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https://www.readbyqxmd.com/read/28634148/iodine-and-freeze-drying-enhanced-high-resolution-microct-imaging-for-reconstructing-3d-intraneural-topography-of-human-peripheral-nerve-fascicles
#1
Liwei Yan, Yongze Guo, Jian Qi, Qingtang Zhu, Liqiang Gu, Canbin Zheng, Tao Lin, Yutong Yu, Zitao Zeng, Sha Yu, Shuang Zhu, Xiang Zhou, Xi Zhang, Yunfei Du, Zhi Yao, Yao Lu, Xiaolin Liu
BACKGROUND: The precise annotation and accurate identification of the topography of fascicles to the end organs are prerequisites for studying human peripheral nerves. NEW METHOD: In this study, we present a feasible imaging method that acquires 3D high-resolution (HR) topography of peripheral nerve fascicles using an iodine and freeze-drying (IFD) micro-computed tomography (microCT) method to greatly increase the contrast of fascicle images. RESULTS: The enhanced microCT imaging method can facilitate the reconstruction of high-contrast HR fascicle images, fascicle segmentation and extraction, feature analysis, and the tracing of fascicle topography to end organs, which define fascicle functions...
June 17, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28632654/an-overview-of-cardiac-computed-tomography-in-adults-with-congenital-heart-disease
#2
Pal Suranyi, Akos Varga-Szemes, Anthony M Hlavacek
Familiarity with congenital heart disease (CHD) and its manifestations in adults is becoming increasingly important for the practicing cardiothoracic imager. The use of computed tomographic angiography is becoming commonplace not only in adults with a history and subsequent interventions for CHD as a child but also in de novo detection of-typically-milder, survivable forms of CHD, which are clinically suspected because of declining cardiac performance, cardiac events, or murmurs. Occasionally, adult CHD (ACHD) is found incidentally on scans performed for other indications (eg, trauma or neoplasm staging) because of improvements in computed tomographic technology and advanced visualization...
July 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28631796/isomerization-versus-dissociation-of-phenylalanylglycyltryptophan-radical-cations
#3
Xiaoyan Mu, Justin Kai-Chi Lau, Cheuk-Kuen Lai, K W Michael Siu, Alan C Hopkinson, Ivan K Chu
Four isomers of the radical cation of tripeptide phenylalanylglycyltryptophan, in which the initial location of the radical center is well defined, have been isolated and their collision-induced dissociation (CID) spectra examined. These ions, the π-centered [FGWπ˙](+), α-carbon- [FGα˙W](+), N-centered [FGWN˙](+) and ζ-carbon- [Fζ˙GW](+) radical cations, were generated via collision-induced dissociation (CID) of transition metal-ligand-peptide complexes, side chain fragmentation of a π-centered radical cation, homolytic cleavage of a labile nitrogen-nitrogen single bond, and laser induced dissociation of an iodinated peptide, respectively...
June 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28628778/effects-of-incubation-time-and-filtration-method-on-kd-of-indigenous-selenium-and-iodine-in-temperate-soils
#4
T Almahayni, E Bailey, N M J Crout, G Shaw
In this study, the effects of incubation time and the method of soil solution extraction and filtration on the empirical distribution coefficient (Kd) obtained by de-sorbing indigenous selenium (Se) and iodine (I) from arable and woodland soils under temperate conditions were investigated. Incubation time had a significant soil- and element-dependent effect on the Kd values, which tended to decrease with the incubation time. Generally, a four-week period was sufficient for the desorption Kd value to stabilise...
June 16, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28627007/optical-molecular-imaging-guided-radiation-therapy-part-1-integrated-x-ray-and-bioluminescence-tomography
#5
Junwei Shi, Thirupandiyur S Udayakumar, Zhiqun Wang, Nesrin Dogan, Alan Pollack, Yidong Yang
PURPOSE: X-ray CT faces challenges in differentiating tumors from surrounding healthy tissues. A bioluminescence tomography (BLT) system which can directly reconstruct the internal luminescent tumors, was developed and integrated with CT system to accurately guide radiation dose delivery. METHODS: The BLT system, employing a lens-coupled CCD camera, was physically registered with an onboard cone beam CT system in an image guided small animal arc radiation treatment system (iSMAART)...
