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Endocrine disrupting chemicals

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https://www.readbyqxmd.com/read/28637324/the-effects-of-phytosterols-on-the-sexual-behavior-and-reproductive-function-in-the-japanese-quail-coturnix-coturnix-japonica
#1
Mohammad Ibrahim Qasimi, Kentaro Nagaoka, Gen Watanabe
Phytosterols (PS) are plant origin sterols naturally found in many foods and added as food additives. Since 1950, PS have attracted considerable attention due to their ability to lower serum cholesterol and inhibit cardiovascular disease (CVD). However, recent studies have found that PS act as endocrine-disrupting chemicals in laboratory animals. Therefore, this study was aimed at finding the mechanism(s) for PS effects on the sexual behaviors and reproductive functions in male Japanese quails (Coturnix coturnix japonica)...
June 16, 2017: Poultry Science
https://www.readbyqxmd.com/read/28637041/the-effects-of-fungicides-on-human-3%C3%AE-hydroxysteroid-dehydrogenase-1-and-aromatase-in-human-placental-cell-line-jeg-3
#2
Shuyan Cao, Leping Ye, Ying Wu, Baiping Mao, Lanlan Chen, Xiudi Wang, Ping Huang, Ying Su, Ren-Shan Ge
Placenta secretes a large amount of progesterone and estradiol, which are critical for maintaining pregnancy. In human placenta, 3β-hydroxysteroid dehydrogenase 1 (HSD3B1) catalyzes pregnenolone to form progesterone, and aromatase (CYP19A1) catalyzes testosterone into estradiol. Fungicides display antifungal activities and are widely used to prevent fungal infections in agricultural plants. These chemicals include azoles, such as tebuconazole (TEB), triadimefon (TRI), and vinclozolin (VCZ) or organotins, such as tributyltin (TBT) and tetrabutyltin (TTBT)...
June 22, 2017: Pharmacology
https://www.readbyqxmd.com/read/28636878/lycium-barbarum-polysaccharide-alleviates-nonylphenol-exposure-induced-testicular-injury-in-juvenile-zebrafish
#3
Ze-Yong Tang, Dong Sun, Chun-Wei Qian, Qi Chen, Shun-Shan Duan, Sheng-Yun Sun
Nonylphenol is an endocrine disrupting chemicals that can disrupt the organisms' reproductive system, and exists widely in rivers and lakes. Lycium barbarum polysaccharide (LBP) is the main active constituent (about 10%) in Lycium barbarum, which is used to protect reproductive health. In this study, we investigated whether LBP can alleviate nonylphenol exposure induced testicular injury in juvenile zebrafish. We detected histological alteration, anti-oxidant enzyme profile and P450 gene transcription to assess LBP effect on testicular development...
June 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28634868/occurrence-removal-and-health-risk-assessment-of-phthalate-esters-in-the-process-streams-of-two-different-wastewater-treatment-plants-in-lagos-and-ogun-states-nigeria
#4
O O Olujimi, O A Aroyeun, T F Akinhanmi, T A Arowolo
Phthalate esters (PEs) are one of the environmentally active organic pollutants capable of causing endocrine disruption. The levels of PE congeners were determined in the influent and effluent from Covenant Oxidation Pond (COP) and Ikeja Wastewater Treatment Plant (IWWTP). Standard methods were adopted for determining the physical and chemical parameters of the water samples. The water samples for PE congener's determination were collected, acidified and stored at 4 °C prior to liquid-liquid extraction and analysis by gas chromatograph...
