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Endocrine disrupting chemicals

Kadeem A Richardson, Patrick R Hannon, Yvette J Johnson-Walker, Maung Sun Myint, Jodi A Flaws, Romana A Nowak
Di-(2-ethylhexyl) phthalate (DEHP) is an endocrine-disrupting chemical that has been shown to impair normal reproductive function in males and females. This study investigated whether adult exposure to environmental and occupational doses of DEHP alters homeostasis of uterine proliferation, morphology, and number of uterine glands. Adult female CD1 mice were orally dosed with DEHP (0, 20 μg/kg/day, 200 μg/kg/day, 20 mg/kg/day or 200 mg/kg/day) for 30 days. Results indicated that DEHP at 200 μg/kg/day caused a reduction in epithelial cell proliferation in the uterus (p < ...
February 16, 2018: Reproductive Toxicology
Hoang Van Luong, Pham The Tai, Muneko Nishijo, Do Minh Trung, Pham Ngoc Thao, Pham Van Son, Nguyen Van Long, Nguyen Tung Linh, Hisao Nishijo
Dioxins are endocrine-disrupting chemicals, and their effects on reproductive functions are well-documented. The aim of the present study was to measure the levels of reproductive hormones in 42 men residing near a dioxin-contaminated area in Vietnam. We measured levels of 17 2,3,7,8-substituted congeners of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) and four non-ortho polychlorinated biphenyls (PCBs) in blood. Levels of follicle-stimulating hormone, luteinizing hormone, progesterone, prolactin, estradiol, and total testosterone were measured in serum...
February 13, 2018: Science of the Total Environment
Ying Li, Ruifang Su, Jingyue Xu, Jiaxin Bie, Rui Sun, Luokai Wang, Xin Liu, Chunyan Sun
A novel aptamers-based fluorescence resonance energy transfer (FRET) assay was developed employing the oppositely charged thioglycolic acid-capped CdTe quantum dots (TGA-CdTe QDs) and cysteamine-stabilized gold nanoparticles (cysteamine-AuNPs). The fluorescence of TGA-CdTe QDs was significantly quenched with addition of cysteamine-AuNPs via the FRET. The FRET process can be modulated by 17β-estradiol in that the specific recognition between 17β-estradiol and aptamers could show different effects on the aptamers-mediated aggregation of cysteamine-AuNPs, and correspondingly adjust the FRET process...
March 1, 2018: Journal of Nanoscience and Nanotechnology
Jill A Jenkins, Michael R Rosen, Rassa O Draugelis-Dale, Kathy R Echols, Leticia Torres, Carla M Wieser, Constance A Kersten, Steven L Goodbred
Lake Mead National Recreational Area (LMNRA) serves as critical habitat for several federally listed species and supplies water for municipal, domestic, and agricultural use in the Southwestern U.S. Contaminant sources and concentrations vary among the sub-basins within LMNRA. To investigate whether exposure to environmental contaminants is associated with alterations in male common carp (Cyprinus carpio) gamete quality and endocrine- and reproductive parameters, data were collected among sub-basins over 7 years (1999-2006)...
February 10, 2018: Environmental Research
Gang Liu, Klodian Dhana, Jeremy D Furtado, Jennifer Rood, Geng Zong, Liming Liang, Lu Qi, George A Bray, Lilian DeJonge, Brent Coull, Philippe Grandjean, Qi Sun
BACKGROUND: The potential endocrine-disrupting effects of perfluoroalkyl substances (PFASs) have been demonstrated in animal studies, but whether PFASs may interfere with body weight regulation in humans is largely unknown. This study aimed to examine the associations of PFAS exposure with changes in body weight and resting metabolic rate (RMR) in a diet-induced weight-loss setting. METHODS AND FINDINGS: In the 2-year POUNDS Lost randomized clinical trial based in Boston, Massachusetts, and Baton Rouge, Louisiana, that examined the effects of energy-restricted diets on weight changes, baseline plasma concentrations of major PFASs were measured among 621 overweight and obese participants aged 30-70 years...
February 2018: PLoS Medicine
Dragana Samardzija Nenadov, Kristina Pogrmic-Majkic, Svetlana Fa, Bojana Stanic, Aleksandra Tubic, Nebojsa Andric
Humans are exposed not only to single endocrine disruptors, but also to chemical mixtures that can adversely affect their reproductive health. Steroidogenesis in reproductive tissues is emerging as the key target of endocrine disruptor action. Here, we analyzed the effect of environmental chemical mixtures with estrogenic activity on steroidogenic processes in immature rat granulosa cells and whether the observed steroidogenic effects were mediated through estrogen receptors. Extracts from untreated wastewater were prepared by solid-phase extraction and silica gel fractionation...
