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https://www.readbyqxmd.com/read/29904334/sleep-disorders-associated-with-alzheimer-s-disease-a-perspective
#1
REVIEW
Anna Brzecka, Jerzy Leszek, Ghulam Md Ashraf, Maria Ejma, Marco F Ávila-Rodriguez, Nagendra S Yarla, Vadim V Tarasov, Vladimir N Chubarev, Anna N Samsonova, George E Barreto, Gjumrakch Aliev
Sleep disturbances, as well as sleep-wake rhythm disturbances, are typical symptoms of Alzheimer's disease (AD) that may precede the other clinical signs of this neurodegenerative disease. Here, we describe clinical features of sleep disorders in AD and the relation between sleep disorders and both cognitive impairment and poor prognosis of the disease. There are difficulties of the diagnosis of sleep disorders based on sleep questionnaires, polysomnography or actigraphy in the AD patients. Typical disturbances of the neurophysiological sleep architecture in the course of the AD include deep sleep and paradoxical sleep deprivation...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29903598/trial-protocol-cognitive-functional-therapy-compared-with-combined-manual-therapy-and-motor-control-exercise-for-people-with-non-specific-chronic-low-back-pain-protocol-for-a-randomised-controlled-trial
#2
Fabiana Terra Cunha Belache, Cíntia Pereira de Souza, Jessica Fernandez, Julia Castro, Paula Dos Santos Ferreira, Elizana Rodrigues de Sousa Rosa, Nathalia Cristina Gimenez de Araújo, Felipe José Jandre Reis, Renato Santos de Almeida, Leandro Alberto Calazans Nogueira, Luís Cláudio Lemos Correia, Ney Meziat-Filho
INTRODUCTION: Chronic low back pain is a public health problem, and there is strong evidence that it is associated with a complex interaction of biopsychosocial factors. Cognitive functional therapy is an intervention that deals with potentially modifiable multidimensional aspects of pain (eg, provocative cognitive, movement and lifestyle behaviours). There is evidence (from a single randomised, controlled trial) that cognitive functional therapy is better than combined manual therapy and motor control exercise...
June 11, 2018: Journal of Physiotherapy
https://www.readbyqxmd.com/read/29898972/diffuse-lewy-body-disease-manifesting-as-corticobasal-syndrome-a-rare-form-of-lewy-body-disease
#3
Koji Kasanuki, Keith A Josephs, Tanis J Ferman, Melissa E Murray, Shunsuke Koga, Takuya Konno, Nobutaka Sakae, Adam Parks, Ryan J Uitti, Jay A Van Gerpen, Neill R Graff-Radford, Zbigniew K Wszolek, Dennis W Dickson
OBJECTIVE: To describe clinical and pathologic characteristics of diffuse Lewy body disease (DLBD) manifesting as corticobasal syndrome (CBS). METHODS: In 523 autopsy-confirmed cases of DLBD, we identified 11 patients diagnosed with CBS. For comparison, we studied 22 DLBD brains with antemortem presentation of dementia with Lewy bodies (DLB). Given previous studies suggesting the importance of pathology in peri-Rolandic cortices in CBS, we used digital pathology to count Lewy bodies and to quantify intracytoplasmic and neuritic α-synuclein and phospho-tau burden in the motor cortex...
June 13, 2018: Neurology
https://www.readbyqxmd.com/read/29892042/sleep-disordered-breathing-circulating-exosomes-and-insulin-sensitivity-in-adipocytes
#4
Abdelnaby Khalyfa, David Gozal, Juan F Masa, José Maria Marin, Zhuanghong Qiao, Jaime Corral, Mónica González, Sergi Marti, Leila Kheirandish-Gozal, Carlos Egea, M-Ángeles Sánchez-Quiroga, Francisco J Gómez de Terreros, F Javier Barca
BACKGROUND: Sleep-disordered-breathing (SDB), which is characterized by chronic intermittent hypoxia (IH) and sleep fragmentation (SF), is a prevalent condition that promotes metabolic dysfunction, particularly among patients suffering from obstructive hypoventilation syndrome (OHS). Exosomes are generated ubiquitously, are readily present in the circulation, and their cargo may exert substantial functional cellular alterations in both physiological and pathological conditions. However, the effects of plasma exosomes on adipocyte metabolism in patients with OHS or in mice subjected to IH or SF mimicking SDB are unclear...
