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https://www.readbyqxmd.com/read/29344353/effects-of-tnf-receptor-blockade-on-in-vitro-cell-survival-and-response-to-negative-energy-balance-in-dairy-cattle
#1
C A Martel, L K Mamedova, J E Minton, M Garcia, C Legallet, B J Bradford
Background: Associative data and some controlled studies suggest that the inflammatory cytokine tumor necrosis factor (TNF) α can induce fatty liver in dairy cattle. However, research demonstrating that TNFα is a necessary component in the etiology of bovine fatty liver is lacking. The aim of this work was to evaluate whether blocking TNFα signaling with a synthetic cyclic peptide (TNF receptor loop peptide; TRLP) would improve liver metabolic function and reduce triglyceride accumulation during feed restriction...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29330817/effect-of-levofloxacin-pazufloxacin-enrofloxacin-and-meloxicam-on-the-immunolocalization-of-abcg-2-transporter-protein-in-rabbit-retina
#2
Adil Mehraj Khan, Satyavan Rampal, Naresh Kumar Sood
Adenosine triphosphate-binding cassette (ABC) sub-family G member-2 (ABCG-2) is a transporter protein, implicated for multi-drug efflux from tissues. This study evaluated the effect of fluoroquinolones; levofloxacin, pazufloxacin and enrofloxacin, and non-steroidal anti-inflammatory drug, meloxicam; on the immunolocalization of ABCG-2 transporter protein of rabbit retinas. Thirty-two male rabbits were randomly divided in to eight groups. Control group was gavaged, 2% benzyl alcohol in 5% dextrose since these chemicals are excipients of the drug preparations used in the treatment groups of this study...
January 12, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29322434/protection-from-reperfusion-injury-with-intracoronary-n-acetylcysteine-in-patients-with-stemi-undergoing-primary-percutaneous-coronary-intervention-in-a-cardiac-tertiary-center
#3
Younes Nozari, Azadeh Eshraghi, Azita Hajhossein Talasaz, Mostafa Bahremand, Jamshid Salamzadeh, Mojtaba Salarifar, Hamidreza Pourhosseini, Arash Jalali, Seyedeh Hamideh Mortazavi
BACKGROUND: Evidence suggests that oxidative stress plays a principal role in myocardial damage following ischemia/reperfusion events. Recent studies have shown that the antioxidant properties of N-acetylcysteine (NAC) may have cardioprotective effects in high doses, but-to the best of our knowledge-few studies have assessed this. OBJECTIVES: Our objective was to investigate the impact of high-dose NAC on ischemia/reperfusion injury. METHODS: We conducted a randomized double-blind placebo-controlled trial in which 100 consecutive patients with ST-elevation myocardial infarction undergoing percutaneous coronary intervention (PCI) were randomly assigned to the case group (high-dose NAC 100 mg/kg bolus followed by intracoronary NAC 480 mg during PCI then intravenous NAC 10 mg/kg for 12 h) or the control group (5% dextrose)...
January 10, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29302623/molecular-characterization-of-environmental-cladosporium-species-isolated-from-iran
#4
I Ghiaie Asl, M Motamedi, G R Shokuhi, N Jalalizand, A Farhang, H Mirhendi
Background and Purpose: Cladosporium species are ubiquitous, saprobic, dematiaceous fungi, only infrequently associated with human and animal opportunistic infections. Materials and Methods: Airborne samples were collected using the settle plate method, and soil samples were obtained from a depth of 5-10 cm of the superficial soil layer. Samples were cultured on Sabouraud dextrose agar (SDA) plates, incubated at 25°C, and examined daily for fungal colonies for two to three weeks...
March 2017: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/29290890/intravenous-fluid-selection-rationales-in-acute-clinical-management
#5
Wing Yan Shirley Cheung, Wai Kwan Cheung, Chun Ho Lam, Yeuk Wai Chan, Hau Ching Chow, Ka Lok Cheng, Yau Hang Wong, Chak Wah Kam
BACKGROUND: Intravenous fluid (IVF) is commonly used in acute clinical management. This study aimed to review the choice and primary considerations in IVF prescriptions and to evaluate the adequacy of guidelines and trainings on it in the New Territories West Cluster (NTWC) of Hong Kong. METHODS: This is a descriptive study based on data collected from an online survey. Data were processed by SPSS for statistical analysis. This study focused on a general description and doctor-nurse between group comparison...
