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Zinc immunity immune supplements

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https://www.readbyqxmd.com/read/29920420/effect-of-selected-drugs-on-zinc-accumulation-in-teeth-of-laboratory-animals
#1
Włodzimierz Opoka, Joanna Piotrowska, Adam Krakowski, Agata Kryczyk, Kinga Sałat, Małgorzata Zygmunt, Tadeusz Librowski, Bożena Muszyńska
BACKGROUND: Zinc (Zn) is a micronutrient and essential element of life and its deficiency causes severe disorders of numerous body systems, such as immune, reproductive and central nervous system. Zinc supplementation affects wound healing and sexual development. The interactions between drugs administration and Zn level in tissues are not fully understood. The aim of the study was to demonstrate differences in Zn content in teeth of laboratory animals that have undergone pharmacological tests...
February 5, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29914030/zinc-exacerbates-tau-pathology-in-a-tau-mouse-model
#2
Kristen M Craven, William R Kochen, Carlos M Hernandez, Jane M Flinn
Hyperphosphorylated tau protein is a key pathology in Alzheimer's disease (AD), frontotemporal dementia, chronic traumatic encephalopathy, and Parkinson's disease. The essential trace element zinc exacerbates tauopathy in vitro as well as in a Drosophila model of AD. However, the interaction has never been assessed behaviorally or biochemically in mammals. Zinc supplementation is prevalent in society, finding use as a treatment for macular degeneration and cataracts, and is also taken as an immune system booster with high levels appearing in multivitamins marketed toward the elderly...
June 9, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29747074/high-dose-zinc-oral-supplementation-after-stem-cell-transplantation-causes-an-increase-of-trecs-and-cd4-na%C3%A3-ve-lymphocytes-and-prevents-ttv-reactivation
#3
Lorenzo Iovino, Francesco Mazziotta, Giovanni Carulli, Francesca Guerrini, Riccardo Morganti, Valentina Mazzotti, Fabrizio Maggi, Lisa Macera, Enrico Orciuolo, Gabriele Buda, Edoardo Benedetti, Francesco Caracciolo, Sara Galimberti, Mauro Pistello, Mario Petrini
INTRODUCTION: Zinc plays an important role in thymic function and immune homeostasis. We performed a prospective clinical trial using a high-dose zinc oral supplementation to improve the immune reconstitution after hematopoietic stem cell transplant (HSCT). PATIENTS AND METHODS: We enrolled 18 patients undergoing autologous HSCT for multiple myeloma. Nine patients were randomized to receive only a standard antimicrobial prophylaxis; whereas, nine patients received in addition 150 mg/day of zinc from day +5 to day +100 after transplant...
May 2, 2018: Leukemia Research
https://www.readbyqxmd.com/read/29713463/zinc-as-an-adjunct-therapy-in-the-management-of-severe-pneumonia-among-gambian-children-randomized-controlled-trial
#4
RANDOMIZED CONTROLLED TRIAL
Stephen Howie, Christian Bottomley, Osaretin Chimah, Readon Ideh, Bernard Ebruke, Uduak Okomo, Charles Onyeama, Simon Donkor, Onike Rodrigues, Mary Tapgun, Marie Janneh, Claire Oluwalana, Bankole Kuti, Godwin Enwere, Pamela Esangbedo, Conor Doherty, Grant Mackenzie, Brian Greenwood, Tumani Corrah, Andrew Prentice, Richard Adegbola, Syed Zaman
Background: The benefit of zinc as an adjunct therapy for severe pneumonia is not established. We assessed the benefit of adjunct zinc therapy for severe pneumonia in children and determined whether the study children were zinc deficient. Methods: This was a randomized, parallel group, double-blind, placebo-controlled trial with an allocation ratio of 1:1 conducted in children with severe pneumonia to evaluate the efficacy of daily zinc as an adjunct treatment in preventing 'treatment failure' (presence of any sign of severe pneumonia) on day-5 and day-10 and in reducing the time to resolution of signs of severe pneumonia...
