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https://www.readbyqxmd.com/read/28919126/low-dose-ct-for-the-diagnosis-of-appendicitis-in-adolescents-and-young-adults-locat-a-pragmatic-multicentre-randomised-controlled-non-inferiority-trial
#1
Hyuk Jung Kim, Byeong Geon Jeon, Chong Kun Hong, Kye Won Kwon, Seung Bong Han, Soya Paik, Suk Ki Jang, Young Rock Ha, Young Sik Kim, Min Hee Lee, Boem Ha Yi, Eung Jin Shin, Hae Kyung Lee, Hee Kyung Kim, Ho Jung Kim, Jae Hyung Choi, Young Soon Cho, Min-Jeong Kim, Dong Kyu Kim, Ji-Young Choe, Kyueng-Whan Min, Man Sup Lim, Sang Ook Ha, Sang Woo Lim, Youdong Sohn, Young Hwan Lee, Ji Hoon Park, Bon Seung Gu, Hye Seung Lee, Jae Hyuk Lee, Ji Ye Sim, Joonghee Kim, Kyoung Ho Lee, Kyuseok Kim, Soyeon Ahn, Sung-Bum Kang, Yoon Jin Lee, You Hwan Jo, Young Hoon Kim, Yousun Ko, Seung Joon Choi, Bohyung Song, Byung Ho Goh, Chaesuk Lim, Chang Rae Kim, Cho Rong Seo, Eunbaeck Kim, Gio Han, Jae-Hyug Woo, Jinhyun Kim, Kyoungjin Min, Min-A Lee, Min Ju Jeong, Min Kyoung Lee, Yong Su Lim, Young Sup Shim, Sung Bin Park, Chan Woong Kim, Dong Hoon Lee, Seung Eun Lee, Sung Eun Kim, Yoo Shin Choi, Sung Eun Rha, Eun Sun Jung, Gun Hyung Na, Han Joon Kim, Han Mo Yoo, Hye Kyung Chang, Joon Il Choi, Kyu Nam Park, Michael Yong Park, Moon Hyung Choi, Sang Hoon Oh, Seung Eun Jung, Sohee Lee, Soo Ah Im, Soo Hyun Kim, Soon Nam Oh, Tae Ho Hong, Won-Kyung Kang, Young Joon Lee, Young Hwan Lee, Dong Baek Kang, Hyun Soo Han, Jeong Woo Choi, Ki-Jung Yoon, Yong Hwang, Seong Sook Hong, Eui Sung Hwang, Heajin Chung, Hye Young Jang, Jiyoung Hwang, Jun Bum Park, Kyung Yul Hur, Yoon Mi Jeen, Young Joo Lee, Young Shin Cho, Han Jin Cho, Inyoung Choi, Jong Hak Park, Jooyeong Kim, Suk Keu Yeom, Sung Woo Moon, Young Sik Kim, Mi Sung Kim, Dong Hyuk Shin, Heon-Ju Kwon, Pil Cho Choi, Sang Kuk Han, Ji Young Woo, Gu Hyun Kang, Han Myun Kim, Hyun Young Choi, Ik Yang, Jae Ho Jang, Jeong Won Kim, Sang Nam Yoon, Won Hee Kim, Yong Soo Jang, Mi-Suk Park, In Cheol Park, Jae Gil Lee, Min Joung Kim, Yong Eun Chung, Jongmee Lee, Baek-Hui Kim, Chang Hee Lee, Jung-Youn Kim, Sanghee Kang, Sung-Hyuk Choi, Yang Shin Park, Seong Whi Cho, Chan Woo Park, Gi Bong Chae, Taek Guen Ohk, Yong-Hwan Jeon, Nurhee Hong, Dae Han Wi, Jun Hee Lee, Jung Nam Kwon, Seok Youn Lee, Weon-Cheol Han, Young Cheol Song, Mi Jeong Kim, Jung Hyeok Kwon, Seoung Kyu Beak, Sung Jin Kim, Woo Ik Choi, Yu Na Kang, Cheong-Il Shin, Dong Ho Lee, Gyeong Hoon Kang, Ijin Joo, Jeong Hee Yoon, Ji Won Park, Kyu Joo Park, Sang Do Shin, Seung-Bum Ryoo, Seung-Yong Jeong, Su Joa Ahn, Tae Han Kim, Won Chang, Yoon-Hye Kwon, Sang Soo Shin, Hee Joon Kim, Ho Goon Kim, Yong Soo Cho, Yoo Duk Choi, Bong Soo Kim, Chang Lim Hyun, Guk Myung Choi, In Ho Jeong, Kyeong Won Kang, Seung Hyoung Kim, Woo Jeong Kim, Young Joon Kang, Kwang Pyo Kim
BACKGROUND: CT radiation is arguably carcinogenic. Results from single-centre studies, mostly retrospective, have advocated lowering the CT radiation dose for the diagnosis of appendicitis. However, adoption of low-dose CT has been slow. We aimed to assess the effectiveness of low-dose CT compared with standard-dose CT in the diagnosis of appendicitis in adolescents and young adults. METHODS: We did this pragmatic, multicentre, randomised controlled non-inferiority trial at 20 South Korean teaching hospitals with little experience with low-dose CT...
