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https://www.readbyqxmd.com/read/29691652/distribution-and-co-localization-of-diversified-natriuretic-peptides-in-the-eel-heart
#1
Yoshio Takei, Noriko Nemoto, Toru Kameya, Hideaki Tamaki, Osamu Katsumata, Susumu Hyodo, Makoto Kusakabe
Atrial and B-type natriuretic peptides (ANP and BNP) are cardiac hormones important for cardiovascular and body fluid regulation. In some teleost species, an additional member of the natriuretic peptide family, ventricular NP (VNP), has been identified. In this study, we examine tissue distribution of these three NPs in the eel heart. Quantitative real-time PCR showed that anp is almost exclusively expressed in atria, bnp equally in atria and ventricles and vnp three-fold more in ventricles than in atria. The amount of bnp transcript overall in the heart was 1/10 those of anp and vnp...
April 25, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29688325/anatomical-hotspots-of-fractionated-electrograms-in-the-left-and-right-atrium-do-they-exist
#2
Roeliene Starreveld, Lisette J M E van der Does, Natasja M S de Groot
Aims: Targeting of complex fractionated electrograms (CFEs) in the atria is not yet beneficial in treating drug-refractory atrial fibrillation (AF). In order to gain insight into potential anatomical hotspots of fractionated electrograms, a structured literature search was performed. Methods and results: PubMed was searched for studies describing fractionation during human atrial electrophysiological measurements (n = 565), of which 36 articles described the pre-ablation distribution of fractionated electrograms for the left atrium and/or right atrium in at least four regions...
April 20, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29684589/hydrogen-sulfide-donor-nahs-stimulates-anp-secretion-via-the-k-atp-channel-and-the-nos-sgc-pathway-in-rat-atria
#3
Lamei Yu, Byung Mun Park, Yong Jin Ahn, Gi-Ja Lee, Suhn Hee Kim
Hydrogen sulfide (H2 S) is normally produced from L-cysteine in mammalian tissues and related to the pathogenesis of cardiovascular diseases. The aim of this study is to investigate the effects of H2 S donor on atrial natriuretic peptide (ANP) secretion and define its mechanism using normal and isoproterenol (ISP)-treated rats. Several H2 S donors were perfused into isolated beating rat atria, and atrial pressure (AP) and ANP secretion were measured. NaHS augmented high stretch-induced ANP secretion and decreased AP in a dose-dependent manner...
April 20, 2018: Peptides
https://www.readbyqxmd.com/read/29678813/prognostic-significance-of-nuisance-bleeding-in-anticoagulated-patients-with-atrial-fibrillation
#4
Emily C O'Brien, DaJuanicia N Holmes, Laine E Thomas, Gregg C Fonarow, Larry A Allen, Bernard J Gersh, Peter R Kowey, Daniel E Singer, Michael D Ezekowitz, Gerald V Naccarelli, Jack E Ansell, Paul S Chan, Kenneth W Mahaffey, Alan S Go, James V Freeman, James A Reiffel, Eric D Peterson, Jonathan P Piccini, Elaine M Hylek
Background -Bleeding is commonly cited as a reason for stopping oral anticoagulants (OAC). Whether minor bleeding events ("nuisance bleeding", NB) in patients with atrial fibrillation (AF) on OAC are associated with OAC discontinuation, major bleeding and stroke/systemic embolism (SSE), is unknown. Methods -Within the ORBIT-AF prospective, outpatient registry, we identified 6771 patients ≥18 years of age at 172 sites with AF and eligible followup visits. NB was ascertained from the medical record and was defined as minor bleeding that did not require medical attention (e...
April 20, 2018: Circulation
https://www.readbyqxmd.com/read/29677224/dental-shade-guide-variability-for-hues-b-c-and-d-using-cross-polarized-photography
#5
Camila S Sampaio, Jon Gurrea, Marta Gurrea, August Bruguera, Pablo J Atria, Malvin Janal, Estevam A Bonfante, Paulo G Coelho, Ronaldo Hirata
This study evaluated the color variability of hues B, C, and D between the VITA Classical shade guide (Vita Zahnfabrik) and four other VITA-coded ceramic shade guides using a digital camera (Canon EOS 60D) and computer software (Adobe Photoshop CC). A cross-polarizing filter was used to standardize external light sources influencing color match. A total of 275 pictures were taken, 5 per shade tab, for 11 shades (B1, B2, B3, B4, C1, C2, C3, C4, D2, D3, and D4), from the following shade guides: VITA Classical (control); IPS e...