June 11, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29889457/-pharmacological-and-nonpharmacological-treatment-of-insomnias-with-regard-to-sleep-medicine
#5
REVIEW
Béla Faludi, Renáta Rozgonyi
Insomnia - one of the most prevalent sleep complain - has a great impact on the everyday life. Basically two different form of insomnia can be defined: the insomnia disorder and the co-morbid insomnias. To treat adequately determination of background pathology is essential, which is based on the help of Sleep Medicine Centers. According to the newest guidelines, the treatment of insomnia disorder is based on cognitive behavioural therapies followed by pharmaceutical intervention. In this review we provide the short description of cognitive behavioural therapies and basic principles of hypnotic drugs...
May 30, 2018: Ideggyógyászati Szemle
https://www.readbyqxmd.com/read/29883833/rapid-eye-movement-sleep-behavior-disorder-and-the-link-to-alpha-synucleinopathies
#6
REVIEW
Daniel A Barone, Claire Henchcliffe
Rapid eye movement (REM) sleep behavior disorder (RBD) involves REM sleep without atonia in conjunction with a recurrent nocturnal dream enactment behavior, with vocalizations such as shouting and screaming, and motor behaviors such as punching and kicking. Secondary RBD is well described in association with neurological disorders including Parkinson's disease (PD), multiple system atrophy (MSA), and other conditions involving brainstem structures such as tumors. However, RBD alone is now considered to be a potential harbinger of later development of neurodegenerative disorders, in particular PD, MSA, dementia with Lewy bodies (DLB), and pure autonomic failure...
May 29, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29883682/regional-brain-tissue-integrity-in-pediatric-obstructive-sleep-apnea
#7
Leila Kheirandish-Gozal, Ashish K Sahib, Paul M Macey, Mona F Philby, David Gozal, Rajesh Kumar
Children with long-standing obstructive sleep apnea (OSA) show evidence of neural injury and functional deficits in behavioral and cognitive regulatory brain regions that are reflected in symptoms of altered cognitive performance and behaviors. While we earlier showed reduced gray matter volume and increased and reduced regional cortical thicknesses, such structural changes give little indication of the underlying pathology. Brain tissue integrity in pediatric OSA subjects can reflect the nature and extent of injury or structural adaptation, and can be assessed by entropy tissue texture, a measure of local changes in signal intensity patterns from high-resolution magnetic resonance images...
June 5, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29883622/electrophysiological-biomarkers-of-epileptogenicity-after-traumatic-brain-injury
#8
REVIEW
Piero Perucca, Gregory Smith, Cesar Santana-Gomez, Anatol Bragin, Richard Staba
Post-traumatic epilepsy is the architype of acquired epilepsies, wherein a brain insult initiates an epileptogenic process culminating in an unprovoked seizure after weeks, months or years. Identifying biomarkers of such process is a prerequisite for developing and implementing targeted therapies aimed at preventing the development of epilepsy. Currently, there are no validated electrophysiological biomarkers of post-traumatic epileptogenesis. Experimental EEG studies using the lateral fluid percussion injury model have identified three candidate biomarkers of post-traumatic epileptogenesis: pathological high-frequency oscillations (HFOs, 80-300 Hz); repetitive HFOs and spikes (rHFOSs); and reduction in sleep spindle duration and dominant frequency at the transition from stage III to rapid eye movement sleep...
June 5, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29881356/acetylsalicylic-acid-prevents-intermittent-hypoxia-induced-vascular-remodeling-in-a-murine-model-of-sleep-apnea
#9
Monique C Suarez-Giron, Anabel Castro-Grattoni, Marta Torres, Ramon Farré, Ferran Barbé, Manuel Sánchez-de-la-Torre, David Gozal, Cesar Picado, Josep M Montserrat, Isaac Almendros
Study objectives: Chronic intermittent hypoxia (CIH), a hallmark feature of obstructive sleep apnea (OSA), induces accelerated atherogenesis as well as aorta vascular remodeling. Although the cyclooxygenase (COX) pathway has been proposed to contribute to the cardiovascular consequences of OSA, the potential benefits of a widely employed COX-inhibitor such (acetylsalicylic acid, ASA) on CIH-induced vascular pathology are unknown. Therefore, we hypothesized that a common non-selective COX inhibitor such as ASA would attenuate the aortic remodeling induced by CIH in mice...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29868460/anesthesia-preoperative-clinic-evaluation-of-obstructive-sleep-apnea-using-nasal-fiberoptic-videoendoscopy-a-pilot-study-comparison-with-polysomnography
#10
Sandeep Jain, Peter J Kallio, Kenneth Less, Jutta Novalija, Paul S Pagel, Thomas J Ebert
Background: Nasal fiberoptic videoendoscopy is an established technique to assess upper airway pathology in conscious and sedated patients. Objectives: The authors conducted a prospective proof-of-concept pilot study to evaluate whether airway narrowing detected using nasal fiberoptic videoendoscopy in the anesthesia preoperative clinic was capable of defining the severity of obstructive sleep apnea (OSA) in patients scheduled for elective surgery. Methods: After application of topical local anesthesia (4% lidocaine with phenylephrine), sixteen patients (ASA physical status 2 or 3) underwent nasal fiberoptic videoendoscopy in sitting position...
