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https://www.readbyqxmd.com/read/28546098/altered-long-non-coding-rna-expression-profile-in-rabbit-atria-with-atrial-fibrillation-tcons_00075467-modulates-atrial-electrical-remodeling-by-sponging-mir-328-to-regulate-cacna1c
#1
Zhan Li, Ximin Wang, Weizong Wang, Juanjuan Du, Jinqiu Wei, Yong Zhang, Jiangrong Wang, Yinglong Hou
Electrical remodeling has been reported to play a major role in the initiation and maintenance of atrial fibrillation (AF). Long non-coding RNAs (lncRNAs) have been increasingly recognized as contributors to the pathology of heart diseases. However, the roles and mechanisms of lncRNAs in electrical remodeling during AF remain unknown. In this study, the lncRNA expression profiles of right atria were investigated in AF and non-AF rabbit models by using RNA sequencing technique and validated using quantitative real-time polymerase chain reaction (qRT-PCR)...
May 22, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28545623/genetic-determinants-of-hereditary-bradyarrhythmias-a-contemporary-review-of-a-diverse-group-of-disorders
#2
REVIEW
Saman Rezazadeh, Henry J Duff
Bradyarrhythmia is a common clinical presentation. Although the majority of cases are acquired, genetic screening of families with bradyarrhythmia has led to the discovery of a growing number of causative hereditary mutations. These mutations can interfere with any of the steps required for the occurrence of each cardiac cycle, including generation of an action potential in the sinoatrial node, successful exit of the action potential from the node, propagation of the action potential throughout the atria until the depolarization waves reach the atrioventricular node, and finally transmission of the action potential to the ventricles through the His-Purkinje system...
June 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28544313/neuropeptide-y-npy-inhibits-spontaneous-contraction-of-the-mouse-atrium-by-possible-activation-of-the-npy1-receptor
#3
Y Oki, H Teraoka, T Kitazawa
Neuropeptide Y (NPY) causes various central and peripheral actions through activation of G-protein-coupled NPY receptors. Although a species-dependent difference in cardiac actions of NPY has been reported, the responses to NPY have not been examined in mice, widely used experimental animals. This study aimed to clarify the responses to NPY and the receptor subtype involved in the responses in mouse atrium. Neuropeptide Y caused negative inotropic and negative chronotropic actions in spontaneous beating right atria...
March 2017: Autonomic & Autacoid Pharmacology
https://www.readbyqxmd.com/read/28541896/solving-inaccuracies-in-anatomical-models-for-electrocardiographic-inverse-problem-resolution-by-maximizing-reconstruction-quality
#4
Miguel Rodrigo, Andreu Climent, Alejandro Liberos, Ismael Hernandez-Romero, Angel Arenal, Javier Bermejo, Francisco Fernandez-Aviles, Felipe Atienza, Maria Guillem
Electrocardiographic Imaging (ECGI) has become an increasingly used technique for non-invasive diagnosis of cardiac arrhythmias, although the need for medical imaging technology to determine the anatomy hinders its introduction in the clinical practice. This work explores the ability of a new metric based on the inverse reconstruction quality for the location and orientation of the atrial surface inside the torso. Body surface electrical signals from 31 realistic mathematical models and four AF patients were used to estimate the optimal position of the atria inside the torso...
May 23, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28536114/chocolate-and-prevention-of-atrial-fibrillation-what-is-bad-for-the-pancreas-might-be-good-for-the-atria
#5
EDITORIAL
Sean D Pokorney, Jonathan P Piccini
No abstract text is available yet for this article.