April 20, 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29673908/mechanism-underlying-the-contractile-activity-of-utp-in-the-mammalian-heart
#6
Ulrich Gergs, Daniel Rothkirch, Britt Hofmann, Hendrik Treede, Bernard Robaye, Andreas Simm, Christa E Müller, Joachim Neumann
We previously reported that uridine 5'-triphosphate (UTP), a pyrimidine nucleoside triphosphate produced a concentration- and time-dependent increase in the contraction force in isolated right atrial preparations from patients undergoing cardiac bypass surgery due to angina pectoris. The stimulation of the force of contraction was sustained rather than transient. In the present study, we tried to elucidate the underlying receptor and signal transduction for this effect of UTP. Therefore, we measured the effect of UTP on force of contraction, phosphorylation of p38 and ERK1/2, in human atrial preparations, atrial preparations from genetically modified mice, cardiomyocytes from adult mice and cardiomyocytes from neonatal rats...
April 16, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29673050/postnatal-persistence-of-fetal-cardiovascular-remodeling-associated-with-assisted-reproductive-technologies-a-cohort-study
#7
Brenda Valenzuela-Alcaraz, Audrey Serafini, Alvaro Sepulveda-Martínez, Gemma Casals, Merida Rodríguez-López, Laura Garcia-Otero, Monica Cruz-Lemini, Bart Bijnens, Marta Sitges, Juan Balasch, Eduard Gratacos, Fatima Crispi
OBJECTIVE: to assess the postnatal persistence of fetal cardiovascular remodeling associated to assisted reproductive technologies (ART), in children at 3 years of age. DESIGN: A cohort study of children conceived by ART. SETTING: Maternal-Fetal Medicine Unit, Hospital Clinic Barcelona, Spain. POPULATION SAMPLE: 80 singleton pregnancies conceived by ART and 80 spontaneously conceived (controls) followed from fetal life up to childhood...
April 19, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29671888/whole-exome-sequencing-reveals-microsatellites-dna-markers-for-response-to-dofetilide-initiation-in-patients-with-persistent-atrial-fibrillation-a-pilot-study
#8
Nick Kinney, Timothy R Larsen, David M Kim, Robin T Varghese, Steven Poelzing, Harold R Garner, Soufian T AlMahameed
BACKGROUND: Dofetilide is a class III antiarrhythmic drug effective for the treatment of atrial fibrillation (AF). Dofetilide initiation (DI) associate with corrected QT (QTc) interval prolongation. Significant QTc prolongation during DI mandates dose adjustment or discontinuation of the drug. Microsatellite DNA are novel genetic markers associate with congenital and acquired health conditions. OBJECTIVE: The purpose of this study was to explore potential genetic markers for QTc prolongation in response to DI in patients with persistent AF METHODS: We performed Whole Exome sequencing in a cohort of patients with persistent AF undergoing DI...
April 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29666184/atp-sensitive-potassium-channels-in-the-sinoatrial-node-contribute-to-heart-rate-control-and-adaptation-to-hypoxia
#9
Qadeer Aziz, Malcolm Finlay, David Montaigne, Leona Ojake, Yiwen Li, Naomi Anderson, Andreas Ludwig, Andrew Tinker
ATP-sensitive potassium channels (KATP ) contribute to membrane currents in many tissues, are responsive to intracellular metabolism, and open as ATP falls and ADP rises. KATP channels are widely distributed in tissues and are prominently expressed in the heart. They have generally been observed in ventricular tissue, but they are also expressed in the atria and conduction tissues. In this study, we focused on the contribution and role of the inwardly rectifying KATP channel subunit, Kir6.1, in the sinoatrial node (SAN)...
