Ken Kijima, Gentaro Ono, Kazu Kobayakawa, Hirokazu Saiwai, Masamitsu Hara, Shingo Yoshizaki, Kazuya Yokota, Takeyuki Saito, Tetsuya Tamaru, Hirotaka Iura, Yohei Haruta, Kazuki Kitade, Takeshi Utsunomiya, Daijiro Konno, V Reggie Edgerton, Charles Y Liu, Hiroaki Sakai, Takeshi Maeda, Kenichi Kawaguchi, Yoshihiro Matsumoto, Seiji Okada, Yasuharu Nakashima
BACKGROUND: Spinal cord injury (SCI) is a devastating disease that results in permanent paralysis. Currently, there is no effective treatment for SCI, and it is important to identify factors that can provide therapeutic intervention during the course of the disease. Zinc, an essential trace element, has attracted attention as a regulator of inflammatory responses. In this study, we investigated the effect of zinc status on the SCI pathology and whether or not zinc could be a potential therapeutic target...
2023: Frontiers in Immunology