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https://www.readbyqxmd.com/read/28817508/end-tidal-co2-guided-chest-compression-delivery-improves-survival-in-a-neonatal-asphyxial-cardiac-arrest-model
#1
Justin T Hamrick, Jennifer L Hamrick, Utpal Bhalala, Jillian S Armstrong, Jeong-Hoo Lee, Ewa Kulikowicz, Jennifer K Lee, Sapna R Kudchadkar, Raymond C Koehler, Elizabeth A Hunt, Donald H Shaffner
OBJECTIVES: To determine whether end-tidal CO2-guided chest compression delivery improves survival over standard cardiopulmonary resuscitation after prolonged asphyxial arrest. DESIGN: Preclinical randomized controlled study. SETTING: University animal research laboratory. SUBJECTS: 1-2-week-old swine. INTERVENTIONS: After undergoing a 20-minute asphyxial arrest, animals received either standard or end-tidal CO2-guided cardiopulmonary resuscitation...
August 16, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28817507/comparison-of-consent-models-in-a-randomized-trial-of-corticosteroids-in-pediatric-septic-shock
#2
Kusum Menon, Katharine O'Hearn, James Dayre McNally, Anand Acharya, Hector R Wong, Margaret Lawson, Tim Ramsay, Lauralyn McIntyre, Elaine Gilfoyle, Marisa Tucci, David Wensley, Ronald Gottesman, Gavin Morrison, Karen Choong
OBJECTIVES: To describe the use of deferred and prior informed consent models in the context of a low additional risk to standard of care, placebo-controlled randomized controlled trial of corticosteroids in pediatric septic shock. DESIGN: An observational substudy of consent processes in a randomized controlled trial of hydrocortisone versus placebo. SETTING: Seven tertiary level PICUs in Canada. PATIENTS: Children newborn to 17 years inclusive admitted to PICU with suspected septic shock between July 2014 and March 2016...
August 16, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28817378/health-policy-making-for-street-children-challenges-and-strategies
#3
Fatemeh Abdi, Sara Esmaelzadeh Saeieh, Nasibeh Roozbeh, Mansoureh Yazdkhasti
Background The phenomenon of street children is a bio-psychological and social issue that not only harms children, but also endangers the health of a society. In line with the national programs for the development and promotion of street children's health in Iran, health policy making and essential strategies for this group of children will be presented in this paper. This paper will discuss the main issues and challenges of street children's health and, also, health policy and guidelines for this population...
August 17, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28816923/evaluation-of-concurrent-oral-and-long-acting-injectable-antipsychotic-prescribing-at-the-minneapolis-veterans-affairs-health-care-system
#4
Erica Dimitropoulos, Lisa Drogemuller, Kara Wong
BACKGROUND: Antipsychotic polypharmacy is defined as the concomitant prescribing of more than 1 antipsychotic medication for an individual patient. Despite clinical guideline recommendations, long-acting injectable antipsychotics (LAIAs) are often used together with oral antipsychotics (OAPs) to treat a variety of psychiatric illnesses. Little research exists to address this form of antipsychotic polypharmacy, and its role in therapy is poorly understood. The purpose of this evaluation was to determine the prevalence of this prescribing pattern at our facility, identify provider rationale for polypharmacy, and analyze trends...
