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REVIEW
Han Lee, Kuan-Hung Liu, Yu-Hsuan Yang, Jiunn-Der Liao, Bo-Shen Lin, Zheng-Zhe Wu, Alice Chinghsuan Chang, Chin-Chung Tseng, Ming-Cheng Wang, Yau-Sheng Tsai
Patients with end-stage kidney disease (ESKD) rely on dialysis to remove toxins and stay alive. However, hemodialysis alone is insufficient to completely remove all/major uremic toxins, resulting in the accumulation of specific toxins over time. The complexity of uremic toxins and their varying clearance rates across different dialysis modalities poses significant challenges, and innovative approaches such as microfluidics, biomarker discovery, and point-of-care testing are being investigated. This review explores recent advances in the qualitative and quantitative analysis of uremic toxins and highlights the use of innovative methods, particularly label-mediated and label-free surface-enhanced Raman spectroscopy, primarily for qualitative detection...
April 22, 2024: Analyst
#2
JOURNAL ARTICLE
Nikita Pawar, Vaibhav Tiwari, Anurag Gupta, Smita Divyaveer, Imran Rather, Shiv Chadha, Vinant Bhargava, Manish Malik, Ashwani Gupta, Anil Kumar Bhalla, D S Rana, Pallav Gupta
INTRODUCTION: In view of ever-increasing end-stage renal disease (ESRD) population but inadequate availability of suitable donors, ABO-incompatible (ABOi) transplantation can be an important void filler. However, at present, ABOi transplantation is limited to a few centers in India and there is a lack of adequate experience and expertise to guide this program to other centers in the country. METHODS: Data of all the ABOi transplants performed from 2012 to 2021 in a tertiary care hospital was retrospectively analyzed...
2024: Indian Journal of Nephrology
#3
Priya Padmanabhan, Jayameena P, Neena Mampilly, Shinto Francis, Ajmal Sherif, Sunil George, Thomas Mathew
Monoclonal gammopathy of renal significance (MGRS) has gained importance because identifying the monoclonal deposit and addressing it, rather than treating renal dysfunction as the primary pathology, has salvaged the patients from progressing into end-stage renal disease. Since it affects elderly population, there could be a propensity to misdiagnose them with cardiorenal syndrome. We present four patients of MGRS diagnosed from our center. They presented with proteinuria or unexplained renal dysfunction. Three of the patients were diagnosed to have amyloidosis, of which two had lambda-type and one had kappa amyloidosis...
2024: Indian Journal of Nephrology
#4
JOURNAL ARTICLE
Ping-Hsun Lu, Chien-Cheng Lai, Ling-Ya Chiu, I-Hsin Lin, Chih-Chin Iou, Po-Hsuan Lu
OBJECTIVE: Uremic pruritus (UP) is a prevalent and troublesome condition affecting individuals with end-stage renal failure, which results in intense pruritus, depression, as well as poor quality of sleep, significantly impacting their quality of life. According to previous studies, acupuncture and acupoint stimulation have been shown to provide additional benefits in treating UP in dialysis patients. In addition, using acupoints combination may yield superior effectiveness compared to utilizing a singular acupoint...
2024: Tzu chi medical journal
#5
Brennan Marsh-Armstrong, Fernanda Pacheco, Christian Dameff, Jeffrey Tully
Background: Cybersecurity incidents affecting hospitals have grown in prevalence and consequence over the last two decades, increasing the importance of cybersecurity preparedness and response training to minimize clinical disruptions. This work describes the development, execution, and post-exercise assessment of a novel simulation scenario consisting of four interlocking intensive care unit (ICU) patient scenarios. This simulation was designed to demonstrate the management of acute pathologies without access to conventional treatment methods during a cybersecurity incident in order to raise clinician awareness of the increasing incidence and patient safety implications of such events...
