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https://www.readbyqxmd.com/read/28317486/abnormal-clock-gene-expression-and-locomotor-activity-rhythms-in-two-month-old-female-appswe-ps1de9-mice
#1
Olaide Oyegbami, Hilary M Collins, Marie C Pardon, Fran Jp Ebling, David M Heery, Paula M Moran
In addition to cognitive decline, Alzheimer's disease (AD) is also characterized by agitation and disruptions in activity and sleep. These symptoms typically occur in the evening or at night and have been referred to as 'sundowning'. These symptoms are especially difficult for carers and there are no specific drug treatments. There is increasing evidence that these symptoms reflect an underlying pathology of circadian rhythm generation and transmission. We investigated whether a transgenic mouse model relevant to AD (APPswe/PS1dE9) exhibits circadian alterations in locomotor activity and expression of clock genes involved in the regulation of the circadian cycle...
March 17, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28315846/risk-factors-for-early-psychosis-in-pd-insights-from-the-parkinson-s-progression-markers-initiative
#2
Dominic H Ffytche, Joana B Pereira, Clive Ballard, K Ray Chaudhuri, Daniel Weintraub, Dag Aarsland
BACKGROUND: Parkinson's Disease (PD) psychosis refers to the spectrum of illusions, formed hallucinations and delusions that occur in PD. Visual hallucinations and illusions are thought to be caused by specific cognitive and higher visual function deficits and patients who develop such symptoms early in the disease course have greater rates of cognitive decline and progression to dementia. To date, no studies have investigated whether such deficits are found prior to the onset of PD psychosis...
April 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28314820/amyloid-precursor-protein-in-drosophila-glia-regulates-sleep-and-genes-involved-in-glutamate-recycling
#3
Abud Jose Farca Luna, Magali Perier, Laurent Seugnet
The Amyloid Precursor Protein (App) plays a crucial role in Alzheimer disease (AD) via the production and deposition of toxic β-amyloid peptides. App is heavily expressed in neurons where the vast majority of studies investigating its function have been carried out, while almost nothing is known about its function in glia, where it is also expressed, and can potentially participate in the regulation of neuronal physiology. In this report, we investigated whether Appl, the Drosophila homolog of App, could influence sleep-wake regulation when its function is manipulated in glial cells...
March 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28303851/tonic-electromyogram-density-in-multiple-system-atrophy-with-predominant-parkinsonism-and-parkinson-s-disease
#4
Yi Wang, Yun Shen, Kang-Ping Xiong, Pei-Cheng He, Cheng-Jie Mao, Jie Li, Fu-Yu Wang, Ya-Li Wang, Jun-Ying Huang, Chun-Feng Liu
BACKGROUND: Both Parkinson's disease (PD) and multiple system atrophy (MSA) have associated sleep disorders related to the underlying neurodegenerative pathology. Clinically, MSA with predominant parkinsonism (MSA-P) resembles PD in the manifestation of prominent parkinsonism. Whether the amount of rapid eye movement (REM) sleep without atonia could be a potential marker for differentiating MSA-P from PD has not been thoroughly investigated. This study aimed to examine whether sleep parameters could provide a method for differentiating MSA-P from PD...
March 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28302453/brain-rhythm-attractor-breakdown-in-alzheimer-s-disease-functional-and-pathologic-implications
#5
Elissaios Karageorgiou, Keith A Vossel
This perspective binds emerging evidence on the bidirectional relationship between Alzheimer's disease (AD) and sleep disorders through a model of brain rhythm attractor breakdown. This approach explains behavioral-cognitive changes in AD across the sleep-wake cycle and supports a causal association between early brainstem tau pathology and subsequent cortical amyloid-β accumulation. Specifically, early tau dysregulation within brainstem-hypothalamic nuclei leads to breakdown of sleep-wake attractor networks, with patients displaying an attenuated range of behavioral and electrophysiological activity patterns, a "twilight zone" of constant activity between deep rest and full alertness...