April 17, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29663449/mild-hypothermia-33%C3%A2-c-increases-the-inducibility-of-atrial-fibrillation-an-in-vivo-large-animal-model-study
#10
Martin Manninger, Alessio Alogna, David Zweiker, Birgit Zirngast, Stefan Reiter, Viktoria Herbst, Heinrich Maechler, Burkert M Pieske, Frank R Heinzel, Helmut Brussee, Heiner Post, Daniel Scherr
OBJECTIVE: Application of therapeutic mild hypothermia in patients after resuscitation, often accompanied by myocardial infarction, cardiogenic shock and systemic inflammation may impact on cardiac rhythm. We therefore tested susceptibility to atrial arrhythmias during hyperthermia (HT, 40.5°C), normothermia (NT, 38.0°C) and mild hypothermia (MH, 33.0°C). METHODS: Nine healthy, anesthetized closed-chest landrace pigs were instrumented with a quadripolar stimulation catheter in the high right atrium and a decapolar catheter in the coronary sinus...
April 16, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29659778/impact-of-diabetes-mellitus-on-the-contractile-properties-of-the-left-and-right-atrial-myofilaments
#11
Constanze Bening, Khaled Alhussini, Elena-Aura Mazalu, Jonathan Yaqub, Khaled Hamouda, Dejan Radakovic, Christoph Schimmer, Grzegorz Hirnle, Rainer Leyh
OBJECTIVES: The incidence of diabetes mellitus in patients with ischaemic cardiomyopathy is increasing. To evaluate the impact of diabetes mellitus on contractility, we examined the calcium-induced force in left and right atrial myofilaments of patients with and without diabetes. METHODS: We included 149 patients (106 without diabetes, 43 with diabetes), scheduled for elective coronary artery bypass grafting from August 2016 to June 2017. The left and right atria were excised and prepared for skinned fibre measurements (pCa-force curve)...
April 12, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29659148/hydrogen-sulphide-increases-pulmonary-veins-and-atrial-arrhythmogenesis-with-activation-of-protein-kinase-c
#12
Chao-Shun Chan, Yung-Kuo Lin, Yu-Hsun Kao, Yao-Chang Chen, Shih-Ann Chen, Yi-Jen Chen
Hydrogen sulphide (H2 S), one of the most common toxic air pollutants, is an important aetiology of atrial fibrillation (AF). Pulmonary veins (PVs) and left atrium (LA) are the most important AF trigger and substrate. We investigated whether H2 S may modulate the arrhythmogenesis of PVs and atria. Conventional microelectrodes and whole-cell patch clamp were performed in rabbit PV, sinoatrial node (SAN) or atrial cardiomyocytes before and after the perfusion of NaHS with or without chelerythrine (a selective PKC inhibitor), rottlerin (a specific PKC δ inhibitor) or KB-R7943 (a NCX inhibitor)...
April 16, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29653089/modification-of-levosimendan-induced-suppression-of-atrial-natriuretic-peptide-secretion-in-hypertrophied-rat-atria
#13
Lamei Yu, Kuichang Yuan, Byung Mun Park, Suhn Hee Kim
This study aimed to determine the effects of levosimendan, a calcium sensitizer, on atrial contractility and atrial natriuretic peptide (ANP) secretion and its modification in hypertrophied atria. Isolated perfused beating rat atria were used from control and isoproterenol-treated rats. Levosimendan and its metabolite OR-1896 caused a positive inotropic effect and suppressed ANP secretion in rat atria. Similar to levosimendan, the selective phosphodiesterase 3 (PDE3) or PDE4 inhibitor also suppressed ANP secretion...
April 10, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29622589/genome-wide-associations-of-global-electrical-heterogeneity-ecg-phenotype-the-aric-atherosclerosis-risk-in-communities-study-and-chs-cardiovascular-health-study
#14
Larisa G Tereshchenko, Nona Sotoodehnia, Colleen M Sitlani, Foram N Ashar, Muammar Kabir, Mary L Biggs, Michael P Morley, Jonathan W Waks, Elsayed Z Soliman, Alfred E Buxton, Tor Biering-Sørensen, Scott D Solomon, Wendy S Post, Thomas P Cappola, David S Siscovick, Dan E Arking
BACKGROUND: ECG global electrical heterogeneity (GEH) is associated with sudden cardiac death. We hypothesized that a genome-wide association study would identify genetic loci related to GEH. METHODS AND RESULTS: We tested genotyped and imputed variants in black (N=3057) and white (N=10 769) participants in the ARIC (Atherosclerosis Risk in Communities) study and CHS (Cardiovascular Health Study). GEH (QRS-T angle, sum absolute QRST integral, spatial ventricular gradient magnitude, elevation, azimuth) was measured on 12-lead ECGs...