July 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28634325/in-utero-and-lactational-exposure-study-in-rats-to-identify-replacements-for-di-2-ethylhexyl-phthalate
#5
Thomas C Nardelli, Océane Albert, Claudia Lalancette, Martine Culty, Barbara F Hales, Bernard Robaire
Di(2-ethylhexyl) phthalate (DEHP) and other phthalates are ubiquitous environmental contaminants with endocrine disrupting properties. Two novel plasticizers, 1,4 butanediol dibenzoate (BDB) and dioctyl succinate (DOS), have been proposed as potential replacements. Both have desirable properties as plasticizers and minimal in vitro biological effects. Herein, we present an in utero and lactational exposure study comparing DEHP with BDB, DOS, and 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH), a commercial alternative...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634053/using-short-term-bioassays-to-evaluate-the-endocrine-disrupting-capacity-of-the-pesticides-linuron-and-fenoxycarb
#6
Petra Spirhanzlova, Bert De Groef, Freda E Nicholson, Sylvia V H Grommen, Giulia Marras, Anthony Sébillot, Barbara A Demeneix, Sophie Pallud-Mothré, Gregory F Lemkine, Andrew J Tindall, David Du Pasquier
Several short-term whole-organism bioassays based on transgenic aquatic models are now under validation by the OECD (Organization for Economic Co-operation and Development) to become standardized test guidelines for the evaluation of the endocrine activity of substances. Evaluation of the endocrine disrupting capacity of pesticides will be a domain of applicability of these future reference tests. The herbicide linuron and the insecticide fenoxycarb are two chemicals commonly used in agricultural practices...
June 17, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28631836/medaka-extended-one-generation-reproduction-test-meogrt-evaluating-4-nonylphenol
#7
Haruna Watanabe, Yoshifumi Horie, Hitomi Takanobu, Masaaki Koshio, Taisen Iguchi, Norihisa Tatarazako
The Medaka Extended One-Generation Test (MEOGRT) was developed as a multi-generational toxicity test for chemicals, particularly endocrine disrupting chemicals. Briefly, 3 generations of Japanese medaka (Oryzias latipes) are exposed to a chemical over a 20-week period: 3-week in the parental generation (F0), 15-week in the first generation (F1), and 2-week in the second generation (F2). The present study reports the first MEOGRT results concerning branched isomer mixtures of 4-nonylphenol (NP). Adult F0 medaka exposed to NP at 5 actual concentrations (1...
June 20, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28631552/effect-of-2-3-4-4-5-pentachlorobiphenyl-exposure-on-endometrial-receptivity-and-the-methylation-of-hoxa10
#8
Xin-Lan Qu, Ming-Zhang, Yuan-Fang, Hui Wang, Yuan-Zhen Zhang
Polychlorinated biphenyls (PCBs) are one of the most common endocrine-disrupting chemicals and have obvious toxicity on human reproductive development. The aim of our study was to investigate the toxicity of chronic 2,3',4,4',5-pentachlorobiphenyl (PCB 118) exposure on embryo implantation and endometrial receptivity, with the possible mechanism of DNA methylation involved. Virgin CD-1 female mice (3 weeks old) were housed and orally treated with PCB 118 (0, 1, 10, 100 μg/kg) for a month. After mating with fertile males, the pregnant mice were killed on gestation day 4...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28623480/the-current-debate-on-cost-burden-by-human-exposure-to-endocrine-disrupting-chemicals
#9
EDITORIAL
Hermann M Bolt
No abstract text is available yet for this article.
June 16, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28622647/endocrine-disrupting-activity-of-per-and-polyfluoroalkyl-substances-exploring-combined-approaches-of-ligand-and-structure-based-modeling
#10
Supratik Kar, Maria S Sepúlveda, Kunal Roy, Jerzy Leszczynski
Exposure to perfluorinated and polyfluoroalkyl substances (PFCs/PFASs), endocrine disrupting halogenated pollutants, has been linked to various diseases including thyroid toxicity in human populations across the globe. PFASs can compete with thyroxine (T4) for binding to the human thyroid hormone transport protein transthyretin (TTR) which may lead to reduce thyroid hormone levels leading to endocrine disrupting adverse effects. Environmental fate and endocrine-disrupting activity of PFASs has initiated several research projects, but the amount of experimental data available for these pollutants is limited...
