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https://www.readbyqxmd.com/read/28177712/investigating-human-skeletal-muscle-physiology-with-unilateral-exercise-models-when-one-limb-is-more-powerful-than-two
#1
Martin J MacInnis, Chris McGlory, Martin J Gibala, Stuart M Phillips
Direct sampling of human skeletal muscle using the needle biopsy technique can facilitate insight into the biochemical and histological responses resulting from changes in exercise or feeding. However, the muscle biopsy procedure is invasive, and analyses are often expensive, which places pragmatic restraints on sample sizes. The unilateral exercise model can serve to increase statistical power and reduce the time and cost of a study. With this approach, two limbs of a participant are randomized to one of two treatments that can be applied almost concurrently or sequentially depending on the nature of the intervention...
January 24, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28156163/post-infarct-sleep-disruption-and-its-relation-to-cardiac-remodeling-in-a-rat-model-of-myocardial-infarction
#2
Marjan Aghajani, Mahdieh Faghihi, Alireza Imani, Mohammad Reza Vaez Mahdavi, Abbas Shakoori, Tayebeh Rastegar, Hoda Parsa, Saman Mehrabi, Fatemeh Moradi, Ehsan Kazemi Moghaddam
Sleep disruption after myocardial infarction (MI) by affecting ubiquitin-proteasome system (UPS) is thought to contribute to myocardial remodeling and progressive worsening of cardiac function. The aim of current study was to test the hypothesis about the increased risk of developing heart failure due to experience of sleep restriction (SR) after MI. Male Wistar rats (n = 40) were randomly assigned to four experimental groups: (1) Sham, (2) MI, (3) MI and SR (MI + SR) (4) Sham and SR (Sham + SR). MI was induced by permanent ligation of left anterior descending coronary artery...
February 3, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28060373/small-round-blue-cell-tumors-of-the-sinonasal-tract-a-differential-diagnosis-approach
#3
Lester Dr Thompson
One of the most challenging diagnostic categories within tumors of the sinonasal tract is the small round blue cell tumors. Biopsies are usually small and limited, resulting in considerable diagnostic difficulty for practicing surgical pathologists. These tumors share several overlapping histologic and immunophenotypic findings while also showing considerable variation within and between cases. Specific tumor site of origin, imaging findings, and clinical findings must be combined with the histology and pertinent ancillary studies if the correct diagnosis is to be reached...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28057852/endothelin-1-and-et-receptors-impair-left-ventricular-function-by-mediated-coronary-arteries-dysfunction-in-chronic-intermittent-hypoxia-rats
#4
Jin-Wei Wang, Ai-Ying Li, Qiu-Hong Guo, Ya-Jing Guo, James W Weiss, En-Sheng Ji
Obstructive sleep apnea (OSA) results in cardiac dysfunction and vascular endothelium injury. Chronic intermittent hypoxia (CIH), the main characteristic of OSAS, is considered to be mainly responsible for cardiovascular system impairment. This study is aimed to evaluate the role of endothelin-1(ET-1) system in coronary injury and cardiac dysfunction in CIH rats. In our study, Sprague-Dawley rats were exposed to CIH (FiO2 9% for 1.5 min, repeated every 3 min for 8 h/d, 7 days/week for 3 weeks). After 3 weeks, the left ventricular developed pressure (LVDP) and coronary resistance (CR) were measured with the langendorff mode in isolated hearts...
January 2017: Physiological Reports
https://www.readbyqxmd.com/read/27982683/the-in-vivo-effects-of-adenine-induced-chronic-kidney-disease-on-some-renal-and-hepatic-function-and-cyp450-metabolizing-enzymes
#5
M Al Za'abi, A Shalaby, P Manoj, B H Ali
Adenine-induced model of chronic kidney disease (CKD) is a widely used model especially in studies testing novel nephroprotective agents. We investigated the effects of adenine-induced CKD in rats on the activities of some xenobiotic metabolizing enzymes in liver and kidneys, and on some in vivo indicators of drug metabolism (viz pentobarbitone sleeping time, and plasma concentration of theophylline 90 min post administration). CKD was induced by orally feeding adenine (0.25% w/w) for 35 days. Adenine induced all the characteristics of CKD, which was confirmed by biochemical and histological findings...