September 11, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28917177/formation-of-iodinated-thms-during-chlorination-of-water-and-wastewater-in-the-presence-of-different-iodine-sources
#2
Ioanna Pantelaki, Dimitra Voutsa
The formation potential of iodinated trihalomethanes (I-THMs) during chlorination of different organic precursors in the presence of various iodine sources was studied. Organic precursors included humic acid, natural organic matter from river water and wastewater effluent organic matter. Inorganic iodide and two iodinated X-ray contrast media compounds (iopamidol and diatrizoate) were used as iodine sources. The formation potential of I-THMs under different experimental conditions (chlorination contact time, iodide and bromide concentrations) was investigated...
September 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28914777/the-usefulness-of-contrast-enhanced-ultrasound-in-the-assessment-of-early-kidney-transplant-function-and-complications
#3
REVIEW
Sara Álvarez Rodríguez, Vital Hevia Palacios, Enrique Sanz Mayayo, Victoria Gómez Dos Santos, Víctor Díez Nicolás, María Dolores Sánchez Gallego, Javier Lorca Álvaro, Francisco Javier Burgos Revilla
OBJECTIVES: The routine diagnostic method for assessment of renal graft dysfunction is Doppler ultrasound. However, contrast-enhanced ultrasound (CEUS) may provide more information about parenchymal flow and vascular status of kidney allografts. The aim of the study was to assess the effectiveness of CEUS in the immediate post-transplant period, focusing on acute vascular complications. A brief review of available literature and a report of our initial experience is made. MATERIAL AND METHODS: 15 kidney transplant (KT) cases with clinical suspicion of acute surgical complication were assessed with CEUS and conventional Doppler ultrasound (US)...
September 15, 2017: Diagnostics
https://www.readbyqxmd.com/read/28914202/statins-and-contrast-induced-nephropathy-a-systematic-review-and-meta-analysis
#4
Alexandros Briasoulis, Mohan Pala, Tesfaye Telila, Obsinet Merid, Emmanuel Akintoye, Georgia Vogiatzi, Evangelos Oikonomou, Dimitris Tousoulis
Contrast-induced nephropathy (CIN) is a type of acute kidney injury associated with intravascular administration of iodinated contrast, usually reversible. Contrast agents are an essential component of invasive and noninvasive coronary angiography. These agents have been modified over time to enhance patient safety and tolerability, but adverse reactions still occur. CIN has been variably defined, as a rise in serum creatinine of 0.5 mg/dl, or a 25% increase in serum creatinine above baseline within 24-72 hours after the procedure...
