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Zinc immunity immune supplements

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https://www.readbyqxmd.com/read/27882813/dietary-zinc-modifies-diabetic-induced-renal-pathology-in-rats
#1
Wael M Elsaed, Hazem Abdelhamid Mohamed
This study was conducted to investigate how far dietary zinc (Zn) modifies the histomorphological alterations induced by diabetes in rat kidneys. The animals were divided into negative control group (10 rats). Diabetes was induced in thirty animals by streptozotocin. After confirming diabetes, the animals were divided into three groups (n = 10). Group II served as the positive control group (fed on standard diet), group III was fed on Zn deficient diet, and group IV was fed on Zn supplemented diet. Caspase-3 immune staining was used to estimate the caspase activity...
November 24, 2016: Renal Failure
https://www.readbyqxmd.com/read/27843161/adding-interventions-to-mass-measles-vaccinations-in-india
#2
Mira Johri, Stéphane Verguet, Shaun K Morris, Jitendar K Sharma, Usha Ram, Cindy Gauvreau, Edward Jones, Prabhat Jha, Mark Jit
OBJECTIVE: To quantify the impact on mortality of offering a hypothetical set of technically feasible, high-impact interventions for maternal and child survival during India's 2010-2013 measles supplementary immunization activity. METHODS: We developed Lives Saved Tool models for 12 Indian states participating in the supplementary immunization, based on state- and sex-specific data on mortality from India's Million Deaths Study and on health services coverage from Indian household surveys...
October 1, 2016: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/27822236/effect-of-substituting-increasing-levels-of-organic-zn-for-inorganic-zn-on-performance-hematological-and-serum-biochemical-constituents-antioxidant-status-and-immune-response-in-rat
#3
D Nagalakshmi, K Sridhar, P S Swain, A G Reddy
The effect of replacing dietary Zn supplemented from inorganic (ZnCO3) source with organic Zn (Zn methionine; Zn-met) was investigated in 72 rats (98.42 ± 1.483 g) by randomly allotting to 4 diets (6 replicates/diet, 3 rats/replicate). Basal diet was prepared with purified ingredients without Zn. The control diet (AIN-76A) contained 12 ppm of Zn from ZnCO3 (100-I). In the other diets ZnCO3 was replaced with Zn-met at the rates of 50 (50I:50O), 75 (25I:75O) or 100% (100-O). Weekly body weight and daily feed intake were recorded for 14 weeks...
2016: Iranian journal of veterinary research
https://www.readbyqxmd.com/read/27821649/zinc-supplementation-leads-to-immune-modulation-and-improved-survival-in-a-juvenile-model-of-murine-sepsis
#4
Hammad A Ganatra, Brian M Varisco, Kelli Harmon, Patrick Lahni, Amy Opoka, Hector R Wong
Children with severe sepsis are known to have altered zinc homeostasis and decreased circulating zinc levels, suggesting a role for zinc supplementation to improve outcomes. We tested the hypothesis that zinc supplementation would improve survival in a juvenile model of polymicrobial sepsis. Juvenile (13-14-d-old) C57BL/6 mice were treated with 10 mg/kg of zinc via i.p. injections (or vehicle) for 3 d prior to induction of polymicrobial sepsis via i.p. cecal slurry injections. Survival after sepsis was followed for 3 d, and bacterial clearance, ex vivo phagocytosis, systemic inflammatory markers and neutrophil extracellular trap (NET) formation were quantified...
November 7, 2016: Innate Immunity
https://www.readbyqxmd.com/read/27794192/zinc-supplementation-augments-tgf-%C3%AE-1-dependent-regulatory-t-cell-induction
#5
Martina Maywald, Steffen K Meurer, Ralf Weiskirchen, Lothar Rink
SCOPE: Regulatory T cells (Treg) play a pivotal role in immune regulation. For proper immune function, also trace elements such as zinc, and anti-inflammatory cytokines, including transforming growth factor beta 1 (TGF-β1) and interleukin (IL)-10 are indispensable. Hence, in this study the influence of TGF-β1, IL-10, and zinc supplementation on Treg cells differentiation was investigated. METHODS AND RESULTS: A synergistic effect of a combined zinc and TGF-β1 treatment on Foxp3 expression in peripheral blood mononuclear cells and mixed lymphocyte cultures (MLC) was found by performing Western blot analysis...