June 2018: Journal of Global Health
https://www.readbyqxmd.com/read/29684999/effect-of-cuso4-and-nano-copper-on-serum-antioxidant-capacity-in-weaned-piglets
#5
Z Chang, H Zhang, H Dong, K Mehmood, M Ijaz, H I Ahmad, M A Naeem, Q Wu, F Nabi, H Zhu
Copper is the most essential trace element in the animal body. Nano-sized copper particles have been widely used in a number of different animal species in modern medicinal practice. The present study was designed to examine the effect of dietary copper sulfate/(CuSO4) and nano copper supplementation on serum antioxidant capacity of weaning piglets. A total of 28 Duroc piglets (21 days, and weighing ~7 kg) were randomly divided into three equal groups. The control group (n=4) was administered with a normal standard diet; however the CuSO4 (n=12) and nano copper (n=12) groups were treated with 50, 100 and 200 mg/kg/day body weight, respectively...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29675569/effect-of-zinc-sulfate-and-zinc-glycine-chelate-on-concentrations-of-acute-phase-proteins-in-chicken-serum-and-liver-tissue
#6
Łukasz Jarosz, Agnieszka Marek, Zbigniew Grądzki, Ewa Laskowska, Małgorzata Kwiecień
The aim of the study was to determine how inorganic and organic forms of zinc affect the concentrations of C-reactive protein (CRP), serum amyloid A (SAA), alpha-1-acid glycoprotein (α-1-AGP), haptoglobin (Hp), and transferrin (TRF) in the blood and liver tissue of 450 1-day-old Ross 308 chicken. Four experimental groups received one the following: inorganic zinc (ZnSO4 ), a zinc phytase enzyme supplement (ZnSO4 -F), organic zinc in combination with glycine (Zn-Gly), or organic zinc supplemented with phytase (Zn-Gly-F)...
April 19, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29666141/examining-the-effectiveness-of-consuming-flour-made-from-agronomically-biofortified-wheat-zincol-2016-nr-421-for-improving-zn-status-in-women-in-a-low-resource-setting-in-pakistan-study-protocol-for-a-randomised-double-blind-controlled-cross-over-trial-bizifed
#7
Nicola M Lowe, Muhammad Jaffar Khan, Martin R Broadley, Munir H Zia, Harry J McArdle, Edward J M Joy, Heather Ohly, Babar Shahzad, Ubaid Ullah, Gul Kabana, Rashid Medhi, Mukhtiar Zaman Afridi
INTRODUCTION: Dietary zinc (Zn) deficiency is a global problem, particularly in low-income and middle-income countries where access to rich, animal-source foods of Zn is limited due to poverty. In Pakistan, Zn deficiency affects over 40% of the adult female population, resulting in suboptimal immune status and increased likelihood of complications during pregnancy. METHODS AND ANALYSIS: We are conducting a double-blind, randomised controlled feeding study with cross-over design in a low-resource setting in Pakistan...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29565716/whey-protein-supplementation-improves-nutritional-status-glutathione-levels-and-immune-function-in-cancer-patients-a-randomized-double-blind-controlled-trial
#8
Akkarach Bumrungpert, Patcharanee Pavadhgul, Pornpimon Nunthanawanich, Anchalee Sirikanchanarod, Araya Adulbhan
Clinical side effects from medical therapy play an important role in causing malnutrition among cancer patients. Whey protein isolates (WPIs) have the potential to improve the nutritional status of cancer patients. The present study determined the effects of whey protein supplementation on nutritional status, glutathione (GSH) levels, immunity, and inflammatory markers in cancer patients in Thailand. A total of 42 cancer patients (41-63 years old) who received intravenous chemotherapy were randomized in a double-blind controlled trial at the National Cancer Institute in Thailand...
March 12, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29523134/effects-of-herbal-nutraceuticals-and-or-zinc-against-haemonchus-contortus-in-lambs-experimentally-infected
#9
Zora Váradyová, Dominika Mravčáková, Michal Babják, Magdalena Bryszak, Ľubomíra Grešáková, Klaudia Čobanová, Svetlana Kišidayová, Iveta Plachá, Alžbeta Königová, Adam Cieslak, Sylwester Slusarczyk, Lukasz Pecio, Mariusz Kowalczyk, Marián Várady
BACKGROUND: The gastrointestinal parasitic nematode Haemonchus contortus is a pathogenic organism resistant to several anthelmintics. This study assessed the efficacy of a medicinal herbal mixture (Herbmix) and organic zinc, as an essential trace element for the proper functioning of both unspecific and specific immune defensive mechanisms, against experimental infections with H. contortus in lambs. All lambs were infected orally with approximately 5000 third-stage larvae of a strain of H...
March 9, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29518559/effect-of-%C3%AE-1-3-glucan-binding-protein-based-zinc-oxide-nanoparticles-supplemented-diet-on-immune-response-and-disease-resistance-in-oreochromis-mossambicus-against-aeromonas-hydrophila
#10
Mahalingam Anjugam, Baskaralingam Vaseeharan, Arokiadhas Iswarya, Narayanan Gobi, Mani Divya, Merlin P Thangaraj, Preetham Elumalai
Recently, several immunostimulants such as β-glucan, microbial and plant products have been used as dietary supplements to combat disease outbreaks in aquaculture. The present study investigates the potential of Portunus pelagicus β-1, 3 glucan binding protein based zinc oxide nanoparticles (Ppβ-GBP-ZnO NPs) supplemented diet on growth, immune response and disease resistance in Mozambique tilapia, Oreochromis mossambicus. The immune-related protein β-GBP was purified from the haemolymph of P. pelagicus using Sephadex G-100 affinity column chromatography...
