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ORGAN PROTECTION

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https://www.readbyqxmd.com/read/29150986/memory-t-cells-are-significantly-increased-in-rejecting-liver-allografts-of-rhesus-monkeys
#1
Hwajung Kim, Hyeyoung Kim, Sun-Kyung Lee, Xue-Li Jin, Tae Jin Kim, Chanho Park, Jae-Il Lee, Hyo-Sin Kim, Suk Kyun Hong, Kyung Chul Yoon, Sung Woo Ahn, Kyoung-Bun Lee, Nam-Joon Yi, Jaeseok Yang, Kwang-Woong Lee, Wayne J Hawthorne, Kyung-Suk Suh
INTRODUCTION: The Rhesus monkey (RM) is an excellent preclinical model in kidney, heart and islet transplantation that has provided the basis for new immunosuppressive protocols for clinical studies. However, there remain relatively few liver transplantation (LT) models in nonhuman primates. In this study, we analyzed the immune cell populations of PBMCs and secondary lymphoid organs along with livers of normal rhesus monkeys and compared them to those of rejecting liver transplanted recipient's following withdrawal of immunosuppression...
November 18, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29150963/detection-and-quantification-of-two-parasitic-ciliates-boveria-labialis-and-boveria-subcylindrica-ciliophora-scuticociliatia-by-fluorescence-in-situ-hybridization
#2
Zifeng Zhan, Ju Li, Kuidong Xu
The thigmotrich scuticociliates Boveria labialis and Boveria subcylindrica are obligate parasites that may cause high mortality in cultured sea cucumbers and bivalves. Morphological methods can identify these organisms in active state, but are unable to discern them in resting stages. In aquaculture practice, these parasitic ciliates are hard to eradicate when massive infection occurs in sea cucumbers. Thus, early detection and precaution are crucial for the control of these pathogens. Under such circumstances, fluorescence in situ hybridization (FISH) will serve as a fast way to detect and monitor the occurrence of these parasites...
November 18, 2017: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/29150936/the-roles-of-wnt-%C3%AE-catenin-pathway-in-tissue-development-and-regenerative-medicine
#3
REVIEW
Maryam Majidinia, Javad Aghazadeh, Rana Jahanban-Esfahlani, Bahman Yousefi
Regenerative medicine is a translational field which combines tissue engineering and molecular biology to construct spare organs or help injured or defective tissues to regenerate or restore their normal functions. This is particularly important with specific organs such as heart, central nervous system, retina or limbs which possess very limited regenerative capacity. As such, regenerative medicine has received peculiar attention in the last decade. In this regard, Wnt/β-catenin signaling pathway has been subject to intensive research, since it plays many essential roles in the regulation of the progenitor cell fate, developmental decisions, proliferation during embryonic development, and adult tissue homeostasis...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29150926/viral-short-orfs-and-their-possible-functions
#4
REVIEW
Yaara Finkel, Noam Stern-Ginossar, Michal Schwartz
Definition of functional genomic elements is one of the greater challenges of the genomic era. Traditionally, putative short Open Reading Frames (sORFs) coding for less than 100 amino acids were disregarded due to computational and experimental limitations, however it has become clear over the past several years that translation of sORFs is pervasive and serves diverse functions. The development of ribosome profiling, allowing identification of translated sequences genome-wide, revealed wide-spread, previously unidentified translation events...
November 18, 2017: Proteomics
https://www.readbyqxmd.com/read/29150901/expression-of-the-clock-gene-rev-erb%C3%AE-in-the-brain-controls-the-circadian-organization-of-food-intake-and-locomotor-activity-but-not-daily-variations-of-energy-metabolism
#5
Satish Sen, Stéphanie Dumont, Dominique Sage-Ciocca, Sophie Reibel, Paul de Goede, Andries Kalsbeek, Etienne Challet
The nuclear receptor REV-ERBα is part of the molecular clock mechanism and thought to be involved in a variety of biological processes within metabolically active peripheral tissues as well. To investigate whether Rev-erbα (also known as Nr1d1) in the brain plays a role in the daily variations of energy metabolism, feeding behaviour and the sleep-wake cycle, we studied mice with global (GKO) or brain (BKO) deletion of Rev-erbα. Mice were studied both in a light-dark cycle and constant darkness, and 24-h variations of Respiratory quotient (RQ) and energy expenditure, as well as the temporal patterns of rest-activity and feeding behavior were recorded...
