keyword
MENU ▼
Read by QxMD icon Read
search

acid-base metabolism

keyword
https://www.readbyqxmd.com/read/29352709/analysis-of-gut-microbiota-diversity-and-auxiliary-diagnosis-as-a-biomarker-in-patients-with-schizophrenia-a-cross-sectional-study
#1
Yang Shen, Jintian Xu, Zhiyong Li, Yichen Huang, Ye Yuan, Jixiang Wang, Meng Zhang, Songnian Hu, Ying Liang
With the advent of sequencing technology, characterization of schizophrenia with underlying probing of gut microbiome can provide abundant clues for diagnosis and prognosis of schizophrenia. In this study, we first compared the difference of gut microbiota between schizophrenia patients and healthy controls by 16S rRNA sequencing. We further explored whether gut microbiota can be used as a biomarker to assist in the diagnosis of schizophrenia. We restricted inclusion criteria strictly to control confounding bias...
January 15, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29352654/resistance-training-during-a-12-week-protein-supplemented-vlcd-treatment-enhances-weight-loss-outcomes-in-obese-patients
#2
Edward Jo, Phillip R Worts, Marcus L Elam, Ann Frost Brown, Andy V Khamoui, Do-Houn Kim, Ming-Chia Yeh, Michael J Ormsbee, Carla M Prado, Angelina Cain, Katie Snyder, Jeong-Su Kim
BACKGROUND: This investigation evaluated the efficacy by which resistance training enhances body composition, metabolic, and functional outcomes for obese patients undergoing a 12-week medically supervised hypocaloric treatment. METHODS: This was a single-blind, randomized, parallel-group prospective trial. Morbidly obese patients were prescribed a 12-week proprietary very low calorie diet (VLCD) treatment (Optifast®) with supplemental protein (1120 kcals/day) and were placed in one of two groups for 14 weeks: 1) Standard Treatment Control (CON) (n = 5) or 2) Resistance Training (RT) (n = 6)...
December 23, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29351921/inhibitory-effects-of-endogenous-linoleic-acid-and-glutaric-acid-on-the-renal-glucuronidation-of-berberrubine-in-mice-and-on-recombinant-human-ugt1a7-1ab-and-1a9
#3
Na Yang, Sijia Li, Caixia Yan, Runbin Sun, Jun He, Yuan Xie, Ying Peng, Guangji Wang, Jiye Aa
Berberrubine (BRB) has a strong lipid-lowering effect and can be extensively metabolized into berberrubine-9-O-β-D-glucuronide (BRBG) in vivo. Recently, pharmacokinetics studies showed that the production of BRBG was significantly decreased in the urine of mice fed with a high fat diet (HFD), indicating a decreased glucuronidation capacity. Based on the UGT isoform identification, hepatic and renal microsomal incubation, glucuronidation was examined to suggest the metabolism of BRB in liver and kidneys. The results showed that the renal UGT activity for metabolizing BRB markedly decreased, which may be highly related to the decreased expression and activity of renal Ugt1a7c...
January 19, 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29351484/the-serum-metabolomics-signature-of-type-2-diabetes-is-obscured-in-alzheimer-s-disease
#4
Jill K Morris, Brian D Piccolo, Kartik Shankar, John P Thyfault, Sean H Adams
There is evidence for systemic metabolic impairment in Alzheimer's disease (AD), and Type 2 Diabetes (T2D) increases AD risk. Although studies analyzing blood metabolomics signatures have shown differences between cognitively healthy (CH) and AD subjects, these signatures have not been compared to individuals with T2D. We utilized untargeted analysis platforms (primary metabolism and complex lipids) to characterize the serum metabolome of 126 overnight fasted elderly subjects classified into 4 groups based upon AD status (CH or AD) and T2D status (Nondiabetic [ND] or T2D)...
December 26, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29350465/proteomics-analysis-of-skeletal-muscle-from-leptin-deficient-ob-ob-mice-reveals-adaptive-remodeling-of-metabolic-characteristics-and-fiber-type-composition
#5
Milena Schönke, Marie Björnholm, Alexander V Chibalin, Juleen R Zierath, Atul S Deshmukh
Skeletal muscle insulin resistance, an early metabolic defect in the pathogenesis of type 2 diabetes, may be a cause or consequence of altered protein expressions profiles. Proteomics technology offers enormous promise to investigate molecular mechanisms underlying pathologies, however, the analysis of skeletal muscle is challenging. Using state-of-the-art multi-enzyme digestion and filter-aided sample preparation (MED-FASP) and a mass spectrometry (MS) based workflow, we performed a global proteomics analysis of skeletal muscle from leptin-deficient, obese, insulin resistant (ob/ob) and lean mice in mere two fractions in a short time (8 hours/sample)...
