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https://www.readbyqxmd.com/read/28213776/the-importance-of-drug-induced-sedation-endoscopy-d-i-s-e-techniques-in-surgical-decision-making-conventional-versus-target-controlled-infusion-techniques-a-prospective-randomized-controlled-study-and-a-retrospective-surgical-outcomes-analysis
#1
Andrea De Vito, Vanni Agnoletti, Gianluca Zani, Ruggero Massimo Corso, Giovanni D'Agostino, Elisabetta Firinu, Chiara Marchi, Ying-Shuo Hsu, Stefano Maitan, Claudio Vicini
Drug-Induced Sedation Endoscopy (DISE) consists of the direct observation of the upper airways during sedative-induced sleep, allowing the identification of the sites of pharyngeal collapse, which is the main pathological event in Obstructive Sleep Apnea (OSA). The Authors have compared Target Controlled Infusion (TCI) sedation endoscopy (TCI-DISE) technique to conventional DISE (CDISE), performed by a manual bolus injection of sedative agent, to recreate accurately and safely snoring and apnea patterns comparable to natural sleep...
February 17, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28213614/reproductive-dysfunction-and-associated-pathology-in-women-undergoing-military-training
#2
REVIEW
Robert M Gifford, R M Reynolds, J Greeves, R A Anderson, D R Woods
INTRODUCTION: Evidence from civilian athletes raises the question of whether reproductive dysfunction may be seen in female soldiers as a result of military training. Such reproductive dysfunction consists of impaired ovulation with or without long-term subfertility. METHODS: A critical review of pertinent evidence following an extensive literature search. RESULTS: The evidence points towards reduced energy availability as the most likely explanation for exercise-induced reproductive dysfunction...
February 17, 2017: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/28211549/review-of-health-and-risk-behaviours-mental-health-problems-and-suicidal-behaviours-in-young-europeans-on-the-basis-of-the-results-from-the-eu-funded-saving-and-empowering-young-lives-in-europe-seyle-study
#3
REVIEW
Danuta Wasserman
An estimated 800 000 suicide deaths occur worldwide. The global suicide rate is 11.4 per 100 000 population; 15.0/100 000 for males and 8.0/100 000 for females. Globally, suicide is the second leading cause of death in 15-29 year olds. In a collaborative effort to reduce the high rates of suicide and mental health problems among youth across Europe, the European Union 7th Framework funded the Saving and Empowering Young Lives in Europe (SEYLE) project. SEYLE is a randomized controlled trial (RCT) aimed to promote mental health and healthy lifestyles, while preventing psychopathology and suicidal behaviours among adolescents...
December 23, 2016: Psychiatria Polska
https://www.readbyqxmd.com/read/28202825/-ictal-speech-manifesting-as-sleep-talking-a-case-report
#4
Takehiro Suzuki, Yosuke Kakisaka, Yu Kitazawa, Kazutaka Jin, Shiho Sato, Masaki Iwasaki, Mayu Fujikawa, Yoshiyuki Nishio, Akitake Kanno, Nobukazu Nakasato
We present a 28-year-old female patient whose epilepsy started at the age of 19. MRI showed right perisylvian polymicrogyria. She exhibited various seizure symptoms, such as somatosensory aura involving the left leg, dyscognitive seizures, and amnesic seizures. Her mother indicated that the patient sometimes had "sleep talking", which was associated with presence of epileptic seizures of the next day. Long-term video electroencephalography (EEG) revealed that her episodes of "sleep talking" were epileptic events, specifically ictal speech, originating in the right hemisphere...
February 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28188439/the-missing-link-between-sleep-disorders-and-age-related-dementia-recent-evidence-and-plausible-mechanisms
#5
REVIEW
Feng Zhang, Rujia Zhong, Song Li, Raymond Chuen-Chung Chang, Weidong Le
Sleep disorders are among the most common clinical problems and possess a significant concern for the geriatric population. More importantly, while around 40% of elderly adults have sleep-related complaints, sleep disorders are more frequently associated with co-morbidities including age-related neurodegenerative diseases and mild cognitive impairment. Recently, increasing evidence has indicated that disturbed sleep may not only serve as the consequence of brain atrophy, but also contribute to the pathogenesis of dementia and, therefore, significantly increase dementia risk...
