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https://www.readbyqxmd.com/read/28211939/allogeneic-hematopoietic-cell-transplantation-for-primary-refractory-acute-lymphoblastic-leukemia-a-report-from-the-acute-leukemia-working-party-of-the-ebmt
#1
Jiří Pavlů, Myriam Labopin, Anna K Zoellner, Ioanna Sakellari, Matthias Stelljes, Jürgen Finke, Renato Fanin, Gernot Stuhler, Boris V Afanasyev, Adrian J Bloor, Achilles Anagnostopoulos, Mohamad Mohty, Sebastian Giebel, Arnon Nagler
BACKGROUND: Patients with primary refractory acute lymphoblastic leukemia (PREF ALL) who fail to achieve a complete remission (CR) after ≥2 courses of chemotherapy have a dismal prognosis without undergoing allogeneic hematopoietic cell transplantation (HCT). To the authors' knowledge, there currently are no data regarding factors influencing transplantation outcomes. METHODS: The authors retrospectively studied outcomes of transplantation for cases of PREF ALL reported to European Society for Blood and Marrow Transplantation registry...
February 17, 2017: Cancer
https://www.readbyqxmd.com/read/28209741/frequency-characteristics-of-human-muscle-and-cortical-responses-evoked-by-noisy-achilles-tendon-vibration
#2
Robyn Lynne Mildren, Ryan M Peters, Aimee J Hill, Jean-Sebastien Blouin, Mark Gregory Carpenter, J Timothy Inglis
Noisy stimuli, along with linear systems analysis, have proven to be effective for mapping functional neural connections. We explored the use of noisy (10-115 Hz) Achilles tendon vibration to examine proprioceptive reflexes in the triceps surae muscles in standing healthy young adults (n = 8). We also examined the association between noisy vibration and electrical activity recorded over the sensorimotor cortex using electroencephalography. We applied two-minutes of vibration and recorded ongoing muscle activity of the soleus and gastrocnemii using surface electromyography (EMG)...
February 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28208289/atmospheric-pressure-vaporization-mechanism-for-coupling-a-liquid-phase-with-electron-ionization-mass-spectrometry
#3
Veronica Termopoli, Giorgio Famiglini, Pierangela Palma, Maurizio Piergiovanni, Achille Cappiello
A novel liquid chromatography-mass spectrometry (LC-MS) interfacing concept is presented and discussed. The new interface, called liquid-EI (LEI), is based on electron ionization (EI) but, differently from any previous attempt, the vaporization of solutes and mobile phase takes place at atmospheric pressure into a specifically designed region, called "vaporization microchannel", before entering the high-vacuum ion source. The interface is completely independent from the rest of the instrumentation and can be adapted to any gas chromatography/mass spectrometry (GC/MS) system, as an add-on for a rapid LC-MS conversion...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28208087/morphomechanical-alterations-in-the-medial-gastrocnemius-muscle-in-patients-with-a-repaired-achilles-tendon-associations-with-outcome-measures
#4
Wei-Chen Peng, Yi-Ping Chang, Yuan-Hung Chao, S N Fu, Christer Rolf, Tiffany Tf Shih, Sheng-Chu Su, Hsing-Kuo Wang
BACKGROUND: Functional deficits are found in ankles that have sustained an Achilles rupture. This study sought to evaluate and compare the morphomechanical characteristics of the medial gastrocnemius muscle in the legs of participants within six months of a unilateral Achilles repair to determine any correlations between those characteristics and objective outcomes and self-reported functional levels. METHODS: Fifteen participants were assessed via measurements of muscle morphologies (fascicle length, pennation angle, and muscle thickness) in a resting state, the mechanical properties of the proximal aponeurosis of the medial gastrocnemius muscle, the pennation angle during ramping maximal voluntary isometric contractions (MVIC), the heel raise test, and the Taiwan Chinese version of the Lower Extremity Functional Scale (LEFS-TC) questionnaire...
