keyword
MENU ▼
Read by QxMD icon Read
search

infames

keyword
https://www.readbyqxmd.com/read/28209133/house-spider-genome-uncovers-evolutionary-shifts-in-the-diversity-and-expression-of-black-widow-venom-proteins-associated-with-extreme-toxicity
#1
Kerry L Gendreau, Robert A Haney, Evelyn E Schwager, Torsten Wierschin, Mario Stanke, Stephen Richards, Jessica E Garb
BACKGROUND: Black widow spiders are infamous for their neurotoxic venom, which can cause extreme and long-lasting pain. This unusual venom is dominated by latrotoxins and latrodectins, two protein families virtually unknown outside of the black widow genus Latrodectus, that are difficult to study given the paucity of spider genomes. Using tissue-, sex- and stage-specific expression data, we analyzed the recently sequenced genome of the house spider (Parasteatoda tepidariorum), a close relative of black widows, to investigate latrotoxin and latrodectin diversity, expression and evolution...
February 16, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28166513/improving-the-critic-learning-for-event-based-nonlinear-h%C3%A2-control-design
#2
Ding Wang, Haibo He, Derong Liu
In this paper, we aim at improving the critic learning criterion to cope with the event-based nonlinear H∞ state feedback control design. First of all, the H∞ control problem is regarded as a two-player zero-sum game and the adaptive critic mechanism is used to achieve the minimax optimization under event-based environment. Then, based on an improved updating rule, the event-based optimal control law and the time-based worst-case disturbance law are obtained approximately by training a single critic neural network...
January 30, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28146627/polysulfide-scission-reagents-for-the-suppression-of-the-shuttle-effect-in-lithium-sulfur-batteries
#3
Wuxing Hua, Zhi Yang, Huagui Nie, Zhongyu Li, Jizhang Yang, Zeqing Guo, Chunping Ruan, Xi'an Chen, Shaoming Huang
Lithium-sulfur batteries have become an appealing candidate for next-generation energy-storage technologies because of their low cost and high energy density. However, one of their major practical problems is the high solubility of long-chain lithium polysulfides and their infamous shuttle effect, which causes low Coulombic efficiency and sulfur loss. Here, we introduced a concept involving the dithiothreitol (DTT) assisted scission of polysulfides into lithium-sulfur system. Our designed porous carbon nanotube/S cathode coupling with a lightweight graphene/DTT interlayer (PCNTs-S@Gra/DTT) exhibited ultrahigh cycle-ability even at 5 C over 1100 cycles, with a capacity degradation rate of 0...
February 7, 2017: ACS Nano
https://www.readbyqxmd.com/read/28128221/detecting-the-causality-influence-of-individual-meteorological-factors-on-local-pm2-5-concentration-in-the-jing-jin-ji-region
#4
Ziyue Chen, Jun Cai, Bingbo Gao, Bing Xu, Shuang Dai, Bin He, Xiaoming Xie
Due to complicated interactions in the atmospheric environment, quantifying the influence of individual meteorological factors on local PM2.5 concentration remains challenging. The Beijing-Tianjin-Hebei (short for Jing-Jin-Ji) region is infamous for its serious air pollution. To improve regional air quality, characteristics and meteorological driving forces for PM2.5 concentration should be better understood. This research examined seasonal variations of PM2.5 concentration within the Jing-Jin-Ji region and extracted meteorological factors strongly correlated with local PM2...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28118599/mutant-ras-calms-stressed-out-cancer-cells
#5
Kirsten L Bryant, Channing J Der
Mutant RAS-driven cancers are infamously resistant to chemotherapeutics. Reporting in Cell, Grabocka and Bar-Sagi (2016) demonstrate that when subjected to stress, mutant KRAS-dependent lipid production leads to upregulated stress granule formation. This confers not only cell-autonomous cytoprotection but also paracrine establishment of a stress-resistant tumor niche.
