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neutrophil lymphocyte ratio (NLR)

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https://www.readbyqxmd.com/read/29786814/predictive-value-of-preoperative-neutrophil-to-lymphocyte-ratio-while-detecting-bowel-resection-in-hernia-with-intestinal-incarceration
#1
Hande Köksal, Derviş Ateş, Emet Ebru Nazik, İlknur Küçükosmanoğlu, Serap Melek Doğan, Osman Doğru
BACKGROUND: The aim of this study was to evaluate the relationship between preoperative hematological inflammatory markers of the patients who underwent a surgery for incarcerated hernia and intestinal resection requirement. METHODS: The data of 102 patients who underwent a surgery for incarcerated hernia were retrospectively evaluated. Whole blood cell counts were preoperatively measured, and operation types and pathology results were recorded. The patients with intestinal resections were compared with those without any resection in terms of leukocyte number, neutrophil rate, red cell distribution width (RDW), platelet distribution width, neutrophil-to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV)...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29782381/high-baseline-neutrophil-to-lymphocyte-ratio-predicts-worse-outcome-in-patients-with-metastatic-braf-positive-melanoma-treated-with-braf-and-mek-inhibitors
#2
Paweł Teterycz, Paulina Jagodzińska-Mucha, Bożena Cybulska-Stopa, Anna Mariuk-Jarema, Katarzyna Kozak, Hanna Koseła-Paterczyk, Anna M Czarnecka, Marcin Rajczykowski, Robert Dziura, Łukasz Galus, Jacek Mackiewicz, Tomasz Świtaj, Anna Klimczak, Slawomir Falkowski, Rafał Suwiński, Marek Ziobro, Iwona Ługowska, Piotr Rutkowski
Neutrophil-to-lymphocyte ratio (NLR) has been shown to be prognostic in several solid malignancies. There are limited data regarding its value during novel therapies in patients with melanoma. The aim of the study was to assess the practical utility of this ratio in patients with BRAF-mutant melanoma treated with a combination of BRAF and MEK inhibitors (BRAFi/MEKi). We included 215 patients with inoperable or metastatic melanoma who underwent BRAFi/MEKi treatment between October 2015 and June 2017. Baseline NLR and other complete blood count-derived inflammatory markers were tested for association with overall survival and progression-free survival in univariate and multivariate models...
May 18, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29779969/increased-malondialdehyde-vs-reduced-sirtuin-1-in-relation-with-adiposity-atherogenicity-and-hematological-indices-in-metabolic-syndrome-patients-with-and-without-prediabetes
#3
Samar Abu Rkhaya, Nailya Bulatova, Violet Kasabri, Randa Naffa, Reema Alquoqa
BACKGROUND: Sirtuin 1 (SIRT 1) and malondialdehyde (MDA) were implicated in metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) pathophysiology. AIMS AND METHODS: This cross-sectional study aimed to investigate both SIRT 1 and MDA in 30 lean healthy control, 31 normoglycemic MetS subjects and 30 MetS-Pre/T2DM drug naïve. C orrelation studies were established for both biomarkers with adiposity indices [conicity index (CI), waist circumference (WC), weight-to-height (WHtR) ratio, weight-to-hip (WHR) ratio, hip circumference (HC), and body adiposity index (BAI)], hematological indices [red cell distribution width (RDW), mean platelet volume (MPV), platelet-to-lymphcyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR)] and atherogenicity indices (atherogenicity index of plasma (AIP = log10 TG/HDL-C ratio), TC/HDL-C and LDL-C/HDL-C ratios]...