October 29, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27769076/the-role-of-dietary-supplements-in-inflammatory-bowel-disease-a-systematic-review
#6
Roberta E Rossi, Tara Whyand, Charles D Murray, Mark I Hamilton, Dario Conte, Martyn E Caplin
Inflammatory bowel diseases (IBD) are chronic immune disorders of unclear aetiology. Dietary deficiencies may be a potential pathogenic factor in their development. Patients often take food supplements without knowledge of any evidence base. We have therefore assessed the evidence for food supplementation in the management of IBD. A PubMed search was performed for the terms Inflammatory bowel disease; nutritional deficiencies; dietary supplements; curcumin; green tea; vitamin D/other vitamins; folic acid; iron; zinc; probiotics; andrographis paniculata; and boswellia serrate...
December 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27746360/cytocompatibility-and-early-inflammatory-response-of-human-endothelial-cells-in-direct-culture-with-mg-zn-sr-alloys
#7
Aaron F Cipriano, Amy Sallee, Myla Tayoba, Mayra C Cortez Alcaraz, Alan Lin, Ren-Guo Guan, Zhan-Yong Zhao, Huinan Liu
: Crystalline Mg-Zinc (Zn)-Strontium (Sr) ternary alloys consist of elements naturally present in the human body and provide attractive mechanical and biodegradable properties for a variety of biomedical applications. The first objective of this study was to investigate the degradation and cytocompatibility of four Mg-4Zn-xSr alloys (x=0.15, 0.5, 1.0, 1.5wt%; designated as ZSr41A, B, C, and D respectively) in the direct culture with human umbilical vein endothelial cells (HUVEC) in vitro...
October 13, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27660289/interaction-between-2-nutraceutical-treatments-and-host-immune-status-in-the-pediatric-critical-illness-stress-induced-immune-suppression-comparative-effectiveness-trial
#8
Joseph A Carcillo, J Michael Dean, Richard Holubkov, John Berger, Kathleen L Meert, Kanwaljeet J S Anand, Jerry J Zimmerman, Christopher J L Newth, Rick Harrison, Jeri Burr, Douglas F Willson, Carol Nicholson, Michael J Bell, Robert A Berg, Thomas P Shanley, Sabrina M Heidemann, Heidi Dalton, Tammara L Jenkins, Allan Doctor, Angie Webster, Robert F Tamburro
BACKGROUND AND AIMS: The pediatric Critical Illness Stress-induced Immune Suppression (CRISIS) trial compared the effectiveness of 2 nutraceutical supplementation strategies and found no difference in the development of nosocomial infection and sepsis in the overall population. We performed an exploratory post hoc analysis of interaction between nutraceutical treatments and host immune status related to the development of nosocomial infection/sepsis. METHODS: Children from the CRISIS trial were analyzed according to 3 admission immune status categories marked by decreasing immune competence: immune competent without lymphopenia, immune competent with lymphopenia, and previously immunocompromised...
September 22, 2016: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27640333/dietary-vitamin-c-deficiency-depressed-the-gill-physical-barriers-and-immune-barriers-referring-to-nrf2-apoptosis-mlck-nf-%C3%AE%C2%BAb-and-tor-signaling-in-grass-carp-ctenopharyngodon-idella-under-infection-of-flavobacterium-columnare
#9
Hui-Jun Xu, Wei-Dan Jiang, Lin Feng, Yang Liu, Pei Wu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou
This study explored the effects of vitamin C on the physical barriers and immune barriers, and relative mRNA levels of signaling molecules in the gill of grass carp (Ctenopharyngodon idella) under infection of Flavobacterium columnare. The results indicated that compared with optimal vitamin C supplementation, vitamin C deficiency (2.9 mg/kg diet) (1) increased reactive oxygen species, malondialdehyde and protein carbonyl (PC) contents (P < 0.05), decreased the copper/zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities and mRNA levels (P < 0...