September 13, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28912982/severe-thyrotoxicosis-secondary-to-povidone-iodine-from-peritoneal-dialysis
#5
Kirstie Lithgow, Christopher Symonds
A 73-year-old male on home peritoneal dialysis (PD) with recent diagnosis of atrial fibrillation presented with fatigue and dyspnea. Hyperthyroidism was diagnosed with TSH < 0.01 mIU/L and FT4 > 100 pmol/L. He had no personal or family history of thyroid disease. There had been no exposures to CT contrast, amiodarone, or iodine. Technetium thyroid scan showed diffusely decreased uptake. He was discharged with a presumptive diagnosis of thyroiditis. Three weeks later, he had deteriorated clinically...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28912882/atorvastatin-alleviates-iodinated-contrast-media-induced-cytotoxicity-in-human-proximal-renal-tubular-epithelial-cells
#6
Gai-Ling Liu, Rong Lei, Shao-Bin Duan, Mi-Mi Tang, Min Luo, Qian Xu
Contrast media (CM)-induced nephropathy (CIN) is a serious complication of intravascularly applied radiocontrast media. At present, no drugs have been approved for the prevention of CIN. The present study aimed to explore the effects and potential mechanisms of atorvastatin on iodinated CM-induced cytotoxicity in the human proximal renal tubular epithelial cells. The cytotoxic effect of iohexol (50, 100 and 200 mg I/ml) and the protective effect of atorvastatin pretreatment (1, 20 and 40 µM) were assessed...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28901607/bias-variance-tradeoff-in-anticorrelated-noise-reduction-for-spectral-ct
#7
Mats Persson, Fredrik Grönberg
PURPOSE: In spectral CT, basis material decomposition is commonly used to generate a set of basis images showing the material composition at each point in the field of view. The noise in these images typically contains anticorrelations between the different basis images, which leads to increased noise in each basis image. These anticorrelations can be removed by changing the basis functions used in the material decomposition, but the resulting basis images can then no longer be used for quantitative measurements...
September 2017: Medical Physics
https://www.readbyqxmd.com/read/28899867/epidural-interlaminar-injections-in-severe-degenerative-lumbar-spine-fluoroscopy-should-not-be-a-luxury
#8
Dimitrios K Filippiadis, Thomas Rodt, Maria-Chrysanthi Kitsou, Chrysanthi Batistaki, Nikolaos Kelekis, Georgia Kostopanagiotou, Alexis Kelekis
OBJECTIVE: To assess technical efficacy, accuracy, and safety of epidural (interlaminar) injections performed blindly in patients with a severely degenerated lumbar spine. METHODS: Over 12 consecutive months, 138 patients with a severe degenerative lumbar spine underwent epidural (interlaminar) injection as therapy for low back pain and neuralgia. Patients had already undergone a blind epidural infiltration with minimum or no pain reduction. The session was repeated in the angiography suite...
September 12, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28894816/evaluation-of-peripheral-nerve-regeneration-through-biomaterial-conduits-via-micro-ct-imaging
#9
Sarah K Pixley, Tracy M Hopkins, Kevin J Little, David B Hom
OBJECTIVE: Hollow nerve conduits made of natural or synthetic biomaterials are used clinically to aid regeneration of peripheral nerves damaged by trauma or disease. To support healing, conduit lumen patency must be maintained until recovery occurs. New methods to study conduit structural integrity would provide an important means to optimize conduits in preclinical studies. We explored a novel combined technique to examine structural integrity of two types of nerve conduits after in vivo healing...
December 2016: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28892037/induction-and-micro-ct-imaging-of-cerebral-cavernous-malformations-in-mouse-model
#10
Jaesung P Choi, Xi Yang, Matthew Foley, Xian Wang, Xiangjian Zheng
Mutations in the CCM1 (aka KRIT1), CCM2, or CCM3 (aka PDCD10) gene cause cerebral cavernous malformation (CCM) in humans. Mouse models of CCM disease have been established by tamoxifen induced deletion of Ccm genes in postnatal animals. These mouse models provide invaluable tools to investigate molecular mechanism and therapeutic approaches for CCM disease. An accurate and quantitative method to assess lesion burden and progression is essential to harness the full value of these animal models. Here, we demonstrate the induction of CCM disease in a mouse model and the use of the contrast enhanced X-ray micro computed tomography (micro-CT) method to measure CCM lesion burden in mouse brains...
September 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28891160/co2-angiography-colorless-odorless-but-definitely-not-useless
#11
EDITORIAL
Robert D Safian
Contemporary approaches to minimize the risk of acute kidney injury from radiographic contrast (AKI-RC) rely on preferential use of low- or non-ionic contrast; pre-hydration; and limiting contrast volume. This study utilized a meta-analysis of 677 patients to compare the risk of AKI-RC after CO2 peripheral angiography versus iodinated contrast (4.3% vs. 11.1%, odds ratio [OR] 0.465, P = 0.048). There was no difference in AKI-RC in patients with CKD. This study has many limitations. CO2 angiography is an important technique; proper understanding of its strengths and limitations is essential...
