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https://www.readbyqxmd.com/read/28328743/acetylcholine-atropine-interactions-paradoxical-effects-on-atrial-fibrillation-inducibility
#1
Yu Liu, Benjamin J Scherlag, Youqi Fan, Wenfang Xia, He Huang, Sunny S Po
Atropine (ATr) is well known as a cholinergic antagonist, however, at low concentrations ATr could paradoxically accentuate the parasympathetic actions of acetylcholine (ACh). In 22 pentobarbital anesthetized dogs, via a left and right thoracotomy, a leak proof barrier was attached to isolate the atrial appendages (AAs) from the rest of the atria. In Group 1(Ach+ATr+Ach), ACh, 100 mM, was placed on the AA followed by the application of ATr, 2mg/cc. The average AFdur was 17±7 minutes. After ATr was applied to the AA and ACh again tested, the AFdur was markedly attenuated (2±2 minutes, p<0...
March 21, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28322838/effect-of-antiarrhythmic-drugs-on-small-conductance-calcium-activated-potassium-channels
#2
Rafel Simó Vicens, Daniel R P Sauter, Morten Grunnet, Jonas G Diness, Bo H Bentzen
Atrial fibrillation (AF) is the most common type of arrhythmia. Current pharmacological treatment for AF is moderately effective and/or increases the risk of serious ventricular adverse effects. To avoid ventricular adverse effects, a new target has been considered, the small conductance calcium-activated K(+) channels (KCa2.X, SK channels). In the heart, KCa2.X channels are functionally more important in atria compared to ventricles, and pharmacological inhibition of the channel confers atrial selective prolongation of the cardiac action potential and converts AF to sinus rhythm in animal models of AF...
March 18, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28320863/rac1-gtpase-regulates-11%C3%AE-hydroxysteroid-dehydrogenase-type-2-and-fibrotic-remodeling
#3
Daniel Lavall, Pia Schuster, Nadine Jacobs, Andrey Kazakov, Michael Böhm, Ulrich Laufs
The aim of the study was to characterize the role of Rac1 GTPase for the mineralocorticoid receptor (MR) mediated pro-fibrotic remodeling. Transgenic mice with cardiac overexpression of constitutively active Rac1 (RacET) develop an age-dependent phenotype with atrial dilatation, fibrosis and atrial fibrillation. Expression of MR was similar in RacET and wild-type (WT) mice. The expression of 11β hydroxysteroid dehydrogenase type 2 (11β-HSD2) was age-dependently upregulated in the atria and the left ventricles of RacET mice on mRNA and protein level...
March 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28318421/the-kaleidoscopic-nature-of-griefgrief-is-a-journey-finding-your-path-through-loss-by-kenneth-j-doka-new-york-ny-atria-books-2016-304-pp-isbn-978-1476771480-26-00-hardcover
#4
https://www.readbyqxmd.com/read/28316327/obstructive-primary-cardiac-t-cell-lymphoma-a-case-report-from-senegal
#5
Simon Antoine Sarr, Abdou Majib Gaye, Fatou Aw, Jean de Dieu Nzambaza, Malick Bodian, Kana Babaka, Mouhamadou Bamba Ndiaye, Adama Kane, Maboury Diao, Serigne Abdou Ba
BACKGROUND Cardiac lymphoma is a rare entity, defined by the non-extra cardiac location at diagnosis. CASE REPORT Our patient was a 32-year-old female with no particular medical history, who presented with right heart failure with recurrent ascites and pleural effusion. There was a progressive worsening exertional dyspnea. On admission, examination revealed an irregular tachycardia at 170 beats per minute (bpm) and congestive heart failure. The electrocardiogram scored full tachyarrhythmia by atrial fibrillation with an average ventricular rate of 179 cycles per minute...