April 5, 2024: Research Square
#6
JOURNAL ARTICLE
Jin Hwa Kim, Young Sang Lyu, BongSeong Kim, Mee Kyung Kim, Sang Yong Kim, Ki-Hyun Baek, Ki-Ho Song, Kyungdo Han, Hyuk-Sang Kwon
AIMS: To evaluate the effects of initiating sodium-glucose cotransporter-2 (SGLT2) inhibitors on cardiorenal outcomes and mortality compared to dipeptidyl peptidase-4 (DPP-4) inhibitors as active comparators in patients diagnosed with type 2 diabetes with a history of percutaneous coronary intervention (PCI). MATERIALS AND METHODS: We used an active-comparator, new-user design and nationwide data from the National Health Insurance Service in South Korea from 2014 to 2019...
April 21, 2024: Diabetes, Obesity & Metabolism
#7
JOURNAL ARTICLE
Xuerui Yang, Jun Yang, Youjia Zeng, Ling Peng, Xingzheng Liu, Jinying Mo, Taifen Wang, Yutong Yao, Yihou Zheng, Gaofeng Song
OBJECTIVE: Cardiovascular disease (CVD) represents the primary cause of mortality in patients afflicted with end-stage renal disease and undergoing peritoneal dialysis (PD) treatment. Galectin-3 (Gal-3), a molecule known to exhibit a correlation with CVD mortality garners considerable interest. The objective of this study was to explore the potential association between serum Gal-3 levels and other CVD risk factors among PD patients. METHODS: In this cross-sectional study, a total of 114 PD patients with a minimum of 3 months of PD treatment were enrolled...
April 20, 2024: Clinical and Experimental Nephrology
#8
JOURNAL ARTICLE
Masaomi Nangaku, William G Herrington, Shinya Goto, Shoichi Maruyama, Naoki Kashihara, Kohjiro Ueki, Jun Wada, Hirotaka Watada, Eitaro Nakashima, Ryonfa Lee, Dan Massey, Kaitlin J Mayne, Aiko Tomita, Richard Haynes, Sibylle J Hauske, Takashi Kadowaki
BACKGROUND: EMPA-KIDNEY assessed the effects of empagliflozin 10 mg once daily vs. placebo in 6609 patients with chronic kidney disease (CKD) at risk of progression, including 612 participants from Japan. METHODS: Eligibility required an estimated glomerular filtration rate (eGFR) of ≥ 20 < 45; or ≥ 45 < 90 ml/min/1.73m2 with a urinary albumin-to-creatinine ratio (uACR) of ≥ 200 mg/g...
April 20, 2024: Clinical and Experimental Nephrology
#9
JOURNAL ARTICLE
Ammar Abdulrahman Jairoun, Chong Chee Ping, Baharudin Ibrahim
Predicting the course of kidney disease in individuals with both type 1 and type 2 diabetes mellitus (DM) is a significant clinical and policy challenge. In several regions, DM is now the leading cause of end-stage renal disease. The aim of this study to identify both modifiable and non-modifiable risk factors, along with clinical markers and coexisting conditions, that increase the likelihood of stage 3-5 chronic kidney disease (CKD) development in individuals with type 2 DM in the United Arab Emirates (UAE)...
April 19, 2024: Scientific Reports
#10
JOURNAL ARTICLE
Prantik Das, Alison Booth, Robert Donaldson, Noami Berfeld, Beth Nordstrom, Robert Carroll, Poonam Dhokia, Andrew Clark, Luis Vaz
BACKGROUND AND OBJECTIVE: Considering the rapidly evolving treatment landscape of renal cell carcinoma (RCC), recent descriptions of the RCC population in the UK are lacking, as are real-world data on treatment and patient outcomes. To analyse the demographic and clinical characteristics, treatment patterns, and overall survival of patients with RCC using national data sets in England. PATIENTS AND METHODS: This was a retrospective cohort study of patients diagnosed with RCC (all stages) between 2014-2018 using demographic, clinical, cancer registration, and treatment data...
March 22, 2024: Clinical Genitourinary Cancer
#11
JOURNAL ARTICLE
Penina Dienstag, Rana Halsa, Keren Tzukert, Ashraf Imam, Abed Khalaileh, Aryeh Dienstag
Living donor kidney transplantation (LDKT) is one of the most effective treatment options for people suffering from end stage renal disease. Traditionally, LDKT can be either: "directed" or "non-directed," based on whether the recipient is specified by the donor. Recently there has been an increase in conditional and semidirected live kidney donation among strangers; where the donor specifies characteristics of the recipient whom they wish to donate to. This practice has both gained popularity and sparked controversy in the State of Israel through the non-profit organization Matnat Chaim...
