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https://www.readbyqxmd.com/read/28315063/the-effect-of-regadenoson-on-the-integrity-of-the-human-blood-brain-barrier-a-pilot-study
#1
Sadhana Jackson, Richard T George, Martin A Lodge, Anna Piotrowski, Richard L Wahl, Sachin K Gujar, Stuart A Grossman
Regadenoson is an FDA approved adenosine receptor agonist which increases blood-brain barrier (BBB) permeability in rodents. Regadenoson is used clinically for pharmacologic cardiac stress testing using SPECT or CT imaging agents that do not cross an intact BBB. This study was conducted to determine if standard doses of regadenoson transiently disrupt the human BBB allowing higher concentrations of systemically administered imaging agents to enter the brain. Patients without known intracranial disease undergoing clinically indicated pharmacologic cardiac stress tests were eligible for this study...
March 17, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28267987/prospective-ecg-triggering-cardiac-ct-for-infants-with-complex-congenital-heart-disease-using-low-dose-contrast-medium-low-tube-voltage-and-adaptive-statistical-iterative-reconstruction
#2
S-Y Wang, W Gao, Y-M Zhong, A-M Sun, Q Wang, L-W Hu, H-S Qiu, J-Y Li
AIM: To demonstrate the clinical value of prospective electrocardiography (ECG)-triggered cardiac computed tomography (CT) with low concentration contrast medium, low tube voltage, and adaptive statistic iterative reconstruction (ASIR) to reduce both radiation and contrast dose in examining infants with complex congenital heart disease (CHD). MATERIALS AND METHODS: Forty-four consecutive infants (19 male, 25 female, age: 8.06±4.33 months, weight: 7.31±1.36 kg) with complex CHD underwent prospective ECG-triggered low-dose cardiac CT using 80 kVp and 120 mA...
March 4, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28091791/a-novel-scalable-robust-downstream-process-for-oncolytic-rat-parvovirus-isoelectric-point-based-elimination-of-empty-particles
#3
Barbara Leuchs, Veronika Frehtman, Markus Riese, Marcus Müller, Jean Rommelaere
The rodent protoparvovirus H-1PV, with its oncolytic and oncosuppressive properties, is a promising anticancer agent currently under testing in clinical trials. This explains the current demand for a scalable, good manufacturing practice-compatible virus purification process yielding high-grade pure infectious particles and overcoming the limitations of the current system based on density gradient centrifugation. We describe here a scalable process offering high purity and recovery. Taking advantage of the isoelectric point difference between full and empty particles, it eliminates most empty particles...
January 14, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27935551/organotypic-soft-tissue-co-cultures-morphological-changes-in-microvascular-endothelial-tubes-after-incubation-with%C3%A2-iodinated-contrast-media
#4
S Kaessmeyer, J Sehl, M Khiao In, B Hiebl, R Merle, F Jung, R P Franke, J Plendl
INTRODUCTION: Clinical complications like thrombosis or anaphylaxis have been described to go along with the intra-venous or intra-arterial injection of iodinated contrast media (CM). It has been suggested that the administration of CM affects rheological parameters and thereby causes reduced blood velocity in microvessels. In vitro studies revealed significant buckling of endothelial cells after exposure to CM reducing the lumen of vessels. The aim of this study was to test the influence of CM on three-dimensional microvascular tubules with open lumina within an organotypic soft-tissue co-culture assay in vitro...
2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27925466/a-prospective-evaluation-of-contrast-and-radiation-dose-and-image-quality-in-cardiac-ct-in-children-with-complex-congenital-heart-disease-using-low-concentration-iodinated-contrast-agent-and-low-tube-voltage-and-current
#5
RANDOMIZED CONTROLLED TRIAL
Qiao-Ru Hou, Wei Gao, Ai-Min Sun, Qian Wang, Hai-Sheng Qiu, Fang Wang, Li-Wei Hu, Jian-Ying Li, Yu-Min Zhong
OBJECTIVE: To the assess image quality, contrast dose and radiation dose in cardiac CT in children with congenital heart disease (CHD) using low-concentration iodinated contrast agent and low tube voltage and current in comparison with standard dose protocol. METHODS: 110 patients with CHD were randomized to 1 of the 2 scan protocols: Group A (n = 45) with 120 mA tube current and contrast agent of 270 mgI/ml in concentration (Visipaque(™); GE Healthcare Ireland, Co...