January 19, 2018: Proteomics
https://www.readbyqxmd.com/read/29350007/-the-metabolic-profilings-study-of-serum-and-spinal-cord-from-acute-spinal-cord-injury-rats-%C3%A2-h-nmr-spectroscopy
#6
Hua-Hui Hu, Xiao-Long Huang, Ren-Fu Quan, Zong-Bao Yang, Jing-Jing Xu
OBJECTIVE: To establish the rat model of acute spinal cord injury, followed by aprimary study on this model with ¹H NMR based on metabonomics and to explore the metabonomics and biomarkers of spinal cord injury rat. METHODS: Twenty eight-week-old adult male SD rats of clean grade, with body weight of (200±10) g, were divided into sham operation group and model group in accordance with the law of random numbers, and every group had 10 rats. The rats of sham operation group were operated without damaging the spinal cord, and rats of model group were made an animal model of spinal cord incomplete injury according to the modified Allen's method...
February 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349734/alternative-soilless-media-using-olive-mill-and-paper-waste-for-growing-ornamental-plants
#7
Antonios Chrysargyris, Omiros Antoniou, Andreas Tzionis, Munoo Prasad, Nikolaos Tzortzakis
Peat-based growing media are not ecologically sustainable and peat extraction threatens sensitive peatland ecosystem. In this study, olive-stone waste (OSW) and paper waste (PW) were used in different ratios-as growing media-for ornamental crop production, as peat (P) substitutes. Marigold (Calendula officinalis L.), petunia (Petunia x hybrita L.) and matthiola (Matthiola incana L.) plants were grown in (1) P (100%), (2) P:OSW (90%:10%), (3) P:OSW (70%:30%), and (4) P:OSW:PW (60%:20%:20%). The physicochemical properties of these substrates and the effects on plant growth were determined...
January 18, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29348849/reduced-levels-of-n-methyl-2-pyridone-5-carboxamide-and-lysophosphatidylcholine-16-0-in-the-serum-of-patients-with-intrahepatic-cholangiocarcinoma-and-the-correlation-with-recurrence-free-survival
#8
Kyung-Hee Kim, Jungnam Joo, Boram Park, Sang-Jae Park, Woo Jin Lee, Sung-Sik Han, Tae Hyun Kim, Eun Kyung Hong, Sang Myung Woo, Byong Chul Yoo
We searched for metabolic biomarkers that may predict the prognosis of patients with intrahepatic cholangiocarcinoma (IHCC). To this end, a total of 237 serum samples were obtained from IHCC patients (n = 87) and healthy controls (n = 150), and serum metabolites were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Two stratified algorithms were used to select the metabolites, the levels of which predicted the prognosis of IHCC patients. We performed MS/MS and multiple-reaction-monitoring MS analyses to identify and quantify the selected metabolites...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348723/metabolite-profiling-of-fermented-ginseng-extracts-by-gas-chromatography-mass-spectrometry
#9
Seong-Eun Park, Seung-Ho Seo, Kyoung In Lee, Chang-Su Na, Hong-Seok Son
Background: Ginseng contains many small metabolites such as amino acids, fatty acids, carbohydrates, and ginsenosides. However, little is known about the relationships between microorganisms and metabolites during the entire ginseng fermentation process. We investigated metabolic changes during ginseng fermentation according to the inoculation of food-compatible microorganisms. Methods: Gas chromatography mass spectrometry (GC-MS) datasets coupled with the multivariate statistical method for the purpose of latent-information extraction and sample classification were used for the evaluation of ginseng fermentation...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29348423/a-tissue-mimetic-nano-fibrillar-hybrid-injectable-hydrogel-for-potential-soft-tissue-engineering-applications
#10
Neda Latifi, Meisam Asgari, Hojatollah Vali, Luc Mongeau
While collagen type I (Col-I) is commonly used as a structural component of biomaterials, collagen type III (Col-III), another fibril forming collagen ubiquitous in many soft tissues, has not previously been used. In the present study, the novel concept of an injectable hydrogel with semi-interpenetrating polymeric networks of heterotypic collagen fibrils, with tissue-specific Col-III to Col-I ratios, in a glycol-chitosan matrix was investigated. Col-III was introduced as a component of the novel hydrogel, inspired by its co-presence with Col-I in many soft tissues, its influence on the Col-I fibrillogenesis in terms of diameter and mechanics, and its established role in regulating scar formation...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29347914/in-depth-proteomic-analysis-of-boar-spermatozoa-through-shotgun-and-gel-based-methods
#11
Jean M Feugang, Shengfa F Liao, Scott T Willard, Peter L Ryan
BACKGROUND: Mature spermatozoa contain numerous epididymal and seminal plasma proteins, which full identification through high-throughput technologies may allow for a better understanding of the sperm biology. Therefore, we conducted a global proteomic analysis of boar spermatozoa through shotgun and gel-based methodologies. RESULTS: The total proteins were extracted from mature spermatozoa and subjecsted to proteome analyses. Functional analyses of gene ontology representations and pathway enrichments were conducted on the shotgun dataset, followed by immunology and gene expression validations...
