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neutrophil/lymphocyte ratio (NLR)

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https://www.readbyqxmd.com/read/27920556/the-prognostic-value-of-systemic-and-local-inflammation-in-patients-with-laryngeal-squamous-cell-carcinoma
#1
Jie Wang, Shengzi Wang, Xinmao Song, Wenjiao Zeng, Shuyi Wang, Fu Chen, Hao Ding
BACKGROUND: Cancer-related systemic inflammation has been demonstrated to be associated with poor outcome in multiple types of cancers. Meanwhile, the local inflammation, which is characterized by dense intratumoral immune infiltrate, is a favorable predictor of survival outcome. PURPOSE: To evaluate the role of systemic and local inflammation in predicting outcome in patients with laryngeal squamous cell carcinoma. PATIENTS AND METHODS: In this retrospective study, 120 patients who had undergone postoperative radiotherapy were enrolled...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27919983/prognostic-significance-of-inflammatory-and-nutritional-parameters-in-patients-with-esophageal-cancer
#2
Tatsuya Miyazaki, Makoto Sakai, Makoto Sohda, Naritaka Tanaka, Takehiko Yokobori, Yoko Motegi, Masanobu Nakajima, Minoru Fukuchi, Hiroyuki Kato, Hiroyuki Kuwano
BACKGROUND: We evaluated the following preoperative prognostic factors in patients who underwent esophagectomy for esophageal cancer: C-Reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), serum albumin, prognostic nutritional index (PNI), and body mass index (BMI). PATIENTS AND METHODS: This retrospective study included 173 men and 19 women with a mean age of 65.8 years (range=42-86 years) who were scheduled to undergo esophagectomy for esophageal cancer...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919192/predictive-value-of-neutrophil-lymphocyte-ratio-in-renal-prognosis-of-patients-with-granulomatosis-with-polyangiitis
#3
Hamit Küçük, Berna Göker, Özkan Varan, Burak Dumludag, Şeminur Haznedaroğlu, Mehmet Akif Öztürk, Abdurrahman Tufan, Tugce Emiroglu, Yasemin Erten
INTRODUCTION: Granulomatosis with polyangiitis (GPA) is a rare necrotizing vasculitis, which usually involves the upper and lower respiratory systems and kidneys and often have a relapsing course. Neutrophil/lymphocyte ratio (NLR) has been shown to be a useful marker predicting not only progressive disease, but also mortality in various inflammatory diseases. We aimed to investigate the roles of NLR in predicting the extend of clinical involvement and prognosis of patients with GPA. MATERIALS AND METHODS: Consecutive newly diagnosed GPA patients who had follow-up for at least 6 months between 2010 and 2016 at Gazi University Internal Medicine-Rheumatology clinic were retrospectively analyzed...
December 5, 2016: Renal Failure
https://www.readbyqxmd.com/read/27918494/associations-between-neutrophil-gelatinase-associated-lipocalin-neutrophil-to-lymphocyte-ratio-atrial-fibrillation-and-renal-dysfunction-in-chronic-heart-failure
#4
Onur Argan, Dilek Ural, Guliz Kozdag, Tayfun Sahin, Serdar Bozyel, Mujdat Aktas, Kurtulus Karauzum, Irem Yilmaz, Emir Dervis, Aysen Agir
BACKGROUND Atrial fibrillation (AF) and renal dysfunction are two common comorbidities in patients with chronic heart failure with reduced ejection fraction (HFrEF). This study evaluated the effect of permanent AF on renal function in HFrEF and investigated the associations of atrial fibrillation, neutrophil gelatinase-associated lipocalin (NGAL), and neutrophil-to-lymphocyte ratio (NLR) with adverse clinical outcome. MATERIAL AND METHODS Serum NGAL levels measured by ELISA and NLR were compared between patients with sinus rhythm (HFrEF-SR, n=68), with permanent AF (HFrEF-AF, n=62), and a healthy control group (n=50)...
December 5, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27917647/admission-neutrophil-count-and-neutrophil-to-lymphocyte-ratio-predict-90-day-outcome-in-intracerebral-hemorrhage
#5
Chuanyuan Tao, Xin Hu, Jiajing Wang, Junpeng Ma, Hao Li, Chao You
AIM: Inflammation plays a role in secondary brain injury after intracerebral hemorrhage (ICH). We aimed to determine the prognostic significance of admission white blood cell (AWC), neutrophil count (ANC), lymphocyte count, monocyte count and neutrophil to lymphocyte ratio (NLR) for 90-day outcome after ICH. PATIENTS & METHODS: A total of 336 patients with spontaneous ICH were retrospectively investigated. Clinical outcome was assessed by modified Rankin Scale at 90 days...
