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Juan Carlos

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https://www.readbyqxmd.com/read/28936986/characterizing-endourologist-learning-curve-during-percutaneous-nephrolithotomy-implications-on-occupational-dose-and-patients
#1
Jacobo Guiu-Souto, Carlos Otero-Martínez, Daniel Pérez-Fentes, Carlos Fernández-Baltar, Juan F Sánchez-García, Camilo García-Freire, Miguel Pombar, Juan Pardo-Montero
In this study we have characterized the learning curve of percutaneous nephrolithotomy procedures over 301 cases for six years. Different surrogate parameters of clinical expertise have been used, such as dose area product, total procedure time, fluoroscopy time and personal equivalent doses. In addition, two different endourologists have been monitored; one of whom was subjected to a specific Radiation Protection training (ICRP 85). Eye lens dose is estimated from thermoluminescent dosimeters. Significant differences are observed between both endourologists, especially in the fluoroscopy time...
September 22, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28936923/egfr-pathway-subgroups-in-chilean-colorectal-cancer-patients-detected-by-mutational-and-expression-profiles-associated-to-different-clinicopathological-features
#2
Karin Alvarez, Paulina Orellana, Cynthia Villarroel, Luis Contreras, Hiroshi Kawachi, Maki Kobayashi, Ana Maria Wielandt, Marjorie De la Fuente, Juan Carlos Triviño, Udo Kronberg, Pilar Carvallo, Francisco López-Köstner
Colorectal cancer is a multistep process affecting several signaling pathways including EGFR (epidermal growth factor receptor), a therapeutic target for metastatic disease. Our aim was to characterize the mutational and expression profiles of the EGFR pathway in colorectal tumors and to integrate these results according to five previously defined groups. We screened seven genes for mutations ( KRAS-BRAF-PIK3CA-PIK3R1-AKT1-MAP2K1-PTEN) and six proteins (EGFR-p110α-p85α-PTEN-phosphoAKT-phosphoMEK1) by immunohistochemistry, PTEN deletion, and MSI...
September 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28935290/objectives-and-methodology-of-biobadaser-phase-iii
#3
Carlos Sanchez-Piedra, M Victoria Hernández Miguel, Javier Manero, Rosa Roselló, Jesús Tomás Sánchez-Costa, Carlos Rodríguez-Lozano, Cristina Campos, Eduardo Cuende, Jesús Carlos Fernández-Lopez, Sagrario Bustabad, Raquel Martín Domenech, Eva Pérez-Pampín, Javier Del Pino-Montes, Ana Milena Millan-Arcineas, Federico Díaz-González, Juan Jesús Gómez-Reino
OBJECTIVE: Describe the objectives, methods and results of the first year of the new version of the Spanish registry of adverse events involving biological therapies and synthetic drugs with an identifiable target in rheumatic diseases (BIOBADASER III). METHODOLOGY: Multicenter prospective registry of patients with rheumatic inflammatory diseases being treated with biological drugs or synthetic drugs with an identifiable target in rheumatology departments in Spain...
September 18, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28933845/quantum-many-body-effects-in-defective-transition-metal-oxide-superlattices
#4
Juan Arturo Santana, Rohan Mishra, Jaron T Krogel, Albina Y Borisevich, Paul R C Kent, Sokrates T Pantelides, Fernando A Reboredo
Strong electronic correlations, interfaces, defects and disorder each individually challenge theoretical methods for predictions of materials properties. These challenges are all simultaneously present in complex transition metal-oxide interfaces and superlattices, which are known to exhibit unique and unusual properties caused by multiple coupled degrees of freedom and strong electronic correlations. Here we show that ab initio quantum Monte-Carlo (QMC) solutions of the many-electron problem are now possible for the full complexity of these systems...
September 21, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28932280/assessment-of-cross-cultural-adaptations-of-patient-reported-shoulder-outcome-measures-in-spanish-a-systematic-review
#5
REVIEW
Sara Gómez-Valero, Fernando García-Pérez, Mariano Tomás Flórez-García, Juan Carlos Miangolarra-Page
BACKGROUND: The present study aimed to conduct a systematic review of self-administered shoulder-disability functional assessment questionnaires adapted to Spanish, analyzing the quality of the transcultural adaptation and the clinimetric properties of the new version. METHODS: A search of the main biomedical databases was conducted to locate Spanish shoulder function assessment scales. The authors reviewed the papers and considered whether the process of adaptation of the questionnaire had followed international recommendations, and whether its psychometric properties had been appropriately assessed...
