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https://www.readbyqxmd.com/read/28721478/differentiation-of-renal-cell-carcinoma-subtypes-with-different-iodine-quantification-methods-using-single-phase-contrast-enhanced-dual-energy-ct-areal-vs-volumetric-analyses
#1
Chenchen Dai, Yingli Cao, Yan Jia, Yuqin Ding, Ruofan Sheng, Mengsu Zeng, Jianjun Zhou
PURPOSE: To investigate the possibility of iodine quantification during a single nephrographic phase in characterizing renal cell carcinoma (RCC) subtypes and if there is a difference between areal and volumetric iodine quantification methods. MATERIALS AND METHODS: This retrospective study included 110 patients with 113 histopathologically confirmed RCCs scanned by dual-energy CT at the nephrographic phase before surgeries. For each lesion, an areal measurement of the iodine concentration with maximum enhancement (I max enhan) and the iodine concentration with maximum area among slices (I max area), as well as a volumetric iodine concentration of the whole-tumor (I volume), were evaluated by two independent radiologists...
July 18, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28720415/assessment-of-cirrhotic-liver-enhancement-with-multiphasic-computed-tomography-using-a-faster-injection-rate-late-arterial-phase-and-weight-based-contrast-dosing
#2
Kathleen Eddy, Andreu F Costa
PURPOSE: This study aimed to update our liver computed tomography (CT) protocol according to published guidelines, and to quantitatively evaluate the effect of these modifications. METHODS: The modified liver CT protocol employed a faster injection rate (5 vs 3 mL/s), later arterial phase (20-second vs 10-second postbolus trigger), and weight-based dosing of iodinated contrast (1.7 mL/kg vs 100 mL fixed dose). Liver and vascular attenuation values were measured on CTs of patients with cirrhosis from January to September 2015 (old protocol, n = 49) and from October to December 2015 (modified protocol, n = 31)...
July 15, 2017: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/28720393/maxillary-nerve-blocks-in-horses-an-experimental-comparison-of-surface-landmark-and-ultrasound-guided-techniques
#3
Stephanie Stauffer, Beckie Cordner, Jonathon Dixon, Thomas Witte
OBJECTIVE: The aim of this preliminary proof-of-concept study was to evaluate and compare the success and complication rate of infiltration of the maxillary nerve of cadaver heads using previously described surface landmarks, standard ultrasound and a novel needle guidance positioning ultrasound system (SonixGPS). STUDY DESIGN: Prospective, anatomical, method-comparison study. ANIMALS: Thirty-eight equine cadaver heads. METHODS: Twenty-six veterinary students performed the three methods consecutively on cadaver heads using an 18 gauge, 8...
April 6, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28718888/assessing-lung-function-using-contrast-enhanced-dual-energy-computed-tomography-for-potential-applications-in-radiation-therapy
#4
Andréanne Lapointe, Houda Bahig, Danis Blais, Hugo Bouchard, Édith Filion, Jean-François Carrier, Stéphane Bedwani
PURPOSE: There is an increasing interest in the evaluation of lung function from physiological images in radiation therapy treatment planning to reduce the extent of post-radiation toxicities. The purpose of this work is to retrieve reliable functional information from contrast-enhanced dualenergy computed tomography (DECT) for new applications in radiation therapy. The functional information obtained by DECT is also compared with other methods using single energy CT (SECT) and single-photon emission computed tomography (SPECT) with CT...
July 18, 2017: Medical Physics
https://www.readbyqxmd.com/read/28717277/contrast-induced-nephropathy-in-urological-imaging-a-comparison-with-cardiology-interventions
#5
Manas Babu, Devesh Bansal, Sony Bhaskar Mehta, Biju Pillai, Hariharan Krishnamoorthy, Thankachan Attacharil
INTRODUCTION: Published studies about contrast-induced nephropathy (CIN) mainly focus on cardiac intervention and rarely focus on patients undergoing urological contrast investigations. We aimed to determine the association and effect of intravenous (IV) iodinated contrast material on the incidence of CIN in a group of patients undergoing urology investigation and compare the results with that of cardiology interventions. METHODS: This prospective study was performed in patients undergoing IV contrast studies in Urology and those undergoing coronary interventions, in our institution for 1 year...