2018: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29273611/physical-compatibility-of-fosfomycin-for-injection-with-select-i-v-drugs-during-simulated-y-site-administration
#6
Marguerite L Monogue, Safa S Almarzoky Abuhussain, Joseph L Kuti, David P Nicolau
PURPOSE: The results of a study to determine the physical compatibility of ZTI-01 (fosfomycin for injection) in 0.9% sodium chloride or 5% dextrose during simulated Y-site administration with 37 i.v. antimicrobials and 58 nonantimicrobials are reported. METHODS: Fosfomycin, an epoxide antibiotic with broad-spectrum activity against multidrug-resistant bacteria, is marketed in the United States only in an oral formulation with limited bioavailability, but an i.v...
January 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29261735/docosahexaenoic-acid-but-not-eicosapentaenoic-acid-improves-septic-shock-induced-arterial-dysfunction-in-rats
#7
Alexandra Boivin, Mélanie Burban, Raphaël Clere-Jehl, Pierrick Le Borgne, Hamid Merdji, Cyril Auger, Valérie Schini-Kerth, Ferhat Meziani, Julie Helms
INTRODUCTION: Long chain n-3 fatty acid supplementation may modulate septic shock-induced host response to pathogen-induced sepsis. The composition of lipid emulsions for parenteral nutrition however remains a real challenge in intensive care, depending on their fatty acid content. Because they have not been assessed yet, we aimed at determining the respective effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) during septic shock-induced vascular dysfunction. METHODS: In a peritonitis-induced septic shock model, rats were infused with EPA, DHA, an EPA/DHA mixture or 5% dextrose (D5) during 22 hours...
2017: PloS One
https://www.readbyqxmd.com/read/29226148/transition-from-deep-regional-blocks-toward-deep-nerve-hydrodissection-in-the-upper-body-and-torso-method-description-and-results-from-a-retrospective-chart-review-of-the-analgesic-effect-of-5-dextrose-water-as-the-primary-hydrodissection-injectate-to-enhance
#8
Stanley K H Lam, Kenneth Dean Reeves, An-Lin Cheng
Deep nerve hydrodissection uses fluid injection under pressure to purposely separate nerves from areas of suspected fascial compression, which are increasingly viewed as potential perpetuating factors in recalcitrant neuropathic pain/complex regional pain. The usage of 5% dextrose water (D5W) as a primary injectate for hydrodissection, with or without low dose anesthetic, could limit anesthetic-related toxicity. An analgesic effect of 5% dextrose water (D5W) upon perineural injection in patients with chronic neuropathic pain has recently been described...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29222967/stimulation-of-the-endogenous-incretin-glucose-dependent-insulinotropic-peptide-by-enteral-dextrose-improves-glucose-homeostasis-and-inflammation-in-murine-endotoxemia
#9
Faraaz Ali Shah, Srikanth Singamsetty, Lanping Guo, Byron W Chuan, Sherie McDonald, Bryce A Cooper, Brett J O'Donnell, Darko Stefanovski, Burton Wice, Yingze Zhang, Christopher P O'Donnell, Bryan J McVerry
Loss of glucose homeostasis during sepsis is associated with increased organ dysfunction and higher mortality. Novel therapeutic strategies to promote euglycemia in sepsis are needed. We have previously shown that early low-level intravenous (IV) dextrose suppresses pancreatic insulin secretion and induces insulin resistance in septic mice, resulting in profound hyperglycemia and worsened systemic inflammation. In this study, we hypothesized that administration of low-level dextrose via the enteral route would stimulate intestinal incretin hormone production, potentiate insulin secretion in a glucose-dependent manner, and thereby improve glycemic control in the acute phase of sepsis...
November 21, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29204776/implications-of-hyperthermic-intraperitoneal-chemotherapy-perfusion-related-hyperglycemia
#10
Camille L Stewart, Ana Gleisner, Alison Halpern, Irada Ibrahim-Zada, Rodrigo Asturias Luna, Nathan Pearlman, Csaba Gajdos, Barish Edil, Martin McCarter
BACKGROUND: Hyperthermic intraperitoneal chemotherapy (HIPEC) administration can be associated with hyperglycemia during perfusion. Little is known about this effect, and no previous studies have examined patient characteristics associated with perfusion-related hyperglycemia. METHODS: We retrospectively identified consecutive patients at a single institution treated with HIPEC from 8/2003 to 10/2016 who had intraoperative blood glucose measured. Hypertonic 1.5% dextrose-containing peritoneal dialysate was used as carrier solution in all patients...