October 2017: Shoulder & Elbow
https://www.readbyqxmd.com/read/28931867/accuracy-and-reliability-of-cone-beam-computed-tomography-for-linear-and-volumetric-mandibular-condyle-measurements-a-human-cadaver-study
#6
Verónica García-Sanz, Carlos Bellot-Arcís, Virginia Hernández, Pedro Serrano-Sánchez, Juan Guarinos, Vanessa Paredes-Gallardo
The accuracy of Cone-Beam Computed Tomography (CBCT) on linear and volumetric measurements on condyles has only been assessed on dry skulls. The aim of this study was to evaluate the reliability and accuracy of linear and volumetric measurements of mandibular condyles in the presence of soft tissues using CBCT. Six embalmed cadaver heads were used. CBCT scans were taken, followed by the extraction of the condyles. The water displacement technique was used to calculate the volumes of the condyles and three linear measurements were made using a digital caliper, these measurements serving as the gold standard...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28930947/the-mortality-ascent-hourly-risk-of-death-for-hemodynamically-unstable-trauma-patients-at-level-ii-versus-level-i-trauma-centers
#7
Juan P Herrera-Escobar, Arturo J Rios-Diaz, Cheryl Zogg, Lindsey L Wolf, Alyssa Harlow, Eric B Schneider, Zara Cooper, Carlos A Ordonez, Ali Salim, Adil H Haider
BACKGROUND: Severely injured trauma patients have higher in-hospital mortality at Level II versus Level I Trauma Centers (TCs). In order to better understand these differences, we sought to determine if there were any time-periods during which hemodynamically unstable trauma patients are at higher risk of death at Level II versus Level I TCs within the first 24 hours post-admission. STUDY DESIGN: Trauma patients aged 18-64 years, with Injury Severity Score ≥15, SBP <90 mmHg at admission, and treated at Level II or Level I TCs, were identified using the 2007-2012 National Trauma Data Bank...
September 20, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28928416/zika-virus-infection-confers-protection-against-west-nile-virus-challenge-in-mice
#8
Ángela Vázquez-Calvo, Ana-Belén Blázquez, Estela Escribano-Romero, Teresa Merino-Ramos, Juan-Carlos Saiz, Miguel A Martín-Acebes, Nereida Jiménez de Oya
Flaviviruses are RNA viruses that constitute a worrisome threat to global human and animal health. Zika virus (ZIKV), which was initially reported to cause a mild disease, recently spread in the Americas, infecting millions of people. During this recent epidemic, ZIKV infection has been linked to serious neurological diseases and birth defects, specifically Guillain-Barrè syndrome (GBS) and microcephaly. Because information about ZIKV immunity remains scarce, we assessed the humoral response of immunocompetent mice to infection with three viral strains of diverse geographical origin (Africa, Asia and America)...
September 20, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28925969/caffeine-improves-basketball-performance-in-experienced-basketball-players
#9
Carlos Puente, Javier Abián-Vicén, Juan José Salinero, Beatriz Lara, Francisco Areces, Juan Del Coso
The aim of this study was to determine the effect of caffeine intake on overall basketball performance in experienced players. A double-blind, placebo-controlled, randomized experimental design was used for this investigation. In two different sessions separated by one week, 20 experienced basketball players ingested 3 mg of caffeine/kg of body mass or a placebo. After 60 min, participants performed 10 repetitions of the following sequence: Abalakov jump, Change-of-Direction and Acceleration Test (CODAT) and two free throws...