February 10, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28179566/human-and-rat-gut-microbiome-composition-is-maintained-following-sleep-restriction
#6
Shirley L Zhang, Lei Bai, Namni Goel, Aubrey Bailey, Christopher J Jang, Frederic D Bushman, Peter Meerlo, David F Dinges, Amita Sehgal
Insufficient sleep increasingly characterizes modern society, contributing to a host of serious medical problems. Loss of sleep is associated with metabolic diseases such as obesity and diabetes, cardiovascular disorders, and neurological and cognitive impairments. Shifts in gut microbiome composition have also been associated with the same pathologies; therefore, we hypothesized that sleep restriction may perturb the gut microbiome to contribute to a disease state. In this study, we examined the fecal microbiome by using a cross-species approach in both rat and human studies of sleep restriction...
February 8, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28170100/vulnerable-narcissism-is-mostly-a-disorder-of-neuroticism
#7
Joshua D Miller, Donald R Lynam, Colin Vize, Michael Crowe, Chelsea Sleep, Jessica L Maples-Keller, Lauren R Few, W Keith Campbell
OBJECTIVE: Increasing attention has been paid to the distinction between the dimensions of narcissistic grandiosity and vulnerability. We examine the degree to which basic traits underlie vulnerable narcissism with a particular emphasis on the importance of neuroticism and agreeableness. METHODS: Across four samples (undergraduate, online community, clinical-community), we conduct dominance analyses to partition the variance predicted in vulnerable narcissism by the five-factor model personality domains...
February 7, 2017: Journal of Personality
https://www.readbyqxmd.com/read/28167915/the-role-of-acute-intermittent-hypoxia-in-neutrophil-generated-superoxide-sympathovagal-balance-and-vascular-function-in-healthy-subjects
#8
Germana P L Almeida, Ivani C Trombetta, Felipe X Cepeda, Elaine Hatanaka, Rui Curi, Cristiano Mostarda, Maria C Irigoyen, José A S Barreto-Filho, Eduardo M Krieger, Fernanda M Consolim-Colombo
Introduction: Recurrent hypoxia (HPX), a hallmark of the obstructive sleep apnea (OSA), impairs autonomic balance, and increases arterial blood pressure (BP). Oxidative stress is one of the mechanisms involved in these alterations. The cumulative effect of acute intermittent HPX and the chronicity may determine whether the response crosses the threshold from having protective value to pathology. However, the impact of acute intermittent HPX-reoxygenation on markers of oxidative stress in healthy individuals remains to be fully understood...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28147322/vegf-promotes-cartilage-angiogenesis-by-phospho-erk1-2-activation-of-dll4-signaling-in-temporomandibular-joint-osteoarthritis-caused-by-chronic-sleep-disturbance-in-wistar-rats
#9
Yabing Dong, Gaoyi Wu, Ting Zhu, Hongyu Chen, Yong Zhu, Guoxiong Zhu, Fabin Han, Huaqiang Zhao
Chronic sleep disturbance (CSD) has been linked to the development of temporomandibular joint osteoarthritis (TMJ-OA). While the pathogenesis of TMJ-OA is unclear, recent studies indicate that osteochondral angiogenesis is important. We developed a rat model of CSD induced TMJ-OA to investigate the changes caused by sleep disturbance and to correlate them with vascular invasion in the TMJ. We found pathological alterations and an increased microvessel density in the rat TMJ following CSD. VEGF, Dll4 and p-ERK1/2, the expression of angiogenic factors, were highly expressed in the rat mandibular condylar cartilage and their expression increased with CSD...
January 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28139776/accurate-discrimination-of-the-wake-sleep-states-of-mice-using-non-invasive-whole-body-plethysmography
#10
Stefano Bastianini, Sara Alvente, Chiara Berteotti, Viviana Lo Martire, Alessandro Silvani, Steven J Swoap, Alice Valli, Giovanna Zoccoli, Gary Cohen
A major limitation in the study of sleep breathing disorders in mouse models of pathology is the need to combine whole-body plethysmography (WBP) to measure respiration with electroencephalography/electromyography (EEG/EMG) to discriminate wake-sleep states. However, murine wake-sleep states may be discriminated from breathing and body movements registered by the WBP signal alone. Our goal was to compare the EEG/EMG-based and the WBP-based scoring of wake-sleep states of mice, and provide formal guidelines for the latter...