July 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28711443/regional-distribution-of-pulmonary-blood-volume-with-dual-energy-computed-tomography-results-in-42-subjects
#6
Paul Felloni, Alain Duhamel, Jean-Baptiste Faivre, Jessica Giordano, Suonita Khung, Valérie Deken, Jacques Remy, Martine Remy-Jardin
RATIONALE AND OBJECTIVES: The noninvasive approach of lung perfusion generated from dual-energy computed tomography acquisitions has entered clinical practice. The purpose of this study was to analyze the regional distribution of iodine within distal portions of the pulmonary arterial bed on dual-source, dual-energy computed tomography examinations in a cohort of subjects without cardiopulmonary pathologies. MATERIALS AND METHODS: The study population included 42 patients without cardiorespiratory disease, enabling quantitative and qualitative analysis of pulmonary blood volume after administration of a 40% contrast agent...
July 12, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28711207/dual-energy-computed-tomography-applications-for-the-evaluation-of-the-spine
#7
REVIEW
Peter Komlosi, Max Wintermark
Capturing the energy-dependent x-ray attenuation of different tissues, dual-energy computed tomography offers multiple benefits in the imaging of the spine, such as bone and iodinated contrast removal, monosodium urate imaging, and robust reduction of beam-hardening artifacts. The emerging new applications of this technique include bone marrow imaging in acute trauma and myeloinfiltrative disorders, improved bone density determination, and noninvasive assessment of spinal gout.
August 2017: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/28711206/miscellaneous-and-emerging-applications-of-dual-energy-computed-tomography-for-the-evaluation-of-pathologies-in-the-head-and-neck
#8
REVIEW
Tommaso D'Angelo, Silvio Mazziotti, Giorgio Ascenti, Julian L Wichmann
Dual-energy computed tomography (DECT) and its specific algorithms and applications have been increasingly recognized in clinical practice as a valuable advance in technology beyond what is possible with the established postprocessing capabilities of single-energy multidetector computed tomography, mainly because of its potential benefits regarding image quality and contrast. DECT may represent an alternative approach to purely attenuation-based imaging of the head and neck, because it provides a material-specific visualization based on spectral information...
August 2017: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/28711203/dual-energy-computed-tomography-angiography-of-the-head-and-neck-and-related-applications
#9
REVIEW
Shahmir Kamalian, Michael H Lev, Stuart R Pomerantz
Dual-energy computed tomography (DECT) has become an increasingly widespread and useful component of the neuroimaging armamentarium, offering automated bone removal, metallic artifact reduction, and improved characterization of iodinated contrast enhancement. The application of these techniques to CT neuroangiography enables a number of benefits including more efficient 3D post-processing, contrast dose reduction opportunities, successful differentiation of hemorrhage from contrast staining following thromboembolic recanalization therapy, improved detection of active contrast extravasation in the setting of intracranial hemorrhage, and more precise characterization of atheromatous steno-occlusive disease...
August 2017: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/28711201/dual-energy-computed-tomographic-applications-for-differentiation-of-intracranial-hemorrhage-calcium-and-iodine
#10
REVIEW
Ranliang Hu, Atul Padole, Rajiv Gupta
This article reviews the physical principles of dual-energy material decomposition and its current implementation. Clinical applications of dual-energy material decomposition including differentiation of calcification from hemorrhage and iodinated contrast from hemorrhage are highlighted, and their applications to neuroimaging are reviewed.