February 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/27771227/diagnostic-accuracy-of-noninvasive-64-row-computed-tomographic-coronary-angiography-ccta-compared-with-myocardial-perfusion-imaging-mpi-the-picture-study-a-prospective-multicenter-trial
#6
Matthew J Budoff, Dong Li, Ella A Kazerooni, Gregory S Thomas, Jennifer H Mieres, Leslee J Shaw
RATIONALE AND OBJECTIVES: Although multiple studies have shown excellent accuracy statistics for noninvasive angiography by coronary computed tomographic angiography (CCTA), most studies comparing nuclear imaging to CCTA were performed on patients already referred for cardiac catheterization, introducing referral and selection bias. This prospective trial evaluated the diagnostic accuracy of 64-row CCTA to detect obstructive coronary stenosis compared to myocardial perfusion imaging (MPI), using quantitative coronary angiography (QCA) as a reference standard...
January 2017: Academic Radiology
https://www.readbyqxmd.com/read/27755006/diagnostic-accuracy-of-visipaque-enhanced-coronary-computed-tomographic-angiography-a-prospective-multicenter-trial
#7
MULTICENTER STUDY
Matthew J Budoff, Nove Kalia, Jason Cole, Rine Nakanishi, Negin Nezarat, Joseph L Thomas
BACKGROUND: Although several studies have shown promise for noninvasive angiography by coronary computed tomographic angiography (CCTA), few prospective multicenter trials have been conducted. This study evaluated the diagnostic accuracy of Visipaque enhanced CCTA to detect obstructive coronary stenosis compared with quantitative coronary angiography (QCA). PATIENTS AND METHODS: Three sites prospectively enrolled 77 patients (58.1% men, 54 years) with chest pain referred for invasive coronary angiography (ICA)...
January 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/27577509/a-prospective-evaluation-of-the-contrast-radiation-dose-and-image-quality-of-contrast-enhanced-ct-scans-of-paediatric-abdomens-using-a-low-concentration-iodinated-contrast-agent-and-low-tube-voltage-combined-with-70-asir-algorithm
#8
Xiaoxia Wang, Yumin Zhong, Liwei Hu, Lianyan Xue, Meihua Shi, Haisheng Qiu, Jianying Li
PURPOSE: To quantitatively and subjectively assess the image quality of and radiation dose for an abdominal enhanced computed tomography (CT) scan with a low tube voltage and a low concentration of iodinated contrast agent in children. METHODS: Forty-eight patients were randomised to one of the two following protocols: Group A (n=24, mean age 46.96±44.65 months, mean weight 15.71±9.11 kg, BMI 16.48±2.40 kg/m(2) ) and Group B (n=24, mean age 41.33±44.59 months, mean weight 18...
September 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27551339/value-of-liver-computed-tomography-with-iodixanol-270-80-kvp-and-iterative-reconstruction
#9
Diomidis Botsikas, Isabelle Barnaure, Sylvain Terraz, Christoph D Becker, Anastasia Kalovidouri, Xavier Montet
AIM: To evaluate the image quality of hepatic multidetector computed tomography (MDCT) with dynamic contrast enhancement. METHODS: It uses iodixanol 270 mg/mL (Visipaque 270) and 80 kVp acquisitions reconstructed with sinogram affirmed iterative reconstruction (SAFIRE(®)) in comparison with a standard MDCT protocol. Fifty-three consecutive patients with known or suspected hepatocellular carcinoma underwent 55 CT examinations, with two different four-phase CT protocols...
July 28, 2016: World Journal of Radiology
https://www.readbyqxmd.com/read/27225455/torsten-alm%C3%A3-n-1931-2016-the-father-of-non-ionic-iodine-contrast-media
#10
Ulf Nyman, Olle Ekberg, Peter Aspelin
The Swedish radiologist Torsten Almén is the first clinical radiologist ever to have made a fundamental contribution to intravascular contrast medium design, the development of non-ionic contrast media. He became emotionally triggered by the patients' severe pain each time he injected the ionic "high-osmolar" contrast media when performing peripheral arteriographies in the early 1960s. One day he got a flash of genius that combined the observation of pain, a pathophysiological theory and how to eliminate it with suitable contrast media chemistry...
