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https://www.readbyqxmd.com/read/28938796/complex-interactions-of-circadian-rhythms-eating-behaviors-and-the-gastrointestinal-microbiota-and-their-potential-impact-on-health
#1
Jennifer L Kaczmarek, Sharon V Thompson, Hannah D Holscher
Human health is intricately intertwined with the composition and function of the trillions of microorganisms that make up the gastrointestinal (GI) microbiome. The GI microbiome is essentially a microbial organ that provides metabolic, immunologic, and protective functions for the host. Habitual diet, changes in macronutrient composition, and consumption of nondigestible dietary fibers have all been shown to impact the human GI microbiome. Intriguingly, the impact of diet on the microbiome may be related not only to what humans eat but also to the timing of food consumption...
September 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28938519/gilaburu-viburnum-opulus-l-fruit-extract-alleviates-testis-and-sperm-damages-induced-by-taxane-based-chemotherapeutics
#2
Serpil Sarıözkan, Gaffari Türk, Ayşe Eken, Latife Çakır Bayram, Ayşe Baldemir, Gülden Doğan
In this study, it was aimed to investigate the possible protective effects of gilaburu (Viburnum opulus L., Glb) fruit extract on testis and sperm damages induced by docetaxel (DTX) and paclitaxel (PTX) chemotherapeutics in rats. Sixty adult male Wistar albino rats were divided into 6 equal groups, 10 animals each. The groups were created as control (weekly i.p. saline injection), Glb (weekly i.p. saline injection and daily oral 100mg/kg Glb), DTX (weekly i.p. injection of 5mg/kg DTX), PTX (weekly i.p. injection of 4mg/kg PTX), DTX+Glb (weekly i...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28938194/sulforaphane-mitigates-cadmium-induced-toxicity-pattern-in-human-peripheral-blood-lymphocytes-and-monocytes
#3
Nouf Abdulkareem Omer Alkharashi, Vaiyapuri Subbarayan Periasamy, Jegan Athinarayanan, Ali A Alshatwi
Cadmium (Cd) is a highly toxic and widely distributed heavy metal that induces various diseases in humans through environmental exposure. Therefore, alleviation of Cd-induced toxicity in living organisms is necessary. In this study, we investigated the protective role of sulforaphane on Cd-induced toxicity in human peripheral blood lymphocytes and monocytes. Sulforaphane did not show any major reduction in the viability of lymphocytes and monocytes. However, Cd treatment at a concentration of 50μM induced around 69% cell death...
August 31, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28938005/recombinant-vaccines-of-a-cd4-t-cell-epitope-promote-efficient-control-of-paracoccidioides-brasiliensis-burden-by-restraining-primary-organ-infection
#4
Rodrigo Assunção Holanda, Julián Esteban Muñoz, Lucas Santos Dias, Leandro Buffoni Roque Silva, Julliana Ribeiro Alves Santos, Sthefany Pagliari, Érica Leandro Marciano Vieira, Tatiane Alves Paixão, Carlos Pelleschi Taborda, Daniel Assis Santos, Oscar Bruña-Romero
Paracoccidioidomycosis (PCM) is an infectious disease endemic to South America, caused by the thermally dimorphic fungi Paracoccidioides. Currently, there is no effective human vaccine that can be used in prophylactic or therapeutic regimes. We tested the hypothesis that the immunogenicity of the immunodominant CD4+ T-cell epitope (P10) of Paracoccidioides brasiliensis gp43 antigen might be significantly enhanced by using a hepatitis B virus-derived particle (VLP) as an antigen carrier. This chimera was administered to mice as a (His)6-purified protein (rPbT) or a replication-deficient human type 5 adenoviral vector (rAdPbT) in an immunoprophylaxis assay...
September 22, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28937661/a-spectral-probe-for-detection-of-aluminum-iii-ions-using-surface-functionalized-gold-nanoparticles
#5
Surendra Shinde, Dae-Young Kim, Rijuta Ganesh Saratale, Asad Syed, Fuad Ameen, Gajanan Ghodake
A simple green route has been developed for the synthesis of casein peptide functionalized gold nanoparticles (AuNPs), in which casein peptide acts as a reducing as well as the stabilizing agent. In this report, AuNPs have been characterized on the basis of spectroscopic and microscopic results; which showed selective and sensitive response toward Al(3+) in aqueous media, and Al(3+) induces aggregation of AuNPs. The sensing study performed for Al(3+) revealed that the color change from red to blue was due to a red-shift in the surface plasmon resonance (SPR) band and the formation of aggregated species of AuNPs...