June 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28626876/optical-molecular-imaging-guided-radiation-therapy-part-2-integrated-x-ray-and-fluorescence-molecular-tomography
#6
Junwei Shi, Thirupandiyur S Udayakumar, Zhiqun Wang, Nesrin Dogan, Alan Pollack, Yidong Yang
PURPOSE: Differentiating tumor from its surrounding soft tissues is challenging for x-ray computed tomography (CT). Fluorescence molecular tomography (FMT) can directly localize the internal tumors targeted with specific fluorescent probes. A FMT system was developed and integrated onto a CT guided irradiator to improve tumor localization for image guided radiation. METHODS: The FMT system was aligned orthogonal to the cone beam CT onboard our previously developed image guided small animal arc radiation treatment system (iSMAART)...
June 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28624023/enhanced-radiation-damage-caused-by-iodinated-contrast-agents-during-ct-examination
#7
Ling Wang, Qiang Li, Xi-Ming Wang, Guang-Yu Hao, Jie-Bao, Su Hu, Chun-Hong Hu
OBJECTIVE: To access the effect of iodinate contrast agent (ICA) on DNA double-stand breaks (DSBs) in human peripheral blood lymphocytes during computed tomography (CT) examinations. MATERIALS AND METHODS: This present study was approved by the institutional ethics committee; written informed patient consent was obtained from 70 patients. A total of 48 patients underwent computed tomography urography (CTU), in which only one time CT scanning was examined after injecting ICA, and 22 patients received unenhanced whole abdominal CT, among them 10 patients were selected to get ICA injection immediately after irradiation...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28622245/iodinated-contrast-medium-renal-toxicity-the-phantom-menace-or-much-ado-about-nothing
#8
Karim Lakhal, Stephan Ehrmann, Vincent Robert-Edan
No abstract text is available yet for this article.
July 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28622166/quantitative-analysis-of-iodine-image-of-dual-energy-computed-tomography-at-rest-comparison-with-99mtc-tetrofosmin-stress-rest-single-photon-emission-computed-tomography-myocardial-perfusion-imaging-as-the-reference-standard
#9
Takehiro Nakahara, Takuji Toyama, Masahiro Jinzaki, Ryotaro Seki, Yuichiro Saito, Tetsuya Higuchi, Minoru Yamada, Masashi Arai, Yoshito Tsushima, Sachio Kuribayashi, Masahiko Kurabayashi
PURPOSE: Dual-energy computed tomography (DECT) can be used for visual determination of iodine distribution in the myocardium (iodine image); however, the accuracy and reproducibility of the process remains debatable. Because of the low contrast-to-noise ratio of CT, we hypothesized that quantitative measurement may be more accurate for detecting myocardial ischemia. In this study, we evaluated our quantitative method by comparing it with visual analysis using Tc-tetrofosmin (TF) stress-rest single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) as the reference standard...