April 17, 2024: American Journal of Transplantation
#12
JOURNAL ARTICLE
Caroline M Hsu, Nien Chen Li, Eduardo K Lacson, Daniel E Weiner, Susan Paine, Karen Majchrzak, Christos Argyropoulos, Maria-Eleni Roumelioti, V Shane Pankratz, Dana Miskulin, Harold J Manley, Page Salenger, Doug Johnson, H Keith Johnson, Antonia Harford
RATIONALE & OBJECTIVE: Reasons for transfer from peritoneal dialysis (PD) to hemodialysis (HD) remain incompletely understood. Among incident and prevalent patients receiving PD, we evaluated the association between prior treatment with HD and PD technique survival. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: Adults who initiated PD at a Dialysis Clinic, Inc. (DCI) outpatient facility between January 1, 2010 and September 30, 2019...
April 17, 2024: American Journal of Kidney Diseases
#13
JOURNAL ARTICLE
B Kaya, B Mete, M Balal, N Seyrek, I Karayaylali
UNLABELLED: OBJECTIVE: Identifying reliable predictors of mortality in end-stage renal disease patients is crucial for patient outcomes. Aortic knob width is a radiographic parameter used to assess cardiovascular diseases and atherosclerosis. This study investigated the association between aortic knob width and mortality in hemodialysis patients. PATIENTS AND METHODS: The study included data collected between 2007 and 2022 from 103 patients aged between 18 and 85 who had been undergoing hemodialysis treatment for at least one year...
April 2024: European Review for Medical and Pharmacological Sciences
#14
Rakesh Reddy Devireddy, Osama Qaqi
Arteriovenous grafts (AVGs) provide vascular access for hemodialysis in patients with end-stage renal disease (ESRD). However, vascular access thrombosis often occurs, requiring frequent reinterventions to maintain access patency. This report describes the successful use of the InThrill Thrombectomy System (Irvine, CA: Inari Medical) for macerating and removing thrombus from an occluded and heavily thrombosed AVG. A 47-year-old male was sent to our institute for a thrombosed right upper extremity arteriovenous access with a HeRO graft (South Jordan, UT: Merit Medical)...
March 2024: Curēus
#15
JOURNAL ARTICLE
Brittany A Boerstra, Rianne Boenink, Megan E Astley, Marjolein Bonthuis, Samar Abd ElHafeez, Federico Arribas Monzón, Anders Åsberg, Pazit Beckerman, Samira Bell, Aleix Cases Amenós, Pablo Castro de la Nuez, Marc A G J Ten Dam, Alicja Debska-Slizien, Nikola Gjorgjievski, Rebecca Giudotti, Jaakko Helve, Kristine Hommel, Alma Idrizi, Ólafur S Indriðason, Faiçal Jarraya, Julia Kerschbaum, Kirill S Komissarov, Nadiia Kozliuk, Milica Kravljaca, Mathilde Lassalle, Johan M De Meester, Mai Ots-Rosenberg, Zoe Plummer, Danilo Radunovic, Olena Razvazhaieva, Halima Resic, Olga Lucía Rodríguez Arévalo, Carmen Santiuste de Pablos, Nurhan Seyahi, María Fernanda Slon-Roblero, Maria Stendahl, Miloreta Tolaj-Avdiu, Sara Trujillo-Alemán, Ieva Ziedina, Edita Ziginskiene, Alberto Ortiz, Kitty J Jager, Vianda S Stel, Anneke Kramer
BACKGROUND: The European Renal Association (ERA) Registry collects data on kidney replacement therapy (KRT) in patients with end-stage kidney disease (ESKD). This paper is a summary of the ERA Registry Annual Report 2021, including a comparison across treatment modalities. METHODS: Data was collected from 54 national and regional registries from 36 countries, of which 35 registries from 18 countries contributed individual patient data and 19 registries from 19 countries contributed aggregated data...