November 18, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29150628/artificial-topography-changes-the-growth-strategy-of-spartina-alterniflora-case-study-with-wave-exposure-as-a-comparison
#6
Hualong Hong, Minyue Dai, Haoliang Lu, Jingchun Liu, Jie Zhang, Chaoqi Chen, Kang Xia, Chongling Yan
This paper reports findings about the growth of Spartina alterniflora (Loisel.) near an engineered coastal protection defences to discover the potential influences on vegetation growth from the artificial topography. Impacts of the artificial topography on the sediment element composition were detected by comparing the fixed effects caused by artificial topography and wave exposure using linear mixed models. Surficial sediments under the impacts of artificial topography contain elevated levels of biogenic elements and heavy metals, including C (and organic carbon), N, S, Al, Fe, Mn, Cu, Zn, As, Cd, Cr, Ni, and Pb...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150518/molecular-characterization-of-an-endozoicomonas-like-organism-causing-infection-in-king-scallop-pecten-maximus-l
#7
Irene Cano, Ronny van Aerle, Stuart Ross, David W Verner-Jeffreys, Richard K Paley, Georgina Rimmer, David Ryder, Patrick Hooper, David Stone, Stephen W Feist
One of the fastest growing fisheries in the UK is the king scallop Pecten maximus L., also currently rated as the second most valuable. Mass mortality events in scallops have been reported world-wide, often with the causative agent(s) remaining uncharacterized. In May 2013 and 2014, two mass mortality events affecting king scallops were recorded in the Lyme Bay Marine Protected Area (MPA), in South West England. Histopathological examination showed gill epithelial tissues infected with intracellular microcolonies of bacteria (IMC), resembling rickettsia-like organisms (RLOs), often with bacteria released in vascular spaces...
November 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29150340/placental-transfer-and-levels-of-mercury-selenium-vitamin-e-and-docosahexaenoic-acid-in-maternal-and-umbilical-cord-blood
#8
Mineshi Sakamoto, Hing Man Chan, José L Domingo, Chihaya Koriyama, Katsuyuki Murata
Methylmercury (MeHg) is a neurotoxicant known to affect the developing fetal brain as a sensitive target organ. As most mercury (Hg) in blood is MeHg, total mercury (THg) levels in blood are used to estimate the body burden of MeHg. The nutrients selenium (Se), vitamin E, and docosahexaenoic acid (DHA) are protective against MeHg toxicity. We compared maternal and cord blood concentrations of biochemical substances, THg and Se, vitamin E, DHA, and other elements, fatty acids, and amino acids in 54 Japanese mother-newborn pairs to elucidate the fetal risk of MeHg toxicity...
November 14, 2017: Environment International
https://www.readbyqxmd.com/read/29149946/organ-donation-a-comparison-of-donating-and-nondonating-families-in-turkey
#9
F Can, S Hovardaoglu
Based on public opinion surveys, although 75% of people state that they would donate the organs of one of their relatives, in reality, the rate of the people who donate the organs of their relatives is 24%. To decrease the organ shortage, the key point is to understand the difference between intention and real behavior. For this reason, in this study, analyses of variables related to the potential organ donor families' decisions of approval or refusal for organ harvesting were analyzed. The interviews were conducted with 101 families who made a decision about organ donation between 2010 and 2014...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149940/immune-activation-in-sepsis
#10
REVIEW
Andrew Conway-Morris, Julie Wilson, Manu Shankar-Hari
Sepsis is caused by a dysregulated host response to infection. Immune responses determine the characteristics of sepsis. The body's protection against infection involves danger signal surveillance and recognition from nonself, effector functions in response to sensing danger signals, homeostatic regulation, and generation of immunologic memory. During sepsis, the immune system is activated by pathogen-associated and host-derived molecular patterns. Detecting these molecular patterns generates multisystem responses...
