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https://www.readbyqxmd.com/read/28651189/sex-specific-effects-of-difenoconazole-on-the-growth-hormone-endocrine-axis-in-adult-zebrafish-danio-rerio
#1
Miaomiao Teng, Suzhen Qi, Wentao Zhu, Yao Wang, Dezhen Wang, Yang Yang, Hui Li, Chenglong Li, Kai Dong, Chengju Wang
Difenoconazole, as one of the most widely used triazole fungicides, is applied to protect crops, fruits, and vegetables. It has been reported that difenoconazole can enter the environment and impair aquatic organisms, but whether difenoconazole can disrupt the growth hormone (GH) balance in adult zebrafish (Danio rerio) is still unclear. In this study, adult female and male zebrafish were exposed to difenoconazole (0, 5, 50, and 500µg/L) for seven days. The results revealed that the bioaccumulation of difenoconazole and its primary metabolite difenoconazole alcohol in females were both larger than that in males...
June 23, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28651092/role-of-proteoglycans-on-the-biochemical-and-biomechanical-properties-of-dentin-organic-matrix
#2
Cristina de Mattos Pimenta Vidal, Ariene Arcas Leme-Kraus, Momina Rahman, Ana Paula Farina, Ana K Bedran-Russo
OBJECTIVE: Proteoglycans (PGs) are multifunctional biomacromolecules of the extracellular matrix of collagen-based tissues. In teeth, besides a pivotal regulatory role on dentin biomineralization, PGs provide mechanical support to the mineralized tissue and compressive strength to the biosystem. This study assessed enzymatic protocols for selective PGs removal from demineralized dentin to determine the roles of these biomacromolecules in the bulk mechanical properties and biostability of type I collagen...
June 16, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28651091/loggerhead-sea-turtles-caretta-caretta-a-target-species-for-monitoring-litter-ingested-by-marine-organisms-in-the-mediterranean-sea
#3
Marco Matiddi, Sandra Hochsheid, Andrea Camedda, Matteo Baini, Cristiano Cocumelli, Fabrizio Serena, Paolo Tomassetti, Andrea Travaglini, Stefano Marra, Tommaso Campani, Francesco Scholl, Cecilia Mancusi, Ezio Amato, Paolo Briguglio, Fulvio Maffucci, Maria Cristina Fossi, Flegra Bentivegna, Giuseppe Andrea de Lucia
Marine litter is any persistent, manufactured or processed solid material discarded, disposed of or abandoned in the marine and coastal environment. Ingestion of marine litter can have lethal and sub-lethal effects on wildlife that accidentally ingests it, and sea turtles are particularly susceptible to this threat. The European Commission drafted the 2008/56/EC Marine Strategy Framework Directive with the aim to achieve a Good Environmental Status (GES), and the loggerhead sea turtle (Caretta caretta, Linnaeus 1758) was selected for monitoring the amount and composition of litter ingested by marine animals...
June 23, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28650593/hhv-6-in-liver-transplantation-a-literature-review
#4
REVIEW
Tuan L Phan, Irmeli Lautenschlager, Raymund R Razonable, Flor M Munoz
Human herpesvirus 6 (HHV-6A and HHV-6B) can cause primary infection or reactivate from latency in liver transplant recipients, which can result in a variety of clinical syndromes, including fever, hepatitis, encephalitis, and higher rates of graft dysfunction as well as indirect effects including increased risks of mortality, CMV disease, hepatitis C progression and greater fibrosis scores. Although HHV-6 infection is currently diagnosed by quantifying viral DNA in plasma or blood, biopsy to demonstrate histopathologic effects of HHV-6 remains the gold standard for diagnosis of end-organ disease...
