Patrick Bidulka, David G Lugo-Palacios, Orlagh Carroll, Stephen O'Neill, Amanda I Adler, Anirban Basu, Richard J Silverwood, Jonathan W Bartlett, Dorothea Nitsch, Paul Charlton, Andrew H Briggs, Liam Smeeth, Ian J Douglas, Kamlesh Khunti, Richard Grieve
OBJECTIVE: To compare the effectiveness of three commonly prescribed oral antidiabetic drugs added to metformin for people with type 2 diabetes mellitus requiring second line treatment in routine clinical practice. DESIGN: Cohort study emulating a comparative effectiveness trial (target trial). SETTING: Linked primary care, hospital, and death data in England, 2015-21. PARTICIPANTS: 75 739 adults with type 2 diabetes mellitus who initiated second line oral antidiabetic treatment with a sulfonylurea, DPP-4 inhibitor, or SGLT-2 inhibitor added to metformin...
May 8, 2024: BMJ: British Medical Journal