December 5, 2016: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27911876/neutrophil-to-lymphocyte-ratio-platelet-to-lymphocyte-ratio-and-their-dynamic-changes-during-chemotherapy-is-useful-to-predict-a-more-accurate-prognosis-of-advanced-biliary-tract-cancer
#6
Kyoung-Min Cho, Hyunkyung Park, Do-Youn Oh, Tae-Yong Kim, Kyung-Hun Lee, Sae-Won Han, Seock-Ah Im, Tae-You Kim, Yung-Jue Bang
BACKGROUND AND PURPOSE: Systemic inflammation is known to promote carcinogenesis in biliary tract cancer (BTC). Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are indicative of systemic inflammation. We evaluated the clinical significance of systemic inflammation measured by NLR and PLR in patients with advanced BTC. Additionally, we also co-analyzed the dynamics of NLR and PLR during chemotherapy. METHODS: We reviewed 450 patients with unresectable BTC receiving palliative chemotherapy...
November 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27911233/elevated-preoperative-neutrophil-to-lymphocyte-ratio-as-a-predictor-of-worse-survival-after-resection-in-patients-with-brain-metastasis
#7
Koichi Mitsuya, Yoko Nakasu, Takeshi Kurakane, Nakamasa Hayashi, Hideyuki Harada, Kazuhiko Nozaki
OBJECTIVE The median postoperative survival duration of patients with brain metastases who undergo tumor resection is 12 months. Most of these patients die of systemic metastases or the progression of primary cancer but not brain metastases. The criteria for indicating resection are still controversial. Systemic assessment is restricted, especially in patients who need emergent management for their large-size or life-threatening brain metastases. The neutrophil-to-lymphocyte ratio (NLR) is reported to correlate with survival time or progression-free survival in patients with various cancers...
December 2, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27911007/assessment-of-subclinical-atherosclerosis-in-hidradenitis-suppurativa
#8
José C Pascual, Iris González, Diego Corona, Patricia Hispán, José M Ramos, José Sánchez-Paya, Gregor B Jemec
BACKGROUND: Patients with Hidradenitis Suppurativa (HS) have an increased prevalence of traditional cardiovascular (CV) risk factors. OBJECTIVE: Our aim was to investigate the association between subclinical atherosclerosis, detected by carotid ultrasound, and HS. METHODS: A prospective observation and analytical study assessing subclinical atherosclerosis using carotid ultrasound in patients with HS. RESULTS: A total of 62 HS-patients and 62 matched-controls were studied...
December 2, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27909873/neutrophil-to-lymphocyte-ratio-associated-with-prognosis-of-lung-cancer
#9
V Bar-Ad, J Palmer, L Li, Y Lai, B Lu, R E Myers, Z Ye, R Axelrod, J M Johnson, M Werner-Wasik, S W Cowan, N R Evans, B T Hehn, C C Solomides, C Wang
PURPOSE: Many studies recently focus on complicated and expensive genomic tests, but the prognostic values of biochemical markers which are easily obtained in clinics are largely overlooked and without further exploration. This study assesses the association of neutrophil-lymphocyte-ratio (NLR) with prognosis of lung cancer patients. METHODS: In 1032 patients with histologically confirmed lung cancer, the association of pretreatment NLR values with overall survival (OS) was evaluated using a Cox proportional hazards model and the temporal relationship of longitudinal NLR was assessed using a mixed effects model...
December 1, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27908556/the-relationship-between-neutrophil-to-lymphocyte-ratio-and-intracerebral-hemorrhage-in-type-2-diabetes-mellitus
#10
Peng Luo, Rui Li, Siyuan Yu, Tingting Xu, Shufan Yue, Yongli Ji, Xin Chen, Haiting Xie
INTRODUCTION: Chronic systematic inflammation has been suggested to be associated with the occurrence and development of cardiovascular events. Low-grade systematic inflammation persists in type 2 diabetes mellitus (T2DM) patients. In addition, the risk of cerebral hemorrhage in these patients is increased compared with non-diabetic patients. Neutrophil-to-lymphocyte ratio (NLR) is the ratio derived by dividing the neutrophil count with the lymphocyte count from a peripheral blood sample...
November 28, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27907929/critical-evaluation-of-the-potential-prognostic-value-of-the-pretreatment-derived-neutrophil-lymphocyte-ratio-under-consideration-of-c-reactive-protein-levels-in-clear-cell-renal-cell-carcinoma
#11
Orietta Dalpiaz, Theresa Luef, Maximilian Seles, Michael Stotz, Tatjana Stojakovic, Karl Pummer, Richard Zigeuner, Georg C Hutterer, Martin Pichler
BACKGROUND: We investigated the prognostic value of the pretreatment-derived neutrophil-lymphocyte ratio (dNLR) and original NLR in relation to the commonly used inflammation marker C-reactive protein (CRP) in a large cohort of patients with clear cell renal cell carcinoma (RCC). METHODS: Clinicopathological data from 587 consecutive non-metastatic clear cell RCC patients, operated between 2000 and 2010 at a single tertiary academic center, were evaluated retrospectively...