September 19, 2017: Nutrients
https://www.readbyqxmd.com/read/28924378/vasopressin-mediates-the-renal-damage-induced-by-limited-fructose-rehydration-in-recurrently-dehydrated-rats
#10
Fernando E García-Arroyo, Edilia Tapia, Mónica G Blas-Marron, Guillermo Gonzaga, Octaviano Silverio, Magdalena Cristóbal, Horacio Osorio, Abraham S Arellano-Buendía, Cecilia Zazueta, Omar Emiliano Aparicio-Trejo, Juan G Reyes-García, José Pedraza-Chaverri, Virgilia Soto, Carlos Roncal-Jiménez, Richard J Johnson, Laura G Sánchez-Lozada
Recurrent dehydration and heat stress cause chronic kidney damage in experimental animals. The injury is exacerbated by rehydration with fructose-containing beverages. Fructose may amplify dehydration-induced injury by directly stimulating vasopressin release and also by acting as a substrate for the aldose reductase-fructokinase pathway, as both of these systems are active during dehydration. The role of vasopressin in heat stress associated injury has not to date been explored. Here we show that the amplification of renal damage mediated by fructose in thermal dehydration is mediated by vasopressin...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28923171/potential-early-biomarkers-of-sarcopenia-among-independent-older-adults
#11
Ana Coto Montes, José Antonio Boga, Carlos Bermejo Millo, Adrián Rubio González, Yaiza Potes Ochoa, Ignacio Vega Naredo, Marta Martínez Reig, Luis Romero Rizos, Pedro Manuel Sánchez Jurado, Juan Jose Solano, Pedro Abizanda, Beatriz Caballero
OBJECTIVES: There are no tools or biomarkers for a quantitative analysis of sarcopenia. STUDY DESIGN: Cross-sectional study of the diagnosis of sarcopenia in 200 independent adults aged 70 years or over. MAIN OUTCOME MEASURES: Sarcopenia was defined as loss of muscle mass together with low strength and/or loss of physical performance. We considered different clinical parameters and assayed potential blood biomarkers (cell energetic metabolism, muscle performance, inflammation, infection and oxidative stress)...
October 2017: Maturitas
https://www.readbyqxmd.com/read/28922519/a-cost-minimisation-analysis-of-olive-oil-versus-hyperoxygenated-fatty-acid-treatment-for-the-prevention-of-pressure-ulcers-in-primary-health-care-a-randomised-controlled-trial
#12
Inmaculada Lupiañez-Pérez, Juan Carlos Morilla-Herrera, Shakira Kaknani-Uttumchanchandani, Yolanda Lupiañez-Perez, Magdalena Cuevas-Fernandez-Gallego, Francisco Martin-Santos, Jorge Caro-Bautista, Jose Miguel Morales-Asencio
Pressure ulcers represent a major current health problem and cause an important economic impact on the health care system. Most studies on the prevention of pressure ulcers have been carried out in hospital contexts, with respect to the use of hyperoxygenated fatty acids, and to date no studies have specifically examined the use of olive oil-based treatments. AIM: To evaluate the cost of using extra virgin olive oil, rather than hyperoxygenated fatty acids, in the prevention of pressure ulcers among persons with impaired mobility and receiving home care...
September 18, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28922404/eco-epidemiological-analysis-of-rickettsial-seropositivity-in-rural-areas-of-colombia-a-multilevel-approach
#13
Juan C Quintero V, Luis E Paternina T, Alexander Uribe Y, Carlos Muskus, Marylin Hidalgo, Juliana Gil, Astrid Vanessa Cienfuegos G, Lisardo Osorio Q, Carlos Rojas A
Rickettsiosis is a re-emergent infectious disease without epidemiological surveillance in Colombia. This disease is generally undiagnosed and several deadly outbreaks have been reported in the country in the last decade. The aim of this study is to analyze the eco-epidemiological aspects of rickettsial seropositivity in rural areas of Colombia where outbreaks of the disease were previously reported. A cross-sectional study, which included 597 people living in 246 households from nine hamlets in two municipalities of Colombia, was conducted from November 2015 to January 2016...
September 18, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28922333/rock-inhibitor-ripasudil-as-coadjuvant-after-descemetorhexis-without-an-endothelial-graft
#14
Virgilio Galvis, Alejandro Tello, Johanna P Fuquen, Carlos A Rodríguez-Barrientos, Juan Martín Grice
No abstract text is available yet for this article.
September 14, 2017: Cornea
https://www.readbyqxmd.com/read/28920955/mir-25-93-mediates-hypoxia-induced-immunosuppression-by-repressing-cgas
#15
Min-Zu Wu, Wei-Chung Cheng, Su-Feng Chen, Shin Nieh, Carolyn O'Connor, Chia-Lin Liu, Wen-Wei Tsai, Cheng-Jang Wu, Lorena Martin, Yaoh-Shiang Lin, Kou-Juey Wu, Li-Fan Lu, Juan Carlos Izpisua Belmonte
The mechanisms by which hypoxic tumours evade immunological pressure and anti-tumour immunity remain elusive. Here, we report that two hypoxia-responsive microRNAs, miR-25 and miR-93, are important for establishing an immunosuppressive tumour microenvironment by downregulating expression of the DNA sensor cGAS. Mechanistically, miR-25/93 targets NCOA3, an epigenetic factor that maintains basal levels of cGAS expression, leading to repression of cGAS during hypoxia. This allows hypoxic tumour cells to escape immunological responses induced by damage-associated molecular pattern molecules, specifically the release of mitochondrial DNA...
