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Seong-Won Han, Dae-Yeon Lee, Dong-Sung Choi, Boram Han, Jin-Sun Kim, Hae-Dong Lee
This study aimed to examine whether muscle force and tendon stiffness in a muscle -tendon complex alter synchronously following 8-week whole-body vibration (WBV) training in older people. Forty older women aged 65 years and older, were randomly assigned into Control (CON, n=15) and WBV training groups (Exposure Time (ET, n=13) and Vibration Intensity (VI, n=12)). For the training groups, 4-week detraining period was subjected following the training period. Throughout the training/detraining period, force of the medial gastrocnemius (MG) muscle and stiffness of the Achilles tendon were assessed 4 times (0, 4, 8, and 12-week) using a combined system of dynamometer and ultrasonography...
October 21, 2016: Journal of Aging and Physical Activity
Lee M Margolis, Donato A Rivas, Maria Berrone, Yassine Ezzyat, Andrew J Young, James P McClung, Roger A Fielding, Stefan M Pasiakos
Short-term (5-10 days) calorie restriction (CR) downregulates muscle protein synthesis, with consumption of a high protein-based diet attenuating this decline. Benefit of increase protein intake is believed to be due to maintenance of amino acid-mediated anabolic signaling through the mechanistic target of rapamycin complex 1 (mTORC1), however, there is limited evidence to support this contention. The purpose of this investigation was to determine the effects of prolonged CR and high protein diets on skeletal muscle mTORC1 signaling and expression of associated microRNA (miR)...
2016: Frontiers in Physiology
Michel van Schaardenburgh, Martin Wohlwend, Øivind Rognmo, Erney J R Mattsson
PURPOSE: Mitochondria are essential for energy production in the muscle cell and for this they are dependent upon a sufficient supply of oxygen by the circulation. Exercise training has shown to be a potent stimulus for physiological adaptations and mitochondria play a central role. Whether changes in mitochondrial respiration are seen after exercise in patients with a reduced circulation is unknown. The aim of the study was to evaluate the time course and whether one session of calf raise exercise stimulates mitochondrial respiration in the calf muscle of patients with peripheral vascular disease...
2016: PloS One
Teresa E Flaxman, Tine Alkjær, Erik B Simonsen, Michael R Krogsgaard, Daniel L Benoit
INTRODUCTION: Knee muscles are commonly labelled as flexors or extensors and aptly stabilize the knee against sagittal plane loads. However, how these muscles stabilize the knee against adduction-abduction and rotational loads remains unclear. Our study sought to: (1) classify muscle roles as they relate to joint stability by quantifying the relationship between individual muscle activation patterns and internal net joint moments in all three loading planes, and (2) determine if these roles change with increasing force levels...
October 14, 2016: Medicine and Science in Sports and Exercise
Koki Takane, Yu Hasegawa, Lin Bowen, Takashi Yokoo, Shokei Kim-Mitsuyama
OBJECTIVE: Increasing evidences suggest that patients with Alzheimer's disease (AD) show not only cognitive impairment but also physical disorder including cardiac dysfunction and sarcopenia. In this study, we investigated whether central angiotensin II, inducer of oxidative stress, led to the organ dysfunction in a mouse model of AD. DESIGN AND METHOD: 5XFAD which is an animal model of AD and C57BL/6 (WT) were each assigned to 1) normal saline and 2) angiotensin II (20 mg/kg/h) groups...
September 2016: Journal of Hypertension
J A DE Fuentes-Vicente, M Cabrera-Bravo, J N Enríquez-Vara, M I Bucio-Torres, A E Gutiérrez-Cabrera, D G Vidal-López, J A Martínez-Ibarra, P M Salazar-Schettino, A Córdoba-Aguilar
Little is known about how the virulence of a human pathogen varies in the environment it shares with its vector. This study focused on whether the virulence of Trypanosoma cruzi (Trypanosomatida: Trypanosomatidae), the causal agent of Chagas' disease, is related to altitude. Accordingly, Triatoma dimidiata (Hemiptera: Reduviidae) specimens were collected at three different altitudes (300, 700 and 1400 m a.s.l.) in Chiapas, Mexico. The parasite was then isolated to infect uninfected T. dimidiata from the same altitudes, as well as female CD-1 mice...