January 23, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28111035/postmortem-concentrations-of-gamma-hydroxybutyrate-ghb-in-peripheral-blood-and-brain-tissue-differentiating-between-postmortem-formation-and-antemortem-intake
#6
Ragnar Thomsen, Brian Schou Rasmussen, Sys Stybe Johansen, Kristian Linnet
Gamma-hydroxybutyrate (GHB) is a recreational drug, a drug of abuse, as well as an endogenous molecule in mammals. The drug has become infamous as a tool for drug-facilitated sexual assault. GHB is found in low concentrations in living humans, while at postmortem the concentration of GHB rises due to fermentation processes. The endogenous nature of GHB leads to difficulty in interpretation of concentrations, as the source of GHB is not obvious. Postmortem brain and blood samples were collected from 221 individuals at autopsy...
January 5, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28088476/a-chimeric-protein-of-abrin-and-abrus-precatorius-agglutinin-that-neutralizes-abrin-mediated-lethality-in-mice
#7
Vinita Tiwari, Shradha Bagaria, Anjali A Karande
Abrin, a type II ribosome inactivating protein from the Abrus precatorius plant, is extremely toxic. It has been shown to be 75 times more potent than its infamous sister toxin, ricin and their potential use in bio-warfare is a cause of major concern. Although several vaccine candidates are under clinical trials for ricin, none are available against abrin. The present study proposes a chimeric protein, comprising of 1-123 amino acids taken from the A chain of abrin and 124-175 amino acids from Abrus precatorius agglutinin A chain, as a vaccine candidate against abrin intoxication...
January 11, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28080046/application-of-2-aminothiazoline-4-carboxylic-acid-as-a-forensic-marker-of-cyanide-exposure
#8
Monika Rużycka, Joanna Giebułtowicz, Marcin Fudalej, Paweł Krajewski, Piotr Wroczyński
Cyanides are infamous for their highly poisonous properties. Accidental cyanide poisoning occurs frequently, but occasionally, intentional poisonings also occur. Inhalation of fumes generated by fire may also cause cyanide poisoning. There are many limitations in direct analysis of cyanide. 2-Aminothiazoline-4-carboxylic acid (ATCA), a cyanide metabolite, seems to be the only surrogate that is being used in the detection of cyanide because of its stability and its cyanide-dependent quality in a biological matrix...
February 20, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28026089/synonymous-somatic-variants-in-human-cancer-are-not-infamous-a-plea-for-full-disclosure-in-databases-and-publications
#9
Thierry Soussi, Peter E M Taschner, Yardena Samuels
Single Nucleotide Variants (SNVs) are the most frequent genetic changes found in human cancer. Most driver alterations are missense and nonsense variants localized in the coding region of cancer genes. Unbiased cancer genome sequencing shows that synonymous SNVs (sSNVs) can be found clustered in the coding regions of several cancer oncogenes or tumor suppressor genes suggesting purifying selection. sSNVs are currently underestimated, as they are usually discarded during analysis. Furthermore, several public databases do not display sSNVs, which can lead to analytical bias and the false assumption that this mutational event is uncommon...
December 27, 2016: Human Mutation
https://www.readbyqxmd.com/read/27981238/new-insights-into-autoinducer-2-signaling-as-a-virulence-regulator-in-a-mouse-model-of-pneumonic-plague
#10
Eric C Fitts, Jourdan A Andersson, Michelle L Kirtley, Jian Sha, Tatiana E Erova, Sadhana Chauhan, Vladimir L Motin, Ashok K Chopra
The Enterobacteriaceae family members, including the infamous Yersinia pestis, the causative agent of plague, have a highly conserved interbacterial signaling system that is mediated by the autoinducer-2 (AI-2) quorum-sensing molecule. The AI-2 system is implicated in regulating various bacterial virulence genes in diverse environmental niches. Deletion of the gene encoding the synthetic enzyme for the AI-2 substrate, luxS, leads to either no significant change or, paradoxically, an increase in in vivo bacterial virulence...
