Gaoxiang Li, Mengru Gao, Shuangshuang Zhang, Tianliang Dai, Fei Wang, Jinke Geng, Jia Rao, Xuejia Qin, Jizhao Qian, Li Zuo, Meng Zhou, Lixin Liu, Hong Zhou
Sleep deficiency is frequently associated with intestinal inflammatory conditions and has been increasingly recognized as a public health concern worldwide. However, the effects of sleep deficiency on intestinal goblet cells (GCs), which play a major role in intestinal barrier formation, remain elusive. Herein, we determined the effects of sleep deprivation on intestinal GCs using a sleep-deprivation mouse model. Sleep deprivation impaired the intestinal mucosal barrier and decreased the expression of tight junction proteins...
October 31, 2023: American Journal of Pathology