August 2017: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/28710576/the-effect-of-iodine-uptake-on-radiation-dose-absorbed-by-patient-tissues-in-contrast-enhanced-ct-imaging-implications-for-ct-dosimetry
#11
Kostas Perisinakis, Antonis Tzedakis, Kostas Spanakis, Antonios E Papadakis, Adam Hatzidakis, John Damilakis
OBJECTIVES: To investigate the effect of iodine uptake on tissue/organ absorbed doses from CT exposure and its implications in CT dosimetry. METHODS: The contrast-induced CT number increase of several radiosensitive tissues was retrospectively determined in 120 CT examinations involving both non-enhanced and contrast-enhanced CT imaging. CT images of a phantom containing aqueous solutions of varying iodine concentration were obtained. Plots of the CT number increase against iodine concentration were produced...
July 14, 2017: European Radiology
https://www.readbyqxmd.com/read/28708723/preliminary-results-can-dual-energy-computed-tomography-help-distinguish-cardiogenic-pulmonary-edema-and-acute-interstitial-lung-disease
#12
Hitoshi Takeuchi, Shigeru Suzuki, Haruhiko Machida, Takuya Ishikawa, Eiko Ueno
OBJECTIVE: We compared iodine concentration in pulmonary ground-glass opacity on iodine density images of contrast-enhanced chest dual-energy computed tomography (DECT) between patients with cardiogenic pulmonary edema (CPE) and acute interstitial lung disease (AILD). METHODS: Five of 12 patients who underwent contrast-enhanced chest DECT to exclude pulmonary embolism were clinically diagnosed with CPE and 7, with AILD. We compared the mean CT value on monochromatic images at 65 keV and iodine concentration on iodine density images between the affected and normal areas...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28708716/the-influence-of-contrast-agent-s-osmolarity-on-iodine-delivery-protocol-in-coronary-computed-tomography-angiography-comparison-between-iso-osmolar-iodixanol-320-and-low-osmolar-iomeprol-370
#13
Xiaohan Yang, Weiwei Huang, Wangyan Liu, Yinsu Zhu, Yi Xu, Guanyu Yang, Lijun Tang, Xiaomei Zhu
OBJECTIVES: This study aims to assess whether iodine-contained contrast agents with different osmolarity affect iodine delivery protocol during coronary computed tomography angiography (CCTA). METHODS: Patients who underwent CCTA were randomized to receive contrast media either iodixanol-320 (iso-osmolar group) or iopromide-370 (low-osmolar group). Contrast protocols were recorded. Tube voltage of 100 kV was chosen for patients with body mass index of less than or equal to 25 (n = 224) and tube voltage of 120 kV for patients with body mass index of greater than 25 (n = 165)...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28705916/biodistribution-and-dosimetry-of-18-f-meta-fluorobenzyl-guanidine-mfbg-a-first-in-human-pet-ct-imaging-study-of-patients-with-neuroendocrine-malignancies
#14
Neeta Pandit-Taskar, Pat B Zanzonico, Kevin D Staton, Jorge A Carrasquillo, Diane Reidy-Lagunes, Serge K Lyashchenko, Eva Burnazi, Hanwen Zhang, Jason S Lewis, Ronald Blasberg, Steven M Larson, Wolfgang Andreas Weber, Shakeel Modak
Introduction: Iodine-123-meta-iodobenzylguanidine ((123)I-MIBG) imaging is currently a mainstay in the evaluation of many neuroendocrine tumors, especially neuroblastoma. (123)I-MIBG imaging has several limitations that can be overcome by the use of a PET agent. (18)F-MFBG is a positron emission tomography (PET) analog of MIBG that may allow for single-day, high-resolution quantitative imaging. We conducted a first-in-human study of (18)F-MFBG PET imaging to evaluate the safety, feasibility, pharmacokinetics, and dosimetry of (18)F-MFBG in neuroendocrine tumors (NETs)...
July 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28703119/dna-double-strand-break-dsb-induction-and-cell-survival-in-iodine-enhanced-computed-tomography-ct
#15
Seth W Streitmatter, Robert D Stewart, Peter A Jenkins, Tatjana Jevremovic
A multi-scale Monte Carlo model is proposed to assess the dosimetric and biological impact of iodine-based contrast agents commonly used in computed tomography. As presented, the model integrates the general purpose MCNP6 code system for larger-scale radiation transport and dose assessment with the Monte Carlo damage simulation to determine the sub-cellular characteristics and spatial distribution of initial DNA damage. The repair-misrepair-fixation model is then used to relate DNA double strand break (DSB) induction to reproductive cell death...
