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Endocrine disrupting chemicals

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https://www.readbyqxmd.com/read/29218402/linking-inter-individual-variability-to-endocrine-disruptors-insights-for-epigenetic-inheritance
#1
Sarah E Latchney, Ashley M Fields, Martha Susiarjo
Endocrine disrupting chemicals (EDCs) can induce a myriad of adverse health effects. An area of active investigation is the multi- and transgenerational inheritance of EDC-induced adverse health effects referring to the transmission of phenotypes across multiple generations via the germline. The inheritance of EDC-induced adverse health effects across multiple generations can occur independent of genetics, spurring much research into the transmission of underlying epigenetic mechanisms. Epigenetic mechanisms play important roles in the development of an organism and are responsive to environmental exposures...
December 7, 2017: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29216490/phthalate-esters-on-urban-airborne-particles-levels-in-pm10-and-pm2-5-from-mexico-city-and-theoretical-assessment-of-lung-exposure
#2
Raúl Omar Quintana-Belmares, Annette M Krais, Bahare Kourangi Esfahani, Irma Rosas-Pérez, Daniel Mucs, Rebeca López-Marure, Åke Bergman, Ernesto Alfaro-Moreno
Endocrine disrupting chemicals (EDCs) from the environment are associated with reproductive abnormalities (i.e. decreased sperm concentration; increased endometriosis) and alterations of the cardiovascular system (i.e. increased blood pressure and risk of coronary disease). Some phthalates esters have been identified as EDCs, for which inhalation is considered as one of the routes of exposure. However, only little is known regarding inhalational exposure to EDCs via urban airborne particles. In the present study, we report the monthly concentration of 8 phthalate esters measured in PM10 and PM2...
December 4, 2017: Environmental Research
https://www.readbyqxmd.com/read/29215352/emergent-contaminants-in-the-wastewater-effluents-of-two-highly-populated-tropical-cities
#3
Sheila M Soler-Llavina, Jorge R Ortiz-Zayas
Exposure to the anthropogenic chemicals known as endocrine disrupting compounds (EDCs) may result in negative biological effects. Low levels of EDCs in the environment aggravate the problem as exposure is constant. Urban areas concentrate pollution as greater volumes are released from human activities. Water for public supply is particularly vulnerable as the sewage treatment facilities may not eliminate EDCs. The goal was to assess estrogenicity and effectiveness of removal of phthalates in primary and tertiary wastewater treatment facilities in urban cities in the tropical island of Puerto Rico...
October 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/29214797/high-throughput-in-vitro-data-to-inform-prioritization-of-ambient-water-monitoring-and-testing-for-endocrine-active-chemicals
#4
Wendy J Heiger-Bernays, Susanna Wegner, David Dix
The presence of industrial chemicals, consumer product chemicals, and pharmaceuticals is well documented in waters in the US and globally. Most of these chemicals lack health-protective guidelines and many have been shown to have endocrine bioactivity. There is currently no systematic or national prioritization for monitoring waters for chemicals with endocrine disrupting activity. We propose Ambient Water Bioactivity Concentrations (AWBCs) generated from high throughput data as a health-based screen for endocrine bioactivity of chemicals in water...
December 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29211466/identification-of-unknown-antiandrogenic-compounds-in-surface-waters-by-effect-directed-analysis-eda-using-a-parallel-fractionation-approach
#5
Matthias Muschket, Carolina Di Paolo, Andrew J Tindall, Gerald Touak, Audrey Phan, Martin Krauss, Kristina Kirchner, Thomas Benjamin Seiler, Henner Hollert, Werner Brack
Among all the nuclear-receptor mediated endocrine disruptive effects, antiandrogenicity is frequently observed in aquatic environments and may pose a risk to aquatic organisms. Linking these effects to responsible chemicals is challenging and a great share of antiandrogenic activity detected in the environment has not been explained yet. To identify drivers of this effect at a hot spot of antiandrogenicity in the German river Holtemme, we applied effect-directed analysis (EDA) including a parallel fractionation approach, a downscaled luciferase reporter gene cell-based anti-AR-CALUX assay and LC-HRMS/MS non-target screening...