September 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27076400/visipaque-a-step-forward-a-historical-review
#11
REVIEW
T Almén
No abstract text is available yet for this article.
May 2016: Acta Radiologica
https://www.readbyqxmd.com/read/26784323/iodixanol-has-a-favourable-fibrinolytic-profile-compared-to-iohexol-in-cardiac-patients-undergoing-elective-angiography-a-double-blind-randomized-parallel-group-study
#12
RANDOMIZED CONTROLLED TRIAL
Andrew T Treweeke, Benjamin H Maskrey, Kirsty Hickson, John H Miller, Stephen J Leslie, Ian L Megson
BACKGROUND: There is no consensus and a limited evidence base for choice of contrast agents (CA) in angiography. This study evaluated the impact of iohexol and iodixanol CA on fibrinolytic factors (tissue plasminogen activator [t-PA] and plasminogen activator inhibitor-1 [PAI-1]), as well as platelet-monocyte conjugates in cardiac patients undergoing elective angiography in a double-blind, randomised parallel group study. METHODS: Patients (men, 50-70 years old; n = 12) were randomised to receive either iohexol (Omnipaque; n = 6) or iodixanol (Visipaque; n = 6) during elective angiography at Raigmore Hospital, Inverness, UK...
2016: PloS One
https://www.readbyqxmd.com/read/26773574/the-assessment-of-thrombotic-markers-utilizing-ionic-versus-non-ionic-contrast-during-coronary-angiography-and-intervention-trial
#13
RANDOMIZED CONTROLLED TRIAL
Binita Shah, Jeffrey S Berger, Nicole Allen, Yu Guo, Steven P Sedlis, Jinfeng Xu, Adriana Perez, Michael Attubato, James Slater, Frederick Feit
OBJECTIVE: To determine how two different types of iodinated contrast media (CM), low-osmolar ionic dimer ioxaglate (Hexabrix) and iso-osmolar non-ionic dimer iodixanol (Visipaque), affect multiple indices of hemostasis. BACKGROUND: In vitro models demonstrate differential effects of ionic and non-ionic CM on markers of hemostasis. METHODS: This blinded endpoint trial randomized 100 patients to ioxaglate or iodixanol. The primary endpoint was change in endogenous thrombin potential (ETP) following diagnostic angiography...
November 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/26635433/contrast-media-injector-technology-renal-safety-during-coronarography
#14
Ermina Mujicic, Ekrem Kevric, Senija Rasic, Amina Selimovic, Nermir Granov, Dinka Music
AIM: This study sought to assess whether the volume and osmolarity of contrast media (CM) influences the occurrence of contrast induced nephropathy (CIN) following coronarography procedure. CIN can be defined as an increase in the serum concentration of creatinine greater than a 25% from baseline during the period of 12 to 48 hours after the administration of radiocontrast media. MATERIAL AND METHODS: We examined 100 patients without diabetes with serum creatinine concentration from 45 mmol/l to 141 mmol/l and 100 patients with diabetes with serum creatinine concentration from 46 mmol/l to 161 mmol/l who underwent coronary angiography...
October 2015: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/26428284/compatibility-of-epirubicin-loaded-dc-bead%C3%A2-with-different-non-ionic-contrast-media
#15
Iman Sarakbi, Irene Krämer
PURPOSE: The aim of this study was to determine the compatibility of epirubicin-loaded DC bead™ with different non-ionic contrast media over a period of seven days when stored light protected under refrigerated conditions. METHODS: DC bead™ (2 ml) (Biocompatibles UK Ltd) of the bead size 70-150 µm ( = DC bead M1) or bead size 100-300 µm were loaded with 75 mg epirubicin powder formulation (Farmorubicin® dissolved in 3 ml water for injection to a concentration of 25 mg/ml) or 76 mg epirubicin injection solution (Epimedac® 2 mg/ml) within 2 h or 6 h, respectively...
