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Growth hormone treatment

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https://www.readbyqxmd.com/read/29667478/retro-inverso-follicle-stimulating-hormone-peptide-mediated-polyethylenimine-complexes-for-targeted-ovarian-cancer-gene-therapy
#1
Mengyu Zhang, Mingxing Zhang, Jing Wang, Qingqing Cai, Ran Zhao, Yi Yu, Haiyan Tai, Xiaoyan Zhang, Congjian Xu
BACKGROUND: The development of nanoparticle drug delivery systems with targeted ligands has the potential to increase treatment efficiency in ovarian cancer. METHODS: We developed a 21-amino acid peptide, YTRDLVYGDPARPGIQGTGTF (L-FP21) conjugated to polyethylenimine (PEI) and methoxy polyethylene glycol (mPEG) to prepare a nanoparticle drug vehicle to target follicle-stimulating hormone receptor (FSHR) in ovarian cancer. At the same time, we optimized the ligand of the nanoparticle vehicle using D-peptides, which consist of D-amino acids (D-FP21)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29666169/impact-of-transitional-care-on-endocrine-and-anthropometric-parameters-in-prader-willi-syndrome
#2
Anne-Cécile Paepegaey, Muriel Coupaye, Asma Jaziri, Florence Menesguen, Béatrice Dubern, Michel Polak, Jean-Michel Oppert, Maithe Tauber, Graziella Pinto, Christine Poitou
CONTEXT: The transition of patients with Prader-Willi syndrome (PWS) to adult life for medical care is challenging because of multiple comorbidities, including hormone deficiencies, obesity, and cognitive and behavioral disabilities. OBJECTIVE: To assess endocrine management, and metabolic and anthropometric parameters of PWS adults who received (n=31) or not (n=64) transitional care, defined as specialized pediatric care followed by a structured care pathway to a multidisciplinary adult team...
April 17, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29663325/a-new-approach-to-the-treatment-of-acute-myeloid-leukaemia-targeting-the-receptor-for-growth-hormone-releasing-hormone
#3
Joaquin J Jimenez, Gina M DelCanto, Petra Popovics, Aymee Perez, Ailin Vila Granda, Irving Vidaurre, Ren-Zhi Cai, Ferenc G Rick, Ronan T Swords, Andrew V Schally
Growth hormone-releasing hormone (GHRH) is secreted by the hypothalamus and acts on the pituitary gland to stimulate the release of growth hormone (GH). GHRH can also be produced by human cancers, in which it functions as an autocrine/paracrine growth factor. We have previously shown that synthetic antagonistic analogues of GHRH are able to successfully suppress the growth of 60 different human cancer cell lines representing over 20 cancers. Nevertheless, the expression of GHRH and its receptors in leukaemias has never been examined...
April 16, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29662499/nad-kinases-metabolic-targets-controlling-redox-co-enzymes-and-reducing-power-partitioning-in-plant-stress-and-development
#4
REVIEW
Bin-Bin Li, Xiang Wang, Li Tai, Tian-Tian Ma, Abdullah Shalmani, Wen-Ting Liu, Wen-Qiang Li, Kun-Ming Chen
NAD(H) and NADP(H) are essential co-enzymes which dominantly control a number of fundamental biological processes by acting as reducing power and maintaining the intracellular redox balance of all life kingdoms. As the only enzymes that catalyze NAD(H) and ATP to synthesize NADP(H), NAD Kinases (NADKs) participate in many essential metabolic reactions, redox sensitive regulation, photosynthetic performance and also reactive oxygen species (ROS) homeostasis of cells and therefore, play crucial roles in both development and stress responses of plants...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29662271/does-growth-hormone-treatment-affect-patients-with-and-without-a-mitochondrial-disorder-differentially
#5
Josef Finsterer
No abstract text is available yet for this article.