January 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29149653/prevalence-of-internet-addiction-and-its-risk-and-protective-factors-in-a-representative-sample-of-senior-high-school-students-in-taiwan
#11
Min-Pei Lin, Jo Yung-Wei Wu, Jianing You, Wei-Hsuan Hu, Cheng-Fang Yen
The aim of this study investigated the prevalence of Internet addiction (IA) in a large representative sample of secondary school students and identified the risk and protective factors. Using a crosssectional design, 2170 participants were recruited from senior high schools throughout Taiwan using both stratified and cluster sampling. The prevalence of IA was 17.4% (95% confidence interval, 15.8%-19.0%). High impulsivity, low refusal self-efficacy of Internet use, high positive outcome expectancy of Internet use, high disapproving attitude of Internet use by others, depressive symptoms, low subjective well-being, high frequency of others' invitation to Internet use, and high virtual social support was all independently predictive in the logistic regression analysis...
November 14, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/29149592/dynamics-under-the-telomeric-bridge
#12
Sabrina Pisano, Eric Gilson, Marie-Josèphe Giraud-Panis
In this issue of Molecular Cell, Kim et al. (2017) have studied the structure and organization of the shelterin protein complex protecting telomeres in Schizosaccharomyces pombe and humans and discovered an allosteric structural transition that drives the formation of the shelterin complex and participates in telomere length regulation.
November 16, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29149432/ebola-in-the-netherlands-2014-2015-costs-of-preparedness-and-response
#13
Anita W M Suijkerbuijk, Corien M Swaan, Marie-Josee J Mangen, Johan J Polder, Aura Timen, Wilhelmina L M Ruijs
The recent epidemic of Ebola virus disease (EVD) resulted in countries worldwide to prepare for the possibility of having an EVD patient. In this study, we estimate the costs of Ebola preparedness and response borne by the Dutch health system. An activity-based costing method was used, in which the cost of staff time spent in preparedness and response activities was calculated based on a time-recording system and interviews with key professionals at the healthcare organizations involved. In addition, the organizations provided cost information on patient days of hospitalization, laboratory tests, personal protective equipment (PPE), as well as the additional cleaning and disinfection required...
November 17, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/29149404/the-translational-controlled-tumour-protein-tctp-biological-functions-and-regulation
#14
Ulrich-Axel Bommer
The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein present in essentially all eukaryotic organisms and involved in many fundamental cell biological and disease processes. It was first discovered about 35 years ago, and it took an extended period of time for its multiple functions to be revealed, and even today we do not yet fully understand all the details. Having witnessed most of this history, in this chapter, I give a brief overview and review the current knowledge on the structure, biological functions, disease involvements and cellular regulation of this protein...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/29149266/association-between-prior-antibiotic-therapy-and-subsequent-risk-of-community-acquired-infections-a-systematic-review
#15
Umer Malik, David Armstrong, Mark Ashworth, Alex Dregan, Veline L'Esperance, Lucy McDonnell, Mariam Molokhia, Patrick White
Background: Antibiotic use can have negative unintended consequences including disruption of the human microbiota, which is thought to protect against pathogen overgrowth. We conducted a systematic review to assess whether there is an association between exposure to antibiotics and subsequent risk of community-acquired infections. Methods: We searched MEDLINE, EMBASE and Web of Science for studies published before 30 June 2017, examining the association between antibiotic use and subsequent community-acquired infection...
November 14, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29148575/effects-of-spot-parameters-in-pencil-beam-scanning-treatment-planning
#16
Aafke Christine Kraan, Nicolas Depauw, Ben Clasie, Marina Giunta, Tom Madden, Hanne M Kooy
BACKGROUND: Spot size σ (in-air at isocenter), inter-spot spacing d, and spot charge q influence dose delivery efficiency and plan quality in Intensity Modulated Proton Therapy (IMPT) treatment planning. The choice and range of parameters varies among different manufacturers. The goal of this work is to demonstrate the influence of the spot parameters on dose quality and delivery in IMPT treatment plans, to show their interdependence, and to make practitioners aware of the spot parameter values for a certain facility...