April 5, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29615932/synaptic-plasticity-in-cardiac-innervation-and-its-potential-role-in-atrial-fibrillation
#15
REVIEW
Jesse L Ashton, Rebecca A B Burton, Gil Bub, Bruce H Smaill, Johanna M Montgomery
Synaptic plasticity is defined as the ability of synapses to change their strength of transmission. Plasticity of synaptic connections in the brain is a major focus of neuroscience research, as it is the primary mechanism underpinning learning and memory. Beyond the brain however, plasticity in peripheral neurons is less well understood, particularly in the neurons innervating the heart. The atria receive rich innervation from the autonomic branch of the peripheral nervous system. Sympathetic neurons are clustered in stellate and cervical ganglia alongside the spinal cord and extend fibers to the heart directly innervating the myocardium...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29615521/contribution-of-active-atrial-contraction-to-cardiac-output-in-anesthetized-american-alligators-alligator-mississippiensis
#16
William Joyce, Janna Crossley, Ruth M Elsey, Tobias Wang, Dane A Crossley
Ventricular filling may occur directly from the venous circulation during early diastole or via atrial contraction in late diastole. The contribution of atrial contraction to ventricular filling is typically small in mammals (10-40%), but has been suggested to predominate in reptiles. We investigated the importance of atrial contraction in filling of the ventricle in American alligators ( Alligator mississippiensis ) by bypassing both atria (with the use of ligatures to prevent atrial filling) and measuring the resultant effects on cardiac output in anesthetized animals...
April 3, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29608504/inter-atrial-shunting-a-novel-device-based-therapy-for-patients-with-heart-failure
#17
Brian Kw Yum, William H Frishman
Heart failure patients with either reduced ejection fraction (HFrEF) or preserved ejection fraction (HFpEF) experience a high mortality rate. The most recent pharmacologic advance for treating patients with HFrEF has been with sacubitril/valsartan. Along with pharmaceutical research, there has been interest in device-based therapies as another treatment approach. One novel interventional device therapy that has shown promise in early tests and trials is the inter-atrial shunt device developed by Corvia Medical Inc...
March 30, 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29604419/the-role-of-nt-proanp-and-nt-probnp-in-af-patients-association-with-af-progression-phenotypes
#18
Petra Büttner, Katja Schumacher, Borislav Dinov, Samira Zeynalova, Philipp Sommer, Andreas Bollmann, Daniela Husser, Gerhard Hindricks, Jelena Kornej
BACKGROUND: Electro-anatomical remodeling in atrial fibrillation (AF) leads to disease initiation and perpetuation. While atrial natriuretic peptide (ANP) is specifically expressed in the atria and is involved in atrial remodeling, B-type natriuretic peptide (BNP) is associated with mortality and cardiovascular events in AF. OBJECTIVE: To investigate association between NT-proBNP and NT-proANP levels with three AF progression phenotypes: persistent AF, left atrial diameter (LAD) dilatation and left atrial low voltage areas (LVA)...
March 28, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29600407/what-is-this-image-2018-image-6-result-cardiac-fdg-uptake-predominantly-affecting-the-atria
#19
Sarah Cuddy, Barbara J McNeil, Ayaz Aghayev, Sharmila Dorbala
No abstract text is available yet for this article.
March 29, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29598867/role-of-stress-kinase-jnk-in-binge-alcohol-evoked-atrial-arrhythmia
#20
Jiajie Yan, Justin K Thomson, Weiwei Zhao, Xianlong Gao, Fei Huang, Biyi Chen, Qingrong Liang, Long-Sheng Song, Michael Fill, Xun Ai
BACKGROUND: Excessive binge alcohol drinking has acute cardiac arrhythmogenic effects, including promotion of atrial fibrillation (AF), which underlies "Holiday Heart Syndrome." The mechanism that couples binge alcohol abuse with AF susceptibility remains unclear. We previously reported stress-activated c-Jun N-terminal kinase (JNK) signaling contributes to AF development. This is interesting because JNK is implicated in alcohol-caused organ malfunction beyond the heart. OBJECTIVES: The purpose of this study was to detail how JNK promotes binge alcohol-evoked susceptibility to AF...
April 3, 2018: Journal of the American College of Cardiology
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