2018: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29661866/reciprocal-effects-of-antiretroviral-drugs-used-to-treat-hiv-infection-on-the-fibroblast-growth-factor-21-%C3%AE-klotho-system
#6
Ricardo Moure, Pere Domingo, Joan Villarroya, Laura Gasa, José M Gallego-Escuredo, Tania Quesada-López, Samantha Morón-Ros, Alberto F Maroto, Gracia M Mateo, Joan C Domingo, Francesc Villarroya, Marta Giralt
Following antiretroviral therapy, HIV-infected patients show increased circulating levels of the antidiabetic hormone fibroblast growth factor-21 (FGF21). In contrast, expression of the FGF21-obligatory co-receptor β-Klotho (KLB) is reduced in target tissues. This situation is comparable to the FGF21 resistance status observed in obesity and type-2 diabetes. Here, we performed the first systematic study of the effects of distinct members of different antiretroviral drug classes on the FGF21/KLB system in human hepatic, adipose, and skeletal muscle cells...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29660876/copper-oxide-nanoparticles-and-bulk-copper-oxide-combined-with-indole-3-acetic-acid-alter-aluminum-boron-and-iron-in-pisum-sativum-seeds
#7
Loren Ochoa, Nubia Zuverza-Mena, Illya A Medina-Velo, Juan Pedro Flores-Margez, José R Peralta-Videa, Jorge L Gardea-Torresdey
The interaction of CuO nanoparticles (nCuO), a potential nanopesticide, with the growth hormone indole-3-acetic acid (IAA) is not well understood. This study aimed to evaluate the nutritional components in seeds of green pea (Pisum sativum) cultivated in soil amended with nCuO at 50 or 100mgkg-1 , with/without IAA at 10 or 100μM. Similar treatments including bulk CuO (bCuO) and CuCl2 were set as controls. Bulk CuO at 50mgkg-1 reduced seed yield (52%), compared with control. Bulk CuO at 50mgkg-1 and nCuO at 100mgkg-1 , plus IAA at 100μM, increased iron in seeds (41 and 42%, respectively), while nCuO at 50mgkg-1 , plus IAA at 100μM reduced boron (80%, respect to control and 63%, respect to IAA at 100μM)...
April 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29659862/effects-of-hormonal-growth-promotants-on-beef-quality-a-meta-analysis
#8
I J Lean, H M Golder, N M Lees, P McGilchrist, J E P Santos
Background: Benefits of hormonal growth promotants (HGP) include production efficiency, profit, and reduced environmental effects for beef cattle. Questions remain about effects of HGP on beef quality, particularly on measures of toughness such as Warner-Bratzler shear force (WBSF), tenderness, and other taste-panel attributes of beef. Objective: To assess the effects of HGP on beef quality using the results of randomized controlled trials. Design: Searches of 3 databases...
April 6, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29659365/-association-between-diabetic-ketoacidosis-and-acromegaly
#9
Paloma Ocampo, Juan Manuel Duarte, Ricardo Barcia, Cecilia Arévalo
Diabetes mellitus occurs in nearly 10% of patients with acromegaly and is secondary to insulin resistance caused by high levels of growth hormone. Diabetes ketoacidosis has been described as a rare complication of acromegaly, resulting from a relative insulin deficiency caused by growth hormone excess. We described the case of a 38 year-old man who presented to the emergency room with a 6-week history of polydipsia, polyuria, polyphagia and weight loss. He also had nausea, vomiting and abdominal pain from two days before admission...
2018: Medicina
https://www.readbyqxmd.com/read/29658833/gonadopenia-and-aging-in-men
#10
Sandeep Singh Dhindsa, Michael S Irwig, Kathleen Wyne
OBJECTIVE: The decrease in testosterone levels that occurs with aging has become an important clinical issue both due to the growth of the geriatric population and patient interest in testosterone therapy. The decision to assess for testosterone deficiency and the ability to determine whether the benefits exceed the risks require a comprehensive evaluation of the aging patient. This article is part of a series of papers focused on the endocrinology of aging. This review addresses common issues needed for clinical decision making, including how to interpret test results, differential diagnosis, potential impact of testosterone treatment on insulin resistance and cardiovascular disease, and options for therapy...