January 18, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29345102/the-mycobiota-of-the-sand-fly-phlebotomus-perniciosus-involvement-of-yeast-symbionts-in-uric-acid-metabolism
#12
Elena Martin, Ilaria Varotto Boccazzi, Leone De Marco, Gioia Bongiorno, Matteo Montagna, Luciano Sacchi, Priscilla Mensah, Irene Ricci, Luigi Gradoni, Claudio Bandi, Sara Epis
The knowledge of the fungal mycobiota of arthropods, including the vectors of human and animal diseases, is still limited. Here, we investigated the mycobiota associated with the sand fly Phlebotomus perniciosus, the main vector of leishmaniasis in the western Mediterranean area, by a culture-dependent approach (microbiological analyses and sequencing of the 26S rRNA gene), internal transcribed spacer (ITS) rRNA amplicon-based next-generation sequencing, fluorescence in situ hybridisation (FISH), and genome sequencing of the dominant yeast species...
January 18, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29344508/acid-base-and-electrolyte-disorders-in-patients-with-and-without-chronic-kidney-disease-an-update
#13
REVIEW
Tsering Dhondup, Qi Qian
Kidneys play a pivotal role in the maintenance and regulation of acid-base and electrolyte homeostasis, which is the prerequisite for numerous metabolic processes and organ functions in the human body. Chronic kidney diseases compromise the regulatory functions, resulting in alterations in electrolyte and acid-base balance that can be life-threatening. In this review, we discuss the renal regulations of electrolyte and acid-base balance and several common disorders including metabolic acidosis, alkalosis, dysnatremia, dyskalemia, and dysmagnesemia...
December 2017: Kidney Diseases
https://www.readbyqxmd.com/read/29344504/new-findings-on-the-pathogenesis-of-distal-renal-tubular-acidosis
#14
REVIEW
Francesco Trepiccione, Federica Prosperi, Luigi Regenburgh de la Motte, Christian A Hübner, Regine Chambrey, Dominique Eladari, Giovambattista Capasso
Background: Distal renal tubular acidosis (dRTA) is characterized by an impairment of the urinary acidification process in the distal nephron. Complete or incomplete metabolic acidosis coupled with inappropriately alkaline urine are the hallmarks of this condition. Genetic forms of dRTA are caused by loss of function mutations of either SLC4A1, encoding the AE1 anion exchanger, or ATP6V1B1 and ATP6V0A4, encoding for the B1 and a4 subunits of the vH+ATPase, respectively. These genes are crucial for the function of A-type intercalated cells (A-IC) of the distal nephron...
December 2017: Kidney Diseases
https://www.readbyqxmd.com/read/29342113/mitochondria-oxidative-stress-and-the-kynurenine-system-with-a-focus-on-ageing-and-neuroprotection
#15
REVIEW
Katalin Sas, Elza Szabó, László Vécsei
In this review, the potential causes of ageing are discussed. We seek to gain insight into the main physiological functions of mitochondria and discuss alterations in their function and the genome, which are supposed to be the central mechanisms in senescence. We conclude by presenting the potential modulating role of the kynurenine pathway in the ageing processes. Mitochondrial dynamics are supposed to have important physiological roles in maintaining cell homeostasis. During ageing, a decrease in mitochondrial dynamics was reported, potentially compromising the function of mitochondria...