June 15, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28620616/the-impact-of-combining-a-low-tube-voltage-acquisition-with-iterative-reconstruction-on-total-iodine-dose-in-coronary-ct-angiography
#10
Toon Van Cauteren, Gert Van Gompel, Kaoru Tanaka, Douwe E Verdries, Dries Belsack, Koenraad H Nieboer, Inneke Willekens, Paul Evans, Sven Macholl, Guy Verfaillie, Steven Droogmans, Johan de Mey, Nico Buls
OBJECTIVES: To assess the impact of combining low-tube voltage acquisition with iterative reconstruction (IR) techniques on the iodine dose in coronary CTA. METHODS: Three minipigs underwent CCTA to compare a standard of care protocol with two alternative study protocols combining low-tube voltage and low iodine dose with IR. Image quality was evaluated objectively by the CT value, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) in the main coronary arteries and aorta and subjectively by expert reading...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28619517/acute-sialadenitis-as-adverse-reaction-to-iodinated-contrast
#11
S Sánchez García, D Rubio Solís, L Terán Álvarez, J Calvo Blanco
Swelling of the salivary glands after administration of iodinated contrast is a very rare adverse reaction. Its etiology is not clear and although it has a benign course associated complications have been reported. We report two cases of acute bilateral sialadenitis after intravenous iodinated contrast in 60 and 63 year-old men who underwent a computed tomography scan in the previous days.
June 12, 2017: Radiología
https://www.readbyqxmd.com/read/28616978/synthesis-and-pre-clinical-characterization-of-a-cationic-iodinated-imaging-contrast-agent-ca4-and-its-use-for-quantitative-computed-tomography-of-ex-vivo-human-hip-cartilage
#12
Rachel C Stewart, Amit N Patwa, Hrvoje Lusic, Jonathan D Freedman, Michel Wathier, Brian D Snyder, Ali Guermazi, Mark W Grinstaff
Contrast agents that go beyond qualitative visualization and enable quantitative assessments of functional tissue performance represent the next generation of clinically useful imaging tools. An optimized and efficient large-scale synthesis of the cationic iodinated contrast agent (CA4+) is described for imaging articular cartilage. Contrast enhanced CT (CECT) using CA4+ reveals significantly greater agent uptake of CA4+ in articular cartilage compared to similar anionic or nonionic agents, and CA4+ uptake follows Donnan Equilibrium...
June 15, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28616535/effect-of-intravenous-infusion-of-iodinated-contrast-media-on-the-coronary-blood-flow-in-dogs
#13
Thura T Abd, Asim I Shafique, Hayder S Yasir, Jung-Hee Seo, Richard T George, Rajat Mittal, Albert C Lardo
BACKGROUND: Coronary computed tomography angiography (CCTA) is obtained using peripheral intravenous iodinated contrast agents (ICA) injection. There is continuing attempts to derive coronary physiological information like coronary blood flow (CBF) and/or fractional flow reserve from CCTA images. However, no data is available regarding the effect of peripheral intravenous injection of ICA on CBF. METHODS: A series of 4 experiments was performed using healthy mongrel dogs...
September 2016: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28609415/effect-of-povidone-iodine-5-on-the-cornea-vision-and-subjective-comfort
#14
William H Ridder, Caren Oquindo, Kavita Dhamdhere, James Burke
PURPOSE: To determine the effects of povidone iodine 5% (Betadine 5%) applied to the eye on visual function, corneal integrity, and subjective complaints. METHODS: Ten subjects were chosen to participate in this study (average age 40.6 ± 19.6; age range 22-68). LogMAR acuity, contrast sensitivity, corneal fluorescein staining, and subjective complaints were measured before and after 60 μl of Betadine 5% or saline were applied to one eye (eligibility visit, baseline, 5, 30, and 60 minutes and 4 and 24 hours post-application)...
June 10, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28606252/-research-on-the-effect-of-iodinate-contrast-agent-on-the-dna-radiation-damage-at-ct
#15
L Wang, Q Li, W Zhong, S Hu, C H Hu
Objective: To evaluate the effect of iodinate contrast agent (ICA) on the formation of DNA double-stand breaks (DSBs) in human peripheral blood lymphocytes during computed tomography (CT) examinations. Methods: Peripheral venous blood (16 ml/person) of 36 volunteers were collected during the period of February to May 2016. Each blood sample was divided into 8 tubes and 4 groups on average, which were marked as groups of A, B, C, D randomly. 25 μl ICA was respectively added into one tube of each group and the groups of B, C, D accepted the same CT scan for once, twice and three times...