December 16, 2016: Physiological Research
https://www.readbyqxmd.com/read/27842547/health-related-quality-of-life-in-patients-with-barrett-s-esophagus
#6
Chi-Yang Chang, Lukas Jyuhn-Hsiarn Lee, Jung-Der Wang, Ching-Tai Lee, Chi-Ming Tai, Tao-Qian Tang, Jaw-Town Lin
BACKGROUND: Gastroesophageal reflux disease (GERD) has become a major health problem globally, affecting patients' health-related quality of life (HRQOL). Barrett's esophagus (BE) is a precancerous lesion associated with GERD. BE patients might not only suffer from HRQOL losses by GERD but also face psychological distress due to the increased risk of developing cancer. However, the majority of patients in Asia have shorter BE segment which is different from the West. This study aimed to determine whether the HRQOL in BE patients were worse than in healthy referents in Taiwan...
November 14, 2016: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/27832434/monitoring-of-venus-transgenic-cell-migration-during-pregnancy-in-non-transgenic-rabbits
#7
N Lipták, O I Hoffmann, A Kerekes, G Iski, D Ernszt, K Kvell, L Hiripi, Z Bősze
Cell transfer between mother and fetus were demonstrated previously in several species which possess haemochorial placenta (e.g. in humans, mice, rats, etc.). Here we report the assessment of fetal and maternal microchimerism in non-transgenic (non-TG) New Zealand white rabbits which were pregnant with transgenic (TG) fetuses and in non-TG newborns of TG does. The TG construct, including the Venus fluorophore cDNA driven by a ubiquitous cytomegalovirus enhancer, chicken ß-actin promoter (CAGGS), was previously integrated into the rabbit genome by Sleeping Beauty transposon system...
November 10, 2016: Transgenic Research
https://www.readbyqxmd.com/read/27731822/effect-of-calcium-hypochlorite-and-chloramine-on-blood-biochemistry-and-sodium-pentobarbital-induced-sleeping-time-in-mice
#8
Sidra Ishaq, Muhammad Adil Rasheed, Muhammad Ashraf, Imran Altaf, Saima Rehmat, Ghulam Fatima
Disinfectants are chemical agents used to eradicate, deactivate or kill microorganisms. Chemical disinfectants especially chlorine compound are extensively used for water sanitization. Among these calcium hypochlorite and chloramines are commonly used now a day. Large number of chemical compounds, drugs and endogenous substances are metabolized by hepatic enzymes known as cytochrome P450 enzyme system. Many chemicals are capable of enzyme induction. Enzyme induction may change the metabolism of other drugs and endogenous substances which may alter the plasma concentration of these chemicals...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27688824/soluble-receptor-for-advanced-glycation-end-product-ameliorates-chronic-intermittent-hypoxia-induced-renal-injury-inflammation-and-apoptosis-via-p38-jnk-signaling-pathways
#9
Xu Wu, Wenyu Gu, Huan Lu, Chengying Liu, Biyun Yu, Hui Xu, Yaodong Tang, Shanqun Li, Jian Zhou, Chuan Shao
Obstructive sleep apnea (OSA) associated chronic kidney disease is mainly caused by chronic intermittent hypoxia (CIH) triggered tissue damage. Receptor for advanced glycation end product (RAGE) and its ligand high mobility group box 1 (HMGB1) are expressed on renal cells and mediate inflammatory responses in OSA-related diseases. To determine their roles in CIH-induced renal injury, soluble RAGE (sRAGE), the RAGE neutralizing antibody, was intravenously administered in a CIH model. We also evaluated the effect of sRAGE on inflammation and apoptosis...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27672276/melatonin-modulates-adiponectin-expression-on-murine-colitis-with-sleep-deprivation
#10
Tae Kyun Kim, Young Sook Park, Haing-Woon Baik, Jin Hyun Jun, Eun Kyung Kim, Jae Woong Sull, Ho Joong Sung, Jin Woo Choi, Sook Hee Chung, Myung Chan Gye, Ju Yeon Lim, Jun Bong Kim, Seong Hwan Kim
AIM: To determine adiponectin expression in colonic tissue of murine colitis and systemic cytokine expression after melatonin treatments and sleep deprivation. METHODS: The following five groups of C57BL/6 mice were used in this study: (1) group I, control; (2) group II, 2% DSS induced colitis for 7 d; (3) group III, 2% DSS induced colitis and melatonin treatment; (4) group IV, 2% DSS induced colitis with sleep deprivation (SD) using specially designed and modified multiple platform water baths; and (5) group V, 2% DSS induced colitis with SD and melatonin treatment...