June 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28618666/the-toxicity-of-oil-sands-process-affected-water-ospw-a-critical-review
#11
REVIEW
Chao Li, Li Fu, James Stafford, Miodrag Belosevic, Mohamed Gamal El-Din
Large volumes of oil sands process-affected water (OSPW) are produced by the surface-mining oil sands industry in Alberta. Both laboratory and field studies have demonstrated that the exposure to OSPW leads to many physiological changes in a variety of organisms. Adverse effects include compromised immunological function, developmental delays, impaired reproduction, disrupted endocrine system, and higher prevalence of tissue-specific pathological manifestations. The composition of OSPW varies with several factors such as ore sources, mining process, and tailings management practices...
June 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28617201/a-comprehensive-review-of-regulatory-test-methods-for-endocrine-adverse-health-effects
#12
M K Manibusan, L W Touart
Development of new endocrine disruption-relevant test methods has been the subject of intensive research efforts for the past several decades, prompted in part by mandates in the 1996 Food Quality Protection Act (FQPA). While scientific understanding and test methods have advanced, questions remain on whether current scientific methods are capable of adequately addressing the complexities of the endocrine system for regulatory health and ecological risk assessments. The specific objective of this article is to perform a comprehensive, detailed evaluation of the adequacy of current test methods to inform regulatory risk assessments of whether a substance has the potential to perturb endocrine-related pathways resulting in human adverse effects...
July 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28616630/experimental-and-computational-insights-on-the-recognition-mechanism-between-the-estrogen-receptor-%C3%AE-with-bisphenol-compounds
#13
Huiming Cao, Fengbang Wang, Yong Liang, Hailin Wang, Aiqian Zhang, Maoyong Song
Certain bisphenols (BPs) have been regarded as endocrine-disrupting chemicals due to their structural similarities to bisphenol A (BPA), a well-known weak estrogenic chemical. However, very limited data are currently available on the relationship between estrogenic activity and the structure of BP analogs. Therefore, we systematically investigated the estrogenic potency of 14 selected BP analogs with typical structures using experimental and computational methods. Most of the tested BP analogs exhibited weak estrogenic activities in both cell proliferation and MVLN assays with the exception of TBBPA, TCBPA and TBBPS...
June 14, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28611354/chronic-low-dose-exposure-to-a-mixture-of-environmental-endocrine-disruptors-induces-micrornas-isomirs-deregulation-in-mouse-concomitant-with-intratesticular-estradiol-reduction
#14
Julio Buñay, Eduardo Larriba, Ricardo D Moreno, Jesús Del Mazo
Humans are environmentally exposed not only to single endocrine-disrupting chemicals (EDCs) but to mixtures that affect their reproductive health. In reproductive tissues, microRNAs (miRNAs) are emerging as key targets of EDCs. Here, we analysed changes in the testis "miRNome" (and their biogenesis mechanism) in chronically exposed adult mice to a cocktail of five EDCs containing 0.3 mg/kg-body weight (BW)/day of each phthalate (DEHP, DBP, BBP) and 0.05 mg/kg-BW/day of each alkylphenol (NP, OP), from conception to adulthood...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28602421/endocrine-disruption-effects-in-male-and-intersex-roach-rutilus-rutilus-l-from-french-rivers-an-integrative-approach-based-on-subcellular-to-individual-responses
#15
Perrine Geraudie, Marie Gerbron, Christophe Minier
Among the chemicals found in the aquatic environment, some have been reported to interact with the endocrine system of organisms and have been identified as endocrine disrupting compounds. In this study, we have assessed the biological effects due to environmental estrogenic compounds in adult male roach (Rutilus rutilus). Wild fish were collected in the Seine river, and one of its affluent, the Epte river in Normandy, France and impacts on endocrine and reproductive functions have been assessed. This study provides innovative data on the intersex condition in wild fish that are crucial to understand estrogenic contamination impacts and maintenance of sustainable fish population...