February 13, 2018: Journal of Applied Toxicology: JAT
Xiaoming Song, Yujuan Wen, Yuanyuan Wang, Muhammad Adeel, Yuesuo Yang
The emerging endocrine disrupting chemicals posed high risk and much uncertainty to eco-environment and human health. An analytical method, developed for the simultaneous determination of five steroid estrogens in groundwater and soil based upon solid phase extraction and gas chromatography-mass spectrometry, was applied to investigate the distribution of estrone and 17β-estradiol around Shenyang City with particular focus on penetrating from surface to groundwater in this study. Mean concentrations of the estrone and 17β-estradiol were 55...
January 19, 2018: Chemosphere
(no author information available yet)
The extensive database on BPA provides strong evidence of its adverse effects on reproductive, neurobehavioral, metabolic functions and mammary gland. Disruption of estrogenic pathway is central in the mediation of these effects although other modes of action may be involved. BPA has a weak affinity for ERα/β but interaction with extranuclearly located pathways activated by estrogens such as ERRγ and GPER reveals how BPA can act at low doses. The effects are observed later in life after developmental exposure and are associated with pathologies of major societal concern in terms of severity, incidence, impact on quality of life, burden on public health system...
February 8, 2018: Molecular and Cellular Endocrinology
Germaine M Buck Louis, Melissa M Smarr, Liping Sun, Zhen Chen, Masato Honda, Wei Wang, Rajendiran Karthikraj, Jennifer Weck, Kurunthachalam Kannan
Growing evidence supports the importance of men's exposure to non-persistent endocrine disruptors (EDCs) and couple fecundability, as measured by time-to-pregnancy (TTP). This evolving literature contrasts with the largely equivocal findings reported for women's exposures and fecundity. While most evidence relies upon urinary concentrations, quantification of EDCs in seminal plasma may be more informative about potential toxicity arising within the testes. We analyzed 5 chemical classes of non-persistent EDCs in seminal plasma for 339 male partners of couples who were recruited prior to conception and who were followed daily until pregnant or after one year of trying...
February 6, 2018: Environmental Research
Sarah A Sapouckey, Christopher D Kassotis, Susan C Nagel, Laura N Vandenberg
Unconventional oil and gas operations (UOG), which combine hydraulic fracturing (fracking) and directional drilling, involve the use of hundreds of chemicals including many with endocrine disrupting properties. Two previous studies examined mice exposed during early development to a 23-chemical mixture of UOG compounds (UOG-MIX) commonly used or produced in the process. Both male and female offspring exposed prenatally to one or more doses of UOG-MIX displayed alterations to endocrine organ function and serum hormone concentrations...
February 7, 2018: Endocrinology
Mengchen Xu, Rui Zhang, Wei Song, Wansong Zong, Rutao Liu
As an endocrine-disrupting chemical, bisphenol A (BPA), can affect normal endocrine function of hormone. This paper studied the toxic effect of BPA on acid phosphatase at the molecular level by multi-spectroscopic measurements, molecular docking, and enzyme activity experiment. BPA could enhance the fluorescence intensity, change the structure, and cause an increased hydrophobicity of acid phosphatase. Hydrogen bond interaction and van der Waals forces were the main forces to generate the BPA-acid phosphatase complex on account of the negative ΔH (- 36...
February 8, 2018: Environmental Science and Pollution Research International
Hien Ho, Tsunemi Watanabe
The ubiquitous surfactants nonylphenol (NP) and its ethoxylates (NPEOs), which are known as endocrine disrupters, have appeared in the lists of restricted chemical substances, monitoring programs, and environmental quality standards of many countries due to their adverse effects. Recent studies have reported alarming levels of NP, as the final metabolite of NPEOs, in Vietnamese urban waters, whilst response to this issue is negligible. With the aim of addressing how the public perceives and expects to avoid the risk of endocrine disrupting surfactants (EDSs), the study tested the hypothesized roles of specific knowledge, general knowledge, and perceived uncertainty using structural equation modelling...