March 20, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28315567/a-practical-guide-for-building-a-highway-between-atria-during-transseptal-puncture-without-radiation
#6
Yuan Yuan, Deyong Long, Caihua Sang, Ling Tao, Jianzeng Dong, Changsheng Ma
OBJECTIVE: To investigate whether switching the ablation catheter between the right and left atria through transseptal puncture site can be accurately performed without fluoroscopy. METHODS: Forty patients with persistent atrial fibrillation (mean age, 60.2±7.4 years; 65% males) got "2C3L" approach were randomized in a 1:1 ratio to undergo either crossing interatrial septum guided by fluoroscopy (trackless group) or crossing septum guided by track image that was mapped by Carto3 system (track group)...
March 9, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28314801/characterization-of-foci-and-breakthrough-sites-during-persistent-and-long-standing-persistent-atrial-fibrillation-in-patients-studies-using-high-density-510-512-electrodes-biatrial-epicardial-mapping
#7
Seungyup Lee, Jayakumar Sahadevan, Celeen M Khrestian, Alan Markowitz, Albert L Waldo
BACKGROUND: We previously demonstrated that persistent and long-standing persistent atrial fibrillation is maintained by activation emanating from foci and breakthrough sites of different cycle lengths (CLs). The purpose of this study was to characterize the behavior of focal and nonrandom breakthrough activation identified during high-density mapping of atrial fibrillation in these patients. METHODS AND RESULTS: During open heart surgery, we recorded activation from both atria simultaneously using 510 to 512 epicardial electrodes along with ECG lead II in 12 patients with persistent and long-standing persistent atrial fibrillation...
March 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28293165/-pyr-1-apelin-13-1-12-is-a-biologically-active-ace2-metabolite-of-the-endogenous-cardiovascular-peptide-pyr-1-apelin-13
#8
Peiran Yang, Rhoda E Kuc, Aimée L Brame, Alex Dyson, Mervyn Singer, Robert C Glen, Joseph Cheriyan, Ian B Wilkinson, Anthony P Davenport, Janet J Maguire
Aims: Apelin is a predicted substrate for ACE2, a novel therapeutic target. Our aim was to demonstrate the endogenous presence of the putative ACE2 product [Pyr(1)]apelin-13(1-12) in human cardiovascular tissues and to confirm it retains significant biological activity for the apelin receptor in vitro and in vivo. The minimum active apelin fragment was also investigated. Methods and Results: [Pyr(1)]apelin-13 incubated with recombinant human ACE2 resulted in de novo generation of [Pyr(1)]apelin-13(1-12) identified by mass spectrometry...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28292262/low-adiponectin-is-associated-with-diastolic-dysfunction-in-women-a-cross-sectional-study-from-the-troms%C3%A3-study
#9
Jon V Norvik, Henrik Schirmer, Kirsti Ytrehus, Trond G Jenssen, Svetlana N Zykova, Anne E Eggen, Bjørn O Eriksen, Marit D Solbu
BACKGROUND: Heart failure with preserved ejection fraction is closely associated with diastolic dysfunction and related to obesity and female sex. We investigated whether adiponectin, an adipocyte-secreted protein hormone with cardioprotective effects, was associated with indices of diastolic dysfunction, and whether the association was sex dependent. METHODS: We conducted a cross-sectional study on 1165 women and 896 men without diabetes. We stratified the multivariable adjusted logistic regression analyses and the fractional polynomial regression analyses according to sex, with echocardiographic markers of diastolic dysfunction as dependent variables, and adiponectin as the independent variable of interest...
March 14, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28291708/transvenous-electrical-cardioversion-of-atrial-fibrillation-in-two-dogs
#10
S W Jung, D K Newhard, K Harrelson
Atrial fibrillation is characterized by uncoordinated electrical activation of the atria that leads to the loss of atrial mechanical function and atrial fibrosis as a substrate promoting maintenance of rhythm abnormality. Transvenous electrical cardioversion has not been previously reported in the dog. The authors demonstrate the use of this technique for successful cardioversion of atrial fibrillation in two dogs with dilated cardiomyopathy.
