S Loreti, K Thiele, M De Brucker, C Olsen, J Centelles-Lodeiro, C Bourgain, W Waelput, H Tournaye, G Griesinger, J Raes, S Vieira-Silva, P Arck, C Blockeel, S Mackens
STUDY QUESTION: How do plasma progesterone (P) and dydrogesterone (D) concentrations together with endometrial histology, transcriptomic signatures, and immune cell composition differ when oral dydrogesterone (O-DYD) or micronized vaginal progesterone (MVP) is used for luteal phase support (LPS)? SUMMARY ANSWER: Although after O-DYD intake, even at steady-state, plasma D and 20αdihydrodydrogesterone (DHD) concentrations spiked in comparison to P concentrations, a similar endometrial signature was observed by histological and transcriptomic analysis of the endometrium...
February 1, 2024: Human Reproduction