November 2016: MSphere
https://www.readbyqxmd.com/read/27977209/greatly-suppressed-shuttle-effect-for-improved-lithium-sulfur-battery-performance-through-short-chain-intermediates
#11
Na Xu, Tao Qian, Xuejun Liu, Jie Liu, Yu Chen, Chenglin Yan
The high solubility of long-chain lithium polysulfides and their infamous shuttle effect in lithium sulfur battery lead to rapid capacity fading along with low Coulombic efficiency. To address above issues, we propose a new strategy to suppress the shuttle effect for greatly enhanced lithium sulfur battery performance mainly through the formation of short-chain intermediates during discharging, which allows significant improvements including high capacity retention of 1022 mAh/g with 87% retention for 450 cycles...
December 15, 2016: Nano Letters
https://www.readbyqxmd.com/read/27911396/automated-quantification-and-analysis-of-cell-counting-procedures-using-imagej-plugins
#12
Jacob O'Brien, Heyam Hayder, Chun Peng
The National Institute of Health's ImageJ is a powerful, freely available image processing software suite. ImageJ has comprehensive particle analysis algorithms which can be used effectively to count various biological particles. When counting large numbers of cell samples, the hemocytometer presents a bottleneck with regards to time. Likewise, counting membranes from migration/invasion assays with the ImageJ plugin Cell Counter, although accurate, is exceptionally labor intensive, subjective, and infamous for causing wrist pain...
November 17, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27865287/surgical-management-of-pancreatic-neuroendocrine-tumors
#13
REVIEW
Jason B Liu, Marshall S Baker
Pancreatic neuroendocrine tumors (PNETs) are a rare, heterogeneous group of neoplasms infamous for their endocrinopathies. Up to 90% of PNETs, however, are nonfunctional and are frequently detected incidentally on axial imaging during the evaluation of vague abdominal symptoms. Surgery remains the mainstay of therapy for patients diagnosed with both functional and nonfunctional PNETs. However, the multifaceted nature of PNETs challenges treatment decision making. In general, resection is recommended for patients with acceptable perioperative risk and amenable lesions...
December 2016: Surgical Clinics of North America
https://www.readbyqxmd.com/read/27810634/early-plant-embryogenesis-dark-ages-or-dark-matter
#14
REVIEW
Martin Bayer, Daniel Slane, Gerd Jürgens
In nearly all flowering plants, the basic body plan is laid down during embryogenesis. In Arabidopsis, the crucial cell types are established extremely early as reflected in the stereotypic sequence of oriented cell divisions in the developing young embryo. Research into early embryogenesis was especially focused on the role of the infamous tryptophan derivative auxin in establishing embryo polarity and generating the main body axis. However, it is becoming obvious that the mere link to auxin does not provide any mechanistic understanding of early embryo patterning...
October 31, 2016: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/27690453/surface-adsorption-energetics-studied-with-gold-standard-wavefunction-based-ab-initio-methods-small-molecule-binding-to-tio2-110
#15
Adam M Kubas, Daniel Berger, Harald Oberhofer, Dimitrios Maganas, Karsten Reuter, Frank Neese
Coupled cluster theory with single, double and perturbative triple excitations (CCSD(T)) is widely considered to be the 'gold standard' of ab initio quantum chemistry. Using the domain-based pair natural orbital local correlation concept (DLPNO-CCSD(T)), these calculations can be performed on systems with hundreds of atoms at an accuracy of about 99.9% of the canonical CCSD(T) method. This allows for ab initio calculations providing reference adsorption energetics at solid surfaces with an accuracy approaching 1 kcal/mol...
October 3, 2016: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/27662861/vetiver-plantlets-in-aerated-system-degrade-phenol-in-illegally-dumped-industrial-wastewater-by-phytochemical-and-rhizomicrobial-degradation
#16
Tanapon Phenrat, Pimpawat Teeratitayangkul, Isarawut Prasertsung, Rattapoohm Parichatprecha, Peerapong Jitsangiam, Narong Chomchalow, Siriwan Wichai
This research evaluated the feasibility of using vetiver plantlets (Vetiveria zizanioides (L.) Nash) on a floating platform with aeration to degrade phenol (500 mg/L) in illegally dumped industrial wastewater (IDIWW). The IDIWW sample was from the most infamous illegal dumping site at Nong Nae subdistrict, Phanom Sarakham district, Chachoengsao province, Thailand. Laboratory results suggested that phenol degradation by vetiver involves two phases: Phase I, phytopolymerization and phyto-oxidation assisted by root-produced peroxide (H2O2) and peroxidase (POD), followed by phase II, a combination of phase I with enhanced rhizomicrobial degradation...