March 13, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28293468/a-method-for-independent-component-graph-analysis-of-resting-state-fmri
#6
Demetrius Ribeiro de Paula, Erik Ziegler, Pubuditha M Abeyasinghe, Tushar K Das, Carlo Cavaliere, Marco Aiello, Lizette Heine, Carol di Perri, Athena Demertzi, Quentin Noirhomme, Vanessa Charland-Verville, Audrey Vanhaudenhuyse, Johan Stender, Francisco Gomez, Jean-Flory L Tshibanda, Steven Laureys, Adrian M Owen, Andrea Soddu
INTRODUCTION: Independent component analysis (ICA) has been extensively used for reducing task-free BOLD fMRI recordings into spatial maps and their associated time-courses. The spatially identified independent components can be considered as intrinsic connectivity networks (ICNs) of non-contiguous regions. To date, the spatial patterns of the networks have been analyzed with techniques developed for volumetric data. OBJECTIVE: Here, we detail a graph building technique that allows these ICNs to be analyzed with graph theory...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28275652/altered-sleep-and-eeg-power-in-the-p301s-tau-transgenic-mouse-model
#7
Jerrah K Holth, Thomas E Mahan, Grace O Robinson, Andreia Rocha, David M Holtzman
OBJECTIVE: Sleep disturbances are prevalent in human tauopathies yet despite the importance of sleep, little is known about its relationship with tau pathology. Here, we investigate this interaction by analyzing sleep and tau pathology throughout tauopathy disease progression in P301S human tau transgenic mice. METHODS: P301S and wild-type mice were analyzed by electroencephalography (EEG)/electromyography at 3, 6, 9, and 11 months of age for sleep/wake time, EEG power, and homeostatic response...
March 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28269505/feasibility-study-for-the-assessment-of-cardio-respiratory-coupling-in-newborn-infants
#8
Maristella Lucchini, William P Fifer, Manuela Ferrario, Maria G Signorini
Cardio Respiratory Coupling (CRC) plays a key role during infant development. Nonetheless, mechanisms underlying it are still mostly unexplained and tools to assess it are often inadequate to understand its functioning. This study aims to evaluate the feasibility of CRC activity detection and quantification analyzing ECG and respiration of newborn healthy subjects. Cross-spectral analysis (coherence) and a novel application of a nonlinear method (Bivariate Phase Rectified Signal Averaging) were applied on 10 minutes recording from 4 subjects...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269503/differentiation-of-spindle-associated-hippocampal-hfos-based-on-a-correlation-analysis
#9
Daniel Lachner Piza, Jonas C Bruder, Julia Jacobs, Andreas Schulze-Bonhage, Thomas Stieglitz, Matthias Dumpelmann
High Frequency Oscillations (HFOs) have been described as biomarkers of epileptogenic tissue; however their pathological/physiological classification poses a challenge to their predictive power. For the population of ripples co-occurring with sleep spindles, those ripples improving the antiparallel correlation of ripple-peaks and sleep spindle-troughs were classified as coupled-ripples and the rest as uncoupled-ripples. For the same population of ripples two reference groups called in-SOZ and non-SOZ were formed according to the ripples' location inside or outside the seizure onset zone (SOZ)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28257719/-closed-reduction-principles-can-manage-diverse-conditions-of-temporomandibular-joint-vertical-height-loss-from-displaced-condylar-fractures-to-idiopathic-condylar-resorption
#10
Dorrit W Nitzan, Sandro Palla
PURPOSE: The aim of this case series was to describe a modification of the classic "closed reduction" technique to manage unilateral or anterior open bite owing to a loss in vertical height (LVH) caused by several disorders and pathologies other than displaced condylar fractures. MATERIALS AND METHODS: The protocol included insertion of an occlusal appliance to increase the height of the premature contact and the width of the open bite, stabilization of the dental arches by rigid arches, and the use, during sleep, of rubber bands in the open bite region to pull the mandible cranially...