September 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28888725/-impact-of-rotational-coronary-angiography-in-the-amount-of-iodinated-contrast-and-the-exposition-to-ionizing-radiations-in-patients-undergoing-invasive-coronary-procedures-a-systematic-review-and-meta-analysis
#12
Diego Fernández-Rodríguez, Leydimar Anmad Shihadeh, José L Martos-Maine, Patricia Couto-Comba, Alejandro Quijada-Fumero, Raquel Pimienta, José J Grillo-Pérez, Marcos Rodríguez-Esteban, Horacio Pérez-Hernández, Julio Hernández-Afonso, Francisco Bosa Ojeda
BACKGROUND: Invasive coronary procedures involve the administration of iodinated contrast and the exposure to ionizing radiations, increasing morbidity and mortality. The rotational coronary angiography (RCA) allows acquiring multiple projections with a unique injection of iodinated contrast. To date, there were no meta-analysis specifically comparing RCA and conventional coronary angiography (CCA) in patients undergoing invasive coronary procedures, whether diagnostic or diagnostic and therapeutic...
September 6, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28888094/low-dose-scanning-technology-combined-with-low-concentration-contrast-material-in-renal-computed-tomography-angiography-cta-a-preliminary-study
#13
Sulan Liu, Wei Li, Hao Shi, Huaqiang Sheng, Jingli Fan, Jingzhen He, Hongjun Sun
BACKGROUND This study is to investigate the feasibility of low iodine concentration contrast material (CM) combined with low tube voltage and adaptive statistical iterative reconstruction (ASIR) in renal computed tomography angiography (CTA). MATERIAL AND METHODS A total of 136 patients were enrolled in this prospective trial, and randomly divided into two groups: group A (n=68) and group B (n=68). Group A received 120-kVp and iopromide (370 mg/mL) with filtered back projection (FBP) reconstruction, and group B received 100-kVp and iodixanol (270 mg/mL) with ASIR 40% (ASIR40)...
September 9, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28876979/general-anaesthesia-for-patients-with-a-history-of-a-contrast-medium-induced-anaphylaxis-a-useful-prophylaxis
#14
Ingrid Boehm, Knud Nairz, John Morelli, Patricia Silva Hasembank Keller, Johannes Thomas Heverhagen
Contrast-enhanced radiological examinations are important diagnostic tools in modern medicine. Currently, all approved and available iodinated and gadolinium-based contrast agents are safe and well tolerated by most patients. However, approximately 2% of patients receiving iodinated contrast media (CM) exhibit hypersensitivity reactions. Patients with a history of such a reaction are at increased risk upon re-exposure. Therefore, they are subjected to a prophylaxis such as injection of anti-allergy drugs or general anesthesia...
September 6, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28874655/serum-neutrophil-gelatinase-associated-lipocalin-and-urinary-kidney-injury-molecule-1-as-potential-biomarkers-of-subclinical-nephrotoxicity-after-gadolinium-based-and-iodinated-based-contrast-media-exposure-in-pediatric-patients-with-normal-kidney-function
#15
Brankica Spasojević-Dimitrijeva, Jelena Kotur-Stevuljević, Milan Đukić, Dušan Paripović, Gordana Miloševski-Lomić, Vesna Spasojević-Kalimanovska, Polina Pavićević, Jadranka Mitrović, Mirjana Kostić
BACKGROUND New renal biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) show promise in early diagnosis of contrast media induced acute kidney injury (CI-AKI). The purpose of our study was to compare the subclinical nephrotoxicity (a condition without changes in standard renal biomarkers) of gadolinium-based contrast media (Gd-DTPA, gadopentetate dimeglumine) and iodinated-based contrast media (iopromide) in pediatric patients with normal kidney function...