August 15, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28816041/contact-engineering-of-molybdenum-ditelluride-field-effect-transistors-through-rapid-thermal-annealing
#5
Jiancui Chen, Zhihong Feng, Shuangqing Fan, Sigang Shi, Yuchen Yue, Wanfu Shen, Yuan Xie, Enxiu Wu, Chongling Sun, Jing Liu, Hao Zhang, Wei Pang, Dong Sun, Wei Feng, Yiyu Feng, Sen Wu, Daihua Zhang
Understanding and engineering the interface between metal and two-dimensional materials are of great importance to the research and development of Nano-electronics. In many cases the interface of meal and 2D materials can dominate the transport behavior of the devices. In this study, we focus on the metal contacts of MoTe2 (molybdenum ditelluride) FETs (field effect transistors) and demonstrate how to use post annealing treatment to modulate their transport behaviors in a controlled manner. We have also carried out low temperature and transmission electron microscopy studies to understand the mechanisms behind the prominent effect of the annealing process...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28815982/bridge-the-gap-the-need-for-harmonized-regulatory-and-ethical-standards-for-postmarketing-observational-studies
#6
REVIEW
Hisashi Urushihara, Louise Parmenter, Shimon Tashiro, Kenji Matsui, Nancy Dreyer
Drug safety issues do not respect national borders. Hence, addressing a safety question may necessitate globally coordinated efforts between regulatory authorities and market authorization holders (MAHs) to draw reliable conclusions. Regulatory authorities have shared responsibility with MAHs sponsoring postmarketing nonintervention studies in determining study goals and design. Their shared accountabilities include what will be investigated and how the data will be retrieved to ensure appropriate study quality required for regulatory decision making...
August 16, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28815796/new-graduate-nurses-preparation-for-recognition-and-prevention-of-failure-to-rescue-a-qualitative-study
#7
Elizabeth K Herron
AIM AND OBJECTIVE: To explore new graduate nurses' experiences with recognition and prevention of failure to rescue. BACKGROUND: Failure to rescue is recognized as a quality of care indicator, a core measure of nursing care in hospitals, and a determinant for staffing in acute care facilities. Clinical reasoning is an essential component in preventing failure to rescue and should be emphasized in nursing education and new graduate orientation. Many nurses graduate without the ability to use clinical reasoning in providing patient care which can lead to adverse patient outcomes...
August 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28815699/application-of-the-condensed-protocol-for-the-nia-aa-guidelines-for-the-neuropathologic-assessment-of-alzheimer-s-disease-in-an-academic-clinical-practice
#8
Rajnish Bharadwaj, Patrick J Cimino, Margaret E Flanagan, Caitlin S Latimer, Luis F Gonzalez-Cuyar, Gordana Juric-Sekhar, Thomas J Montine, Desiree A Marshall, C Dirk Keene
AIMS: In response to concerns regarding resource expenditures required to fully implement the 2012 NIA-AA Sponsored Guidelines for the neuropathologic assessment of Alzheimer's disease (AD), we previously developed a sensitive and cost-reducing Condensed Protocol (CP) at the University of Washington (UW) Alzheimer's Disease Research Center (ADRC) that consolidated the recommended NIA-AA protocol into fewer cassettes requiring fewer immunohistochemical stains. The CP was not designed to replace NIA-AA protocols, but instead to make the NIA-AA criteria accessible to clinical and forensic neuropathology practices where resources limit full implementation of NIA-AA guidelines...
August 16, 2017: Histopathology
https://www.readbyqxmd.com/read/28815485/screening-for-osteoporosis-in-older-men-operating-characteristics-of-proposed-strategies-for-selecting-men-for-bmd-testing
#9
Susan J Diem, Katherine W Peters, Margaret L Gourlay, John T Schousboe, Brent C Taylor, Eric S Orwoll, Jane A Cauley, Lisa Langsetmo, Carolyn J Crandall, Kristine E Ensrud
BACKGROUND: The optimal approach for selecting men for bone mineral density (BMD) testing to screen for osteoporosis is uncertain. OBJECTIVE: To compare strategies for selecting older men for screening BMD testing. DESIGN: Prospective cohort study. PARTICIPANTS: A total of 4043 community-dwelling men aged ≥70 years at four US sites. MAIN MEASURES: BMD at the total hip, femoral neck, and lumbar spine using dual-energy x-ray absorptiometry (DXA)...