October 18, 2016: Medical and Veterinary Entomology
Kristen T Crowell, David I Soybel, Charles H Lang
Muscle deconditioning is commonly observed in patients surviving sepsis. Little is known regarding the molecular mechanisms regulating muscle protein homeostasis during the recovery or convalescence phase. We adapted a sepsis-recovery mouse model that uses cecal ligation and puncture (CLP), followed 24 h later by cecal resection and antibiotic treatment, to identify putative cellular pathways regulating protein synthesis and breakdown in skeletal muscle. Ten days after CLP, body weight and food consumption did not differ between control and sepsis-recovery mice, but gastrocnemius weight was reduced...
October 5, 2016: Shock
Naruto Yoshida, Shun Kunugi, Sonoko Mashimo, Yoshihiro Okuma, Akihiko Masunari, Shogo Miyazaki, Tatsuya Hisajima, Shumpei Miyakawa
BACKGROUND: The purpose of this study is to examine the effects of different strike forms, during cutting, on knee joint angle and lower limb muscle activity. METHODS: Surface electromyography was used to measure muscle activity in individuals performing cutting manoeuvres involving either rearfoot strikes (RFS) or forefoot strikes (FFS). Three-dimensional motion analysis was used to calculate changes in knee angles, during cutting, and to determine the relationship between muscle activity and knee joint angle...
December 2016: Sports Medicine—Open
Subha Ghosh, Rahul Renapurkar, Subha V Raman
BACKGROUND: The objective of this study was to evaluate patients with known hereditary cardiac conduction and myocardial disease (HCCMD) caused by a lamin A/C gene mutation for skeletal muscle involvement using magnetic resonance imaging (MRI) computed tomography (CT). METHODS: Twenty-one patients with the diagnosis of HCCMD were available for study. Of these 21, 11 had MRI scans of the lower legs. The 11 that had an MRI were compared to a control group of 17 healthy controls...
October 2016: Cardiovascular Diagnosis and Therapy
Susanne M Kaiser, Oliver Harms, Martin Konar, Anne Staudacher, Anna Langer, Cetina Thiel, Martin Kramer, Sebastian Schaub, Kerstin H von Pückler
OBJECTIVES: To describe clinical, radiographic, and magnetic resonance imaging (MRI) findings in 16 dogs diagnosed with gastrocnemius musculotendinopathy. METHODS: Retrospective evaluation of medical records, radiographs, and MRI results, as well as follow-up completed by telephone questionnaire. RESULTS: Most dogs had chronic hindlimb lameness with no history of trauma or athletic activities. Clinical examination revealed signs of pain on palpation without stifle joint instability...
October 14, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Hyun Ho Shin, Young Hoon Jeon, Seung Won Jang, Sae Young Kim
Muscular hypertrophy is caused mainly due to myopathic disorder. But, it is also rarely produced by neurogenic disorder. A 74-year-old woman complained of right calf pain with hypertrophy for several years. Recent lumbar spine magnetic resonance imaging (MRI) showed central and lateral canal narrowing at the L4-L5 intervertebral space. Lower extremity MRI revealed fatty change of right medial head of the gastrocnemius and soleus, causing right calf hypertrophy. Electrodiagnostic examinations including electromyography and nerve conduction velocity testing demonstrated 5(th) lumbar and 1(st) sacral polyradiculopathy...
October 2016: Korean Journal of Pain
Mingxin Li, Lidong Zhai, Wanfu Wei
Rheumatoid arthritis, a synthesized form of adjuvant arthritis exhibited throughout many animal species, inhibits liver function and circulation of IGF-I and contributes to the degradation of skeletal muscle mass. One of the primary goals of the present study is determining whether a high-Methionine (high-Met) diet is capable of reducing the adverse effects of arthritis, namely, loss of body mass. Following adjuvant injection, forty arthritic rats were randomly assigned to either a control group with a basal diet or a high-Met group with the same basal diet + 0...
2016: Mediators of Inflammation
Peng Ma, Ling Yao, Xuemei Lin, Tieguang Gu, Xianglu Rong, Robert Batey, Johji Yamahara, Jianwei Wang, Yuhao Li
Apple pomace is a by-product of the processing of apple for juice, cider or wine preparation. Rosemary is a herb commonly used as spice and flavoring agent in food processing. Evidence suggests that both apple pomace and rosemary have rich bioactive molecules with numerous metabolic effects. To provide more information for using apple pomace and rosemary as functional foods for management of metabolism-associated disorders, the present study investigated the insulin-sensitizing effect of a mixture of apple pomace and rosemary extract (AR)...