September 6, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28862627/analysis-of-the-microvascular-morphology-and-hemodynamics-of-breast-cancer-in-mice-using-spring-8-synchrotron-radiation-microangiography
#16
Masae Torii, Toshifumi Fukui, Masashi Inoue, Shotaro Kanao, Keiji Umetani, Mikiyasu Shirai, Tadakatsu Inagaki, Hirotsugu Tsuchimochi, James T Pearson, Masakazu Toi
Tumor vasculature is characterized by morphological and functional abnormalities. However, analysis of the dynamics in blood flow is still challenging because of limited spatial and temporal resolution. Synchrotron radiation (SR) microangiography above the K-edge of the iodine contrast agent can provide high-contrast imaging of microvessels in time orders of milliseconds. In this study, mice bearing the human breast cancer cell lines MDAMB231 and NOTCH4 overexpression in MDAMB231 (MDAMB231(NOTCH4+)) and normal mice were assessed using SR microangiography...
September 1, 2017: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/28860894/high-pitch-coronary-ct-angiography-at-70-kvp-adopting-a-protocol-of-low-injection-speed-and-low-volume-of-contrast-medium
#17
Ruiqi Feng, Jiajie Tong, Xiaofei Liu, Yu Zhao, Liang Zhang
OBJECTIVE: To evaluate the feasibility and image quality (IQ) of prospectively high-pitch coronary CT angiography (CCTA) with low contrast medium injection rate at 70 kVp. MATERIALS AND METHODS: One hundred and four patients with suspected coronary artery disease (body mass index < 26 kg/m(2), sinus rhythm and heart rate < 70 beats/min) were prospectively enrolled and randomly divided into two groups. In group A and group B, 28 mL and 40 mL of 370 mgI/mL iodinated contrast media was administrated at a flow rate of 3...
September 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28856901/type-2-endoleaks-in-endovascular-aortic-repair-cone-beam-ct-and-automatic-vessel-detection-to-guide-the-embolization
#18
Anna Maria Ierardi, Filippo Pesapane, Nicola Rivolta, Enrico Maria Fumarola, Salvatore Alessio Angileri, Filippo Piacentino, Gianpaolo Carrafiello
Background Dual-phase cone beam computed tomography (DP-CBCT) and automatic vessel detection (AVD) software are helpful tools for detecting arteries before planned endovascular interventions. Purpose To evaluate the usefulness of DP-CBCT and AVD software in guiding the trans-arterial embolization (TAE) of challenging T2 lumbar endoleaks (T2-L-EL). Material and Methods Ten patients with T2-L-EL were included in this study. The accuracy of DP-CBCT and the AVD software was defined by the ability to detect the endoleak and arterial feeding vessel, respectively...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28856420/iodine-based-contrast-media-multiple-myeloma-and-monoclonal-gammopathies-literature-review-and-esur-contrast-media-safety-committee-guidelines
#19
Fulvio Stacul, Michele Bertolotto, Henrik S Thomsen, Gabriele Pozzato, Donatella Ugolini, Marie-France Bellin, Georg Bongartz, Olivier Clement, Gertraud Heinz-Peer, Aart van der Molen, Peter Reimer, Judith A W Webb
OBJECTIVES: Many radiologists and clinicians still consider multiple myeloma (MM) and monoclonal gammopathies (MG) a contraindication for using iodine-based contrast media. The ESUR Contrast Media Safety Committee performed a systematic review of the incidence of post-contrast acute kidney injury (PC-AKI) in these patients. METHODS: A systematic search in Medline and Scopus databases was performed for renal function deterioration studies in patients with MM or MG following administration of iodine-based contrast media...
August 30, 2017: European Radiology
https://www.readbyqxmd.com/read/28842112/rcr-audit-of-compliance-with-uk-guidelines-for-the-prevention-and-detection-of-acute-kidney-injury-in-adult-patients-undergoing-iodinated-contrast-media-injections-for-ct
#20
L H Cope, K J Drinkwater, D C Howlett
AIM: To determine radiology departmental compliance with current UK guidance on contrast-induced acute kidney injury (CI-AKI) and to provide data on the incidence of clinically significant post-contrast AKI (PC-AKI) in computed tomography (CT) practice. MATERIALS AND METHODS: A questionnaire was sent to all UK acute National Health Service (NHS) providers (NHS boards in Scotland, local health boards in Wales, NHS trusts in England and health and social care trusts in Northern Ireland) to assess compliance of provider protocols with current UK guidelines for the prevention, recognition, and management of CI-AKI...
August 22, 2017: Clinical Radiology
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