May 15, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29774997/-the-significance-of-lymphocyte-to-monocyte-ratio-in-peripheral-blood-of-patients-with-benign-and-malignant-laryngeal-lesions
#4
D Q Wu, X S Huang
Objective: The aim of this study is to investigate the value of preoperative peripheral blood lymphocyte to monocyte ratio (LMR) in differentiating laryngeal squamous cell carcinoma (LSCC), laryngeal precancerous lesions (LPL) and laryngeal benign lesions (LBL). Method: Four hundred and five cases of laryngeal lesions diagnosed by pathology (154 cases of LSCC, 83 cases of LPL and 168 cases of LBL) were collected. LSCC group was further divided into T1 group, T2 group and T3-4 group based on T stage. The levels of neutrophils, lymphocytes, monocytes, hemoglobin, platelet and other blood indexes were measured, as well as compared the LMR, neutrophil to lymphocyte ratio (NLR) and other parameters in each group...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29774108/prognostic-and-diagnostic-impact-of-fibrinogen-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-on-thymic-epithelial-tumors-outcome
#5
Stefan Janik, Thomas Raunegger, Philipp Hacker, Bahil Ghanim, Elisa Einwallner, Leonhard Müllauer, Ana-Iris Schiefer, Julia Moser, Walter Klepetko, Hendrik Jan Ankersmit, Bernhard Moser
Background: Peripheral blood-derived inflammation-based markers, such as Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Fibrinogen have been identified as prognostic markers in various solid malignancies. Here we aimed to investigate the prognostic and diagnostic impact of NLR, PLR, and Fibrinogen in patients with thymic epithelial tumors (TETs). Results: Pretreatment Fibrinogen serum concentrations, NLRs and PLRs were highest in patients with TCs and advanced tumor stages...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29768325/is-nucleate-cell-count-and-neutrophil-to-lymphocyte-ratio-related-to-patients-with-audiographically-distinct-sudden-sensorineural-hearing-loss
#6
Yuanyuan Sun, Liang Xia, Hui Wang, Zhengnong Chen, Yaqin Wu, Bin Chen, Haibo Shi, Yanmei Feng, Shankai Yin
The aim of this study was to investigate the possible relationships between sudden sensorineural hearing loss (SSNHL) patients with distinct audiographic data and nucleate cell count and neutrophil to lymphocyte ratio (NLR).SSNHL patients differed in audiographic curves were included, 40 with low-frequency SSNHL (LF-SSNHL), 33 with high-frequency SSNHL (HF-SSNHL), 36 with all-frequency SSNHL (AF-SSNHL), 34 with total-deafness SSNHL (TD-SSNHL), and 31 age- and sex-matched healthy controls. Peripheral venous blood samples were collected and nucleate cell such as white blood cell (WBC), neutrophil and lymphocyte, and NLR were measured...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29768257/systemic-immune-inflammation-index-sii-is-useful-to-predict-survival-outcomes-in-patients-after-liver-transplantation-for-hepatocellular-carcinoma-within-hangzhou-criteria
#7
Hongyuan Fu, Jun Zheng, Jianye Cai, Kaining Zeng, Jia Yao, Liang Chen, Hui Li, Jiebin Zhang, Yingcai Zhang, Hui Zhao, Yang Yang
BACKGROUND: There is growing evidence that the systemic immune-inflammation index (SII), a novel prognostic biomarker based on peripheral lymphocyte, neutrophil, and platelet counts, is associated with poor prognosis for several tumors. However, the prognostic value of SII in patients with hepatocellular carcinoma (HCC) who undergo liver transplantation (LT) remains unclear. The aim of this study was to determine the correlation between SII and prognosis in these patients. METHODS: This retrospective study involved 150 patients with HCC who underwent LT within the Hangzhou criteria...
May 11, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29767470/early-increase-of-neutrophil-to-lymphocyte-ratio-predicts-30-day-mortality-in-patients-with-spontaneous-intracerebral-hemorrhage
#8
Fei Wang, Feng Xu, Ye Quan, Li Wang, Jian-Jun Xia, Ting-Ting Jiang, Li-Juan Shen, Wen-Hui Kang, Yong Ding, Li-Xia Mei, Xue-Feng Ju, Shan-You Hu, Xiao Wu
AIMS: To examine whether early rise of neutrophil-to-lymphocyte ratio (NLR) after patient hospitalization correlates with 30-day mortality in patients with spontaneous intracerebral hemorrhage (ICH). METHODS: This retrospective study included all patients receiving treatment for spontaneous ICH between January 2015 and September 2016 at the Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences in Shanghai, China. NLR was determined at admission (T1), at 24-48 hours (T2) and 5-7 days (T3)...