December 4, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29172744/identification-of-mothball-powder-composition-by-float-tests-and-melting-point-tests
#11
Ka Yuen Tang
INTRODUCTION: The aim of the study was to identify the composition, as either camphor, naphthalene, or paradichlorobenzene, of mothballs in the form of powder or tiny fragments by float tests and melting point tests. METHODS: Naphthalene, paradichlorobenzene and camphor mothballs were blended into powder and tiny fragments (with sizes <1/10 of the size of an intact mothball). In the float tests, the mothball powder and tiny fragments were placed in water, saturated salt solution and 50% dextrose solution (D50), and the extent to which they floated or sank in the liquids was observed...
November 24, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/29172109/the-oral-glucose-test-predicts-laminitis-risk-in-ponies-fed-a-diet-high-in-nonstructural-carbohydrates
#12
A D Meier, M A de Laat, D B Reiche, C C Pollitt, D M Walsh, J M McGree, M N Sillence
The aim of this study was to investigate the relationship between laminitis development in ponies and insulin/glucose concentrations in response to the oral glucose test (OGT) and a dietary challenge high in nonstructural carbohydrates (NSCs). After undergoing an OGT (1 g dextrose/kg BW in feed), 37 ponies with 2-h serum insulin concentrations ranging from 22 to 1,133 μIU/mL were subjected to a diet challenge period (DCP), consuming 12 g NSC/kg BW/d for up to 18 d. Insulin and glucose responses were measured on day 2 of the DCP...
November 16, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29122175/enhancing-taxol-production-in-a-novel-endophytic-fungus-aspergillus-aculeatinus-tax-6-isolated-from-taxus-chinensis-var-mairei
#13
Weichuan Qiao, Fei Ling, Lei Yu, Yifang Huang, Ting Wang
Taxol is a curatively effective but rare anti-tumor agent extracted from Taxus (yew) barks; however, the high cost and low production of the extraction method have limited its widespread use. In this study, fungi isolated from Taxus chinensis var. mairei were tested for their ability to produce taxol. High performance liquid chromatography combined with mass spectrometry confirmed that Aspergillus aculeatinus Tax-6, one of the endophytic fungi, could produce taxol in potato dextrose agar liquid medium. NaOAc, Cu(2+), and salicylic acid were introduced into the medium to enhance taxol production of strain Tax-6 because NaOAc is an important precursor of taxol, Cu(2+) may enhance the activity of oxidase and catalyze the formation of taxol, and salicylic acid could be an elicitor signal...
December 2017: Fungal Biology
https://www.readbyqxmd.com/read/29101774/dextrose-prolotherapy-for-chronic-shoulder-pain-a-case-report
#14
Casey Seenauth, Vance Inouye, Jeffrey O Langland
Context • Shoulder pain is one of the most common pain complaints reported by patients. Consensus is lacking on its ideal treatment, and many different treatments are available and used. Prolotherapy is an injection-based therapy that has shown significant results in treating many common musculoskeletal pain conditions, including osteoarthritis, lateral epicondylosis, and low-back pain. Objective • The study intended to evaluate the use of dextrose prolotherapy in the treatment of shoulder pain. Design • The research team performed a case study...
January 2018: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29101501/severe-hypernatraemic-dehydration-and-unconsciousness-in-a-care-dependent-inpatient-treated-with-empagliflozin
#15
Georg Gelbenegger, Nina Buchtele, Christian Schoergenhofer, Martin Roeggla, Michael Schwameis
A 66-year-old Caucasian male became unconscious 2 weeks after initiation of add-on therapy with empagliflozin for poorly controlled type 2 diabetes mellitus. The inpatient had recently suffered focal pontine stroke, rendering him bedridden and requiring increased nursing care, including assistance with drinking. The patient had received empagliflozin 10 mg once daily for glycaemic control. Investigations revealed hypernatraemia (164 mmol/l), a urine glucose level of 3935 mg/dl, and a creatinine level of 2...