November 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/29148211/effect-of-tetrahydrofuran-on-the-solubilisation-and-depolymerisation-of-cellulose-in-a-biphasic-system
#17
Changwei Hu, Zhicheng Jiang, Pingping Zhao, Jianmei Li, Xudong Liu
The dissolution of cellulose from biomass is a crucial but complicated issue for the utilisation of biomass resources, because of the extreme insolubility of cellulose. Herein, a biphasic NaCl-H2O-tetrahydrofuran system was studied, where most of the pure microcrystalline cellulose (M-cellulose, 96.6% conversion at 220 oC) and that contained in actual biomass were converted. Nearly a half of O(6)H***O(3) intermolecular hydrogen bonding could be broken by THF in H2O-THF co-solvent system, whereas the cleavage of O(2)H***O(6) intramolecular hydrogen bonding by H2O was significantly inhibited...
November 17, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29148086/novel-gene-fusion-of-prcc-mitf-defines-a-new-member-of-mit-family-translocation-renal-cell-carcinoma-clinicopathologic-analysis-and-detection-of-the-gene-fusion-by-rna-sequencing-and-fish
#18
Qiu-Yuan Xia, Xiao-Tong Wang, Sheng-Bing Ye, Xuan Wang, Rui Li, Shan-Shan Shi, Ru Fang, Ru-Song Zhang, Heng-Hui Ma, Zhen-Feng Lu, Qin Shen, Wei Bao, Xiao-Jun Zhou, Qiu Rao
AIMS: MITF, TFE3, TFEB and TFEC belong to the same microphthalmia-associated transcription factor family (MiT). Two transcription factors in this family have been identified in two unusual types of renal cell carcinoma (RCC): Xp11 translocation RCC harboring TFE3 gene fusions and t(6;11) RCC harboring a MALAT1-TFEB gene fusion. The 2016 World Health Organization classification of renal neoplasia grouped these two neoplasms together under the category of MiT family translocation RCC. RCCs associated with the other two MiT family members, MITF and TFEC, have rarely been reported...
November 17, 2017: Histopathology
https://www.readbyqxmd.com/read/29147724/glabrous-cmgl-encodes-a-hd-zip-iv-transcription-factor-playing-roles-in-multicellular-trichome-initiation-in-melon
#19
Huayu Zhu, Xiaofen Sun, Qi Zhang, Pengyao Song, Qianmei Hu, Xiaojing Zhang, Xiang Li, Jianbin Hu, Junsong Pan, Shouru Sun, Yiqun Weng, Luming Yang
Map-based cloning identified CmGL that encodes a HD-ZIP type IV transcription factor that controls multicellular trichome initiation in melon. Trichomes are small hairs covering the aerial parts of plants that originate from the epidermal cells, which can protect plants against the damage by insects and pathogens. The regulatory pathway of unicellular trichomes has been well studied in the model plant Arabidopsis. Little is known about the genetic control and regulation of trichome development in melon (Cucumis melo L...
November 17, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29147557/the-diversity-and-utility-of-amyloid-fibrils-formed-by-short-amyloidogenic-peptides
#20
REVIEW
Zahraa S Al-Garawi, Kyle L Morris, Karen E Marshall, Jutta Eichler, Louise C Serpell
Amyloidogenic peptides are well known for their involvement in diseases such as type 2 diabetes and Alzheimer's disease. However, more recently, amyloid fibrils have been shown to provide scaffolding and protection as functional materials in a range of organisms from bacteria to humans. These roles highlight the incredible tensile strength of the cross-β amyloid architecture. Many amino acid sequences are able to self-assemble to form amyloid with a cross-β core. Here we describe our recent advances in understanding how sequence contributes to amyloidogenicity and structure...
December 6, 2017: Interface Focus
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