May 23, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28535942/gallic-acid-increases-atrial-natriuretic-peptide-secretion-and-mechanical-dynamics-through-activation-of-pkc
#6
Xia Liu, Ying Zhang, Lan Hong, Chun-Ji Han, Bo Zhang, Shuai Zhou, Cheng-Zhe Wu, Li-Ping Liu, Xun Cui
AIMS: Gallic acid (GA) protects against myocardial ischemia-reperfusion (I/R) injury, prevents cardiac hypertrophy and fibrosis, and has anti-inflammatory activity in the heart. However, its effects in regulating atrial natriuretic peptide (ANP) secretion are unknown. The aim of this study was to determine the function of GA in regulating ANP secretion and atrial dynamics in rat atria. KEY FINDINGS: GA (0.01, 0.05, and 0.1μmol/L) significantly increased atrial ANP secretion and induced positive inotropy dose-dependently...
May 20, 2017: Life Sciences
https://www.readbyqxmd.com/read/28534025/atrial-fibrillation-dynamics-and-ionic-block-effects-in-six-heterogeneous-human-3d-virtual-atria-with-distinct-repolarization-dynamics
#7
Carlos Sánchez, Alfonso Bueno-Orovio, Esther Pueyo, Blanca Rodríguez
Atrial fibrillation (AF) usually manifests as reentrant circuits propagating through the whole atria creating chaotic activation patterns. Little is yet known about how differences in electrophysiological and ionic properties between patients modulate reentrant patterns in AF. The goal of this study is to quantify how variability in action potential duration (APD) at different stages of repolarization determines AF dynamics and their modulation by ionic block using a set of virtual whole-atria human models...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28529049/heterogeneity-of-transverse-axial-tubule-system-in-mouse-atria-remodeling-in-atrial-specific-na-ca-2-exchanger-knockout-mice
#8
Xin Yue, Rui Zhang, Brian Kim, Aiqun Ma, Kenneth D Philipson, Joshua I Goldhaber
Transverse-axial tubules (TATs) are commonly assumed to be sparse or absent in atrial myocytes from small animals. Atrial myocytes from rats, cats and rabbits lack TATs, which results in a characteristic "V"-shaped Ca release pattern in confocal line-scan recordings due to the delayed rise of Ca in the center of the cell. To examine TAT expression in isolated mouse atrial myocytes, we loaded them with the membrane dye Di-4-ANEPPS to label TATs. We found that >80% of atrial myocytes had identifiable TATs...
May 19, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28524623/upper-gastrointestinal-complications-following-ablation-therapy-for-atrial-fibrillation
#9
S-Y Park, M Camilleri, D Packer, K Monahan
BACKGROUND: Following ablation therapy for cardiac arrhythmias, patients may develop upper gastrointestinal (UGI) symptoms. The vagus nerve is close to the atria and may be affected by ablating energy. AIM: To identify structural or functional complications in UGI tract following ablation for atrial fibrillation (AF) and clinical outcomes and association with vagal dysfunction. METHODS: Using natural language processing of electronic medical records and an AF ablation database of 5380 patients treated during 17 years, we identified 40 patients with UGI complications...
May 19, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28523323/discovery-of-a-new-mutation-in-the-desmin-gene-in-a-young-patient-with-cardiomyopathy-and-muscular-weakness
#10
Ruxandra Oana JurcuŢ, Alexandra Eugenia Bastian, Sebastian Militaru, Aura Popa, Emilia Manole, Bogdan Alexandru Popescu, Jonna Tallila, Bogdan Ovidiu Popescu, Carmen Doina Ginghină
A 25-year-old woman with a five years history of syncope, mild left ventricular hypertrophy and moderately enlarged atria, was diagnosed with third degree atrioventricular heart block alternating with atrioventricular heart block 2:1, and received a dual chamber pacemaker. After three years of evolution, she developed atrial fibrillation, marked biatrial enlargement, severely depressed longitudinal myocardial velocities, associated with mild girdle weakness and slight increase in creatine kinase level. The diagnosis of restrictive cardiomyopathy with mild skeletal myopathy imposed the screening for a common etiology...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28522161/effect-of-blue-and-violet-light-on-polymerization-shrinkage-vectors-of-a-cq-tpo-containing-composite
#11
Camila S Sampaio, Pablo J Atria, Frederick A Rueggeberg, Satoshi Yamaguchi, Marcelo Giannini, Paulo G Coelho, Ronaldo Hirata, Regina M Puppin-Rontani
OBJECTIVE: To evaluate the effect of light-curing wavelengths on composite filler particle displacement, and thus to visualize localized polymerization shrinkage in a resin-based composite (RBC) containing camphorquinone (CQ) and Lucirin TPO (TPO). METHODS: Three light-curing units (LCUs) were used to light-cure a RBC containing CQ and TPO: a violet-only, a blue-only, and a dual-wavelength, conventional (Polywave(®), emitting violet and blue wavelengths simultaneously)...