2016: American Journal of Translational Research
Marco Hagen, Gerrit Schwiertz, Karl B Landorf, Hylton B Menz, George S Murley
The pronators and supinators play a key role in the medio-lateral stability of the ankle joint complex (i.e. talo-crural and subtalar joints). We hypothesized that each shank muscle has a specific activation pattern determined by its anatomical course around the axes of the subtalar and talo-crural joints. A secondary objective was to examine the effect of foot posture on these activation patterns. Forty-nine young adults (25 normal-arched feet, 24 flat-arched feet) performed maximum voluntary isometric contractions against manual resistance in four movement directions: plantarflexion (PF), dorsiflexion (DF), pronation (PRO) and supination (SUP)...
October 6, 2016: Human Movement Science
María Emilia Garcia Denegri, Gladys P Teibler, Silvana L Maruñak, David R Hernández, Ofelia C Acosta, Laura C Leiva
Bothrops alternatus snake venom is particularly characterized for inducing a prominent haemorrhage and affecting hemostasis as a consequence of 43.1% of metallo-proteinases and less than 10% of PLA2 (almost all non-myotoxic phospholipases) in its venomics. In addition, myonecrosis is the major local effect in viper envenoming which might lead to permanent sequela. Then, the rebuilding of the microvasculature at the local injured site acquires significance since represents one of the pivotal stages for subsequent skeletal muscle regeneration either at morphological or functional aspects...
October 6, 2016: Toxicon: Official Journal of the International Society on Toxinology
Cristina Caresio, Massimo Salvi, Filippo Molinari, Kristen M Meiburger, Marco Alessandro Minetto
Musculoskeletal ultrasound imaging allows non-invasive measurement of skeletal muscle thickness. Current techniques generally suffer from manual operator dependency, while all the computer-aided approaches are limited to be semi-automatic or specifically optimized for a single muscle. The aim of this study was to develop and validate a fully automatic method, named MUSA (Muscle UltraSound Analysis), for measurement of muscle thickness on longitudinal ultrasound images acquired from different skeletal muscles...
October 6, 2016: Ultrasound in Medicine & Biology
Manuel Villanueva, Álvaro Iborra, Guillermo Rodríguez, Pablo Sanz-Ruiz
BACKGROUND: Isolated gastrocnemius contracture is thought to lead to numerous conditions. Although many techniques have been described for gastrocnemius recession, potential anesthetic, cosmetic, and wound-related complications can lead to patient dissatisfaction. Open and endoscopic recession techniques require epidural anesthesia, lower limb ischemia, and stitches and may lead to damage of the sural nerve, which is not under the complete control of the surgeon at all stages of the procedure...
October 3, 2016: BMC Musculoskeletal Disorders
Alba Chacon-Cabrera, Joaquim Gea, Esther Barreiro
Skeletal muscle dysfunction and atrophy are characteristic features accompanying chronic conditions. Epigenetic events regulate muscle mass and function maintenance. We hypothesized that the pattern of epigenetic events (muscle-enriched microRNAs and histone acetylation) and acetylation of transcription factors known to signal muscle wasting may differ between early- and late-time points in skeletal muscles of mice exposed to hindlimb immobilization (I) and recovery following I. Body and muscle weights, grip strength, muscle-enriched microRNAs, histone deacetylases (HDACs), acetylation of proteins, histones, and transcription factors (TF), myogenic TF factors, and muscle phenotype were assessed in gastrocnemius of mice exposed to periods (1, 2, 3, 7, 15 and 30 days, I groups) of hindlimb immobilization, and in those exposed to reloading for different periods of time (1, 3, 7, 15, and 30 days, R groups) following 7-day immobilization...
October 7, 2016: Journal of Cellular Physiology
Masaaki Katayama
OBJECTIVE: To report appositional augmentation of Achilles tendon rupture in a toy breed dog with an intact flexor digitorum lateralis (FDL) muscle tendon. STUDY DESIGN: Clinical case report. ANIMALS: Two-year-old spayed female Toy Poodle with Achilles tendon rupture. METHODS: The Achilles tendon was accidentally ruptured by hair clippers during grooming. The dog demonstrated a plantigrade stance without digital flexion of the right hind limb...
October 6, 2016: Veterinary Surgery: VS
Chris Tijs, Jaap H van Dieën, Guus C Baan, Huub Maas
Force transmission between rat ankle plantar-flexors has been found for physiological muscle lengths and relative positions, but only with all muscles maximally activated. The aims of this study were to assess intermuscular mechanical interactions between ankle plantar-flexors during (i) fully passive conditions, (ii) excitation of soleus (SO), (iii) excitation of lateral gastrocnemius (LG), and (iv) during co-activation of SO, and LG (SO&LG). We assessed effects of proximal lengthening of LG and plantaris (PL) muscles (i...
2016: Frontiers in Physiology
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