December 1, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27904614/the-predictive-value-of-blood-neutrophil-lymphocyte-ratio-in-patients-with-end-stage-liver-cirrhosis-following-abo-incompatible-liver-transplantation
#12
Bingyi Lin, Lei Geng, Zhiyun Zheng, Junjun Jia, Tian Shen, Jing Zhang, Lin Zhou, Shusen Zheng
BACKGROUND: The study was designed to assess the role of preoperative neutrophil, lymphocyte, and neutrophil-lymphocyte ratio (NLR) in predicting survival outcomes of ABO-incompatible liver transplantation (LT). MATERIALS AND METHODS: We retrospectively collected the demographic and clinical characteristics of 71 patients with end-stage liver cirrhosis following ABO-incompatible LT in this study. Kaplan-Meier survival analysis and Cox multiple factors regression analysis were performed to determine the independent risk factors from preoperative blood parameters for poor prognosis...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27900086/pretreatment-prognostic-nutritional-index-is-a-significant-predictor-of-prognosis-in-patients-with-cervical-cancer-treated-with-concurrent-chemoradiotherapy
#13
Junko Haraga, Keiichiro Nakamura, Chiaki Omichi, Takeshi Nishida, Tomoko Haruma, Tomoyuki Kusumoto, Noriko Seki, Hisashi Masuyama, Norihisa Katayama, Susumu Kanazawa, Yuji Hiramatsu
This study investigated whether pretreatment neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and prognostic nutritional index (PNI) are prognostic factors in patients with cervical cancer who undergo concurrent chemoradiotherapy (CCRT) and radiotherapy (RT). A total of 131 patients who underwent CCRT and RT for cervical cancer were retrospectively investigated and the correlations of NLR, PLR and PNI with clinical parameters and prognosis were assessed in CCRT and RT. The CCRT and RT groups had a median progression-free survival (PFS) of 41...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27899854/association-of-neutrophil-to-lymphocyte-ratio-with-the-severity-and-morphology-of-coronary-atherosclerotic-plaques-detected-by-multidetector-computerized-tomography
#14
Ahmet Hakan Ateş, Kudret Aytemir, Duygu Koçyiğit, Muhammed Ulvi Yalcin, Kadri Murat Gürses, Hikmet Yorgun, Uğur Canpolat, Tuncay Hazırolan, Necla Özer
BACKGROUND: Studies have demonstrated a consistent relationship between white blood cell (WBC) counts and coronary artery disease (CAD). The neutrophil/lymphocyte ratio (NLR) has been considered as a potential marker for identifying individuals under risk of CAD and associated events. In this study, we aimed to evaluate whether NLR was associated with the severity and morphology of coronary atherosclerotic plaques shown by multidetector computed tomography (MDCT). METHODS: Our study population consisted of 684 patients who underwent dual-source 64 slice MDCT for the assessment of CAD...