August 16, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28815374/the-roles-of-physical-activity-and-sedentary-behavior-on-hispanic-children-s-mental-health-a-motor-skill-perspective
#10
Xiangli Gu, M Jean Keller, Karen H Weiller-Abels, Tao Zhang
PURPOSE: Motor competence (MC) has been recognized as the foundation for life-time moderate-to-vigorous physical activity (MVPA) as well as an influential factor in reducing sedentary behavior during childhood. Guided by Blair et al.'s health model, the purpose of this study was to examine the behavioral mechanism of mental health including physical, psychosocial, and cognitive health among Hispanic children related to MC and MVPA. METHODS: A prospective research design was used with two-wave assessments across one academic year...
August 16, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28814392/temporal-eating-patterns-associations-with-nutrient-intakes-diet-quality-and-measures-of-adiposity
#11
Rebecca M Leech, Anna Timperio, Katherine M Livingstone, Anthony Worsley, Sarah A McNaughton
Background: Some evidence suggests that higher energy intake (EI) later in the day is associated with poor diet quality and obesity. However, EI at one eating occasion (EO) is also dependent on EI at surrounding EOs. Studies that examine the distribution of EOs across the day are rare.Objective: The aim of this study was to examine associations between temporal eating patterns, nutrient intakes, diet quality, and measures of adiposity in a representative sample of Australian adults.Design: Dietary data from two 24-h recalls collected during the cross-sectional 2011-2012 Australian National Nutrition and Physical Activity Survey were analyzed (n = 4544 adults, aged ≥19 y)...
August 16, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28814378/mhealth-technologies-for-palliative-care-patients-at-the-interface-of-in-patient-to-outpatient-care-protocol-of-feasibility-study-aiming-to-early-predict-deterioration-of-patient-s-health-status
#12
Gudrun Theile, Vanessa Klaas, Gerhard Tröster, Matthias Guckenberger
BACKGROUND: Palliative care patients are a particularly vulnerable population and one of the critical phases in patients' trajectories is discharge from specialized in-patient palliative care into outpatient care, where availability of a palliative care infrastructure is highly variable. A relevant number of potentially avoidable readmissions and emergency visits of palliative patients is observed due to rapid exacerbation of symptoms indicating the need for a closer patient monitoring...
August 16, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28814256/current-issues-in-intravenous-fluid-use-in-hospitalized-children
#13
Jennifer Fuchs, Sarah T Adams, Julie Byerley
BACKGROUND: Fluid and electrolyte therapy is an important component in the care of the hospitalized child. Previous pediatric guidelines have followed the Holliday-Segar method of calculating and delivering maintenance IV fluids, using hypotonic fluids in maintenance therapy. However, research demonstrates that hypotonic fluids can lead to iatrogenic hyponatremia and that isotonic fluid is a safer alternative. OBJECTIVE: To provide the ideal approach to intravenous (IV) fluid use in the hospitalized child and determine the safety and effectiveness of isotonic maintenance fluid therapy...
August 16, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28814233/statins-in-acute-coronary-syndromes
#14
Manolis Vavuranakis, Maria Kariori, Gerasimos Siasos, Konstantinos Kalogeras, Dimitris Tousoulis
BACKGROUND: Patients with acute coronary syndrome (ACS) frequently experience recurrent adverse events from the cardiovascular system comparing to either healthy individuals or individuals with stable coronary artery disease. This is attributed to the inflammatory cascade that is activated during ACS resulting in increased risk for rupture of vulnerable plaques. OBJECTIVE: Therefore, it is of great importance to avoid recurrent events with treatment aiming at secondary prevention which includes the management of lipid profile besides alteration in the lifestyle and habits...
August 15, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28813753/pre-guideline-trends-associated-with-chest-radiograph-usage-for-pediatric-community-acquired-pneumonia-in-emergency-department-settings
#15
Eric W Jones, Benjamin Meyer, Aaron M Berg, Benson S Hsu
BACKGROUND: Health care spending in the U.S. totaled $3 trillion in 2014 and continues to increase rapidly. Minimizing waste through clinical guidelines is a promising strategy to reduce spending without compromising patient care. In 2011, clinical guidelines recommended against the use of chest X-ray (CXR) for diagnosis of community-acquired pneumonia (CAP) in pediatric ambulatory settings. However, use of CXR has not changed post-guideline. Thus, understanding the drivers of CXR utilization prior to guideline implementation could improve guideline adherence...