May 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29514007/supplementation-of-grape-seed-and-skin-extract-to-orlistat-therapy-prevents-high-fat-diet-induced-murine-spleen-lipotoxicity
#11
Takwa Bedhiafi, Kamel Charradi, Mouna Ben Azaiz, Mohamed Mahmoudi, Issam Msakni, Khawla Jebari, Ammar Bouziani, Ferid Limam, Ezzedine Aouani
Spleen is the largest lymphoid organ and obesity is related to an elevated risk of immunity dysfunction and the mechanism whereby fat adversely affects the spleen is poorly understood. This study was designed to assess the effectiveness of grape seed and skin extract (GSSE) and orlistat (Xenical, Xe) on high fat diet (HFD)-induced spleen lipotoxicity. Obese rats were treated either with GSSE (4 g/kg bw) or Xe (2 mg/kg bw) or GSSE + Xe and monitored for weight loss during 3 months. Animals were then sacrificed and their spleen used for the evaluation of lipotoxicity-induced oxidative stress and inflammation as well as the putative protection afforded by GSSE and Xe treatment...
March 7, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29493020/effects-of-zinc-oxide-nanoparticles-on-the-egg-quality-immune-response-zinc-retention-and-blood-parameters-of-laying-hens-in-the-late-phase-of-production
#12
M Abedini, F Shariatmadari, M A Karimi Torshizi, H Ahmadi
The objective of this study was to evaluate the effects of dietary supplementation with zinc oxide nanoparticles (ZnO-NPs) on the performance, egg quality, Zn retention, immunity responses, superoxide dismutase activity (SOD), egg malondialdehyde (MDA) content, and serum parameters in laying hens in the late phase of production. A total of 288 laying hens at 64 weeks of age were randomly assigned to 4 treatments with 6 replicates, and 12 birds within each group. Experimental diets included a corn-soybean meal-based diet (without Zn supplementation) and a basal diet supplemented with 80 mg/kg of Zn-oxide, ZnO-NPs, and Zn-methionine...
June 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29468611/influences-of-copper-zinc-loaded-montmorillonite-on-growth-performance-mineral-retention-intestinal-morphology-mucosa-antioxidant-capacity-and-cytokine-contents-in-weaned-piglets
#13
L F Jiao, Q H Zhang, H Wu, C C Wang, S T Cao, J Feng, C H Hu
The effects of copper/zinc-loaded montmorillonite (Cu/Zn-Mt) on growth performance, mineral retention, intestinal morphology, mucosa antioxidant capacity, and cytokine contents in weaned piglets were investigated in the present study. One hundred eight piglets weaned at 21 ± 1 days of age (Duroc × Landrace× Yorkshire; average initial weight of 6.36 kg) were allotted to three treatments for 2 weeks. The three treatments were as follows: (1) control group: basal diet; (2) Cu/Zn-Mt group: basal diet + 39 mg/kg Cu and 75 mg/kg Zn as Cu/Zn-Mt; (3) Cu + Zn + Mt group: basal diet + mixture of CuSO4 , ZnSO4 , and Mt (equal amount of Cu, Zn, and Mt to the Cu/Zn-Mt group)...
February 21, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29439842/zinc-supplementation-plays-a-crucial-role-in-t-helper-9-differentiation-in-allogeneic-immune-reactions-and-non-activated-t-cells
#14
Martina Maywald, Fudi Wang, Lothar Rink
T helper (Th) 9 cells play a critical role in immune-mediated diseases, including allergic airway inflammation, autoimmune diseases, and cancer development. Thus, the promotion or suppression of Th9 cell differentiation, transcriptional control, and function is very important for a healthy immune system. Interestingly, T cell maturation, differentiation and function are highly dependent on the individuals' zinc status. This is especially seen in zinc deficient individuals as in the elderly population often suffering of autoimmunity and increased incidence of infections...