September 18, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28920852/experimental-transmission-to-a-calf-of-an-isolate-of-spanish-classical-scrapie
#16
Rosa Bolea, Carlos Hedman, Óscar López-Pérez, Belén Marín, Enríc Vidal, Martí Pumarola, Fabien Corbière, Antonio Romero, Bernardino Moreno, Inmaculada Martín-Burriel, Olivier Andréoletti, Juan José Badiola
Multiple theories exist regarding the origin of bovine spongiform encephalopathy (BSE). An early and prominent theory proposed that BSE was the result of the adaptation of sheep scrapie to cattle. The reports to date indicate that the distribution of the pathological prion protein (PrPSc) in experimental bovine scrapie is largely restricted to the central nervous system (CNS). Here, we describe pathological findings in a calf intracerebrally inoculated with a Spanish classical scrapie isolate. While clinical disease was observed 30 months after inoculation and PrPSc was detected in the CNS, the corresponding phenotype differed from that of BSE...
September 18, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28920641/using-global-surgical-indicators-to-improve-trauma-care-in-latin-america
#17
Gregory Peck, Saurabh Saluja, David N Blitzer, Deesha Sarma, Geoffrey A Anderson, Edgar Rodas, Jorge Esteban Foianini, Juan Carlos Puyana, John Meara, Carlos Morales, Carlos Ordonez, Vicente Gracias
No abstract text is available yet for this article.
April 2017: Bulletin of the American College of Surgeons
https://www.readbyqxmd.com/read/28918144/short-communication-molecular-epidemiology-of-streptococcus-agalactiae-differs-between-countries
#18
J Reyes, M Chaffer, Juan Carlos Rodriguez-Lecompte, Javier Sánchez, Ruth N Zadoks, Natasha Robinson, Ximena Cardona, N Ramírez, G P Keefe
Group B Streptococcus or Streptococcus agalactiae continue to be challenging for milk quality programs in countries with emerging dairy industries, such as Colombia, where high prevalence has been reported. Molecular typing of isolates is needed to understand the variability and epidemiology of this pathogen and to develop effective control and eradication programs. We characterized the molecular profile of Strep. agalactiae isolated from cows with subclinical mastitis in 21 Colombian dairy herds and measured diversity within and between herds using multilocus sequence typing...
September 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28917558/cardiac-sympathectomy-for-the-management-of-ventricular-arrhythmias-refractory-to-catheter-ablation
#19
Travis Richardson, Ricardo Lugo, Pablo Saavedra, George Crossley, Walter Clair, Sharon Shen, Juan Carlos Estrada, Jay Montgomery, M Benjamin Shoemaker, Christopher Ellis, Gregory F Michaud, Eric Lambright, Arvindh Kanagasundram
BACKGROUND: Catheter ablation is now a mainstay of therapy for ventricular arrhythmias (VA). However, there are scenarios where either physiologic or anatomical factors make ablation less likely to be successful. OBJECTIVES: To demonstrate that cardiac sympathetic denervation (CSD) may be an alternate therapy for patients with difficult to ablate VA. METHODS: We identified all patients referred for CSD at a single center for indications other than LQTS and CPVT who had failed catheter ablation...
September 13, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28917382/a-new-evidence-based-risk-stratification-system-for-cutaneous-squamous-cell-carcinoma-into-low-intermediate-and-high-risk-groups-with-implications-for-management
#20
REVIEW
Christian L Baum, Adam C Wright, Juan-Carlos Martinez, Christopher J Arpey, Jerry D Brewer, Randall K Roenigk, Clark C Otley
Most primary cutaneous squamous cell carcinomas are cured with surgery. A subset, however, may develop local and nodal metastasis that may eventuate in disease-specific; death. This subset has been variably termed high risk. Herein, we review; an emerging body of data on the risks of these outcomes and propose an evidence-based; risk stratification for low-, intermediate-, and high-risk tumors that takes into; account both tumor and patient characteristics. Finally, we discuss a framework for; management of these tumors on the basis of data, when available, and our; recommendations when data are sparse...
September 13, 2017: Journal of the American Academy of Dermatology
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