February 8, 2018: International Journal of Environmental Research and Public Health
Hajime Kojima
Non-animal alternative test methods have developed in the field of genotoxicity, endocrine disrupter, irritation and skin sensitization, and these are used the safety evaluation of chemical, pesticide, pharmaceutical and cosmetic for regulatory use. For the systemic toxicological endpoints of repeated dose toxicity, carcinogenicity, immunotoxicity and reproductive toxicity, new test methods are expected to be developed in the future worldwide. I believe Japan will make a significant contribution to these developments...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
Ahmad Negintaji, Alireza Safahieh, Hossein Zolgharnein, Soheila Matroodi
Bisphenol A (BPA) is a known environmental endocrine-disrupting chemical that is widely used in plastics manufacturing. BPA enters in the aquatic environment mainly through urban and industrial sewage effluents, thereby posing a potential threat to organisms living in these ecosystems. This study was conducted to investigate the effect of BPA on VTG production with direct (sodium dodecyl sulfate-polyarylamide gel electrophoresis) and indirect (alkali-labile phosphate (ALP), total plasma calcium and protein) methods in immature male yellowfin seabream ( Acanthopagrus latus) as a marine fish model...
January 1, 2018: Toxicology and Industrial Health
John P Lombardo, Joshua A Peck
In two experiments, male and female Sprague-Dawley rats were exposed to Polychlorinated Biphenyls (PCBs) to assess the effect PCBs, an estrogenic endocrine disrupting chemical (EEDC), would have on the voluntary consumption of alcohol. There are several EEDCs in our food that are known to increase estrogen in adolescent females. Our objective was to assess the effect that increasing estrogen, by adding the EEDC PCBs would have on volitional intake of alcohol. In Experiment 1, pregnant dams were exposed from gestational days 5-19 to a 1:1 mixture of Aroclor 1254/1260...
February 2, 2018: Environmental Pollution
A Angel Ezhilarasi, J Judith Vijaya, K Kaviyarasu, L John Kennedy, R Jothi Ramalingam, Hamad A Al-Lohedan
In the present study, we report the green synthesis of NiO nanoparticles using Aegle marmelos as a fuel and this method is ecofriendly and cost effective. The plant Aegle marmelos is used in the field of pharmaceuticals to cure diseases like chronic diarrhea, peptic ulcers and dysentery in India for nearly 5 centuries. The as-prepared nanoparticles were confirmed as pure face centered cubic phase and single crystalline in nature by XRD. The formation of agglomerated spherical nanoparticles was shown by HR-SEM and HR-TEM images...
January 30, 2018: Journal of Photochemistry and Photobiology. B, Biology
Anna Katharina Vingskes, Nicole Spann
Many widely used healthcare products contain antiseptics, whose persistence in aquatic environments, soils, and sediments leads to the contamination of ecosystems and adversely affects wildlife. Recently, the impact not only of high but also low doses of contaminants and mixtures of several chemicals has become a focus of concern. In this study, toxicity tests of the antiseptics triclosan (TCS) and triclocarban (TCC) were performed in an aquatic test medium using the nematode Caenorhabditis elegans. Nominal concentrations of TCS and TCC were tested in separate single-substance toxicity tests (96-h-exposure), focussing on growth and reproduction endpoints...
February 6, 2018: Ecotoxicology
Erin M Kollitz, Lauren De Carbonnel, Heather M Stapleton, P Lee Ferguson
Brominated phenolic compound (BPCs) are found in the environment, and in human and wildlife tissues, and some are considered to have endocrine disrupting activities. The goal of this study was to determine how structural differences of three BPC classes impact binding affinities for the thyroid receptor beta (TRβ) in humans and zebrafish. BPC classes included halogenated bisphenol A (BPA) derivatives, halogenated oxidative transformation products of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), and brominated phenols...
February 2, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Mónica Morales, Pedro Martínez-Paz, Paloma Sánchez-Argüello, Gloria Morcillo, José Luis Martínez-Guitarte
Bisphenol A (BPA), a known endocrine disrupting chemical (EDC) that can mimic the action of oestrogens by interacting with hormone receptors, is potentially able to influence reproductive functions in vertebrates and invertebrates. The freshwater pulmonate Physa acuta is a sensitive organism to xenobiotics appropriate for aquatic toxicity testing in environmental studies. This study was conducted to explore the effects of BPA on the Gastropoda endocrine system. The effects following a range of exposure times (5-96h) to BPA in P...
January 31, 2018: Ecotoxicology and Environmental Safety
Kristen J Polinski, Dana Dabelea, Richard F Hamman, John L Adgate, Antonia M Calafat, Xiaoyun Ye, Anne P Starling
BACKGROUND: Phthalates and phenols are suspected endocrine disrupting chemicals that may adversely impact fetal outcomes following in utero exposure. Understanding predictors of exposure to phthalates and phenols during the prenatal period is important. METHODS: We measured urinary concentrations of 15 phthalate metabolites and 11 phenols in 446 pregnant women enrolled in the Healthy Start pre-birth cohort. Creatinine-adjusted geometric means (GM) for each urinary biomarker were compared across categories of potential sociodemographic and dietary predictors...
January 30, 2018: Environmental Research
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