March 10, 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/28290802/-electroimpedance-methods-of-investigation-of-cardiac-activity
#11
A I Malakhov, A N Tikhomirov, S I Shchukin, I A Kudashov, A V Kobelev, Yu N Belenkov, G A Shakaryants, M V Kozhevnikova, V Yu Kaplunova
of the present work was assessment of possibility to use modern electroimpedace methods for the study of activity of the heart. Electroimpemdace methods of measurement for many years remained in the shadow of other diagnostic methods because of low accuracy in evaluation of various parameters. At present, there are technologies of measurement which allow to carry out electroimpedance investigations of cardiac activity dynamically and with acceptable accuracy. In this article, we present methods of electroimpedace measurements created in Institute of Biomedical Equipment of N...
December 2016: Kardiologiia
https://www.readbyqxmd.com/read/28290788/-the-myocardial-sleeves-of-the-pulmonary-veins-potential-implications-for-atrial-fibrillation
#12
Y V Egorov, L V Rozenshtrauh
Pulmonary veins (PVs) are thought to play an important role in the initiation of atrial fibrillation. However, systematic microelectrode studies from different regions of the left atria and PV myocardium remain limited. METHODS AND RESULTS: A 2-microelectrode technique was used to characterize electrophysiological properties of rat left atrial and PV myocardium, at baseline and during electrical stimulation. PV myocardium was characterized by prolonged action potential duration (APD) (74+/-2 ms in the PV mouth vs...
February 2017: Kardiologiia
https://www.readbyqxmd.com/read/28290548/atrial-structure-function-and-arrhythmogenesis-in-aged-and-frail-mice
#13
Hailey J Jansen, Motahareh Moghtadaei, Martin Mackasey, Sara A Rafferty, Oleg Bogachev, John L Sapp, Susan E Howlett, Robert A Rose
Atrial fibrillation (AF) is prevalent in aging populations; however not all individuals age at the same rate. Instead, individuals of the same chronological age can vary in health status from fit to frail. Our objective was to determine the impacts of age and frailty on atrial function and arrhythmogenesis in mice using a frailty index (FI). Aged mice were more frail and demonstrated longer lasting AF compared to young mice. Consistent with this, aged mice showed longer P wave duration and PR intervals; however, both parameters showed substantial variability suggesting differences in health status among mice of similar chronological age...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28287088/sfrp5-identifies-murine-cardiac-progenitors-for-all-myocardial-structures-except-for-the-right-ventricle
#14
Masayuki Fujii, Akane Sakaguchi, Ryo Kamata, Masataka Nagao, Yutaka Kikuchi, Silvia M Evans, Masao Yoshizumi, Akihiko Shimono, Yumiko Saga, Hiroki Kokubo
Upon acquirement of pulmonary circulation, the ancestral heart may have been remodelled coincidently with, or accompanied by, the production and rearrangement of progenitor cells. However, the progenitor populations that give rise to the left ventricle (LV) and sinus venosus (SV) are still ambiguous. Here we show that the expression of Secreted frizzled-related protein Sfrp5 in the mouse identifies common progenitors for the outflow tract (OFT), LV, atrium and SV but not the right ventricle (RV). Sfrp5 expression begins at the lateral sides of the cardiac crescent, excluding early differentiating regions, and continues in the venous pole, which gives rise to the SV...
March 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28287029/gender-influence-on-the-adaptation-of-atrial-performance-to-training
#15
Laura Sanchis, Maria Sanz-De La Garza, Bart Bijnens, Genevieve Giraldeau, Gonzalo Grazioli, Josefa Marin, Luigi Gabrielli, Silvia Montserrat, Marta Sitges
BACKGROUND: High-intensity training has been associated with atrial remodelling and arrhythmias in men. Our purpose was to analyse atrial performance in female endurance athletes, compared to male athletes and controls. METHODS: This was a cross-sectional study. We included four groups: female athletes, females controls, male athletes and male controls. Left (LA) and right atrial (RA) volumes and function were assessed using 2D and speckle-tracking echocardiography to determine peak atrial strain-rate at atrial (SRa) and ventricular contraction (SRs), as surrogates of atrial contractile and reservoir function, respectively...