September 22, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28937634/the-physiological-and-pathological-implications-of-the-formation-of-hydrogels-with-a-specific-focus-on-amyloid-polypeptides
#6
REVIEW
Létitia Jean, Alex C Foley, David J T Vaux
Hydrogels are water-swollen and viscoelastic three-dimensional cross-linked polymeric network originating from monomer polymerisation. Hydrogel-forming polypeptides are widely found in nature and, at a cellular and organismal level, they provide a wide range of functions for the organism making them. Amyloid structures, arising from polypeptide aggregation, can be damaging or beneficial to different types of organisms. Although the best-known amyloids are those associated with human pathologies, this underlying structure is commonly used by higher eukaryotes to maintain normal cellular activities, and also by microbial communities to promote their survival and growth...
September 22, 2017: Biomolecules
https://www.readbyqxmd.com/read/28936746/therapeutic-effects-of-ischemic-preconditioned-exosomes-in-cardiovascular-diseases
#7
Shengguang Ding, Zhiqing Fan, Che Lin, Qiying Dai, Jinzhe Zhou, Haitao Huang, Yiming Xu, Chongjun Zhong
Despite years of researches, cardiovascular disease (CVD) remains the most common cause of death around the world. Lots of studies showed that by pretreating with short nonfatal ischemia in in situ organ or distant organ, one could develop tolerance to the following fatal ischemia. The process is called ischemic preconditioning (IPC). IPC prepare the heart for damage by producing inflammatory signals, miRNA, neuro system stimulation and exosomes. Among them, exosomes have been gaining increasing interest since it is characterized by its capability to carry information and its specific ligand-receptor system...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28936623/acute-renal-metabolic-effect-of-metformin-assessed-with-hyperpolarised-mri-in-rats
#8
Haiyun Qi, Per M Nielsen, Marie Schroeder, Lotte B Bertelsen, Fredrik Palm, Christoffer Laustsen
AIMS/HYPOTHESIS: Metformin inhibits hepatic mitochondrial glycerol phosphate dehydrogenase, thereby increasing cytosolic lactate and suppressing gluconeogenesis flux in the liver. This inhibition alters cytosolic and mitochondrial reduction-oxidation (redox) potential, which has been reported to protect organ function in several disease states including diabetes. In this study, we investigated the acute metabolic and functional changes induced by metformin in the kidneys of both healthy and insulinopenic Wistar rats used as a model of diabetes...
September 21, 2017: Diabetologia
https://www.readbyqxmd.com/read/28935938/an-engineered-bispecific-dna-encoded-igg-antibody-protects-against-pseudomonas-aeruginosa-in-a-pneumonia-challenge-model
#9
Ami Patel, Antonio DiGiandomenico, Ashley E Keller, Trevor R F Smith, Daniel H Park, Stephanie Ramos, Katherine Schultheis, Sarah T C Elliott, Janess Mendoza, Kate E Broderick, Megan C Wise, Jian Yan, Jingjing Jiang, Seleeke Flingai, Amir S Khan, Kar Muthumani, Laurent Humeau, Lily I Cheng, Leslie Wachter-Rosati, C Kendall Stover, Niranjan Y Sardesai, David B Weiner
The impact of broad-spectrum antibiotics on antimicrobial resistance and disruption of the beneficial microbiome compels the urgent investigation of bacteria-specific approaches such as antibody-based strategies. Among these, DNA-delivered monoclonal antibodies (DMAbs), produced by muscle cells in vivo, potentially allow the prevention or treatment of bacterial infections circumventing some of the hurdles of protein IgG delivery. Here, we optimize DNA-delivered monoclonal antibodies consisting of two potent human IgG clones, including a non-natural bispecific IgG1 candidate, targeting Pseudomonas aeruginosa...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28935111/evaluation-of-virus-like-particle-based-tumor-associated-carbohydrate-immunogen-in-a-mouse-tumor-model
#10
Suttipun Sungsuwan, Xuanjun Wu, Xuefei Huang
Tumor-associated carbohydrate antigens (TACAs) are attractive targets for anticancer vaccine development. Due to the low immunogenicity of TACAs, a powerful carrier system is needed to boost immune responses. Virus-like particles (VLPs) are an exciting platform for delivering TACAs to the immune system. The high symmetry of VLPs enables the display of TACAs in an organized manner, which in turn can potently activate antibody secreting B cells, eliciting high titers of antiglycan IgG antibodies. In this chapter, the protocol for conjugating a prototypical TACA, the Tn antigen to a VLP, bacteriophage Qβ, is presented...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28934735/effect-of-shikonin-on-spinal-cord-injury-in-rats-via-regulation-of-hmgb1-tlr4-nf-kb-signaling-pathway
#11
Yihui Bi, Yapeng Zhu, Mingkai Zhang, Keke Zhang, Xingyi Hua, Zheng Fang, Jian Zhou, Wenjie Dai, Yixing Cui, Jun Li, Tao You
BACKGROUND/AIMS: Shikonin, a compound extracted from Zicao, has been demonstrated to hold anti-bacterial, anti-inflammatory, and anti-tumor activities in various diseases and it has been shown to protect human organs from injuries. However, the effect of shikonin on the recovery of spinal cord injury (SCI) remains unknown. This study was designed to estimate the potential therapeutic effect and underlying mechanism of shikonin on SCI in vivo. METHODS: In the study, we used HE staining, ELISA assay, transfection assay, TUNEL assay, real time PCR and Western blot to detect the effects of shikonin on spinal cord injury in rats...