July 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28700030/risk-for-adverse-reaction-to-iodinated-contrast-media-a-validation-study
#16
Beatriz Cavalcanti Juchem, Miriam de Abreu Almeida
Objectives: To validate the content of the nursing diagnosis, Risk for adverse reaction to iodinated contrast media, and its nursing interventions and outcomes according to standardized terminologies. Method: Fehring's (1987) model of diagnosis content validation was used, with the participation of experts including registered nurses and physicians. Results: Seventy-four experts validated the title and the definition of the diagnosis, and assessed 28 risk factors, five of which were validated as primary, 22 as secondary, and one was discarded...
July 6, 2017: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/28693693/can-fundus-fluorescein-angiography-be-performed-for-diabetic-patients-on-oral-metformin-%C3%A2
#17
Du Junhui, Li Rong
Metformin is a kind of biguanide hypoglycemic agent that has been widely used in patients with diabetes mellitus. In clinical practice, whether metformin should be stopped before Fundus fluorescein angiography (FFA) remains largely unclear. Some endocrinologists suggest stop metformin before FFA. However, ophthalmologists do not always adopt this opinion in their practice. This situation may lead to disputes between physicians and patients. This article analyzed contrast-induced nephropathy(CIN) and the related contrast agent, as well as the adverse reactions of fluorescein angiography...
June 10, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28687430/management-of-the-lateral-neck-in-well-differentiated-thyroid-cancer
#18
REVIEW
J R Cracchiolo, R J Wong
Lateral neck lymph node metastases in well differentiated thyroid cancer are common, ranging from 30% to 60%, with the majority of these foci identifiable only as microscopic deposits. A skilled ultrasound evaluation of the lymph nodes in the lateral neck is recommended for all patients presenting with newly diagnosed thyroid cancer undergoing surgical management. Ultrasound guided fine needle aspiration biopsy may be used to cytologically confirm suspected lateral neck nodal metastases prior to surgery. For patients with large volume nodal disease, extranodal extension, or multiple nodal metastases, computed tomography (CT) scan of the neck with contrast is an important additional imaging modality to accurately localize disease prior to surgery...
June 22, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28684756/multicolor-spectral-photon-counting-computed-tomography-in-vivo-dual-contrast-imaging-with-a-high-count-rate-scanner
#19
David P Cormode, Salim Si-Mohamed, Daniel Bar-Ness, Monica Sigovan, Pratap C Naha, Joelle Balegamire, Franck Lavenne, Philippe Coulon, Ewald Roessl, Matthias Bartels, Michal Rokni, Ira Blevis, Loic Boussel, Philippe Douek
A new prototype spectral photon-counting computed tomography (SPCCT) based on a modified clinical CT system has been developed. SPCCT analysis of the energy composition of the transmitted x-ray spectrum potentially allows simultaneous dual contrast agent imaging, however, this has not yet been demonstrated with such a system. We investigated the feasibility of using this system to distinguish gold nanoparticles (AuNP) and an iodinated contrast agent. The contrast agents and calcium phosphate were imaged in phantoms...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28683124/hybrid-spectral-ct-reconstruction
#20
Darin P Clark, Cristian T Badea
Current photon counting x-ray detector (PCD) technology faces limitations associated with spectral fidelity and photon starvation. One strategy for addressing these limitations is to supplement PCD data with high-resolution, low-noise data acquired with an energy-integrating detector (EID). In this work, we propose an iterative, hybrid reconstruction technique which combines the spectral properties of PCD data with the resolution and signal-to-noise characteristics of EID data. Our hybrid reconstruction technique is based on an algebraic model of data fidelity which substitutes the EID data into the data fidelity term associated with the PCD reconstruction, resulting in a joint reconstruction problem...
2017: PloS One
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