November 3, 2017: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29076587/high-prevalence-of-candiduria-due-to-non-albicans-candida-species-among-diabetic-patients-a-matter-of-concern
#16
Alireza Esmailzadeh, Hossein Zarrinfar, AbdolMajid Fata, Tanuka Sen
BACKGROUND: Among the fungal pathogens, Candida species are the most common cause of urinary tract infection (UTI). Some predisposing factors such as diabetes mellitus, urinary retention, urinary stasis, renal transplantation, and hospitalization can increase the risk of candiduria. The aim of this cross-sectional study was to evaluate candiduria among type 2 diabetic patients and identification of the Candida isolates. METHOD: Four hundred clean-catch midstream urine specimens were obtained from patients with type 2 diabetes mellitus...
October 27, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29066219/a-randomized-controlled-trial-of-one-bag-vs-two-bag-system-of-fluid-delivery-in-children-with-diabetic-ketoacidosis-experience-from-a-developing-country
#17
N Dhochak, M Jayashree, S Singhi
PURPOSE: To compare one vs. two bag system with respect to blood glucose variability (BGV), time for resolution of acidosis and incidence of hypoglycemia, hypokalemia, and cerebral edema in children with diabetic ketoacidosis (DKA). MATERIAL AND METHODS: In an open labelled randomized controlled trial, thirty consecutive patients ≤12years with DKA were randomized to either one (n=15) or two bag (n=15) system of intravenous fluid delivery. The two bags had similar electrolyte but differing dextrose concentration (none vs...
September 22, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29017019/results-of-combined-single-session-arthrocentesis-and-dextrose-prolotherapy-for-symptomatic-temporomandibular-joint-syndrome-a-case-series
#18
Burak Cezairli, Efe Can Sivrikaya, Mehmet Melih Omezli, Ferhat Ayranci, Neslihan Seyhan Cezairli
OBJECTIVE: Arthrocentesis and prolotherapy are nonsurgical treatments for temporomandibular joint (TMJ) diseases. This study aimed to evaluate the treatment of hypermobility, pain, and displacement of the TMJ by consecutively performing arthrocentesis and prolotherapy in the same session. MATERIALS AND METHODS: In this study, 10 adults with disc displacement and painful, hypermobile TMJ were selected. Arthrocentesis and prolotherapy were consecutively performed using a 30% dextrose solution that was simultaneously injected into five areas: posterior disc attachment, superior joint space, superior and inferior capsular attachments, and stylomandibular ligament...
October 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28967446/-production-of-infectious-units-of-isaria-fumosorosea-hypocreales-cordycipitaceae-from-different-indigenous-isolates-of-northeastern-mexico-using-3-propagation-strategies
#19
Fatima L Gandarilla-Pacheco, Lilia H Morales-Ramos, Benito Pereyra-Alférez, Myriam Elías-Santos, Isela Quintero-Zapata
The aim of this study was to evaluate the production of blastospores and conidia of different native isolates and a strain of Isaria fumosorosea using different propagation techniques. Two liquid culture media of casamino acids and peptone as nitrogen sources and glucose as carbon source for both media cultures were respectively used in the production of blastospores, while for the production of conidia, the fungi were grown in potato dextrose agar; from these cultures, solutions of conidia to a concentration of 1×10(6) per milliliter were prepared to inoculate flasks with Sabouraud dextrose broth for the liquid phase of the biphasic culture, also known as preculture...
September 26, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28955647/purification-characterization-and-statistical-optimization-of-a-thermostable-%C3%AE-amylase-from-desert-actinobacterium-streptomyces-fragilis-da7-7
#20
Krishnasamy Nithya, Chinnasamy Muthukumar, Shine Kadaikunnan, Naiyf S Alharbi, Jamal M Khaled, Dharumadurai Dhanasekaran
In this study, preliminary screening revealed that of 134 desert soil actinobacterial isolates, only 43 isolates produced amylase. Among these, an isolate DA7-7, which was identified as Streptomyces fragilis DA7-7, showed a prominent zone of clearance and significant amount of α-amylase production. The pre-optimization studies showed varying physicochemical and nutrients properties of the medium influenced the enzyme production significantly. Consequently, central composite design was employed with the selected variables (pH, temperature, dextrose, and peptone) for α-amylase production...
October 2017: 3 Biotech
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