November 2016: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27894101/impact-of-hematological-inflammatory-markers-on-clinical-outcome-in-patients-with-salivary-duct-carcinoma-a-multi-institutional-study-in-japan
#15
Daisuke Kawakita, Yuichiro Tada, Yorihisa Imanishi, Shintaro Beppu, Kiyoaki Tsukahara, Satoshi Kano, Hiroyuki Ozawa, Kenji Okami, Yuichiro Sato, Akira Shimizu, Yukiko Sato, Chihiro Fushimi, Soichiro Takase, Takuro Okada, Hiroki Sato, Kuninori Otsuka, Yoshihiro Watanabe, Akihiro Sakai, Koji Ebisumoto, Takafumi Togashi, Yushi Ueki, Hisayuki Ota, Tomotaka Shimura, Toyoyuki Hanazawa, Shingo Murakami, Toshitaka Nagao
The prognostic role of modified Glasgow Prognostic Score (mGPS), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with salivary duct carcinoma (SDC) remains unclear. We conducted a multi-institutional retrospective cohort study of 140 SDC patients. The survival impact of these hematological markers was evaluated using multivariate proportional hazard models.High mGPS (≥1) was significantly associated with worse survival (3-year overall survival (OS): 16.7% vs 66.1%, p-value=0...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27891517/prognostic-significance-of-preoperative-neutrophil-to-lymphocyte-ratio-in-nonmetastatic-renal-cell-carcinoma-a-large-multicenter-cohort-analysis
#16
Seok-Soo Byun, Eu Chang Hwang, Seok Ho Kang, Sung-Hoo Hong, Jinsoo Chung, Tae Gyun Kwon, Hyeon Hoe Kim, Cheol Kwak, Yong-June Kim, Won Ki Lee
Background. The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in nonmetastatic renal cell carcinoma (non-mRCC) is controversial, although NLR has been established as a prognostic factor in several cancers. The objective of our study was to assess the prognostic significance of preoperative NLR in non-mRCC, based on a large, multicenter cohort analysis. Methods. Totally, 1,284 non-mRCC patients undergoing surgery were enrolled from six institutions between 2000 and 2014. Recurrence-free survival (RFS) and cancer-specific survival (CSS) were calculated, and the prognostic significance of NLR was evaluated...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27889946/combined-fibrinogen-and-neutrophil-lymphocyte-ratio-as-a-prognostic-marker-of-advanced-esophageal-squamous-cell-carcinoma
#17
Takashi Kijima, Takaaki Arigami, Yasuto Uchikado, Yoshikazu Uenosono, Yoshiaki Kita, Tetsuhiro Owaki, Shinichiro Mori, Hiroshi Kurahara, Yuko Kijima, Hiroshi Okumura, Kousei Maemura, Sumiya Ishigami, Shoji Natsugoe
Patients with advanced esophageal squamous cell carcinoma (ESCC) is received chemoradiotherapy or chemotherapy for clinical management. However, it is difficult to predict tumor response and prognosis using blood markers before starting treatments. The purpose of this study was to investigate the pre-treatment plasma fibrinogen and neutrophil-lymphocyte ratio (NLR) in patients with advanced ESCC treated with chemoradiotherapy or chemotherapy, and to assess the clinical utility of a combined score using these blood markers, named as the F-NLR (fibrinogen and NLR) score, as a predictor of tumor response and prognosis...
November 27, 2016: Cancer Science
https://www.readbyqxmd.com/read/27888711/preoperative-monocyte-to-lymphocyte-ratio-in-peripheral-blood-predicts-stages-metastasis-and-histological-grades-in-patients-with-ovarian-cancer
#18
Jiangdong Xiang, Lina Zhou, Xing Li, Wei Bao, Taizhong Chen, Xiaowei Xi, Yinyan He, Xiaoping Wan
PURPOSE: The monocyte-to-lymphocyte ratio (MLR) has been shown to be associated with the prognosis of various solid tumors. This study sought to evaluate the important value of the MLR in ovarian cancer patients. METHODS: A total of 133 ovarian cancer patients and 43 normal controls were retrospectively reviewed. The patients' demographics were analyzed along with clinical and pathologic data. The counts of peripheral neutrophils, lymphocytes, monocytes, and platelets were collected and used to calculate the MLR, neutrophil-to-lymphocyte ratio (NLR)...
November 23, 2016: Translational Oncology
https://www.readbyqxmd.com/read/27887858/predictive-value-of-neutrophil-to-lymphocyte-ratio-in-diabetic-wound-healing
#19
Nasibeh Vatankhah, Younes Jahangiri, Gregory J Landry, Robert B McLafferty, Nabil J Alkayed, Gregory L Moneta, Amir F Azarbal
OBJECTIVE: The neutrophil-to-lymphocyte ratio (NLR) has been used as a surrogate marker of systemic inflammation. We sought to investigate the association between NLR and wound healing in diabetic wounds. METHODS: The outcomes of 120 diabetic foot ulcers in 101 patients referred from August 2011 to December 2014 were examined retrospectively. Demographic, patient-specific, and wound-specific variables as well as NLR at baseline visit were assessed. Outcomes were classified as ulcer healing, minor amputation, major amputation, and chronic ulcer...
November 22, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27881836/relationship-between-lesions-in-adenomatous-polyp-dysplasia-colorectal-cancer-sequence-and-neutrophil-to-lymphocyte-ratio
#20
Feyzullah Uçmak, Elif Tuğba Tuncel
BACKGROUND The aim of our study was to evaluate all lesions in the adenoma-dysplasia-cancer sequence of the colon and to examine whether the neutrophil-to-lymphocyte ratio (NLR) can distinguish polyps indicating dysplasia and cancer. MATERIAL AND METHODS A total of 397 patients who had colonoscopic polypectomy between January 2010 and December 2014 were included in our retrospective study. The patients were divided into four groups: patients with hyperplastic polyps, patients with adenomatous polyps, patients with dysplasia, and patients with cancer...
November 24, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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