September 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28934691/the-role-of-ppar-alpha-in-perfluorooctanoic-acid-induced-developmental-cardiotoxicity-and-l-carnitine-mediated-protection-results-of-in-ovo-gene-silencing
#12
Meng Zhao, Qixiao Jiang, Min Geng, Li Zhu, Yunqiu Xia, Aashish Khanal, Chunbo Wang
Perfluorooctanoic acid (PFOA) is a persistent organic pollutant. This study established an in ovo peroxisome proliferator-activated receptor alpha (PPAR alpha) silencing model in chicken embryo heart, and investigated the role of PPAR alpha in PFOA induced developmental cardiotoxicity. The in ovo silencing was achieved by introducing lentivirus expressing PPAR alpha siRNA into ED2 chicken embryo via microinjection (0.05ul/g egg weight). Transfection efficacy was confirmed by fluorescent microscopy and western blotting...
September 14, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28934673/an-analysis-of-chemicals-and-other-constituents-found-in-produced-water-from-hydraulically-fractured-wells-in-california-and-the-challenges-for-wastewater-management
#13
Emily A Chittick, Tanja Srebotnjak
As high-volume hydraulic fracturing (HF) has grown substantially in the United States over the past decade, so has the volume of produced water (PW), i.e., briny water brought to the surface as a byproduct of oil and gas production. According to a recent study (Groundwater Protection Council, 2015), more than 21 billion barrels of PW were generated in 2012. In addition to being high in TDS, PW may contain hydrocarbons, PAH, alkylphenols, naturally occurring radioactive material (NORM), metals, and other organic and inorganic substances...
September 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28934401/lessons-learned-for-reducing-the-negative-impact-of-adverse-events-on-patients-health-professionals-and-healthcare-organizations
#14
Jose Joaquin Mira, Susana Lorenzo, Irene Carrillo, Lena Ferrús, Carmen Silvestre, Pilar Astier, Fuencisla Iglesias-Alonso, Jose Angel Maderuelo, Pastora Pérez-Pérez, Maria Luisa Torijano, Elena Zavala, Susan D Scott
Purpose: To summarize the knowledge about the aftermath of adverse events (AEs) and develop a recommendation set to reduce their negative impact in patients, health professionals and organizations in contexts where there is no previous experiences and apology laws are not present. Data sources: Review studies published between 2000 and 2015, institutional websites and experts' opinions on patient safety. Study selection: Studies published and websites on open disclosure, and the second and third victims' phenomenon...
August 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28934270/assessment-of-the-trophic-state-of-a-hypersaline-carbonatic-environment-vermelha-lagoon-brazil
#15
Lazaro Laut, Maria Virginia Alves Martins, Fabrizio Frontalini, João M Ballalai, Pierre Belart, Renan Habib, Luiz F Fontana, Iara M M M Clemente, Maria Lucia Lorini, João G Mendonça Filho, Vanessa M Laut, Marcos de Souza Lima Figueiredo
Vermelha Lagoon is a hypersaline shallow transitional ecosystem in the state of Rio de Janeiro (Brazil). This lagoon is located in the protected area of Massambaba, between the cities of Araruama and Saquarema (Brazil), and displays two quite uncommon particularities: it exhibits carbonate sedimentation and displays the development of Holocene stromatolites. Due to both particularities, the salt industry and property speculation have been, increasingly, generating anthropic pressures on this ecosystem. This study aims to apply a multiproxy approach to evaluate the trophic state of Vermelha Lagoon based on physicochemical parameters and geochemical data for the quantification and qualification of organic matter (OM), namely total organic carbon (TOC), total sulfur (TS), total phosphorus (TP) and biopolymeric carbon (BPC), including carbohydrates (CHO), lipids (LIP) and proteins (PTN)...