May 15, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28512679/multiphysics-modeling-of-the-atrial-systole-under-standard-ablation-strategies
#12
Julia M Hörmann, Cristóbal Bertoglio, Andreas Nagler, Martin R Pfaller, Felix Bourier, Martin Hadamitzky, Isabel Deisenhofer, Wolfgang A Wall
The aim of this study was to develop a computational framework to compare the impact of standard ablation concepts on the mechanical performance of the atria, since different line combinations cannot be applied in practice to the same patient. For this purpuse, we coupled electro-mechano-hemodynamic mathematical models based on biophysical principles and simulate the contractile performance of the atria. We computed systolic pressures and volumes in two patient-specific atrial geometries (one of normal size and one hypertrophied) with various ablation concepts...
June 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28508519/fetal-cardiac-remodeling-in-twin-pregnancies-conceived-by-assisted-reproductive-technologies
#13
Brenda Valenzuela-Alcaraz, Mónica Cruz-Lemini, Mérida Rodríguez-López, Ana Goncé, Laura García-Otero, Helena Ayuso, Marta Sitges, Bart Bijnens, Juan Balasch, Eduard Gratacós, Fátima Crispi
BACKGROUND: Recent data suggest that singleton fetuses conceived by assisted reproductive technologies (ART) present cardiovascular remodeling that may persist postnatally. Twin pregnancies are more frequent in the ART population, and are associated with increased adverse perinatal outcomes like hypertensive disorders, gestational diabetes and preterm birth. However, it is unknown whether cardiac remodeling is also present in twin pregnancies conceived by ART. Our aim was to assess the presence of fetal cardiac remodeling and dysfunction in twin pregnancies conceived by ART, as compared to spontaneously conceived (SC) ones...
May 15, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28501068/preliminary-evidence-for-the-complete-digital-esthetic-rehabilitation-treatment-case-report-and-1-year-follow-up
#14
Pablo J Atria, Camila S Sampaio, Ronaldo Hirata, Gilbert Jorquera
PURPOSE: To show through computer-aided design and manufacturing technology combined with novel digital acquisition images and the right restorative material that the technology can provide an easier and predictable workflow for general practitioners. BASIC PROCEDURE: This case report presents a fully digital treatment of a 59-year-old patient with tooth-supported crowns and provides a detailed step-by-step digital technique to obtain a successful result. CONCLUSION: By avoiding traditional impression and fixed prosthetic techniques, excellent clinical results can be obtained, minimizing the required steps and simplifying the overall procedure...
June 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/28498436/exposure-to-a-chronic-high-fat-diet-promotes-atrial-structure-and-gap-junction-remodeling-in-rats
#15
Tianyu Meng, Gong Cheng, Yuejiao Wei, Shuting Ma, Yongrong Jiang, Jine Wu, Xin Zhou, Chaofeng Sun
Obesity has been demonstrated to be linked to atrial fibrillation (AF) with atrial enlargement and tissue fibrosis. Long-term high calorie intake is the main reason for the prevalence of obesity. To investigate the possible causes of AF, such as chronic high-fat diet (HFD), and to identify the underlying mechanisms, the present study analyzed a variety of structural and gap junctional electrophysiological alterations in the atria of female rats fed an HFD. After consistent HFD feeding of female rats for 12 weeks, hematoxylin and eosin (H&E) and Masson's staining, RT-qPCR, western blotting, immunofluorescence and TUNEL staining were performed...