December 6, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29208362/feminizing-effects-of-exposure-to-corexit-enhanced-water-accommodated-fraction-of-crude-oil-in-vitro-on-sex-determination-in-alligator-mississippiensis
#6
Cameron E Williams, Nicole A McNabb, Arnold Brunell, Russell H Lowers, Yoshinao Katsu, Demetri D Spyropoulos, Satomi Kohno
Deepwater Horizon spilled over 200 million gallons of oil into the waters of the Gulf of Mexico in 2010. In an effort to contain the spill, chemical dispersants were applied to minimize the amount of oil reaching coastal shorelines. However, the biological impacts of chemically-dispersed oil are not well characterized, and there is a particular lack of knowledge concerning sublethal long-term effects of exposure. This study examined potential estrogenic effects of CWAF, Corexit 9500-enhanced water-accommodated fraction of oil, by examining its effect on estrogen receptors and sex determination in the American alligator, Alligator mississippiensis...
December 2, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29207355/environmental-pollution-and-health-hazards-from-distillery-wastewater-and-treatment-approaches-to-combat-the-environmental-threats-a-review
#7
REVIEW
Pankaj Chowdhary, Abhay Raj, Ram Naresh Bharagava
Distillery industries are the key contributor to the world's economy, but these are also one of the major sources of environmental pollution due to the discharge of a huge volume of dark colored wastewater. This dark colored wastewater contains very high biological oxygen demand, chemical oxygen demand, total solids, sulfate, phosphate, phenolics and various toxic metals. Distillery wastewater also contains a mixture of organic and inorganic pollutants such as melanoidins, di-n-octyl phthalate, di-butyl phthalate, benzenepropanoic acid and 2-hydroxysocaproic acid and toxic metals, which are well reported as genotoxic, carcinogenic, mutagenic and endocrine disrupting in nature...
November 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/29203468/edc-impact-reduced-sperm-counts-in-rats-exposed-to-human-relevant-mixtures-of-endocrine-disrupters
#8
Marta Axelstad, Ulla Hass, Martin Scholze, Sofie Christiansen, Andreas Kortenkamp, Julie Boberg
Human semen quality is declining in many parts of the world, but the causes are ill-defined. In rodents, impaired sperm production can be seen with early life exposure to certain endocrine disrupting chemicals, but the effects of combined exposures are not properly investigated. In this study, we examined the effects of early exposure to the painkiller paracetamol and mixtures of human relevant endocrine disrupting chemicals in rats. One mixture contained four estrogenic compounds, another contained eight anti-androgenic environmental chemicals, and a third mixture contained estrogens, anti-androgens and paracetamol...
December 4, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29202828/calculation-of-the-disease-burden-associated-with-environmental-chemical-exposures-application-of-toxicological-information-in-health-economic-estimation
#9
REVIEW
Philippe Grandjean, Martine Bellanger
Calculation of costs and the Burden of Disease (BoD) is useful in developing resource allocation and prioritization strategies in public and environmental health. While useful, the Disability-Adjusted Life Year (DALY) metric disregards subclinical dysfunctions, adheres to stringent causal criteria, and is hampered by gaps in environmental exposure data, especially from industrializing countries. For these reasons, a recently calculated environmental BoD of 5.18% of the total DALYs is likely underestimated. We combined and extended cost calculations for exposures to environmental chemicals, including neurotoxicants, air pollution, and endocrine disrupting chemicals, where sufficient data were available to determine dose-dependent adverse effects...
December 5, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29199129/evaluating-estrogenic-and-anti-estrogenic-effect-of-endocrine-disrupting-chemicals-edcs-by-zebrafish-danio-rerio-embryo-based-vitellogenin-1-vtg1-mrna-expression
#10
Minjie Chen, Jie Zhang, Shaochen Pang, Chang Wang, Ling Wang, Yonghua Sun, Maoyong Song, Yong Liang
By measuring the vitellogenin 1 (vtg1) expression through quantitative PCR and in situ hybridization, we used the zebrafish embryo as an in vivo model to access the estrogenic or anti-estrogenic effects of several endocrine disrupting chemicals (EDCs), such as natural estrogen 17β-estradiol (E2), estriol (E3), synthetic hormones including diethylstilbestrol (DES), 4-octyl phenol (OP), bisphenol A (BPA), tamoxifen (TMX) and 3-(2,3-dibromopropyl) isocyanurate (TBC). According to our data, the estrogenic effect of the tested chemicals was ranked as: DES>E2>E3>OP > BPA, which is consistent with various in vivo and in vitro models...