June 26, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28650457/fibroblast-growth-factor-19-regulates-skeletal-muscle-mass-and-ameliorates-muscle-wasting-in-mice
#5
Bérengère Benoit, Emmanuelle Meugnier, Martina Castelli, Stéphanie Chanon, Aurélie Vieille-Marchiset, Christine Durand, Nadia Bendridi, Sandra Pesenti, Pierre-Axel Monternier, Anne-Cécile Durieux, Damien Freyssenet, Jennifer Rieusset, Etienne Lefai, Hubert Vidal, Jérôme Ruzzin
The endocrine-derived hormone fibroblast growth factor (FGF) 19 has recently emerged as a potential target for treating metabolic disease. Given that skeletal muscle is a key metabolic organ, we explored the role of FGF19 in that tissue. Here we report a novel function of FGF19 in regulating skeletal muscle mass through enlargement of muscle fiber size, and in protecting muscle from atrophy. Treatment with FGF19 causes skeletal muscle hypertrophy in mice, while physiological and pharmacological doses of FGF19 substantially increase the size of human myotubes in vitro...
June 26, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28650098/disparities-in-eurotransplant-liver-transplantation-waitlist-outcome-between-patients-with-and-without-exceptional-meld
#6
Andreas Umgelter, Alexander Hapfelmeier, Wouter Kopp, Marieke van Rosmalen, Xavier Rogiers, Markus Guba
BACKGROUND: The sickest-first principle in donor-liver allocation can be implemented by allocating organs to cirrhotic patients with the highest Model of End-stage Liver Disease (MELD) scores. For patients with other risk factors, standard (SE) and non-standard exceptions (NSE) have been developed. We investigated whether this system of matched MELD scores achieves similar outcome on the liver transplant waiting-list for various diagnostic groups in Eurotransplant (ET) countries with MELD-based individual allocation (Belgium, The Netherlands and Germany)...
June 26, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28650090/liver-transplantation-in-the-kingdom-of-saudi-arabia
#7
REVIEW
Mohammed Al Sebayel, Faisal Abaalkhail, Saleh Al Abbad, Hamad AlBahili, Hussien Elsiesy, Maha Aleid, Waleed Al-Hamoudi
The first liver transplant in Saudi Arabia was performed in 1991; however, it was not until 1994 that the first structured liver transplant program was launched. Until 1997, all liver transplants in the Kingdom of Saudi Arabia (KSA) were deceased donor liver transplantations. Programs performing liver transplants needed the authorization of the Saudi Center for Organ Transplantation (SCOT), which provides the essential support for organ procurement and allocation as well as regulatory support for organ transplantation in the country...
June 26, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28649988/iron-mediated-soil-carbon-response-to-water-table-decline-in-an-alpine-wetland
#8
Yiyun Wang, Hao Wang, Jin-Sheng He, Xiaojuan Feng
The tremendous reservoir of soil organic carbon (SOC) in wetlands is being threatened by water-table decline (WTD) globally. However, the SOC response to WTD remains highly uncertain. Here we examine the under-investigated role of iron (Fe) in mediating soil enzyme activity and lignin stabilization in a mesocosm WTD experiment in an alpine wetland. In contrast to the classic 'enzyme latch' theory, phenol oxidative activity is mainly controlled by ferrous iron [Fe(II)] and declines with WTD, leading to an accumulation of dissolvable aromatics and a reduced activity of hydrolytic enzyme...
June 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28649777/organization-of-the-catecholaminergic-systems-in-the-brain-of-lungfishes-the-closest-living-relatives-of-terrestrial-vertebrates
#9
Jesús M López, Agustín González
Lungfishes are a group of sarcopterygian fishes currently considered the closest living relatives of tetrapods, and represent an interesting group for the study of evolutionary traits in the transition from fishes to tetrapods. Catecholaminergic systems in the brain are among the most carefully analyzed neurotransmitter systems in the brain of most vertebrate groups. Their organization shows major shared characteristics, although traits particular to each vertebrate class have also been found, primarily between anamniotes and amniotes...
June 26, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28649712/cross-platform-compatibility-of-de-novo-aligned-snps-in-a-non-model-butterfly-genus
#10
Erin O Campbell, Corey S Davis, Julian R Dupuis, Kevin Muirhead, Felix A H Sperling
High-throughput sequencing methods for genotyping genome-wide markers are being rapidly adopted for phylogenetics of non-model organisms in conservation and biodiversity studies. However, the reproducibility of SNP genotyping and degree of marker overlap or compatibility between datasets from different methodologies have not been tested in non-model systems. Using double-digest restriction site associated DNA sequencing, we sequenced a common set of 22 specimens from the butterfly genus Speyeria on two different Illumina platforms, using two variations of library preparation...