February 6, 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29415484/effects-of-interactions-between-zno-nanoparticles-and-saccharides-on-biological-responses
#15
Mi-Ran Go, Jin Yu, Song-Hwa Bae, Hyeon-Jin Kim, Soo-Jin Choi
Zinc oxide (ZnO) nanoparticles (NPs) are widely used as a Zn supplement, because Zn plays a role in many cellular and immune functions but public concern about their potentially undesirable effects on the human body is growing. When NPs are added in food matrices, interactions between NPs and food components occur, which can affect biological systems. In this study, interactions between ZnO NPs and saccharides were investigated by measuring changes in hydrodynamic radius, zeta potential and solubility and by quantifying amounts of adsorbed saccharides on NPs; acacia honey, sugar mixtures (containing equivalent amounts of fructose, glucose, sucrose and maltose) and monosaccharide solutions were used as model compounds...
February 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29402502/influence-of-zinc-supplementation-on-immune-parameters-in-weaned-pigs
#16
Veronika Kloubert, Karoline Blaabjerg, Tina Sørensen Dalgaard, Hanne Damgaard Poulsen, Lothar Rink, Inga Wessels
Zinc is an essential trace element, highly important for a well functioning immune system. In case of zinc deficiency, proper immune functions are not ensured thus leading to various diseases. Weaning of pigs from the sow causes stress, increasing susceptibility to infections. Moreover, low feed intake during the first two weeks post-weaning, accompanied by low zinc intake, results in temporary zinc deficiency. Therefore, supporting the immune system by zinc supplementation might improve its function and thereby the pigs' health and well-being...
January 31, 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29374929/-advances-in-the-research-of-zinc-deficiency-and-zinc-supplementation-treatment-in-patients-with-severe-burns
#17
REVIEW
X X Wang, M J Zhang, X B Li
Zinc is one of the essential trace elements in human body, which plays an important role in regulating acute inflammatory response, glucose metabolism, anti-oxidation, immune and gastrointestinal function of patients with severe burns. Patients with severe burns may suffer from zinc deficiency because of insufficient amount of zinc intake from the diet and a large amount of zinc lose through wounds and urine. Zinc deficiency may affect their wound healing process and prognosis. This article reviews the characteristics of zinc metabolism in patients with severe burns through dynamic monitoring the plasma and urinary concentration of zinc...
January 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29186856/zinc-as-a-gatekeeper-of-immune-function
#18
REVIEW
Inga Wessels, Martina Maywald, Lothar Rink
After the discovery of zinc deficiency in the 1960s, it soon became clear that zinc is essential for the function of the immune system. Zinc ions are involved in regulating intracellular signaling pathways in innate and adaptive immune cells. Zinc homeostasis is largely controlled via the expression and action of zinc "importers" (ZIP 1-14), zinc "exporters" (ZnT 1-10), and zinc-binding proteins. Anti-inflammatory and anti-oxidant properties of zinc have long been documented, however, underlying mechanisms are still not entirely clear...
November 25, 2017: Nutrients
https://www.readbyqxmd.com/read/29166952/effects-of-dietary-live-yeast-supplementation-on-growth-performance-diarrhoea-severity-intestinal-permeability-and-immunological-parameters-of-weaned-piglets-challenged-with-enterotoxigenic-escherichia-coli-k88
#19
Lianqiang Che, Qin Xu, Cheng Wu, Yuheng Luo, Xiaobo Huang, Bo Zhang, Eric Auclair, Tadele Kiros, Zhengfeng Fang, Yan Lin, Shengyu Xu, Bin Feng, Jian Li, De Wu
This study aimed to investigate the effects of dietary live yeast (LY) supplementation on growth, intestinal permeability and immunological parameters of piglets challenged with enterotoxigenic Escherichia coli K88 (ETEC). Piglets weaned at 21 d were allocated into three treatments with six pens and six piglets per pen, receiving the control diet (CON), diets supplemented with antibiotics plus zinc oxide (ANT-ZnO) and LY (Saccharomyces cerevisiae strain CNCM I-4407), respectively, for a period of 2 weeks. On day 8, thirty-six piglets were selected as control without ETEC (CON), CON-ETEC, ANT-ZnO-ETEC and LY-ETEC groups challenged with ETEC until day 10 for sample collections...
December 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29153154/a-100-year-review-from-ascorbic-acid-to-zinc-mineral-and-vitamin-nutrition-of-dairy-cows
#20
W P Weiss
Mineral and vitamin nutrition of dairy cows was studied before the first volume of the Journal of Dairy Science was published and is still actively researched today. The initial studies on mineral nutrition of dairy cows were simple balance experiments (although the methods available at the time for measuring minerals were anything but simple). Output of Ca and P in feces, urine, and milk was subtracted from intake of Ca and P, and if values were negative it was often assumed that cows were lacking in the particular mineral...
December 2017: Journal of Dairy Science
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