alfredo Di Leo
AIM: To assess the evolution of duodenal lymphocytosis (DL), a condition characterized by increased intraepithelial lymphocytes (IELs), over 2 years of follow-up. METHODS: Consecutive patients undergoing upper endoscopy/histology for abdominal pain, diarrhea, weight loss, weakness or other extraintestinal features compatible with celiac disease (CD) were included. Evaluation of IELs infiltrate in duodenal biopsy samples was carried out by CD3-immunohistochemistry and expressed as number of positive cells/100 enterocytes...
June 28, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25993866/-connective-tissue-dysplasia-in-patients-with-celiac-desease-as-a-problem-of-violation-of-adaptation-reserve-islands-of-the-body
#14
E Tkachenko, L S Oreshko, E A Soloveva, A A Shabanova, M S Zhuravleva
Clinically significant dysplasia of connective tissue in patients with celiac disease is often responsible for various visceral disorders. Different disturbances of motor and evacuation functions are often determined in this patients (gastroesophageal reflux, duodenogastral reflux, spastic and hyperkinetic dyskinesia). The clinical course of the celiac disease, associated with connective tissue dysplasia, is characterized by asthenovegetative syndrome, reduced tolerance to physical activity, general weakness, fatigue and emotional instability...
2015: Experimental & Clinical Gastroenterology
https://www.readbyqxmd.com/read/25864344/-carbohydrase-activities-may-serve-as-a-marker-for-small-intestinal-mucosal-recovery-in-patients-with-celiac-disease
#15
A I Parfenov, O V Akhmadullina, E A Sabel'nikova, N I Belostotskii, R B Gudkova, S G Khomeriki
Aim. To clinically evaluate the activity of glucoamylase, maltase, saccharase, and lactase in the small intestinal mucosa (SIM) of patients with celiac disease. Subjects and methods. Twenty-nine patents with celiac disease were examined. The disease was first detected in 8 patients; in the remaining patients, it had been diagnosed 6 months to 35 years before. The diagnosis was verified by histological examinations of duodenal biopsy specimens and by determination of immunoglobulin (Ig) A and G antibodies to tissue transglutaminase (atTG) and gliadin (AGA) by an enzyme-linked immunosorbent assay (ELISA)...
2015: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/25765028/-adult-onset-generalized-autoimmune-enteropathy-involving-small-intestine-and-colon-report-of-a-case-and-review-of-literature
#16
Yumei Lai, Juxiang Ye, Yan Zhang, Hong Chang, Hejun Zhang, Xueying Shi
OBJECTIVE: To investigate the clinicopathologic features of adult-onset autoimmune enteropathy (AIE). METHODS: A case of adult-onset AIE was described along with a literature review. RESULTS: A 41-year-old male patient was admitted for intractable diarrhea for more than three months despite of any dietary restriction or anti-inflammatory therapy. Fat globule was observed by stool examination and Sudan III staining of the stool was positive...
January 2015: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/25724709/increased-risk-of-esophageal-eosinophilia-and-eosinophilic-esophagitis-in-patients-with-active-celiac-disease-on-biopsy
#17
Elizabeth T Jensen, Swathi Eluri, Benjamin Lebwohl, Robert M Genta, Evan S Dellon
BACKGROUND & AIMS: The possible association between eosinophilic esophagitis (EoE) and celiac disease is controversial because prior results have been contradictory. We aimed to determine the relationship between EoE and celiac disease among patients with concomitant esophageal and duodenal biopsies. METHODS: We conducted a cross-sectional study in a U.S. national pathology database by using data from January 2009 through June 2012. Our primary case definition was defined by the presence of esophageal eosinophilia with ≥15 eosinophils per high-power field...
August 2015: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/25667705/celiac-disease-causing-severe-osteomalacia-an-association-still-present-in-morocco
#18
Latifa Tahiri, Hamida Azzouzi, Ghita Squalli, Fatimazahra Abourazzak, Taoufik Harzy
Celiac disease (CD), a malabsorption syndrome caused by hypersensitivity to gliadin fraction of gluten. CD can manifest with classic symptoms; however, significant myopathy and multiple fractures are rarely the predominant presentation of untreated celiac disease. Osteomalacia complicating celiac disease had become more and more rare. We describe here a case of osteomalacia secondary to a longstanding untreated celiac disease. This patient complained about progressive bone and muscular pain, weakness, fractures and skeletal deformities...
2014: Pan African Medical Journal
https://www.readbyqxmd.com/read/25624603/a-young-man-with-hemoptysis-rare-association-of-idiopathic-pulmonary-hemosiderosis-celiac-disease-and-dilated-cardiomyopathy
#19
Gopi C Khilnani, Neetu Jain, Pavan Tiwari, Vijay Hadda, Lavleen Singh
Idiopathic pulmonary hemosiderosis (IPH) is a rare cause of recurrent diffuse alveolar hemorrhage (DAH) with no specific treatment. Herein, we discuss a case of hemoptysis, who had IPH and other rare associations. A 19-year-old man presented with recurrent hemoptysis, generalized weakness and progressive dyspnea for 3 years. Earlier, he was diagnosed with anemia and was treated with blood transfusions and hematinics. On examination he had pallor, tachycardia and was underweight. Investigations revealed low level of hemoglobin (7...
January 2015: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/25577269/racial-differences-in-the-prevalence-of-celiac-disease-in-the-us-population-national-health-and-nutrition-examination-survey-nhanes-2009-2012
#20
Houssam E Mardini, Philip Westgate, Alla Y Grigorian
AIM: To provide an estimate of the prevalence of celiac disease by race/ethnic origin in large sample of US population. METHODS: Data from the 2009-2010 and 2011-2012 NHANES were combined and analyzed. The NHANES is a nationally representative survey with oversampling of certain minorities. Sample-based frequencies were reported and weighted frequencies were used to estimate prevalence. RESULTS: A total of 14,701 participants were checked for tissue transglutaminase (tTG) and endomysial (EMA) IgA antibodies...
June 2015: Digestive Diseases and Sciences
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