May 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28813613/methacholine-challenge-comparison-of-airway-responsiveness-produced-by-a-vibrating-mesh-nebulizer-versus-a-jet-nebulizer
#16
Christianne M Blais, Donald W Cockcroft, Justine Veilleux, Marie-Ève Boulay, Louis-Philippe Boulet, Gail M Gauvreau, Tara X Scime, Richard M Watson, Paul M O'Byrne, Beth E Davis
BACKGROUND: The latest methacholine challenge testing (MCT) guidelines published by the European Respiratory Society recommend the characterization of nebulizers before their use in clinics and research. Such investigations are necessary for accurately determining the provocative dose of methacholine causing a 20% fall in FEV1 (PD20) delivered by a given device. The standard English Wright (Wright) jet nebulizer recommended in the 1999 guidelines by the American Thoracic Society has become difficult to obtain and possesses some characteristics that complicate the calculation of dose delivery from this device (e...
August 16, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28813334/the-future-for-pettlep-a-modern-perspective-on-an-effective-and-established-tool
#17
REVIEW
Dave Collins, Howie J Carson
Over the past 15 years there has been much research into the PETTLEP model of motor imagery, originally designed to improve the quality and impact of imagery interventions on sport performance. This article reviews the most recent trends within this research. Despite a suggested change of underpinning mechanisms involved, there is much support for the positive impact of the model when applied within the sporting context and with engaged participants. The model also appears to have provided impact in fields other than sport, such as medicine and music...
August 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28813010/characterization-of-breakfast-cereals-available-in-the-mexican-market-sodium-and-sugar-content
#18
Claudia Nieto, Sofia Rincon-Gallardo Patiño, Lizbeth Tolentino-Mayo, Angela Carriedo, Simón Barquera
Preschool Mexican children consume 7% of their total energy intake from processed breakfast cereals. This study characterized the nutritional quality and labelling (claims and Guideline Daily Amount (GDA)) of the packaged breakfast cereals available in the Mexican market. Photographs of all breakfast cereals available in the 9 main food retail chains in the country were taken. The nutrition quality of cereals was assessed using the United Kingdom Nutrient Profiling Model (UKNPM). Claims were classified using the International Network for Food and Obesity/non-communicable Diseases Research, Monitoring and Action Support (INFORMAS) taxonomy and the GDA was defined according to the Mexican regulation, NOM-051...
August 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28812946/nurse-researchers-perspectives-on-research-ethics-in-china
#19
Can Gu, Man Ye, Xiaomin Wang, Min Yang, Honghong Wang, Kaveh Khoshnood
BACKGROUND: In China, research ethics is a subject of increasingly formal regulation. However, little is known about how nursing researchers understand the concept of research ethics and the ways in which they can maintain ethical standards in their work. AIM: The aim of this study is to examine nursing researchers' perspectives on research ethics in China. RESEARCH DESIGN: We conducted a descriptive qualitative study. Qualitative research methods enabled us to gain an in-depth understanding of nursing researchers' views on research ethics...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28812845/a-qualitative-assessment-of-the-evidence-utilization-for-health-policy-making-on-the-basis-of-support-tools-in-a-developing-country
#20
Mohammad Hasan Imani-Nasab, Hesam Seyedin, Bahareh Yazdizadeh, Reza Majdzadeh
BACKGROUND: SUPPORT tools consist of 18 articles addressing the health policy-makers so that they can learn how to make evidence-informed health policies. These tools have been particularly recommended for developing countries. The present study tries to explain the process of evidence utilization for developing policy documents in the Iranian Ministry of Health and Medical Education (MoHME) and to compare the findings with those of SUPPORT tools. METHODS: A qualitative research was conducted, using the framework analysis approach...
January 8, 2017: International Journal of Health Policy and Management
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