June 26, 2017: Molecular Ecology Resources
https://www.readbyqxmd.com/read/28649658/niche-localized-tumor-cells-are-protected-from-her2-targeted-therapy-via-upregulation-of-an-anti-apoptotic-program-in-vivo
#11
Jason J Zoeller, Roderick T Bronson, Laura M Selfors, Gordon B Mills, Joan S Brugge
Several lines of evidence suggest that components of the tumor microenvironment, specifically basement membrane and extracellular matrix proteins, influence drug sensitivities. We previously reported differential drug sensitivity of tumor cells localized adjacent to laminin-rich extracellular matrix in three-dimensional tumor spheroid cultures. To evaluate whether differential intra-tumor responses to targeted therapy occur in vivo, we examined the sensitivity of human epidermal growth factor receptor 2-positive tumors to lapatinib using a previously described ductal carcinoma in situ-like model characterized by tumor cell confinement within ductal structures surrounded by an organized basement membrane...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28649269/a-comprehensive-technique-for-artificial-hybridization-in-chickpea-cicer-arietinum
#12
Shweta Kalve, Million Tadege
BACKGROUND: Two crossing techniques for hybridization of chickpea have been reported and include pollination after emasculation and pollination without emasculation. Success of crossing with emasculation varied from 5 to 17%; while the success rate varied from 20 to 50% by pollination without emasculation. The important reason for the low success rate of the two procedures could be lack of detailed information on the flowering stages chosen for crossing together with the environment where plants grow...
2017: Plant Methods
https://www.readbyqxmd.com/read/28649264/genome-wide-analysis-of-the-pvhsp20-family-in-switchgrass-motif-genomic-organization-and-identification-of-stress-or-developmental-related-hsp20s
#13
Haidong Yan, Ailing Zhang, Jing Chen, Xiaoyan He, Bin Xu, Guanqi Xie, Zhiming Miao, Xinquan Zhang, Linkai Huang
Hsp20 proteins exist in all plant species and represent the most abundant small heat shock proteins (sHSPs) in plants. Hsp20s were known as chaperones maintaining cellular homeostasis during heat or other kinds of abiotic stresses. The objective of this study was to understand the phylogenetic relationship, genomic organization, diversification of motif modules, genome localization, expression profiles, and interaction networks of switchgrass (Panicum virgatum L.) Hsp20s (PvHsp20s). A total of 63 PvHsp20s were identified with their consensus as well as unique ACD motifs and gene structures analyzed...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28649055/lonicera-quinquelocularis-a-rich-source-of-antioxidant-for-protection-against-chronic-diseases
#14
Sabahat Zahra Siddiqui, Hina Saleem, Muhammad Athar Abbasi, Azizur Rehman, Muhammad Ajaib
The purpose of the research work was to examine the in vitro antioxidant activity of the different aqueous and organic fractions of Lonicera quinquelocularis Hardwicke. The methanol extract was dissolved in distilled water and fractioned with n-hexane, chloroform, ethyl acetate and n-butanol, successively. The antioxidant potential of the remaining aqueous and organic fractions was determined by using 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging activity, total antioxidant activity, ferric reducing antioxidant power (FRAP) assay, ferric thiocyanate assay and total phenolics method...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28648972/diallyl-trisulfide-a-garlic-polysulfide-protects-against-as-induced-renal-oxidative-nephrotoxicity-apoptosis-and-inflammation-in-rats-by-activating-the-nrf2-are-signaling-pathway
#15
S Miltonprabu, N C Sumedha, P Senthilraja
BACKGROUND: Arsenic (As) contamination is an extremely dangerous global environmental problem as it can enter into the food chain and become bio-accumulated, endangering human health. Chronic As intoxication leads to undesirable toxic effects in various organ systems of the body, especially the kidney. Diallyl trisulfide (DATS) is an organosulfur compound which has been widely known for its uses as antibacterial, antitumorogenic, antioxidant agent and has been also reported to have anti-apoptotic and anti-inflammatory properties...