September 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27632178/a-longitudinal-study-of-surgical-outcome-of-pharmacoresistant-epilepsy-caused-by-focal-cortical-dysplasia
#11
Bo Jin, Jing Wang, Jian Zhou, Shuang Wang, Yuguang Guan, Shuhua Chen
This study aimed to determine the long-term surgical outcome of pharmacoresistant epilepsy caused by focal cortical dysplasia (FCD) and to identify the important predictors of the favorable surgical outcome. The study retrospectively analyzed the data of pharmacoresistant epilepsy patients with histologically proven FCD in our epilepsy center from May 2010 to December 2014. It included 120 patients with a mean follow-up of 34.6 months. Survival analysis and multivariate regression with Cox proportional hazards model were used to evaluate the rate, stability, and predictors of seizure freedom...
December 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27542769/survival-and-proliferation-of-neural-progenitor-derived-glioblastomas-under-hypoxic-stress-is-controlled-by-a-cxcl12-cxcr4-autocrine-positive-feedback-mechanism
#12
Alexandra A Calinescu, Viveka Nand Yadav, Erica Carballo, Padma Kadiyala, Dustin Tran, Daniel Zamler, Robert Doherty, Maithreyi Srikanth, Pedro R Lowenstein, Maria G Castro
PURPOSE: One likely cause of treatment failure in glioblastoma is the persistence of glioma stem-like cells (GSLCs), highly resistant to therapies currently employed. We found that CXCL12 has highest expression in glioma cells derived from neural progenitor cells (NPCs). The development and molecular signature of NPC-derived GBMs were analyzed and the therapeutic effect of blocking CXCL12 was tested. EXPERIMENTAL DESIGN: Tumors were induced by injecting DNA into the lateral ventricle of neonatal mice, using the Sleeping Beauty transposase method...
August 19, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27501738/nocturnal-hypoxia-induced-oxidative-stress-promotes-progression-of-pediatric-non-alcoholic-fatty-liver-disease
#13
Shikha S Sundaram, Ann Halbower, Zhaoxing Pan, Kristen Robbins, Kelley E Capocelli, Jelena Klawitter, Colin T Shearn, Ronald J Sokol
BACKGROUND & AIMS: Oxidative stress is proposed as a central mediator in NAFLD pathogenesis, but the specific trigger for reactive oxygen species generation has not been clearly delineated. In addition, emerging evidence shows that obesity related obstructive sleep apnea (OSA) and nocturnal hypoxia are associated with NAFLD progression in adults. The aim of this study was to determine if OSA/nocturnal hypoxia-induced oxidative stress promotes the progression of pediatric NAFLD. METHODS: Subjects with biopsy proven NAFLD and lean controls were studied...
September 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27499652/a-novel-implantable-device-for-a-minimally-invasive-surgical-treatment-of-obstructive-sleep-apnea-design-and-preclinical-safety-assessment
#14
Edward Gillis, Charles Rampersaud, Emmanuelle Pease, Paul Buscemi
BACKGROUND: In obstructive sleep apnea (OSA), occlusion of the upper airway by soft tissue causes intermittent hypoxemia and can have serious sequelae. A novel implantable medical device for OSA is composed of a linear silicone elastic element held in an extended state by a bioabsorbable external sheath. The implant is delivered to the tongue base or soft palate via a minimally invasive approach. Normal tissue healing anchors the device at the attachment points before the bioabsorbable material dissolves and the elastic element contracts to stabilize the surrounding tissue...
2016: Nature and Science of Sleep
https://www.readbyqxmd.com/read/27485995/hepatoprotective-effect-of-low-doses-of-caffeine-on-ccl4-induced-liver-damage-in-rats
#15
Andrés Uc Cachón, Carlos Quintal-Novelo, Gilberto Medina-Escobedo, Gaspar Castro-Aguilar, Rosa E Moo-Puc
Several studies have shown the hepatoprotective effect of the consumption of coffee and tea, which is mainly attributed to caffeine. Many experimental studies have demonstrated this effect; however, these studies used high caffeine doses that are not related to human consumption. The aim of this study was to evaluate the hepatoprotective effect of low doses of caffeine on carbon tetrachloride (CCl4)-treated rats. Low doses of caffeine (CAFF) 5 and 10 mg/kg (CAFF5 and CAFF10) were evaluated in chronic liver damage induced by CCl4 (0...