May 16, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29765248/preoperative-neutrophil-to-lymphocyte-ratio-as-a-prognostic-predictor-after-curative-intent-surgery-for-hepatocellular-carcinoma-experience-from-a-developing-country
#9
Danijel Galun, Aleksandar Bogdanovic, Jelena Djokic Kovac, Predrag Bulajic, Zlatibor Loncar, Marinko Zuvela
Purpose: The aim of the study was to evaluate a prognostic value of preoperative neutrophil-to-lymphocyte ratio (NLR) on long-term survival of cirrhotic and noncirrhotic hepatocellular cancer (HCC) patients managed by a curative-intent liver surgery in a developing country. Patients and methods: During the study period between November 1, 2001, and December 31, 2012, 109 patients underwent potentially curative hepatectomy for HCC. Data were retrospectively reviewed from the prospectively collected database...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29763889/neutrophil-lymphocyte-ratio-predicts-functional-and-safety-outcomes-after-endovascular-treatment-for-acute-ischemic-stroke
#10
Zhenhui Duan, Huaiming Wang, Zhen Wang, Yonggang Hao, Wenjie Zi, Dong Yang, Zhiming Zhou, Wenhua Liu, Min Lin, Zhonghua Shi, Penghua Lv, Yue Wan, Gelin Xu, Yunyun Xiong, Wusheng Zhu, Xinfeng Liu
BACKGROUND AND OBJECTIVE: Endovascular treatment (EVT) is proven to be safe and effective for treating acute large vessel occlusion stroke (LVOS). The neutrophil-lymphocyte ratio (NLR) reflects systemic inflammation, which plays an important role in the process of treating ischemic stroke. This study aims to explore the relationship between NLR and the clinical outcomes of LVOS patients undergoing EVT. METHODS: Patients were selected from the EVT for acUte Anterior circuLation (ACTUAL) ischemic stroke registry...
May 15, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29761858/predictive-impact-of-the-inflammation-based-indices-in-colorectal-cancer-patients-with-adjuvant-chemotherapy
#11
Yong Tao, Lei Ding, Guan Gen Yang, Jian Ming Qiu, Dong Wang, Hongtao Wang, Chao Fu
Increasing evidences reported that cancer-triggered inflammation was associated with survival prognosis from colorectal cancer (CRC). However, the comprehensive effects of inflammatory-based coNLR-PLR that combines neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) rarely remain to be determined during chemotherapy. We retrospectively analyzed clinical data and baseline laboratory parameters from 153 colorectal cancer patients who underwent palliative adjuvant chemotherapy between January 2009 to January 2012...
May 15, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29761587/neutrophil-to-lymphocyte-ratio-as-a-prognostic-indicator-in-head-and-neck-cancer-a-systematic-review-and-meta-analysis
#12
REVIEW
Tristan Tham, Yonatan Bardash, Saori Wendy Herman, Peter David Costantino
BACKGROUND: The purposes of this systematic review and meta-analysis were to investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and prognosis in head and neck cancer. METHODS: A systematic review and meta-analysis were done to investigate the role of NLR in overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), and progression-free survival (PFS). RESULTS: For qualitative analysis, 33 cohorts with over 10 072 patients were included...
May 14, 2018: Head & Neck
https://www.readbyqxmd.com/read/29761518/the-value-of-inflammation-based-prognostic-scores-in-patients-undergoing-surgical-resection-for-oesophageal-and-gastric-carcinoma
#13
Jiaxin Wen, Matthew Bedford, Ruksana Begum, Harriet Mitchell, James Hodson, John Whiting, Ewen Griffiths
BACKGROUND AND OBJECTIVES: Surgical interventions for oesophagogastric cancer carry a significant burden of morbidity and mortality. A range of inflammation based prognostic scores have been proposed in an attempt to predict outcome. This study evaluated five such prognostic scores in oesophageal and gastric carcinoma patients. METHODS: The modified Glasgow Prognostic Score (mGPS), Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), Prognostic Index (PI), and Prognostic Nutrition Index (PNI) were calculated for 723 consecutive patients undergoing oesophagectomy or gastrectomy at a single center...
May 14, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29760558/pretreatment-hematologic-markers-as-prognostic-predictors-of-gastroenteropancreatic-neuroendocrine-tumors-a-systematic-review-and-meta-analysis
#14
Yu Zhou, Dezhi Li, Ye Lin, Min Yu, Xin Lu, Zhixiang Jian, Ning Na, Baohua Hou
Background: Systemic inflammation can be reflected by peripheral hematologic parameters and combined index like the lymphocyte count, neutrophil count, platelet count, neutrophil-to-lymphocyte (NLR), and platelet-to-lymphocyte ratio (PLR). This systematic review and meta-analysis aimed to summarize the association between the hematologic markers and prognosis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Methods: A computerized systematic search of PubMed, Embase, and Web of Science was conducted up to August 2016...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29758203/pretreatment-neutrophil-lymphocyte-and-platelet-lymphocyte-ratio-predict-clinical-outcome-and-prognosis-for-cervical-cancer
#15
MeiLin Zhu, Min Feng, Fei He, BangCai Han, Ke Ma, XinYu Zeng, ZhiRong Liu, XinLian Liu, Juan Li, Hui Cao, YunDan Liang, Cui Jia, LuShun Zhang
Variations in systemic inflammatory response biomarker levels have been associated with adverse clinical outcome in various malignancies. In this study, we aimed to evaluate the predictive and prognostic role of the pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in cervical cancer. We retrospectively investigated 616 patients who underwent initial radical hysterectomy with pelvic lymphadenectomy for cervical cancer between July 2012 and December 2014 in China. Their clinical and histopathological markers and complete blood counts were obtained and analyzed...