June 6, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28601007/distribution-and-relevance-of-iodinated-x-ray-contrast-media-and-iodinated-trihalomethanes-in-an-aquatic-environment
#16
Zhifa Xu, Xia Li, Xialin Hu, Daqiang Yin
Distribution and relevance of iodinated X-ray contrast media (ICM) and iodinated disinfection byproducts (I-DBPs) in a real aquatic environment have been rarely documented. In this paper, some ICM were proven to be strongly correlated with I-DBPs through investigation of five ICM and five iodinated trihalomethanes (I-THMs) in surface water and two drinking water treatment plants (DWTPs) of the Yangtze River Delta, China. The total ICM concentrations in Taihu Lake and the Huangpu River ranged from 88.7 to 131 ng L(-1) and 102-252 ng L(-1), respectively...
June 2, 2017: Chemosphere
https://www.readbyqxmd.com/read/28592361/ct-imaging-of-solid-renal-masses-pitfalls-and-solutions
#17
REVIEW
S Krishna, C A Murray, M D McInnes, R Chatelain, M Siddaiah, O Al-Dandan, S Narayanasamy, N Schieda
Computed tomography (CT) remains the first-line imaging test for the characterisation of renal masses; however, CT has inherent limitations, which if unrecognised, may result in errors. The purpose of this manuscript is to present 10 pitfalls in the CT evaluation of solid renal masses. Thin section non-contrast enhanced CT (NECT) is required to confirm the presence of macroscopic fat and diagnosis of angiomyolipoma (AML). Renal cell carcinoma (RCC) can mimic renal cysts at NECT when measuring <20 HU, but are usually heterogeneous with irregular margins...
June 4, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28586445/relative-conspicuity-of-gadolinium-based-contrast-agents-in-interventional-pain-procedures
#18
Timothy P Maus, Beth A Schueler, Dixon J Magnuson, Dayne Magnuson
Objective. : To assess the relative radiographic conspicuity of gadolinium-based contrast agents (GBCAs) that may be used in spinal injection procedures when iodine-based contrast agents are contraindicated. Methods. : Eight GBCAs and three iodinated agents of varying iodine concentrations were radiographed under conditions representative of lumbar spinal injections at four kilovoltage peak (kVp) values. Radiographic contrast of each agent was measured as the percent pixel value difference with respect to background...
April 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28583644/improved-detection-of-melanoma-metastases-by-iodine-maps-from-dual-energy-ct
#19
Monika Uhrig, David Simons, David Bonekamp, Heinz-Peter Schlemmer
OBJECTIVE: Metastatic disease in melanoma has an unpredictable nature with deposits in rare locations such as musculature. Dual energy CT (DECT) provides high contrast-visualization of enhancement by using spectral properties of iodine. Purpose of this study was to evaluate whether iodine maps from DECT improve lesion detection in staging examinations of melanoma patients. METHODS: This retrospective study was approved by IRB and written informed consent was obtained from all patients...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28582640/the-causes-of-thrombocytopenia-after-transcatheter-aortic-valve-implantation
#20
Maciej Mitrosz, Remigiusz Kazimierczyk, Bozena Sobkowicz, Ewa Waszkiewicz, Pawel Kralisz, Marek Frank, Jaroslaw Piszcz, Marzenna Galar, Slawomir Dobrzycki, Wlodzimierz J Musial, Tomasz Hirnle, Karol A Kaminski, Agnieszka M Tycinska
INTRODUCTION: Even though thrombocytopenia following transcatheter aortic valve implantation (TAVI) has been described, further investigation of this phenomenon is needed. AIMS: To determine which factors may explain the fall in platelet count that occurs after implantation of a TAVI device, including markers of platelet and blood coagulation activation. MATERIAL AND METHODS: 32 patients without previous indications for dual antiplatelet therapy (mean age 78...
May 26, 2017: Thrombosis Research
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