January 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28126505/-obstructive-sleep-apnea-syndrome-diagnostic-strategies-in-various-clinical-settings
#11
Marie Netchitaïlo, Marie Destors, Cécile Bosc, Jean-Louis Pépin, Renaud Tamisier
Obstructive Sleep Apnea Syndrome (OSAS) is a common disease, whose prevalence and expression may vary depending on the associated pathology, age or gender. Thus, the prevalence of OSAS is up to 80% in case of refractory hypertension. This led up to individualize clinical presentation of clusters, although currently, the individualization of these different phenotypes did not conduct to a specific care or predict different evolution. Offering the best strategy for the right patient remains an important objective...
January 23, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28125251/examining-the-relations-among-the-dsm-5-alternative-model-of-personality-the-five-factor-model-and-externalizing-and-internalizing-behavior
#12
Chelsea E Sleep, Courtland S Hyatt, Joanna Lamkin, Jessica L Maples-Keller, Joshua D Miller
Given long-standing criticisms of the DSM's reliance on categorical models of psychopathology, including the poor reliability and validity of personality-disorder diagnoses, the American Psychiatric Association (APA) published an alternative model (AM) of personality disorders in Section III of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5; APA, 2013), which, in part, comprises 5 pathological trait domains based on the 5-factor model (FFM). However, the empirical profiles and discriminant validity of the AM traits remain in question...
January 26, 2017: Personality Disorders
https://www.readbyqxmd.com/read/28123654/the-relationship-between-epilepsy-sleep-disorders-and-attention-deficit-hyperactivity-disorder-adhd-in-children-a-review-of-the-literature
#13
REVIEW
Felipe Kalil Neto, Renan Noschang, Magda Lahorgue Nunes
OBJECTIVE: To analyze the relationship between epilepsy, sleep disorders, and attention deficit hyperactivity disorder (ADHD). BIBLIOGRAPHIC SEARCH: A literature search of the PubMed database was performed using the following key words: epilepsy, sleep, and ADHD. In total, 91 articles were located in PubMed, 34 were selected for abstract reading and twelve articles were reviewed, in which the main objectives were examine the relationship between epilepsy, sleep and ADHD from several perspectives, including epidemiology, effect of comorbidities on academic performance and the factors leading to diagnostic difficulties among these three disorders...
July 2016: Sleep Science
https://www.readbyqxmd.com/read/28114405/optogenetic-restoration-of-disrupted-slow-oscillations-halts-amyloid-deposition-and-restores-calcium-homeostasis-in-an-animal-model-of-alzheimer-s-disease
#14
Ksenia V Kastanenka, Steven S Hou, Naomi Shakerdge, Robert Logan, Danielle Feng, Susanne Wegmann, Vanita Chopra, Jonathan M Hawkes, Xiqun Chen, Brian J Bacskai
Slow oscillations are important for consolidation of memory during sleep, and Alzheimer's disease (AD) patients experience memory disturbances. Thus, we examined slow oscillation activity in an animal model of AD. APP mice exhibit aberrant slow oscillation activity. Aberrant inhibitory activity within the cortical circuit was responsible for slow oscillation dysfunction, since topical application of GABA restored slow oscillations in APP mice. In addition, light activation of channelrhodopsin-2 (ChR2) expressed in excitatory cortical neurons restored slow oscillations by synchronizing neuronal activity...
2017: PloS One
https://www.readbyqxmd.com/read/28108951/physiological-links-of-circadian-clock-and-biological-clock-of-aging
#15
REVIEW
Fang Liu, Hung-Chun Chang
Circadian rhythms orchestrate biochemical and physiological processes in living organisms to respond the day/night cycle. In mammals, nearly all cells hold self-sustained circadian clocks meanwhile couple the intrinsic rhythms to systemic changes in a hierarchical manner. The suprachiasmatic nucleus (SCN) of the hypothalamus functions as the master pacemaker to initiate daily synchronization according to the photoperiod, in turn determines the phase of peripheral cellular clocks through a variety of signaling relays, including endocrine rhythms and metabolic cycles...