January 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29342096/high-resolution-lipidomics-of-the-early-life-stages-of-the-red-seaweed-porphyra-dioica
#16
Elisabete da Costa, Vitor Azevedo, Tânia Melo, Andreia M Rego, Dmitry V Evtuguin, Pedro Domingues, Ricardo Calado, Rui Pereira, Maria H Abreu, Maria R Domingues
Porphyra dioica is a commercial seaweed consumed all over the world, mostly in the shape of nori sheets used for "sushi" preparation. It is a well-known part of the Asian diet with health benefits, which have been associated, among others, to the high levels of n-3 and n-6 fatty acids in this red alga. However, other highly valued lipids of Porphyra are polar lipids that remain largely undescribed and can have both nutritional value and bioactivity, thus could contribute to the valorization of this seaweed...
January 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29341861/genome-wide-survey-reveals-dynamic-effects-of-folate-supplement-on-dna-methylation-and-gene-expression-during-c2c12-differentiation
#17
Yi Li, Qiang Feng, Miao Guo, Yuding Wang, Yunliang Jiang, Jinyi Xing
Folic acid supplements during pregnancy can prevent neural tube defects and other developmental abnormalities. Here, we explored the effects of folate supplement on gene expression and DNA methylation during C2C12 differentiation. Based on the folic acid concentration, this study comprised three groups: low folate (L), normal folate (N), and high-folate supplement (H). Our analyses revealed that differentiation and the mRNA expression of myogenin in C2C12 cell were enhanced by folic acid, however, the overall methylation percentage in myogenin promoter between different treatment groups was not significantly different (P>0...
January 12, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29340903/characterization-of-ent-kaurene-synthase-and-kaurene-oxidase-involved-in-gibberellin-biosynthesis-from-scoparia-dulcis
#18
Yoshimi Yamamura, Yukari Taguchi, Kei Ichitani, Io Umebara, Ayako Ohshita, Fumiya Kurosaki, Jung-Bum Lee
Gibberellins (GAs) are ubiquitous diterpenoids in higher plants, whereas some higher plants produce unique species-specific diterpenoids. In GA biosynthesis, ent-kaurene synthase (KS) and ent-kaurene oxidase (KO) are key players which catalyze early step(s) of the cyclization and oxidation reactions. We have studied the functional characterization of gene products of a KS (SdKS) and two KOs (SdKO1 and SdKO2) involved in GA biosynthesis in Scoparia dulcis. Using an in vivo heterologous expression system of Escherichia coli, we found that SdKS catalyzed a cyclization reaction from ent-CPP to ent-kaurene and that the SdKOs oxidized ent-kaurene to ent-kaurenoic acid after modification of the N-terminal region for adaptation to the E...
January 16, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29340222/direct-molecular-fishing-of-new-protein-partners-for-human-thromboxane-synthase
#19
A V Svirid, P V Ershov, E O Yablokov, L A Kaluzhskiy, Yu V Mezentsev, A V Florinskaya, T A Sushko, N V Strushkevich, A A Gilep, S A Usanov, A E Medvedev, A S Ivanov
Thromboxane synthase (TBXAS1) catalyzes the isomerization reaction of prostaglandin H2 producing thromboxane A2, the autocrine and paracrine factor in many cell types. A high activity and metastability by these arachidonic acid derivatives suggests the existence of supramolecular structures that are involved in the regulation of the biosynthesis and directed translocation of thromboxane to the receptor. The objective of this study was to identify TBXAS1 protein partners from human liver tissue lysate using a complex approach based on the direct molecular fishing technique, LC-MS/MS protein identification, and protein-protein interaction validation by surface plasmon resonance (SPR)...
October 2017: Acta Naturae
https://www.readbyqxmd.com/read/29339766/the-crystal-structure-of-d-xylonate-dehydratase-reveals-functional-features-of-enzymes-from-the-ilv-ed-dehydratase-family
#20
Mohammad Mubinur Rahman, Martina Andberg, Anu Koivula, Juha Rouvinen, Nina Hakulinen
The Ilv/ED dehydratase protein family includes dihydroxy acid-, gluconate-, 6-phosphogluconate- and pentonate dehydratases. The members of this family are involved in various biosynthetic and carbohydrate metabolic pathways. Here, we describe the first crystal structure of D-xylonate dehydratase from Caulobacter crescentus (CcXyDHT) at 2.7 Å resolution and compare it with other available enzyme structures from the IlvD/EDD protein family. The quaternary structure of CcXyDHT is a tetramer, and each monomer is composed of two domains in which the N-terminal domain forms a binding site for a [2Fe-2S] cluster and a Mg2+ ion...
January 16, 2018: Scientific Reports
keyword
keyword
94124
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"