May 11, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29756613/neutrophil-to-lymphocyte-ratio-as-a-prognostic-factor-for-pharyngocutaneous-fistula-after-total-laryngectomy
#16
F T Aires, R A Dedivitis, M A V Kulcsar, D M Ramos, C R Cernea
The role of systemic inflammatory response as a prognostic factor has been proposed in a variety of cancers. The purpose of this study was to investigate the prognostic value of the pretreatment neutrophil-to-lymphocyte ratio (NLR) in the incidence of pharyngocutaneous fistula (PCF) in patients who underwent total laryngectomy. We conducted a retrospective cohort analysis of 141 patients with squamous cell carcinoma of larynx who underwent total laryngectomy from 2009 to 2015. The incidence of PCF was 49.6%...
February 2018: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29754852/predictors-of-survival-after-yttrium-90-radioembolization-for-colorectal-cancer-liver-metastases
#17
Ashley A Weiner, Bin Gui, Neil B Newman, John L Nosher, Fady Yousseff, Shou-En Lu, Gretchen M Foltz, Darren Carpizo, Jonathan Lowenthal, Darryl A Zuckerman, Ben Benson, Jeffrey R Olsen, Salma K Jabbour, Parag J Parikh
PURPOSE: To identify clinical parameters that are prognostic for improved overall survival (OS) after yttrium-90 radioembolization (RE) in patients with liver metastases from colorectal cancer (CRC). MATERIALS AND METHODS: A total of 131 patients who underwent RE for liver metastases from CRC, treated at 2 academic centers, were reviewed. Twenty-one baseline pretreatment clinical factors were analyzed in relation to OS by the Kaplan-Meier method along with log-rank tests and univariate and multivariate Cox regression analyses...
May 10, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29751991/influence-of-ca125-platelet-count-and-neutrophil-to-lymphocyte-ratio-on-the-immune-system-of-ovarian-cancer-patients
#18
Thaïs Baert, Joke Van Camp, Lisa Vanbrabant, Pieter Busschaert, Annouschka Laenen, Sileny Han, Els Van Nieuwenhuysen, Ignace Vergote, An Coosemans
OBJECTIVE: The effect of CA125, neutrophil to lymphocyte ratio (NLR) and thrombocytosis on survival has been studied in ovarian cancer. This study explores the link between these variables and serum markers of ovarian cancer patients, such as signaling proteins and cytokines. METHODS: Serum samples of 39 patients with high-grade serous ovarian cancer (HGSOC) were collected at diagnosis and were retrospectively analysed for clinical characteristics, clinical parameters (NLR, CA125, platelet count) and immune profile [IL-4 (interleukin), IL-10, IL-13, IL-17, transforming growth factor-β, Arginase-1, Interferon gamma), vascular endothelial growth factor (VEGF), galectin-1 and chemokine (C-C) motif ligand 2...
May 8, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29747317/-value-of-procalcitonin-in-predicting-the-severity-and-prognosis-of-neonates-with-septicemia
#19
J Zhang, D Qu, X X Ren, X D Cui, J Fu
Objective: To explore the value of procalcitonin(PCT) in predicting the severity and prognosis of neonates with septicemia. Methods: The clinical data of the hospitalized neonates over the age of 72 hours with double positive blood cultures from December 1st, 2011 to September 30, 2017 at the neonatal intensive care unit of Children's Hospital Affiliated to Capital Institute of Pediatrics was analyzed retrospectively. Results: A total of 75 neonates were included in the study. There was a significant negative correlation between PCT and neonatal critical illness score ( r =-0...
April 24, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29747314/-prognostic-significance-of-inflammatory-indicators-for-advanced-stage-diffuse-large-b-cell-lymphoma
#20
Y Han, Y Qin, X H He, J L Yang, P Liu, C G Zhang, L Q Zhou, S Y Zhou, L Gui, Y Sun, Y K Shi
Objective: To explore the prognostic significance of inflammatory indicator, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), for advanced-stage diffuse large B-cell lymphoma (DLBCL). Methods: The data of advanced stage DLBCL cases was retrospectively collected, and all the patients were seen from January 2006 to December 2012 in National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences. The patients were divided into the low NLR group (≤5∶1) and the high NLR group (>5∶1); the low PLR group (≤300∶1) and the high PLR group (>300∶1)...
April 24, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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