February 2018: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/29866443/in-vivo-staging-of-pathology-in-rem-sleep-behaviour-disorder-a-multimodality-imaging-case-control-study
#11
Karoline Knudsen, Tatyana D Fedorova, Allan K Hansen, Michael Sommerauer, Marit Otto, Kristina B Svendsen, Adjmal Nahimi, Morten G Stokholm, Nicola Pavese, Christoph P Beier, David J Brooks, Per Borghammer
BACKGROUND: Accumulating evidence suggests that α-synuclein aggregates-a defining pathology of Parkinson's disease-display cell-to-cell transmission. α-synuclein aggregation is hypothesised to start in autonomic nerve terminals years before the appearance of motor symptoms, and subsequently spread via autonomic nerves to the spinal cord and brainstem. To assess this hypothesis, we investigated sympathetic, parasympathetic, noradrenergic, and dopaminergic innervation in patients with idiopathic rapid eye movement (REM) sleep behaviour disorder, a prodromal phenotype of Parkinson's disease...
June 1, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29862455/the-locus-coeruleus-neurotoxin-dsp4-and-or-a-high-sugar-diet-induce-behavioral-and-biochemical-alterations-in-wild-type-mice-consistent-with-alzheimers-related-pathology
#12
Pooja Choudhary, Anthony G Pacholko, Josh Palaschuk, Lane K Bekar
Alzheimer's disease (AD) is the sixth leading cause of death in the United States where it is estimated that one in three seniors dies with AD or another dementia. Are modern lifestyle habits a contributing factor? Increased carbohydrate (sugar) consumption, stress and disruption of sleep patterns are quickly becoming the norm rather than the exception. Interestingly, seven months on a non-invasive high sucrose diet (20% sucrose in drinking water) has been shown to induce behavioral, metabolic and pathological changes consistent with AD in wild-type mice...
June 3, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29848376/a-lightweight-sensing-platform-for-monitoring-sleep-quality-and-posture-a-simulated-validation-study
#13
Richard M Kwasnicki, George W V Cross, Luke Geoghegan, Zhiqiang Zhang, Peter Reilly, Ara Darzi, Guang Zhong Yang, Roger Emery
BACKGROUND: The prevalence of self-reported shoulder pain in the UK has been estimated at 16%. This has been linked with significant sleep disturbance. It is possible that this relationship is bidirectional, with both symptoms capable of causing the other. Within the field of sleep monitoring, there is a requirement for a mobile and unobtrusive device capable of monitoring sleep posture and quality. This study investigates the feasibility of a wearable sleep system (WSS) in accurately detecting sleeping posture and physical activity...
May 30, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29843024/profile-of-neuropsychological-impairment-in-sleep-related-hypermotor-epilepsy
#14
Laura Licchetta, Roberto Poda, Luca Vignatelli, Tommaso Pippucci, Corrado Zenesini, Veronica Menghi, Barbara Mostacci, Sara Baldassari, Federica Provini, Paolo Tinuper, Francesca Bisulli
OBJECTIVE: The aim of this study was to characterize the neuropsychological features of a representative sample of Sleep-related Hypermotor Epilepsy (SHE) patients and to highlight clinical associations. METHODS: This cross-sectional study included 60 consecutive patients with video/video-electroencephalography-documented SHE. All were assessed by measures of intelligence. Individuals with normal scores underwent a standardized battery of tests. The Fisher exact test and Wilcoxon rank-sum test for statistical analysis...
April 30, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29808945/endothelial-microvesicles-in-hypoxic-hypoxia-diseases
#15
REVIEW
Fan Deng, Shuang Wang, Riping Xu, Wenqian Yu, Xianyu Wang, Liangqing Zhang
Hypoxic hypoxia, including abnormally low partial pressure of inhaled oxygen, external respiratory dysfunction-induced respiratory hypoxia and venous blood flow into the arterial blood, is characterized by decreased arterial oxygen partial pressure, resulting in tissue oxygen deficiency. The specific characteristics include reduced arterial oxygen partial pressure and oxygen content. Hypoxic hypoxia diseases (HHDs) have attracted increased attention due to their high morbidity and mortality and mounting evidence showing that hypoxia-induced oxidative stress, coagulation, inflammation and angiogenesis play extremely important roles in the physiological and pathological processes of HHDs-related vascular endothelial injury...