May 9, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28490279/doka-k-j-2016-grief-is-a-journey-finding-your-path-through-loss-doka-k-j-2016-grief-is-a-journey-finding-your-path-through-loss-new-york-ny-atria-books-292-pp-26-00-hardbound-isbn-978-1-4767-7148-9
#16
https://www.readbyqxmd.com/read/28484965/the-protective-role-of-small-heat-shock-proteins-in-cardiac-diseases-key-role-in-atrial-fibrillation
#17
Xu Hu, Denise M S Van Marion, Marit Wiersma, Deli Zhang, Bianca J J M Brundel
Atrial fibrillation (AF) is the most common tachyarrhythmia which is associated with increased morbidity and mortality. AF usually progresses from a self-terminating paroxysmal to persistent disease. It has been recognized that AF progression is driven by structural remodeling of cardiomyocytes, which results in electrical and contractile dysfunction of the atria. We recently showed that structural remodeling is rooted in derailment of proteostasis, i.e., homeostasis of protein production, function, and degradation...
May 8, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28480585/synthesis-and-biological-evaluation-of-new-combined-%C3%AE-%C3%AE-adrenergic-blockers
#18
Andrej Némethy, Peter Vavrinec, Diana Vavrincová-Yaghi, Diana Čepcová, Svetozár Mišúth, Eva Král'ová, Ružena Čižmáriková, Eva Račanská
The synthesis, characterization, and pharmacological evaluation of new aryloxyaminopropanol compounds based on substituted (4-hydroxyphenyl)ethanone with alterations in the alkoxymethyl side chain in position 2 and with 2-methoxyphenylpiperazine in the basic part of the molecule are reported. For the in vitro pharmacological evaluation, isolated aorta and atria from normotensive Wistar rats were used. Compared to naftopidil, compounds with ethoxymethyl, propoxymethyl, butoxymethyl, and methoxyethoxymethyl substituent displayed similar α1 -adrenolytic potency...
May 8, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/28476219/dose-to-heart-substructures-is-associated-with-non-cancer-death-after-sbrt-in-stage-i-ii-nsclc-patients
#19
Barbara Stam, Heike Peulen, Matthias Guckenberger, Frederick Mantel, Andrew Hope, Maria Werner-Wasik, Jose Belderbos, Inga Grills, Nicolette O'Connell, Jan-Jakob Sonke
BACKGROUND AND PURPOSE: To investigate potential associations between dose to heart (sub)structures and non-cancer death, in early stage non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiation therapy (SBRT). METHODS: 803 patients with early stage NSCLC received SBRT with predominant schedules of 3×18Gy (59%) or 4×12Gy (19%). All patients were registered to an average anatomy, their planned dose deformed accordingly, and dosimetric parameters for heart substructures were obtained...
May 2, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28475580/neural-substrate-of-posterior-left-atrium-a-novel-modulation-for-inducibility-and-remodeling-of-atrial-fibrillation-in-canine
#20
Mu Qin, Li Li, Xu Liu, Tao Liu, Shao Bo Shi
BACKGROUND: The neural mechanism of posterior left atrium (PLA) for genesis of atrial fibrillation has not been completely elucidated. We sought to assess the contribution of PLA denervation on atrial fibrillation (AF) inducibility and atrial remodeling. METHODS AND RESULTS: After left thoracotomy in anesthetized dogs (n = 32), electrode catheters were attached to the PLA, left atrial roof, left pulmonary vein and left atrial appendage. Experiment 1 (n = 16): Vagal stimulation (VS group, n = 8) led to more pronounced ERP shortening in PLA than in other sites (CTL:71±7 ms vs VS: 52±6 ms, P<0...
2017: PloS One
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