November 30, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29197755/occurrence-removal-and-risk-of-organic-micropollutants-in-wastewater-treatment-plants-across-china-comparison-of-wastewater-treatment-processes
#11
Weiwei Ben, Bing Zhu, Xiangjuan Yuan, Yu Zhang, Min Yang, Zhimin Qiang
This study investigated the occurrence, removal and risk of 42 organic micropollutants (MPs), including 30 pharmaceuticals and personal care products and 12 endocrine disrupting chemicals, in 14 municipal wastewater treatment plants (WWTPs) distributed across China. The composition profiles of different MP categories in the influent, effluent, and excess sludge were explored and the aqueous removal efficiencies of MPs were determined. Quantitative meta-analysis was performed to compare the efficacies of different wastewater treatment processes in eliminating MPs...
November 30, 2017: Water Research
https://www.readbyqxmd.com/read/29197299/isotope-dilution-gas-chromatography-mass-spectrometry-coupled-with-injection-port-butylation-for-the-determination-of-4-t-octylphenol-4-nonylphenols-and-bisphenol-a-in-human-urine
#12
Shuang-Hung Chung, Wang-Hsien Ding
An analytical method that utilizes isotope-dilution gas chromatography-mass spectrometry (ID-GC-MS) coupled with injection-port butylation was developed. The method was validated, and confirmed to be able to determine the presence of three commonly detected endocrine-disrupting chemicals (EDCs: 4-tert-octylphenol (4-t-OP), 4-nonylphenols (4-NPs) and bisphenol A (BPA)) in human urine with high precision and accuracy. After sample preparation by solid-phase extraction, the extract was introduced into GC-MS via injection-port butylation...
November 29, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29197012/co-culture-of-h295r-adrenocortical-carcinoma-and-bewo-choriocarcinoma-cells-to-study-feto-placental-interactions-focus-on-estrogen-biosynthesis
#13
Andrée-Anne Hudon Thibeault, J Thomas Sanderson, Cathy Vaillancourt
Estrogens are produced in large amounts during pregnancy, as a result of a tightly regulated cooperation between the maternal and fetal adrenal cortex, which produce androgen precursors, and the placental villous trophoblast, which transforms these precursors into estrogens. These estrogens play an important role in proper placental function, in adaptation of the mother to pregnancy, as well as in adequate fetal development. Disruption of estrogen production is associated with poor pregnancy outcomes and fetal malformation or altered fetal programming...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29194390/thyroid-disrupting-chemicals
#14
REVIEW
Valeria Calsolaro, Giuseppe Pasqualetti, Filippo Niccolai, Nadia Caraccio, Fabio Monzani
Endocrine disruptor compounds are exogenous agents able to interfere with a gland function, exerting their action across different functional passages, from the synthesis to the metabolism and binding to receptors of the hormone produced. Several issues, such as different levels and time of exposure and different action across different ages as well as gender, make the study of endocrine disruptors still a challenge. The thyroid is very sensitive to the action of disruptors, and considering the importance of a correct thyroid function for physical and cognitive functioning, addressing this topic should be considered a priority...
December 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29191790/morphological-and-transcriptomic-effects-of-endocrine-modulators-on-the-gonadal-differentiation-of-chicken-embryos-the-case-of-tributyltin-tbt
#15
Jessica Scheider, Fabian Afonso-Grunz, Luzie Jessl, Klaus Hoffmeier, Peter Winter, Jörg Oehlmann
Morphological malformations induced by tributyltin (TBT) exposure during embryonic development have already been characterized in various taxonomic groups, but, nonetheless, the molecular processes underlying these changes remain obscure. The present study provides the first genome-wide screening for differentially expressed genes that are linked to morphological alterations of gonadal tissue from chicken embryos after exposure to TBT. We applied a single injection of TBT (between 0.5 and 30pg as Sn/g egg) into incubated fertile eggs to simulate maternal transfer of the endocrine disruptive compound...