May 29, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29798198/-systematic-review-on-orofacial-myofunctional-therapy-to-treat-obstructive-sleep-apnea-hypopnea-syndrome
#16
REVIEW
L M Wu, X F Wu, Z M Yu, Y Liu
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is an important risk factor for cardiovascular and cerebrovascular diseases. The widespread collapse of the airway, which can't maintain its normal position and structure, is an important cause of OSAHS. Noninvasive ventilator-assisted ventilation is the preferred treatment for OSAHS, but there are shortcomings of poor compliance. Orofacial myofunctional therapy (OMT) is a noninvasive, simple, low-cost, low-risk therapy that is expected to replace noninvasive ventilator-assisted ventilation to a certain extent...
November 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29797753/the-impact-of-stress-on-sleep-pathogenic-sleep-reactivity-as-a-vulnerability-to-insomnia-and-circadian-disorders
#17
REVIEW
David A Kalmbach, Jason R Anderson, Christopher L Drake
Sleep reactivity is the trait-like degree to which stress exposure disrupts sleep, resulting in difficulty falling and staying asleep. Individuals with highly reactive sleep systems experience drastic deterioration of sleep when stressed, whereas those with low sleep reactivity proceed largely unperturbed during stress. Research shows that genetics, familial history of insomnia, female gender and environmental stress influence how the sleep system responds to stress. Further work has identified neurobiological underpinnings for sleep reactivity involving disrupted cortical networks and dysregulation in the autonomic nervous system and hypothalamic-pituitary-adrenal axis...
May 24, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29790977/alpha-synuclein-aggregates-in-labial-salivary-glands-of-idiopathic-rapid-eye-movement-sleep-behavior-disorder
#18
Alx Iranzo, Sergi Borrego, Isabel Vilaseca, Carles Martí, Mónica Serradell, Raquel Sánchez-Valle, Gabor G Kovacs, Francesc Valldeoriola, Carles Gaig, Joan Santamaria, Eduard Tolosa, Ellen Gelpi
Study Objectives : To assess whether biopsy of the labial minor salivary glands safely detects phosphorylated alpha-synuclein (pAS) deposits in idiopathic REM sleep behavior disorder (IRBD), a condition that precedes the cardinal manifestations of synuclein disorders associated with Lewy type pathology, namely Parkinson disease (PD) and dementia with Lewy bodies (DLB). Methods: In a prospective study, labial biopsy of the minor salivary glands was performed in 62 IRBD patients, 13 PD and 10 DLB patients who were initially diagnosed with IRBD, and in 33 controls...
May 22, 2018: Sleep
https://www.readbyqxmd.com/read/29790684/the-effect-of-music-on-the-cardiac-activity-of-a-fetus-in-a-cardiotocographic-examination
#19
Grażyna Gebuza, Marta Zaleska, Marzena Kaźmierczak, Estera Mieczkowska, Małgorzata Gierszewska
BACKGROUND: Music therapy as an adjunct to treatment is rarely used in perinatology and obstetrics, despite the proven therapeutic effect. Auditory stimulation through music positively impacts the health of adults and infants, its special role being observed in the development of prematurely born neonates. It is equally interesting how music impacts fetuses. OBJECTIVES: The aim of this study is to assess the parameters of fetuses through cardiotocographic recording in women in the 3rd trimester of pregnancy while listening to Pyotr Tchaikovsky's "Sleeping Beauty" and "Swan Lake...
April 24, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29789012/novel-tnf-receptor-1-inhibitors-identified-as-potential-therapeutic-candidates-for-traumatic-brain-injury
#20
Rachel K Rowe, Jordan L Harrison, Hongtao Zhang, Adam D Bachstetter, David P Hesson, Bruce F O'Hara, Mark I Greene, Jonathan Lifshitz
BACKGROUND: Traumatic brain injury (TBI) begins with the application of mechanical force to the head or brain, which initiates systemic and cellular processes that are hallmarks of the disease. The pathological cascade of secondary injury processes, including inflammation, can exacerbate brain injury-induced morbidities and thus represents a plausible target for pharmaceutical therapies. We have pioneered research on post-traumatic sleep, identifying that injury-induced sleep lasting for 6 h in brain-injured mice coincides with increased cortical levels of inflammatory cytokines, including tumor necrosis factor (TNF)...
May 22, 2018: Journal of Neuroinflammation
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