September 24, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27641601/the-cellular-prion-protein-controls-notch-signaling-in-neural-stem-progenitor-cells
#17
Séverine Martin-Lannerée, Sophie Halliez, Théo Z Hirsch, Julia Hernandez-Rapp, Bruno Passet, Céline Tomkiewicz, Ana Villa-Diaz, Juan-Maria Torres, Jean-Marie Launay, Vincent Béringue, Jean-Luc Vilotte, Sophie Mouillet-Richard
The prion protein is infamous for its involvement in a group of neurodegenerative diseases known as Transmissible Spongiform Encephalopathies. In the longstanding quest to decipher the physiological function of its cellular isoform, PrP(C) , the discovery of its participation to the self-renewal of hematopoietic and neural stem cells has cast a new spotlight on its potential role in stem cell biology. However, still little is known on the cellular and molecular mechanisms at play. Here, by combining in vitro and in vivo murine models of PrP(C) depletion, we establish that PrP(C) deficiency severely affects the Notch pathway, which plays a major role in neural stem cell maintenance...
September 19, 2016: Stem Cells
https://www.readbyqxmd.com/read/27568585/the-infamous-among-us-enhanced-reputational-memory-for-uncooperative-ingroup-members
#18
Stefanie Hechler, Franz J Neyer, Thomas Kessler
People remember uncooperative individuals better than cooperative ones. We hypothesize that this is particularly true when uncooperative individuals belong to one's ingroup, as their behavior violates positive expectations. Two studies examined the effect of minimal group categorization on reputational memory of the social behavior of particular ingroup and outgroup members. We manipulated uncooperative behavior as the unfair sharing of resources with ingroup members (Study 1), or as descriptions of cheating (Study 2)...
December 2016: Cognition
https://www.readbyqxmd.com/read/27539821/novel-carbon-nanotube-cnt-based-ultrasensitive-sensors-for-trace-mercury-ii-detection-in-water-a-review
#19
Lok R Pokhrel, Nicholas Ettore, Zachary L Jacobs, Asha Zarr, Mark H Weir, Phillip R Scheuerman, Sushil R Kanel, Brajesh Dubey
Infamous for "Mad hatter syndrome" and "Minamata disease", mercury (Hg) is ranked high on the Agency for Toxic Substances and Disease Registry's priority list of hazardous substances for its potent neurologic, renal, and developmental toxicities. Most typical exposures are via contaminated water and food. Although regulations and advisories are exercised at various levels, Hg pollution from both natural and anthropogenic sources has remained a major public health and safety concern. Rapid detection of solvated aqueous Hg(2+) ions at low levels is critical for immediate response and protection of those who are vulnerable (young children, pregnant and breast-feeding women) to acute and chronic exposures to Hg(2+)...
August 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27398081/scorpion-incidents-misidentification-cases-and-possible-implications-for-the-final-interpretation-of-results
#20
REVIEW
Wilson R Lourenço
The aim of this contribution is to bring general information on the classification and in particular on the specific identification of scorpion species dangerous to humans. Several generic groups are taken into consideration, but the Neotropical genus Tityus C. L. Koch, 1836 is used as a major example. The content of this paper is mostly addressed to non-specialists whose research embraces scorpions in several fields such as venom toxins and public health. Although efforts have been made in the last 20 years to create better links between 'true scorpion experts' and non-specialists who use scorpions in their research, such exchanges had never led to a consensus among those different branches of biological and medical research...
2016: Journal of Venomous Animals and Toxins Including Tropical Diseases
keyword
keyword
94148
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"