June 5, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28602118/effects-of-endocrine-disrupting-chemicals-and-epigenetic-modifications-in-ovarian-cancer-a-review
#16
Ratika Samtani, Noopur Sharma, Deepali Garg
Ovarian cancer (OC) is a relatively fatal female reproductive malignancy. Since the underlying causes are uncertain, it brings us to believe that both genetic and external factors contribute toward development of this lethal disorder. Exposure to endocrine-disrupting chemicals (EDCs) in the form of occupational usage of pesticides, fungicides, herbicides, plasticizers, cosmetics, and so on is potentially carcinogenic and their ability to cause epigenetic modifications has led us to hypothesize that they may play a catalytic role in OC progression...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28599657/comparison-of-methods-for-calculating-the-health-costs-of-endocrine-disrupters-a-case-study-on-triclosan
#17
Radka Prichystalova, Jean-Baptiste Fini, Leonardo Trasande, Martine Bellanger, Barbara Demeneix, Laura Maxim
BACKGROUND: Socioeconomic analysis is currently used in the Europe Union as part of the regulatory process in Regulation Registration, Evaluation and Authorisation of Chemicals (REACH), with the aim of assessing and managing risks from dangerous chemicals. The political impact of the socio-economic analysis is potentially high in the authorisation and restriction procedures, however, current socio-economic analysis dossiers submitted under REACH are very heterogeneous in terms of methodology used and quality...
June 9, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28599595/polybrominated-diphenyl-ethers-flame-retardants-in-mother-infant-pairs-in-the-southeastern-u-s
#18
Paul Terry, Craig V Towers, Liang-Ying Liu, Angela A Peverly, Jiangang Chen, Amina Salamova
Polybrominated diphenyl ethers (PBDEs) are commonly used flame retardants in foams, building material, electronics, and textiles. These chemicals leach into the environment, where they persist, and are found today in virtually every population worldwide. Several studies in recent years have detected the presence of PBDEs in maternal and infant samples. However, few of these studies were conducted in the U.S., and few examined paired or matched mother blood-cord blood samples. We analyzed serum from 10 mother-infant pairs for the presence of PBDEs in a patient population in the Southeastern U...
June 9, 2017: International Journal of Environmental Health Research
https://www.readbyqxmd.com/read/28595985/curcumin-inhibits-adipogenesis-induced-by-benzyl-butyl-phthalate-in-3t3-l1-cells
#19
Satoru Sakuma, Maki Sumida, Yukiko Endoh, Ayaka Kurita, Ayana Yamaguchi, Tomoki Watanabe, Tetsuya Kohda, Yui Tsukiyama, Yohko Fujimoto
Phthalates are a group of endocrine disrupting chemicals and may have contributed to the recent global obesity health crisis. Increased adipogenesis via the peroxisome proliferator-activated receptor γ (PPARγ)-CCAAT-enhancer binding protein α (C/EBPα) pathway could be one critical mechanism responsible for phthalate-induced weight gain. On the other hand, curcumin has been shown to inhibit adipogenesis in cells and animal models. The present study was undertaken to evaluate, for the first time, whether curcumin could reduce adipogenesis induced by benzyl butyl phthalate (BBP) via downregulation of the PPARγ-C/EBPα pathway...
June 10, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28592390/greywater-characterization-and-loadings-physicochemical-treatment-to-promote-onsite-reuse
#20
C Noutsopoulos, A Andreadakis, N Kouris, D Charchousi, P Mendrinou, A Galani, I Mantziaras, E Koumaki
Greywater is the wastewater produced in bathtubs, showers, hand basins, kitchen sinks, dishwashers and laundry machines. Segregation of greywater and blackwater and on site greywater treatment in order to promote its reuse for toilet flushing and/or garden irrigation is an interesting option especially in water deficient areas. The objective of this study was to characterize the different greywater sources in Greek households and to evaluate the performance of alternative physicochemical treatment systems to treat several types of greywater...
June 4, 2017: Journal of Environmental Management
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