April 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29657219/paraneoplastic-glomerulopathies-associated-with-hematologic-malignancies
#11
Jeyachandran Dhanapriya, Thanigachalam Dineshkumar, Ramanathan Sakthirajan, Dhanikachalam Surendar, Natarajan Gopalakrishnan, T Balasubramaniyan
Paraneoplastic glomerulopathy (PG) includes a group of glomerular lesions that are not directly related to tumor burden, invasion, or metastasis, but induced by products from tumor cells such as hormones, growth factors, cytokines, and tumor antigens. PG was first described by Galloway in 1922, in which nephrotic syndrome (NS) secondary to Hodgkin's lymphoma was reported. They can present before, at the time of diagnosis, during remission, or at relapse of the hematological malignancies. We present three cases of paraneoplastic NS associated with hematological malignancies...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29656861/efficacy-of-growth-hormone-treatment-in-children-with-type-1-diabetes-mellitus-and-growth-hormone-deficiency-an-analysis-of-kigs-data
#12
Walter Bonfig, Anders Lindberg, Martin Carlsson, Wayne Cutfield, David Dunger, Cecilia Camacho-Hübner, Reinhard W Holl
OBJECTIVE: To analyze first-year treatment growth response and growth hormone (GH) dosage in prepubertal patients with the combination of type 1 diabetes mellitus (T1DM) and growth hormone deficiency (GHD). STUDY DESIGN: A total of 69 patients with T1DM and GHD treated with GH have been enrolled in KIGS (Pfizer International Growth Database). Of these, 24 prepubertal patients had developed T1DM before GHD and were included in this analysis. Of 30 570 patients with GHD without T1DM, 15 024 were prepubertal and served as controls...
April 12, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29655559/associations-between-bone-and-energy-metabolism-in-cows-fed-diets-differing-in-level-of-dietary-cation-anion-difference-and-supplemented-with-cholecalciferol-or-calcidiol
#13
R M Rodney, N P Martinez, P Celi, E Block, P C Thomson, G Wijffels, D R Fraser, J E P Santos, I J Lean
Bone-derived hormones play an important role in metabolism. This study examined the hypothesis that interactions between bone and energy metabolism, particularly those involving osteocalcin, are present in dairy cattle and have feedback mechanisms over time. Associations between metabolites in blood were examined in 32 Holstein cows blocked by parity and milk yield and randomly allocated to diets containing either 0.27 mg/kg dry matter (DM) calcidiol or cholecalciferol for an anticipated intake of 3 mg/d (120,000 IU/d) at 11 kg of DM, and positive (+130 mEq/kg DM) or negative (-130 mEq/kg DM) dietary cation-anion difference (DCAD) from 252 d of gestation to calving...
April 11, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29655555/effects-of-treatment-of-preweaning-dairy-calves-with-recombinant-bovine-somatotropin-on-immune-responses-and-somatotropic-axis
#14
A L Belli, R B Reis, A Veronese, R Moreira, K Flanagan, J Driver, C D Nelson, J A Clapper, M A Ballou, K C Jeong, R C Chebel
Weaning may be associated with negative energy balance and body weight loss when calves are still immunologically immature, predisposing them to infectious diseases. The aim of the present experiment was to investigate the effects of treatment of preweaning dairy calves with recombinant bovine somatotropin (rbST) on the somatotropic axis, selected immune parameters, and hematology of calves around weaning. Thirty-six Holstein female calves were randomly assigned to receive 1.5 to 1.8 mg of rbST (Posilac, Elanco Animal Health, Greenfield, IN) per kilogram of body weight or to receive injections of saline (saline solution 0...
April 11, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29655462/obesity-thrombotic-risk-and-inflammation-in-cancer
#15
Benjamín Rubio-Jurado, Luz-Ma-Adriana Balderas-Peña, Eduardo E García-Luna, María G Zavala-Cerna, Carlos Riebeling-Navarro, Pedro A Reyes, Arnulfo H Nava-Zavala
Neoplasms exhibits a high incidence and mortality rates due to their complex and commonly overlapping clinical, biochemical, and morphologic profiles influenced by acquired or inherited molecular abnormalities, cell of origin, and level of differentiation. Obesity appears related to ~20% of cancers including endometrial, esophageal, colorectal, postmenopausal breast, prostate, and renal. Several factors other than obesity, i.e., insulin, insulin-like growth factor, sexual hormones, and adipokines may play a potential role in neoplasia...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29653366/bufalin-inhibits-glioblastoma-growth-by-promoting-proteasomal-degradation-of-the-na-k-atpase-%C3%AE-1-subunit
#16
Yu-Long Lan, Xun Wang, Jia-Cheng Lou, Jin-Shan Xing, Zhen-Long Yu, Hongjin Wang, Shuang Zou, Xiaochi Ma, Bo Zhang
Chansu is a traditional Chinese medicine that is generally recognized as a specific inhibitor of Na+ /K+ -ATPase. Bufalin, an active component of Chansu, is an endogenous steroid hormone with great potential as a cancer treatment. However, the mechanism by which it exerts its antitumor activity requires further research. Currently, the α1 subunit of Na+ /K+ -ATPase (ATP1A1) is known to exert important roles in tumorigenesis, and the precise mechanisms underlying the effect of Bufalin on the Na+ /K+ -ATPase α1 subunit was therefore investigated in this study to determine its role in glioblastoma treatments...