March 4, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/27485745/effects-of-chronic-sleep-deprivation-on-bone-mass-and-bone-metabolism-in-rats
#16
Xiaowen Xu, Liang Wang, Liying Chen, Tianjiao Su, Yan Zhang, Tiantian Wang, Weifeng Ma, Fan Yang, Wujie Zhai, Yuanyuan Xie, Dan Li, Qiong Chen, Xuemei Fu, Yuanzheng Ma, Yan Zhang
BACKGROUND: This study aimed to assess the effects of chronic sleep deprivation (CSD) on bone mass and bone metabolism in rats. METHODS: Twenty-four rats were randomly divided into CSD and control (CON) groups. Rats were subjected to CSD by using the modified multiple platform method (MMPM) to establish an animal model of CSD. Biochemical parameters such as levels of serum N-terminal propeptide of type I procollagen (PINP), N-terminal cross-linking telopeptide of type I collagen (NTX), growth hormone (GH), estradiol (E2), serum 25(OH)D, and calcium (Ca) were evaluated at 0, 1, 2, and 3 months...
August 2, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27377521/impact-of-single-vs-split-dose-low-volume-bowel-preparations-on-bowel-movement-kinetics-patient-inconvenience-and-polyp-detection-a-prospective-trial
#17
Nicholas Horton, Ari Garber, Henrietta Hasson, Rocio Lopez, Carol A Burke
OBJECTIVES: There are little data on bowel movement (BM) kinetics induced by bowel preparation. Whether single-dose (SID) or split-dose (SPD) regimens differ in terms of patient convenience is unclear. We compared BM kinetics, sleep and travel disruptions, and polyp detection rates in patients undergoing colonoscopy assigned to SID vs. SPDs. METHODS: Patients were randomly assigned to 2-L SID or SPD (SPD1 and SPD2) bowel preparations. Surveys were completed querying the onset, duration, cessation, and intensity of BMs, along with sleep and travel disruption en route to the endoscopy center...
September 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27319814/periodic-persistent-orofacial-pain-due-to-osteomyelitis-of-the-mandible-a-case-report
#18
Ragda Abdalla-Aslan, Chen Nadler, Rafael Benoliel, Yair Sharav, Yaron Haviv
Chronic osteomyelitis of the jaws presents a diagnostic and therapeutic challenge. A 45-year-old woman presented with episodic pain in the right mandible of two and a half years' duration. During active periods, lasting for 2 to 3 weeks, the pain woke the patient from sleep at a regular time, and had features mimicking a variant of cluster headache. However, clinical, radiologic, and histologic findings confirmed the diagnosis of chronic sclerosing osteomyelitis. Conservative treatment, including 6 weeks of intravenous antibiotics, relieved the pain with no signs of recurrence at the 1-year follow-up...
2016: Quintessence International
https://www.readbyqxmd.com/read/27235865/hippocampal-neurogenesis-response-what-can-we-expect-from-two-different-models-of-hypertension
#19
Daniela Pedroso, Ana R Nunes, Lucília N Diogo, Carole Oudot, Emília C Monteiro, Catherine Brenner, Helena L A Vieira
Hypertension is associated with cerebrovascular disease, white matter lesion and cognitive deficit, both in experimental models and clinical observations. Furthermore, in non-clinical models it is shown that hippocampus is affected by hypertension and hypoxia. Herein, two distinct hypertension models were used to study neurogenic response in hippocampus. Dahl salt sensitive (DSS) rat model is a genetic based idiopathic model, while chronic intermittent hypoxia (CIH) mimics the hypertension observed in patients with obstructive sleep apnea (OSA)...
September 1, 2016: Brain Research
https://www.readbyqxmd.com/read/27196421/histological-effects-of-er-yag-laser-irradiation-with-snoring-handpiece-in-the-rat-soft-palate
#20
Tugba Unver, Emre Aytugar, Orhan Ozturan, Tugçe Kıran, Ebru Ademci, Aslihan Usumez
OBJECTIVE: The aim of this study was to assess the effects of laser irradiation with a novel snoring handpiece on the histological structures of the soft palate in a rat model. BACKGROUND: Snoring is a common problem and studies have shown that 20-50% of the population is affected. An apnea-hypopnea index of <5/h without daytime somnolence is documented as simple snoring. No snoring treatment should ever be attempted until a sleep study has been completed to rule out sleep apnea...
August 2016: Photomedicine and Laser Surgery
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