February 7, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28252604/-epidemiology-of-sleep-disorders-in-the-republic-of-tatarstan
#11
E Z Yakupov, Y V Troshina, V V Fedorova, L R Hasanshina, L R Ahatova, D V Artemieva
AIM: To evaluate the variability and severity of sleep disorders in people of the Republic of Tatarstan. MATERIAL AND METHODS: A continuous survey using a questionnaire based on the Epworth Sleepiness Scale, the Hospital Anxiety and Depression Scale (HADS), sleep apnea risk scale, restless leg syndrome scale was performed. The survey was conducted in a random sample of people (n=1156). RESULTS AND CONCLUSION: A high level of sleep disorders associated with anxiety disorders and comorbid pathologies was shown...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28251921/clinical-implications-of-the-melanopsin-based-non-image-forming-visual-system
#12
Alexander Ksendzovsky, I Jonathan Pomeraniec, Kareem A Zaghloul, J Javier Provencio, Ignacio Provencio
Since the discovery of the non-image-forming visual system, tremendous research efforts have been dedicated to understanding its mechanisms and functional roles. Original functions associated with the melanopsin system include the photoentrainment of circadian sleep-wake cycles and the pupillary light reflex. Recent findings, however, suggest a much broader involvement of this system in an array of physiologic responses to light. This newfound insight into the underlying function of the non-image-forming system has revealed the many connections to human pathology and attendant disease states, including seasonal affective disorder, migraine, glaucoma, inherited mitochondrial optic neuropathy, and sleep dysregulation of aging...
March 1, 2017: Neurology
https://www.readbyqxmd.com/read/28251022/the-predictors-of-obesity-hypoventilation-syndrome-in-obstructive-sleep-apnea
#13
Aylin Pıhtılı, Züleyha Bingöl, Esen Kıyan
BACKGROUND: As obesity increases, the frequency of obstructive sleep apnea and obesity hypoventilation syndrome increases also. However, obesity hypoventilation syndrome frequency is not known, as capnography and arterial blood gas analysis are not routinely performed in sleep laboratories. AIMS: To investigate the frequency and predictors of obesity hypoventilation syndrome in obese subjects. STUDY DESIGN: Retrospective clinical study. METHODS: Obese subjects who had arterial blood gas analysis admitted to the sleep laboratory and polysomnography were retrospectively analyzed...
January 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28245482/neuropsychiatric-symptoms-in-alzheimer-disease-vascular-dementia-and-mixed-dementia
#14
Cassandra J Anor, Sean O'Connor, Amardeep Saund, David F Tang-Wai, Ron Keren, Maria Carmela Tartaglia
BACKGROUND/AIMS: Neuropsychiatric symptoms (NPS) are common in Alzheimer disease (AD) and vascular dementia (VaD), and are distressful to patients and caregivers. NPS are likely related to the underlying pathology. Previous studies suggest that frontal lobe lesions and vascular changes such as white matter hyperintensities (WMH) have a significant association with specific NPS. The current study aimed to compare NPS in patients with AD, VaD, and mixed AD/VaD, and to evaluate the differences in the prevalence of NPS in relation to frontal WMH volume...
March 1, 2017: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/28238681/early-amplitude-integrated-electroencephalography-for-monitoring-neonates-at-high-risk-for-brain-injury
#15
Gabriel Fernando Todeschi Variane, Maurício Magalhães, Renato Gasperine, Heitor Castelo Branco Rodrigues Alves, Thiago Luiz Pereira Donoso Scoppetta, Rodrigo de Jesus Gonçalves Figueredo, Francisco Paulo Martins Rodrigues, Alexandre Netto, Marcelo Jenne Mimica, Clery Bernardi Gallacci
OBJECTIVE: This study aimed to correlate amplitude-integrated electroencephalography findings with early outcomes, measured by mortality and neuroimaging findings, in a prospective cohort of infants at high risk for brain injury in this center in Brazil. METHODS: This blinded prospective cohort study evaluated 23 preterm infants below 31 weeks of gestational age and 17 infants diagnosed with hypoxic-ischemic encephalopathy secondary to perinatal asphyxia, with gestational age greater than 36 weeks, monitored with amplitude-integrated electroencephalography in a public tertiary center from February 2014 to January 2015...