April 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29652668/still-too-little-too-late-ten-years-of-growth-hormone-therapy-baseline-data-from-the-nordinet%C3%A2-international-outcome-study
#17
Michel Polak, Daniel Konrad, Birgitte Tønnes Pedersen, Gediminas Puras, Marta Šnajderová
BACKGROUND: We investigated time trends in age, gender, growth hormone (GH) dose and height standard deviation score (SDS) in children with GH deficiency (GHD), born small for gestational age (SGA) or with Turner syndrome (TS) starting GH treatment. METHODS: Data were obtained from children enrolled in the NordiNet® International Outcome Study (IOS) between 2006 and 2015 in the Czech Republic, France, Germany, Serbia and Montenegro (all indications), and Switzerland and the UK (GHD only)...
April 13, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29650694/lymphatic-vasculature-requires-er-estrogen-receptor-%C3%AE-signaling-to-protect-from-lymphedema
#18
Florent Morfoisse, Florence Tatin, Benoit Chapût, Nicole Therville, Charlotte Vaysse, Raphael Métivier, Julie Malloizel-Delaunay, Francoise Pujol, Anne-Claire Godet, Fabienne De Toni, Frederic Boudou, Katia Grenier, David Dubuc, Eric Lacazette, Anne-Catherine Prats, Julie Guillermet-Guibert, Francoise Lenfant, Barbara Garmy-Susini
OBJECTIVE: Estrogens exert beneficial effect on the blood vascular system. However, their role on the lymphatic system has been poorly investigated. We studied the protective effect of the 17β estradiol-the most potent endogenous estrogen-in lymphedema-a lymphatic dysfunction, which results in a massive fluid and fat accumulation in the limb. APPROACH AND RESULTS: Screening of DNA motifs able to mobilize ERs (estrogen receptors) and quantitative real-time polymerase chain reaction analysis revealed that estradiol promotes transcriptional activation of lymphangiogenesis-related gene expression including VEGF (vascular endothelial growth factor)-D, VEGFR (VEGF receptor)-3, lyve-1, and HASs (hyaluronan synthases)...
April 12, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29649764/sleep-after-intranasal-progesterone-vs-zolpidem-and-placebo-in-postmenopausal-women-a-randomized-double-blind-cross-over-study
#19
P Schüssler, M Kluge, M Adamczyk, M E Beitinger, P Beitinger, A Bleifuss, S Cordeiro, C Mattern, M Uhr, T C Wetter, A Yassouridis, R Rupprecht, E Friess, A Steiger
CONTEXT: The loss of progesterone during menopause is linked to sleep complaints of the affected women. Previously we demonstrated sleep promoting effects of oral progesterone replacement in postmenopausal women. The oral administration of progesterone, however, is compromised by individual differences in bioavailability and metabolism of the steroid. OBJECTIVE: We compared the sleep-endocrine effects after intranasal progesterone (MPP22), zolpidem and placebo in healthy postmenopausal women...
April 4, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29644941/role-of-micrornas-in-treatment-response-in-prostate-cancer
#20
Anshuli Razdan, Paul de Souza, Tara Laurie Roberts
Prostate cancer (PCa) is the most common non-skin cancer in men worldwide, resulting in significant mortality and morbidity. Depending on the grade and stage of the cancer, patients may be given radiation therapy, hormonal therapy, or chemotherapy. However, more than half these patients develop resistance to treatment, leading to disease progression and metastases, often with lethal consequences. MicroRNAs (miRNAs) are short, non-coding RNAs, which regulate numerous physiological as well as pathological processes, including cancer...
March 15, 2018: Current Cancer Drug Targets
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