February 8, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28206959/association-of-polymorphisms-rs1800012-in-col1a1-with-sports-related-tendon-and-ligament-injuries-a-meta-analysis
#5
REVIEW
Chunguang Wang, Hao Li, Kang Chen, Bing Wu, Haifeng Liu
It has been reported that the single nucleotide polymorphism (SNP) rs1800012 in COL1A1 might be associated with the susceptibility to sports-related tendon and ligament injuries such as ACL injuries, Achilles tendon injuries, shoulder dislocations and tennis elbow. But the data from different studies have been conflicting. Here we attempted to systematically summarize and clarify the association between the SNP and sports-related tendon and ligament injuries risk. Six eligible studies including 933 cases and 1,381 controls were acquired from PubMed, Web Of Science and Cochrane library databases...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28204479/antimicrobial-strategy-for-severe-community-acquired-legionnaires-disease-a-multicentre-retrospective-observational-study
#6
Jérôme Cecchini, Samuel Tuffet, Romain Sonneville, Muriel Fartoukh, Julien Mayaux, Damien Roux, Achille Kouatchet, Florence Boissier, Martial Tchir, Martial Thyrault, Eric Maury, Sebastien Jochmans, Armand Mekontso Dessap, Christian Brun-Buisson, Nicolas de Prost
No abstract text is available yet for this article.
February 13, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28203592/suture-only-repair-versus-suture-anchor-augmented-repair-for-achilles-tendon-ruptures-with-a-short-distal-stump-a-biomechanical-comparison
#7
Michael A Boin, Matthew A Dorweiler, Christopher J McMellen, Gregory C Gould, Richard T Laughlin
BACKGROUND: Chronic noninsertional Achilles tendinosis can result in an acute Achilles tendon rupture with a short distal stump. In such tendon ruptures, there is a limited amount of adequate tissue that can hold suture, thus presenting a challenge for surgeons who elect to treat the rupture operatively. HYPOTHESIS: Adding suture anchors to the repair construct may result in biomechanically stronger repairs compared with a suture-only technique. STUDY DESIGN: Controlled laboratory study...
January 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28203584/plantaris-excision-reduces-pain-in-midportion-achilles-tendinopathy-even-in-the-absence-of-plantaris-tendinosis
#8
James D F Calder, Joanna M Stephen, C Niek van Dijk
BACKGROUND: It is becoming increasingly apparent that the plantaris can contribute to symptoms in at least a subset of patients with midportion Achilles tendinopathy. However, the nature of its involvement remains unclear. PURPOSE: To determine whether excised plantaris tendons from patients with midportion Achilles tendinopathy display tendinopathic changes and whether the presence of such changes affect clinical outcomes. STUDY DESIGN: Case series; Level of evidence, 4...
December 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28202585/is-human-achilles-tendon-deformation-greater-in-regions-where-cross-sectional-area-is-smaller
#9
Neil D Reeves, Glen Cooper
The Achilles is a long tendon varying in cross-sectional area (CSA) considerably along its length. For the same force, a smaller CSA would experience higher tendon stress and we hypothesised that these areas would therefore undergo larger transverse deformations. A novel magnetic resonance imaging-based approach was implemented to quantify changes in tendon CSA from rest along the length of the Achilles tendon under load conditions corresponding to 10, 20 and 30% of isometric plantar flexor maximum voluntary contraction (MVC)...
February 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28197895/follow-up-of-surgical-and-minimally-invasive-treatment-of-achilles-tendon-pathology-a-brief-diagnostic-imaging-review
#10
REVIEW
A Barile, F Bruno, S Mariani, F Arrigoni, L Brunese, M Zappia, A Splendiani, E Di Cesare, C Masciocchi
The follow-up of an operated tendon is primarily clinical, although clinical examination may not be sufficient in the presence of certain complications. The imaging techniques are of great value not only in the diagnosis of tendon pathologies, but also as an adjunct to clinical evaluation. This is particularly true in the follow-up of patients submitted to surgical tendon reconstruction, by monitoring morphological effects of different interventions and evaluating tendon healing processes. Interpretation of imaging findings requires knowledge of the imaging appearance of the operated tendon during the healing phase, to distinguish between normal postsurgical changes and real pathology, as well as knowledge of surgical technique, postoperative course (including type of prescribed therapy) and possible postoperative complications...