January 20, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28107375/narcolepsy-type-1-is-associated-with-a-systemic-increase-and-activation-of-regulatory-t-cells-and-with-a-systemic-activation-of-global-t-cells
#16
Michel Lecendreux, Guillaume Churlaud, Fabien Pitoiset, Armelle Regnault, Tu Anh Tran, Roland Liblau, David Klatzmann, Michelle Rosenzwajg
Narcolepsy is a rare neurologic disorder characterized by excessive daytime sleepiness, cataplexy and disturbed nocturnal sleep patterns. Narcolepsy type 1 (NT1) has been shown to result from a selective loss of hypothalamic hypocretin-secreting neurons with patients typically showing low CSF-hypocretin levels (<110 pg/ml). This specific loss of hypocretin and the strong association with the HLA-DQB1*06:02 allele led to the hypothesis that NT1 could be an immune-mediated pathology. Moreover, susceptibility to NT1 has recently been associated with several pathogens, particularly with influenza A H1N1 virus either through infection or vaccination...
2017: PloS One
https://www.readbyqxmd.com/read/28106557/blunted-respiratory-responses-in%C3%A2-the%C3%A2-streptozotocin-induced-alzheimer-s-disease-rat-model
#17
Dalton L Ebel, Christopher G Torkilsen, Tim D Ostrowski
Alzheimer's disease (AD) is known for the progressive decline of cognition and memory. In addition to these disease-defining symptoms, impairment of respiratory function is frequently observed and often expressed by sleep-disordered breathing or reduced ability to adjust respiration when oxygen demand is elevated. The mechanisms for this are widely unknown. Postmortem analysis from the brainstem of AD patients reveals pathological alterations, including in nuclei responsible for respiratory control. In this study, we analyzed respiratory responses and morphological changes in brainstem nuclei following intracerebroventricular (ICV) injections of streptozotocin (STZ), a rat model commonly used to mimic sporadic AD...
January 20, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28096295/does-selection-for-short-sleep-duration-explain-human-vulnerability-to-alzheimer-s-disease
#18
Randolph M Nesse, Caleb E Finch, Charles L Nunn
Compared with other primates, humans sleep less and have a much higher prevalence of Alzheimer 's disease (AD) pathology. This article reviews evidence relevant to the hypothesis that natural selection for shorter sleep time in humans has compromised the efficacy of physiological mechanisms that protect against AD during sleep. In particular, the glymphatic system drains interstitial fluid from the brain, removing extra-cellular amyloid beta (eAβ) twice as fast during sleep. In addition, melatonin - a peptide hormone that increases markedly during sleep - is an effective antioxidant that inhibits the polymerization of soluble eAβ into insoluble amyloid fibrils that are associated with AD...
January 16, 2017: Evolution, Medicine, and Public Health
https://www.readbyqxmd.com/read/28089250/pathology-of-behavior-in-pd-what-is-known-and-what-is-not
#19
REVIEW
Kaylena A Ehgoetz Martens, Simon J G Lewis
Abnormal behavior in Parkinson's disease (PD) stems from a complex orchestration of impaired neural networks that result from PD-related neurodegeneration across multiple levels. Typically, cellular and tissue abnormalities generate neurochemical changes and disrupt specific regions of the brain, in turn creating impaired neural circuits and dysfunctional global networks. The objective of this chapter is to provide an overview of the array of pathological changes that have been linked to different behavioral symptoms of PD such as depression, anxiety, apathy, fatigue, impulse control disorders, psychosis, sleep disorders and dementia...
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28061506/role-of-rem-sleep-melanin-concentrating-hormone-and-orexin-hypocretin-systems-in-the-sleep-deprivation-pre-ischemia
#20
Marta Pace, Antoine Adamantidis, Laura Facchin, Claudio Bassetti
STUDY OBJECTIVES: Sleep reduction after stroke is linked to poor recovery in patients. Conversely, a neuroprotective effect is observed in animals subjected to acute sleep deprivation (SD) before ischemia. This neuroprotection is associated with an increase of the sleep, melanin concentrating hormone (MCH) and orexin/hypocretin (OX) systems. This study aims to 1) assess the relationship between sleep and recovery; 2) test the association between MCH and OX systems with the pathological mechanisms of stroke...
2017: PloS One
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