June 22, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28648821/caveolae-protect-notochord-cells-against-catastrophic-mechanical-failure-during-development
#16
Ye-Wheen Lim, Harriet P Lo, Charles Ferguson, Nick Martel, Jean Giacomotto, Guillermo A Gomez, Alpha S Yap, Thomas E Hall, Robert G Parton
The embryonic notochord is a flexible structure present during development that serves as scaffold for formation of the vertebrate spine. This rod-like organ is thought to have evolved in non-vertebrate chordates to facilitate locomotion by providing a rigid but flexible midline structure against which the axial muscles can contract. This hydrostatic "skeleton" is exposed to a variety of mechanical forces during oscillation of the body. There is evidence that caveolae, submicroscopic cup-shaped plasma membrane pits, can buffer tension in cells that undergo high levels of mechanical stress...
June 14, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28648816/how-light-affects-the-life-of-botrytis
#17
REVIEW
Julia Schumacher
Fungi, like other organisms, actively sense the environmental light conditions in order to drive adaptive responses, including protective mechanisms against the light-associated stresses, and to regulate development. Ecological niches are characterized by different light regimes, for instance light is absent underground, and light spectra from the sunlight are changed underwater or under the canopy of foliage due to the absorption of distinct wavelengths by bacterial, algal and plant pigments. Considering the fact that fungi have evolved to adapt to their habitats, the complexities of their 'visual' systems may vary significantly...
June 22, 2017: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/28648620/iron-overload-induces-hypogonadism-in-male-mice-via-extrahypothalamic-mechanisms
#18
Chiara Macchi, Liliana Steffani, Roberto Oleari, Antonella Lettieri, Luca Valenti, Paola Dongiovanni, Antonio Romero-Ruiz, Manuel Tena-Sempere, Anna Cariboni, Paolo Magni, Massimiliano Ruscica
INTRODUCTION: Iron overload leads to multiple organ damage including endocrine organ dysfunctions. Hypogonadism is the most common non-diabetic endocrinopathy in primary and secondary iron overload syndromes. AIM: To explore the molecular determinants of iron overload-induced hypogonadism with specific focus on hypothalamic derangements. A dysmetabolic male murine model fed iron-enriched diet (IED) and cell-based models of gonadotropin-releasing hormone (GnRH) neurons were used...
June 22, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28648410/the-great-unknown-a-systematic-literature-review-about-risk-associated-with-intraoperative-imaging-during-orthopaedic-surgeries
#19
REVIEW
Amir Matityahu, Ryan K Duffy, Sabine Goldhahn, Alexander Joeris, Peter H Richter, Florian Gebhard
INTRODUCTION: Modern techniques in orthopaedic surgery using minimally invasive procedures, and increased use of fluoroscopic imaging present a potential increased risk to surgeons due to ionizing radiation exposure. This article is a systematic review of recent literature on radiation exposure of orthopaedic surgeons. MATERIALS AND METHODS: Pubmed and Cochrane searches were performed on intraoperative radiation exposure covering English and German articles published between 1...
April 21, 2017: Injury
https://www.readbyqxmd.com/read/28648207/stage-progression-and-need-for-renal-replacement-therapy-in-a-renal-protection-programme-in-colombia-a-cohort-study
#20
Carlos Enrique Yepes Delgado, Sara Pérez Dávila, Marcela Montoya Jaramillo, Beatriz Elena Orrego Orozco
BACKGROUND: Due to the global burden represented by chronic kidney disease (CKD), the World Health Organization encouraged the implementation of renal protection programmes (RPP) to affect its incidence through prevention and control measures. OBJECTIVES: To assess the effectiveness of a Colombian RPP in terms of its effect on the stage progression of CKD and the need for renal replacement therapy (RRT). METHODS: An analytical study that monitored 2cohorts of patients diagnosed with CKD...
May 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
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