2017: PloS One
https://www.readbyqxmd.com/read/28934112/biological-mechanisms-by-which-antiproliferative-actions-of-resveratrol-are-minimized
#16
REVIEW
Yih Ho, Yu-Syuan Lin, Hsuan-Liang Liu, Ya-Jung Shih, Shin-Ying Lin, Ai Shih, Yu-Tang Chin, Yi-Ru Chen, Hung-Yun Lin, Paul J Davis
Preclinical and clinical studies have offered evidence for protective effects of various polyphenol-rich foods against cardiovascular diseases, neurodegenerative diseases, and cancers. Resveratrol is among the most widely studied polyphenols. However, the preventive and treatment effectiveness of resveratrol in cancer remain controversial because of certain limitations in existing studies. For example, studies of the activity of resveratrol against cancer cell lines in vitro have often been conducted at concentrations in the low μM to mM range, whereas dietary resveratrol or resveratrol-containing wine rarely achieve nM concentrations in the clinic...
September 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28933343/the-european-medical-corps-first-public-health-team-mission-and-future-perspectives
#17
Joana M Haussig, Ettore Severi, Jonathan Hj Baum, Veerle Vanlerberghe, Amparo Laiseca, Laurent Defrance, Cristina Brailescu, Denis Coulombier, Josep Jansa
The 2013-2016 Ebola epidemic in West Africa challenged traditional international mechanisms for public health team mobilisation to control outbreaks. Consequently, in February 2016, the European Union (EU) launched the European Medical Corps (EMC), a mechanism developed in collaboration with the World Health Organization (WHO) to rapidly deploy teams and equipment in response to public health emergencies inside and outside the EU. Public Health Teams (PHTs), a component of the EMC, consist of experts in communicable disease prevention and control from participating countries and the European Centre for Disease Prevention and Control (ECDC), to support affected countries and WHO in risk assessment and outbreak response...
September 14, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28932662/high-mobility-p-type-organic-semiconducting-interlayer-enhancing-efficiency-and-stability-of-perovskite-solar-cells
#18
Mingyu Zhang, Jiayu Wang, Liang Li, Guanhaojie Zheng, Kuan Liu, Meng Qin, Huanping Zhou, Xiaowei Zhan
A high-mobility p-type organic semiconductor based on benzodithiophene and diketopyrrolopyrrole with linear alkylthio substituents (BDTS-2DPP) is used as a dual function interfacial layer to modify the interface of perovskite/2,2',7,7'-tetrakis(N,N'-di-p-methoxyphenylamine)-9,9'-spirobifluorene in planar perovskite solar cells. The BDTS-2DPP layer can remarkably passivate the surface defects of perovskite through the formation of Lewis adduct between the under-coordinated Pb atoms in perovskite and S atoms in BDTS-2DPP, and also shows efficient hole extraction and transfer properties...
September 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28932603/the-protective-effect-of-naringenin-oxime-on-cisplatin-induced-toxicity-in-rats
#19
Ismail Koyuncu, Abdurrahim Kocyigit, Ataman Gonel, Erkan Arslan, Mustafa Durgun
The aim of this study is to examine the protective effect of naringenin-oxime (NOX) on cisplatin-induced major organ toxicity and DNA damage in rats. Thirty-five male Wistar albino rats were equally split into five groups as follows: control (i.p., 0.1 ml of saline), Cis administration (i.p., 7 mg/kg b.w.), NOX treatment (i.p., 20 mg/kg b.w., daily for ten days), Cis + NOX20, and Cis + NOX40 combination (i.p., 20 and 40 mg/kg b.w., daily for ten days). Serum and peripheral blood mononuclear leukocytes (PBMC) were obtained from blood...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/28932227/targeted-delivery-of-neutralizing-anti-c5-antibody-to-renal-endothelium-prevents-complement-dependent-tissue-damage
#20
Paolo Durigutto, Daniele Sblattero, Stefania Biffi, Luca De Maso, Chiara Garrovo, Gabriele Baj, Federico Colombo, Fabio Fischetti, Antonio F Di Naro, Francesco Tedesco, Paolo Macor
Complement activation is largely implicated in the pathogenesis of several clinical conditions and its therapeutic neutralization has proven effective in preventing tissue and organ damage. A problem that still needs to be solved in the therapeutic control of complement-mediated diseases is how to avoid side effects associated with chronic neutralization of the complement system, in particular, the increased risk of infections. We addressed this issue developing a strategy based on the preferential delivery of a C5 complement inhibitor to the organ involved in the pathologic process...
2017: Frontiers in Immunology
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