February 14, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28194638/achilles-tendon-injuries
#11
REVIEW
Anthony C Egger, Mark J Berkowitz
PURPOSE OF REVIEW: The purpose of this study is to review the current literature of Achilles tendon injuries, specifically chronic tendinopathy and acute ruptures in regard to etiology, diagnosis, treatment options, and outcomes. RECENT FINDINGS: The incidence of Achilles tendon injuries is increasing, but the necessity for surgical intervention is decreasing due to improved conservative therapies, which may provide comparable outcomes without the implied surgical risk...
February 13, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28191281/switching-off-malignant-mesothelioma-exploiting-the-hypoxic-microenvironment
#12
REVIEW
Noushin Nabavi, Kevin L Bennewith, Andrew Churg, Yuzhuo Wang, Colin C Collins, Luciano Mutti
Malignant mesotheliomas are aggressive, asbestos-related cancers with poor patient prognosis, typically arising in the mesothelial surfaces of tissues in pleural and peritoneal cavity. The relative unspecific symptoms of mesotheliomas, misdiagnoses, and lack of precise targeted therapies call for a more critical assessment of this disease. In the present review, we categorize commonly identified genomic aberrations of mesotheliomas into their canonical pathways and discuss targeting these pathways in the context of tumor hypoxia, a hallmark of cancer known to render solid tumors more resistant to radiation and most chemo-therapy...
November 2016: Genes & Cancer
https://www.readbyqxmd.com/read/28188538/virtualization-of-legacy-instrumentation-control-computers-for-improved-reliability-operational-life-and-management
#13
Jonathan E Katz
Laboratories tend to be amenable environments for long-term reliable operation of scientific measurement equipment. Indeed, it is not uncommon to find equipment 5, 10, or even 20+ years old still being routinely used in labs. Unfortunately, the Achilles heel for many of these devices is the control/data acquisition computer. Often these computers run older operating systems (e.g., Windows XP) and, while they might only use standard network, USB or serial ports, they require proprietary software to be installed...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28186882/multi-modality-imaging-enables-detailed-hemodynamic-simulations-in-dissecting-aneurysms-in-mice
#14
Evan Phillips, Paolo Di Achille, Matthew Bersi, Jay Humphrey, Craig Goergen
A multi-modality imaging based modeling approach was used to study complex unsteady hemodynamics and lesion growth in a dissecting abdominal aortic aneurysm model. We combined in vivo ultrasound (geometry and flow) and in vitro optical coherence tomography (geometry) to obtain the high resolution needed to construct detailed hemodynamic simulations over large portions of the murine vasculature, which include fine geometric complexities. We illustrate this approach for a spectrum of dissecting abdominal aortic aneurysms induced in male apolipoprotein E-null mice by high-dose angiotensin II infusion...
February 6, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28186834/elevated-knee-joint-kinetics-and-reduced-ankle-kinetics-are-present-during-jogging-and-hopping-after-achilles-tendon-ruptures
#15
Richard W Willy, Annelie Brorsson, Hayley C Powell, John D Willson, Roy Tranberg, Karin Grävare Silbernagel
BACKGROUND: Deficits in plantarflexor function are common after an Achilles tendon rupture. These deficits may result in an altered distribution of joint loads during lower extremity tasks. HYPOTHESIS: We hypothesized that, regardless of treatment, the Achilles tendon-ruptured limb would exhibit deficits in ankle kinematics and joint power while exhibiting elevated knee joint power and patellofemoral joint loads during walking, jogging, and hopping. We further hypothesized that this loading pattern would be most evident during jogging and hopping...