March 13, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28274566/postoperative-atrial-fibrillation-the-role-of-the-inflammatory-response
#16
Yosuke Ishii, Richard B Schuessler, Sydney L Gaynor, Kiyomi Hames, Ralph J Damiano
OBJECTIVE: Abnormal atrial conduction has been shown to be a substrate for postoperative atrial fibrillation (POAF). This study aimed to determine the relationship between the location of the atrial reentry responsible for POAF, and degree of atrial inflammation. METHODS: Normal mongrel dogs (n = 18) were divided into 3 groups: anesthesia alone (anesthesia), lateral right atriotomy (atriotomy), and lateral right atriotomy with anti-inflammatory therapy (steroid)...
February 9, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28268378/development-of-a-novel-probabilistic-algorithm-for-localization-of-rotors-during-atrial-fibrillation
#17
Prasanth Ganesan, Anthony Salmin, Elizabeth M Cherry, Behnaz Ghoraani
Atrial fibrillation (AF) is an irregular heart rhythm that can lead to stroke and other heart-related complications. Catheter ablation has been commonly used to destroy triggering sources of AF in the atria and consequently terminate the arrhythmia. However, efficient and accurate localization of the AF sustaining sources known as rotors is a major challenge in catheter ablation. In this paper, we developed a novel probabilistic algorithm that can adaptively guide a Lasso diagnostic catheter to locate the center of a rotor...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267553/left-and-right-atrial-feature-tracking-in-acute-myocarditis-a-feasibility-study
#18
Anastasia Dick, Björn Schmidt, Guido Michels, Alexander C Bunck, David Maintz, Bettina Baeßler
PURPOSE: The present study aims at evaluating the feasibility and reproducibility of cardiac magnetic resonance (CMR) feature tracking (FT) derived strain and strain rate (SR) parameters of the left and right atrium (LA, RA) in patients with acute myocarditis as well as their potential to detect diastolic dysfunction. In addition, the diagnostic value of LA and RA strain parameters in the setting of acute myocarditis is investigated. METHODS: CMR cine data of 30 patients with CMR-positive acute myocarditis were retrospectively analyzed...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28265208/effectiveness-of-early-invasive-therapy-for-atrial-tachycardia-in-adult-atrial-baffle-survivors
#19
Elisa A Bradley, Ali N Zaidi, Justin Morrison, Curt J Daniels, Steven Kalbfleisch, Naomi J Kertesz
Adults who underwent complex atrial baffling as children via Mustard or Senning procedures are at heightened risk for atrial arrhythmias. Antiarrhythmic therapies are typically ineffective in this population. Accordingly, our team of pediatric and adult electrophysiologists investigated the effectiveness of early invasive transbaffle-access techniques to perform early radiofrequency ablation at the source of these clinically significant arrhythmias. For this retrospective study, we selected 11 adult survivors of atrial baffling (mean age, 34 ± 9 yr) who underwent clinically indicated electrophysiologic study after no more than one trial of antiarrhythmic therapy...
February 2017: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/28255079/frequency-gradient-within-coronary-sinus-predicts-the-long-term-outcome-of-persistent-atrial-fibrillation-catheter-ablation
#20
Xiaomeng Yin, Ziming Zhao, Lianjun Gao, Dong Chang, Xianjie Xiao, Rongfeng Zhang, Qi Chen, Jie Cheng, Yanzong Yang, Yutao Xi, Yunlong Xia
BACKGROUND: The coronary sinus (CS), as a junction of the atria, contributes to atrial fibrillation (AF) by developing unstable reentry, and isolating the atria by ablation at the CS could terminate AF. The present study evaluated whether AF activities at the CS in a subset of patients contributed to AF maintenance and predicted clinical outcome of ablation. METHODS AND RESULTS: We studied 122 consecutive patients who had a first-time radiofrequency ablation for persistent AF...
March 2, 2017: Journal of the American Heart Association
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