September 15, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27586662/copper-zinc-superoxide-dismutase-cuznsod-an-antioxidant-gene-from-seahorse-hippocampus-abdominalis-molecular-cloning-sequence-characterization-antioxidant-activity-and-potential-peroxidation-function-of-its-recombinant-protein
#10
N C N Perera, G I Godahewa, Jehee Lee
Copper-zinc-superoxide dismutase (CuZnSOD) from Hippocampus abdominalis (HaCuZnSOD) is a metalloenzyme which belongs to the ubiquitous family of SODs. Here, we determined the characteristic structural features of HaCuZnSOD, analyzed its evolutionary relationships, and identified its potential immune responses and biological functions in relation to antioxidant defense mechanisms in the seahorse. The gene had a 5' untranslated region (UTR) of 67 bp, a coding sequence of 465 bp and a 3' UTR of 313 bp. The putative peptide consists of 154 amino acids...
October 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27574828/role-of-dietary-ginger-zingiber-officinale-in-improving-growth-performances-and-immune-functions-of-labeo-rohita-fingerlings
#11
Venkatachalam Sukumaran, Se Chang Park, Sib Sankar Giri
This study evaluated the effects of ginger (Zingiber officinale) as a feeding supplement on the growth, skin mucus immune parameters, and cytokine-related gene expression of Labeo rohita, and its susceptibility to Aeromonas hydrophila infection. Diets containing six different concentrations of dried ginger (0% [basal diet], 0.2% [G2], 0.4% [G4], 0.6% [G6], 0.8% [G8], and 1.0% [G10] were fed to fish (average weight: 12.3 g) for 60 days. Growth parameters were examined at 30 and 60 days post-feeding. Skin mucosal immune responses and gene expression were examined 60 days post-feeding...
October 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27496747/effects-of-injectable-trace-minerals-on-humoral-and-cell-mediated-immune-responses-to-bovine-viral-diarrhea-virus-bovine-herpes-virus-1-and-bovine-respiratory-syncytial-virus-following-administration-of-a-modified-live-virus-vaccine-in-dairy-calves
#12
R A Palomares, D J Hurley, J H J Bittar, J T Saliki, A R Woolums, F Moliere, L J Havenga, N A Norton, S J Clifton, A B Sigmund, C E Barber, M L Berger, M J Clark, M A Fratto
Our objective was to evaluate the effect of an injectable trace mineral (ITM) supplement containing zinc, manganese, selenium, and copper on the humoral and cell mediated immune (CMI) responses to vaccine antigens in dairy calves receiving a modified-live viral (MLV) vaccine containing BVDV, BHV1, PI3V and BRSV. A total of 30 dairy calves (3.5 months of age) were administered a priming dose of the MLV vaccine containing BHV1, BVDV1 & 2, BRSV, PI3V, and an attenuated-live Mannheimia-Pasteurella bacterin subcutaneously (SQ)...
October 1, 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27465530/zinc-induces-dendritic-cell-tolerogenic-phenotype-and-skews-regulatory-t-cell-th17-balance
#13
Mariam Mathew George, Kavitha Subramanian Vignesh, Julio A Landero Figueroa, Joseph A Caruso, George S Deepe
Zinc (Zn) is an essential metal for development and maintenance of both the innate and adaptive compartments of the immune system. Zn homeostasis impacts maturation of dendritic cells (DCs) that are important in shaping T cell responses. The mechanisms by which Zn regulates the tolerogenic phenotype of DCs remain largely unknown. In this study, we investigated the effect of Zn on DC phenotype and the generation of Foxp3(+) regulatory T cells (Tregs) using a model of Histoplasma capsulatum fungal infection. Exposure of bone marrow-derived DCs to Zn in vitro induced a tolerogenic phenotype by diminishing surface MHC class II (MHCII) and promoting the tolerogenic markers, programmed death-ligand (PD-L)1, PD-L2, and the tryptophan degrading enzyme, IDO...
September 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27386604/zinc-supplement-boosts-immunity-in-older-adults
#14
(no author information available yet)
No abstract text is available yet for this article.
March 2016: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/27355911/nutritional-supplements-for-people-being-treated-for-active-tuberculosis
#15
REVIEW
Liesl Grobler, Sukrti Nagpal, Thambu D Sudarsanam, David Sinclair
BACKGROUND: Tuberculosis and malnutrition are linked in a complex relationship. Tuberculosis may cause undernutrition through increased metabolic demands and decreased intake, and nutritional deficiencies may worsen the disease, or delay recovery by depressing important immune functions. At present, there is no evidence-based nutritional guidance for adults and children being treated for tuberculosis. OBJECTIVES: To assess the effects of oral nutritional supplements in people being treated with antituberculous drug therapy for active tuberculosis...