November 27, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29191315/occurrence-and-fate-of-endogenous-steroid-hormones-alkylphenol-ethoxylates-bisphenol-a-and-phthalates-in-municipal-sewage-treatment-systems
#16
Qian Wu, James C W Lam, Karen Y Kwok, Mirabelle M P Tsui, Paul K S Lam
Steroid hormones, alkylphenol ethoxylates (APEOs) and phthalic acid esters (PAEs) are emerging endocrine disrupting chemicals (EDCs) that can interfere with the endocrine function in organisms at low concentrations. The occurrence, distribution behavior, removal rate and the fate of 31 target EDCs in sewage treatment plants, which consist of various treatment facilities and receiving water in Hong Kong, were investigated. Estrone, nonylphenol-di-ethoxylate and diethyl phthalate were found to be dominant in each group of influent samples with concentrations ranging from 11-33, 747-3945 and 445-4635ng/L, respectively...
November 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29191311/analysis-of-pfaas-in-american-alligators-part-1-concentrations-in-alligators-harvested-for-consumption-during-south-carolina-public-hunts
#17
Jessica J Tipton, Louis J Guillette, Susan Lovelace, Benjamin B Parrott, Thomas R Rainwater, Jessica L Reiner
Environmental contamination resulting from the production or release of harmful chemicals can lead to negative consequences for wildlife and human health. Perfluorinated alkyl acids (PFAAs) were historically produced as protective coatings for many household items and currently persist in the environment, wildlife, and humans. PFAAs have been linked to immune suppression, endocrine disruption, and developmental toxicity in wildlife and laboratory studies. This study examines the American alligator, Alligator mississippiensis, as an important indicator of ecosystem contamination and a potential pathway for PFAA exposure in humans...
November 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29190554/a-potential-microrna-regulation-of-immune-related-genes-in-invertebrate-haemocytes
#18
REVIEW
Mario Alberto Burgos-Aceves, Amit Cohen, Yoav Smith, Caterina Faggio
Bivalve mollusks have been employed as sentinel organisms in environmental health programs due to their sedentary lifestyle, filter-feeding behavior and their ability to accumulate pathogens or toxin molecules inside tissues. Endocrine disrupting chemicals (EDCs) can be up taken and bioaccumulated, and due to sensibility of mollusks to these EDCs, being able to cause immune alterations. Recently, microRNAs (miRNAs) were shown to be involved in modulation and buffering developmental processes against the effects of environmental alterations and pathogenic microorganisms...
November 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29187361/diet-dependence-of-metabolic-perturbations-mediated-by-the-endocrine-disruptor-tolylfluanid
#19
Shane Regnier, Andrew Kirkley, Daniel Ruiz, Wakanene Kamau, Qian Wu, Kurunthachalam Kannan, Robert Sargis
Emerging evidence implicates environmental endocrine disrupting chemicals (EDCs) in the pathogenesis of metabolic diseases such as obesity and diabetes; however, the interactions between EDCs and traditional risk factor in disease pathogenesis remain incompletely characterized. The present study interrogates the interaction of the EDC tolylfluanid (TF) and traditional dietary stressors in the promotion of metabolic dysfunction. Eight-week old, male C57BL/6 mice were fed a high fat-high sucrose diet (HFHSD) or a high sucrose diet (HSD), with or without TF supplementation at 100 μg/g, for 12 weeks...
November 29, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29183799/is-testicular-dysgenesis-syndrome-a-genetic-endocrine-or-environmental-disease-or-an-unexplained-reproductive-disorder
#20
REVIEW
Jian-Sheng Xing, Zhi-Ming Bai
Progressive increases in the incidence of male reproductive disorders inclusive of hypospadias, cryptorchidism, poor semen quality, and testicular germ cell cancer (TGCC) have been observed in recent times. The central hypothesis of this study asserted that these disorders may all collectively signify testicular dysgenesis syndrome (TDS). This review aimed to provide evidence verifying the reality of TDS based on four key aspects: environmental endocrine-disrupting chemicals (EDCs), genetic factors, intrauterine growth disorders and lifestyle factors...
November 25, 2017: Life Sciences
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