February 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28182827/chronic-achilles-tendon-rupture-treated-with-allograft-a-case-report
#16
Giuseppe Restuccia, Alessandro Lippi, Francesco Casella, Carmine Citarelli, Federico Sacchetti, Maurizio Benifei
In clinical practice, chronic Achilles tendon ruptures are uncommon. Usually, these lesions are discovered four to six weeks after injuries. More frequently, Achilles tendon ruptures are acute and treated with tendon sutures.1 Many surgical techniques are available to treat chronic lesions such as sutures or V-Y elongation with or without augments.2-3 Our case is about a chronic Achilles tendon rupture discovered two years after injury. Our patient came to our attention with a 6 cm tendon gap. We performed tendon repair with cadaver allograft...
February 7, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28179885/plyometric-training-favors-optimizing-muscle-tendon-behavior-during-depth-jumping
#17
Kuniaki Hirayama, Soichiro Iwanuma, Naoki Ikeda, Ayumi Yoshikawa, Ryoichi Ema, Yasuo Kawakami
The purpose of the present study was to elucidate how plyometric training improves stretch-shortening cycle (SSC) exercise performance in terms of muscle strength, tendon stiffness, and muscle-tendon behavior during SSC exercise. Eleven men were assigned to a training group and ten to a control group. Subjects in the training group performed depth jumps (DJ) using only the ankle joint for 12 weeks. Before and after the period, we observed reaction forces at foot, muscle-tendon behavior of the gastrocnemius, and electromyographic activities of the triceps surae and tibialis anterior during DJ...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28179607/half-a-century-tales-of-familial-hypercholesterolemia-fh-in-japan
#18
Hiroshi Mabuchi
Familial hypercholesterolemia (FH) is a disease characterized by a triad: elevated low-density lipoprotein (LDL) cholesterol, tendon xanthomas, and premature coronary heart disease. Thus, it can be considered as a model disease for hypercholesterolemia and atherosclerotic cardiovascular disease (ASCVD). For the diagnosis of hetero-FH, the detection of Achilles tendon xanthomas by palpation or on X-ray is an indispensable diagnostic skill in clinical lipidology. To prevent the under-diagnosis and under-treatment of FH, the diagnostic criteria should be more convenient and user-friendly...
February 8, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28178883/radiofrequency-based-identification-medical-device
#19
Alessandra Lazzaro, Arianna Corona, Luca Iezzi, Silvia Quaresima, Luca Armisi, Ilaria Piccolo, Carlo Maria Medaglia, Sergio Sbrenni, Pierpaolo Sileri, Nicola Rosato, Achille Lucio Gaspari, Nicola Di Lorenzo
BACKGROUND: A retained surgical item in patients (gossypiboma) is a persisting problem, despite consistent improvements and existing guidelines in counting instruments and sponges. Previous experiences with radiofrequency identification technology (RFID) tracking sponges show that it could represent an innovation, in order to reduce the criticism and increase the effectiveness during surgical procedures. We present an automated system that allows reduction of errors and improves safety in the operating room...
January 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28177984/treatment-of-syndrome-associated-congenital-talipes-equinovarus-using-the-ponseti-method-4-12-years-of-follow-up
#20
Hosam E Matar, Daoud Makki, Neeraj K Garg
to evaluate the effectiveness of the Ponseti method in treating syndrome-associated (nonidiopathic) congenital talipes equinovarus. This was a retrospective consecutive review over a 12-year period in a tertiary centre of all patients with syndrome-associated talipes equinovarus treated with the Ponseti method. The primary outcome measure at the final follow-up was the functional correction of the deformity. There were 16 (28 feet) children, with an average follow-up of 7 years (range: 4-12). The average age at presentation was 6...
February 7, 2017: Journal of Pediatric Orthopedics. Part B
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