February 2024: Clinical Kidney Journal
#16
REVIEW
Xiao-Xiao Gong, Lin-Hai Cao, Hong-Xia Ni, Zi-Yan Zang, Hui Chang
ETHNOPHARMACOLOGICAL RELEVANCE: Diabetic nephropathy (DN) is a typical chronic microvascular complication of diabetes, characterized by proteinuria and a gradual decline in renal function. At present, there are limited clinical interventions aimed at preventing the progression of DN to end-stage renal disease (ESRD). However, Chinese herbal medicine presents a distinct therapeutic approach that can be effectively combined with conventional Western medicine treatments to safeguard renal function...
April 16, 2024: Journal of Ethnopharmacology
#17
JOURNAL ARTICLE
I Vaněčková, J Zicha
A new class of antidiabetic drugs - gliflozins (inhibitors of sodium glucose cotransporter-2; SGLT-2i) stimulate glucose and sodium excretion, thereby contributing to improved glycemic control, weight loss and blood pressure reduction in diabetic patients. Large clinical trials in patients with type 2 diabetes treated with empagliflozin, canagliflozin or dapagliflozin have demonstrated their excellent efficacy in improving many cardiovascular outcomes, including the reduction of death from cardiovascular diseases, non-fatal myocardial infarction or stroke, and hospitalization for heart failure...
April 18, 2024: Physiological Research
#18
JOURNAL ARTICLE
Marianna Nicoletta Rossi, Valentina Matteo, Francesca Diomedi-Camassei, Ester De Leo, Olivier Devuyst, Mohamed Lamkanfi, Ivan Caiello, Elena Loricchio, Francesco Bellomo, Anna Taranta, Francesco Emma, Fabrizio De Benedetti, Giusi Prencipe
Cystinosis is a rare autosomal recessive disorder caused by mutations in the CTNS gene that encodes cystinosin, a ubiquitous lysosomal cystine/H+ antiporter. The hallmark of the disease is progressive accumulation of cystine and cystine crystals in virtually all tissues. At the kidney level, human cystinosis is characterized by the development of renal Fanconi syndrome and progressive glomerular and interstitial damage leading to end-stage kidney disease in the second or third decade of life. The exact molecular mechanisms involved in the pathogenesis of renal disease in cystinosis are incompletely elucidated...
2024: Frontiers in Immunology
#19
JOURNAL ARTICLE
Wenxiang Feng, Nan Zhu, Yubin Xia, Zehai Huang, Jianmin Hu, Zefeng Guo, Yuzhuz Li, Song Zhou, Yongguang Liu, Ding Liu
Kidney transplantation is essential for patients with end-stage renal disease; however, ischemia-reperfusion injury (IRI) during transplantation can lead to acute kidney damage and compromise survival. Recent studies have reported that antiferroptotic agents may be a potential therapeutic strategy, by reducing production of reactive oxygen species (ROS). Therefore, we constructed rutin-loaded polydopamine nanoparticles (PEG-PDA@rutin NPs, referred to as PPR NPs) to eliminate ROS resulting from IRI. Physicochemical characterization showed that the PPR NPs were ∼100 nm spherical particles with good ROS scavenging ability...
April 19, 2024: IScience
#20
JOURNAL ARTICLE
Daniel Lewis, Brenna E Blackburn, Jane Archibeck, Michael J Archibeck, Lucas A Anderson, Jeremy M Gililland, Laura K Certain, Christopher Pelt
BACKGROUND: Vancomycin and tobramycin have traditionally been used in antibiotic spacers. In 2020, our institution replaced tobramycin with ceftazidime. We hypothesized that the use of ceftazidime/vancomycin (CV) in antibiotic spacers would not lead to an increase in treatment failure compared to tobramycin/vancomycin (TV). METHODS: From 2014 to 2022, we identified 243 patients who underwent a stage I revision for periprosthetic joint infection (PJI). The primary outcome was a recurrent infection requiring antibiotic spacer exchange...
April 15, 2024: Journal of Arthroplasty
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