February 23, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28227757/feasibility-study-for-the-assessment-of-cardio-respiratory-coupling-in-newborn-infants
#16
Maristella Lucchini, William P Fifer, Manuela Ferrario, Maria G Signorini, Maristella Lucchini, William P Fifer, Manuela Ferrario, Maria G Signorini, Maristella Lucchini, Maria G Signorini, William P Fifer, Manuela Ferrario
Cardio Respiratory Coupling (CRC) plays a key role during infant development. Nonetheless, mechanisms underlying it are still mostly unexplained and tools to assess it are often inadequate to understand its functioning. This study aims to evaluate the feasibility of CRC activity detection and quantification analyzing ECG and respiration of newborn healthy subjects. Cross-spectral analysis (coherence) and a novel application of a nonlinear method (Bivariate Phase Rectified Signal Averaging) were applied on 10 minutes recording from 4 subjects...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227755/differentiation-of-spindle-associated-hippocampal-hfos-based-on-a-correlation-analysis
#17
Daniel Lachner Piza, Jonas C Bruder, Julia Jacobs, Andreas Schulze-Bonhage, Thomas Stieglitz, Matthias Dumpelmann, Daniel Lachner Piza, Jonas C Bruder, Julia Jacobs, Andreas Schulze-Bonhage, Thomas Stieglitz, Matthias Dumpelmann, Thomas Stieglitz, Matthias Dumpelmann, Jonas C Bruder, Andreas Schulze-Bonhage, Daniel Lachner Piza, Julia Jacobs
High Frequency Oscillations (HFOs) have been described as biomarkers of epileptogenic tissue; however their pathological/physiological classification poses a challenge to their predictive power. For the population of ripples co-occurring with sleep spindles, those ripples improving the antiparallel correlation of ripple-peaks and sleep spindle-troughs were classified as coupled-ripples and the rest as uncoupled-ripples. For the same population of ripples two reference groups called in-SOZ and non-SOZ were formed according to the ripples' location inside or outside the seizure onset zone (SOZ)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225159/a-7-year-follow-up-study-of-obstructive-sleep-apnoea-in-healthy-elderly-the-proof-cohort-study
#18
Emilia Sforza, David Hupin, Vincent Pichot, Jean Claude Barthélémy, Frédéric Roche
BACKGROUND AND OBJECTIVE: Clinical and epidemiological cohort studies have shown that obstructive sleep apnoea (OSA) is a common but largely undiagnosed disorder in senior subjects, where progressive deterioration of the pathology would be expected as a consequence of the ageing processes. Our study examines the longitudinal progression of OSA over a 7-year period in a community-based sample of healthy subjects. METHODS: The sample consisted of 284 volunteers, aged >65 years (52% women, 48% men) accepting clinical and instrumental follow-up at 7 years...
February 22, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28217760/sleep-in-alzheimer-s-disease-beyond-amyloid
#19
Jerrah Holth, Tirth Patel, David M Holtzman
Sleep disorders are prevalent in Alzheimer's disease (AD) and a major cause of institutionalization. Like AD pathology, sleep abnormalities can appear years before cognitive decline and may be predictive of dementia. A bidirectional relationship between sleep and amyloid β (Aβ) has been well established with disturbed sleep and increased wakefulness leading to increased Aβ production and decreased Aβ clearance; whereas Aβ deposition is associated with increased wakefulness and sleep disturbances. Aβ fluctuates with the sleep wake cycle and is higher during wakefulness and lower during sleep...
January 2017: Neurobiology of Sleep and Circadian Rhythms
https://www.readbyqxmd.com/read/28215031/orexin-a-missing-link-between-sleep-disorders-and-heart-failure
#20
REVIEW
Stephen Pan, Carolina S Cabral, Euan A Ashley, Marco V Perez
PURPOSE OF REVIEW: Sleep disorders represent a significant comorbidity in the heart failure population, and there is mounting evidence that treatment of sleep disorders such as obstructive sleep apnea can significantly improve cardiac function. However, the link between these two disorders is still not entirely clear. RECENT FINDINGS: Recently, a novel neurohormonal pathway has been elucidated involving signaling molecules now collectively known as the orexins, which have been implicated in regulating autonomic function during sleep/wake cycles...
April 2017: Current Heart Failure Reports
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