June 29, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27339255/dietary-zinc-oxide-modulates-antioxidant-capacity-small-intestine-development-and-jejunal-gene-expression-in-weaned-piglets
#16
Cui Zhu, Hang Lv, Zhuang Chen, Li Wang, Xiuju Wu, Zhongjian Chen, Weina Zhang, Rui Liang, Zongyong Jiang
The current study was conducted to investigate the effects of dietary zinc oxide (ZnO) on the antioxidant capacity, small intestine development, and jejunal gene expression in weaned piglets. Ninety-six 21-day-old piglets were randomly assigned to three dietary treatments. Each treatment had eight replicates with four piglets per replicate. The piglets were fed either control diet (control) or control diet supplemented with in-feed antibiotics (300 mg/kg chlortetracycline and 60 mg/kg colistin sulfate) or pharmacological doses of ZnO (3000 mg/kg)...
June 23, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27317042/zinc-and-infant-nutrition
#17
M Leigh Ackland, Agnes A Michalczyk
Zinc is essential for a wide variety of cellular processes in all cells. It is a critical dietary nutrient, particularly in the early stages of life. In the early neonatal period, adequate sources of zinc can be obtained from breast milk. In rare circumstances, the mammary gland produces zinc deficient milk that is potentially lethal for exclusively breast-fed infants. This can be overcome by zinc supplementation to the infant. Alterations to key zinc transporters provide insights into the mechanisms of cellular zinc homeostasis...
June 15, 2016: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27260002/zinc-supplementation-induces-cd4-cd25-foxp3-antigen-specific-regulatory-t-cells-and-suppresses-ifn-%C3%AE-production-by-upregulation-of-foxp3-and-klf-10-and-downregulation-of-irf-1
#18
Martina Maywald, Lothar Rink
PURPOSE: The essential trace element zinc plays a fundamental role in immune function and regulation since its deficiency is associated with autoimmunity, allergies, and transplant rejection. Thus, we investigated the influence of zinc supplementation on the Th1-driven alloreaction in mixed lymphocyte cultures (MLC), on generation of antigen-specific T cells, and analyzed underlying molecular mechanisms. METHODS: Cell proliferation and pro-inflammatory cytokine production were monitored by [(3)H]-thymidine proliferation assay and ELISA, respectively...
June 3, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27259355/boron-influences-immune-and-antioxidant-responses-by-modulating-hepatic-superoxide-dismutase-activity-under-calcium-deficit-abiotic-stress-in-wistar-rats
#19
T Vijay Bhasker, N K S Gowda, S Mondal, P Krishnamoorthy, D T Pal, A Mor, S Karthik Bhat, A K Pattanaik
The influence of Boron (B) supplementation on immune and antioxidant status of rats with or without abiotic stress induced by dietary calcium (Ca) restriction was studied in a feeding trial of 90 days. Wistar strain rats (3-4 wk age, n=84) were divided into 7 dietary groups (4 replicates of 3 each) viz., normal-calcium (100%) basal diet alone (NC, control) or supplemented with B at 5 (NCB-5), 10 (NCB-10), 20 (NCB-20) and 40ppm (NCB-40) levels; low-calcium (50%) basal diet alone (LC) or supplemented with 40ppm B (LCB-40)...
July 2016: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27182454/lower-plasma-zinc-levels-in-hyperglycemic-people-living-with-hiv-in-the-mash-cohort
#20
Alicia Sneij, Adriana Campa, Sabrina Sales Martinez, Tiffanie Stewart, Marianna Baum
BACKGROUND: Zinc deficiency is prevalent in HIV and hyperglycemic patients. Antiretroviral therapy (ART) is a treatment to control HIV progression; however it increases the risk for hyperglycemia. The objective of this study was to assess the plasma zinc levels in hyperglycemic people living with HIV (PLWH). METHODS: Secondary analysis was conducted on the data from the Miami Adult Studies in HIV (MASH) cohort in Florida. Patients were categorized into hyperglycemic group (fasting blood glucose ≥100 mg/dL) and normal group (<100 mg/dL)...
February 2016: Journal of AIDS & Clinical Research
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