December 2016: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/26284313/optimization-and-characterization-of-injectable-chitosan-iodixanol-based-hydrogels-for-the-embolization-of-blood-vessels
#16
Ahmed Fatimi, Fatemeh Zehtabi, Sophie Lerouge
Chitosan-thermosensitive hydrogels present interesting features for the embolization of blood vessels, but need to be better characterized and optimized. Chitosan polymer (degree of deacetylation (DDA) of 94%) was purified and combined with Visipaque (VIS), a nonionic isotonic contrast agent composed of iodixanol. A beta-glycerolphosphate (βGP) solution was then added to induce gelation at body temperature. The gelation process was monitored by rheometry, measuring the evolution of the sample storage (G') and loss (G″) moduli as a function of VIS and βGP concentration...
August 18, 2015: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/26185266/effects-of-viscosity-on-power-and-hand-injection-of-iso-osmolar-iodinated-contrast-media-through-thin-catheters
#17
COMPARATIVE STUDY
James J Zhang, Barry Hogstrom, Jiri Malinak, Nobuhiro Ikei
BACKGROUND: It can be challenging to achieve adequate vessel opacification during percutaneous coronary interventions when using thin catheters, hand injection, and iso-osmolar contrast media (CM) such as iodixanol (Visipaque™). PURPOSE: To explore these limitations and the possibility to overcome them with iosimenol, a novel CM. MATERIAL AND METHODS: Three X-ray contrast media with different concentrations were used in this study. A series of in vitro experiments established the relationship between injection pressure and flow rate in angiography catheters under various conditions...
May 2016: Acta Radiologica
https://www.readbyqxmd.com/read/26119271/warming-barium-sulfate-improves-esophageal-leak-detection-in-pig-model
#18
Vignesh Raman, Caitlyn E MacGlaflin, Karen L Moodie, Larry R Kaiser, Cherie P Erkmen
BACKGROUND: Barium esophagograms have poor sensitivity in detecting leaks. We hypothesized that heating barium would decrease viscosity, facilitate extravasation, and enhance its sensitivity in detecting esophageal leaks. METHODS: We characterized the viscosity of barium at increasing temperatures. We measured the radiopacity of barium at 25°C and 50°C. We determined the smallest diameter defect in esophagus that barium can detect by perforating a porcine esophageal segment with angiocatheters of various diameters, injecting barium at 25°C, and observing extravasation of contrast...
December 2015: Journal of Surgical Research
https://www.readbyqxmd.com/read/25831222/coronary-computed-tomography-angiography-predicts-subsequent-cardiac-outcome-events-results-of-the-visipaque-ccta-registry-study
#19
MULTICENTER STUDY
Matthew J Budoff, Stephen A Bloom, Benjamin J W Chow, Arthur B Chandler, Jason H Cole
OBJECTIVES: To evaluate the diagnostic performance and predictive value of coronary computed tomography angiography (CCTA) on subsequent cardiac outcomes. BACKGROUND: CCTA has been suggested as an alternative method to invasive coronary angiography for detection of and ruling out coronary artery disease (CAD). However, the usefulness of CCTA findings in predicting patient outcome in routine clinical practice is still uncertain. MATERIALS AND METHODS: A prospective, multicenter registry study of CCTA with a Visipaque injection 320 mg I/ml was carried out in symptomatic patients suspected of having CAD as part of their medical care...
June 2015: Coronary Artery Disease
https://www.readbyqxmd.com/read/25653965/comparative-study-of-renal-protective-effects-of-allopurinol-and-n-acetyl-cysteine-on-contrast-induced-nephropathy-in-patients-undergoing-cardiac-catheterization
#20
Ashutosh Kumar, Goru Bhawani, Neera Kumari, Kasturi Sn Murthy, Vinod Lalwani, Ch Narasimha Raju
UNLABELLED: Objectives : To evaluate the difference in the renal protective effects of allopurinol and n-acetyl cysteine along with saline hydration in patients of contrast induced nephropathy (CIN) post cardiac interventions. BACKGROUND: CIN remains a common complication of cardiac procedures. Radio contrast agents can cause a reduction in renal function that may be related to oxidative stress underlining various patho- physiologies. Conflicting evidence suggests that administration of allopurinol, a xanthine oxidase inhibitor can prevent CIN...
December 2014: Journal of Clinical and Diagnostic Research: JCDR
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