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Endocrine disrupting chemicals

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https://www.readbyqxmd.com/read/28208233/neonatal-exposure-to-endocrine-disrupting-chemicals-impair-learning-behaviour-by-disrupting-hippocampal-organization-in-male-swiss-albino-mice
#1
Rakesh Bhaskar, Ashish K Mishra, Banalata Mohanty
Hippocampus is highly susceptible to endocrine disrupting chemicals exposure particularly during the critical phase of brain development. In the present study, mice offspring were exposed to endocrine disruptors mancozeb (MCZ) and imidacloprid (IMI) individually (40 mg MCZ and 0.65 mg IMI/kg/day) as well as to their equimixture (40 mg MCZ + 0.65 mg IMI/kg/day) through the diet of lactating mothers from post-natal day (PND) 1 to PND 28. Half of the randomly selected male offspring were killed at PND 29 and the rest half were left unexposed and killed at PND 63...
February 16, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28208107/assessing-the-potential-for-trace-organic-contaminants-commonly-found-in-australian-rivers-to-induce-vitellogenin-in-the-native-rainbowfish-melanotaenia-fluviatilis-and-the-introduced-mosquitofish-gambusia-holbrooki
#2
Philip D Scott, Heather M Coleman, Anne Colville, Richard Lim, Benjamin Matthews, James A McDonald, Ana Miranda, Peta A Neale, Dayanthi Nugegoda, Louis A Tremblay, Frederic D L Leusch
In Australia, trace organic contaminants (TrOCs) and endocrine active compounds (EACs) have been detected in rivers impacted by sewage effluent, urban stormwater, agricultural and industrial inputs. It is unclear whether these chemicals are at concentrations that can elicit endocrine disruption in Australian fish species. In this study, native rainbowfish (Melanotaenia fluviatilis) and introduced invasive (but prevalent) mosquitofish (Gambusia holbrooki) were exposed to the individual compounds atrazine, estrone, bisphenol A, propylparaben and pyrimethanil, and mixtures of compounds including hormones and personal care products, industrial compounds, and pesticides at environmentally relevant concentrations...
February 7, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28205155/endocrine-disruptors-and-obesity
#3
REVIEW
Philippa D Darbre
PURPOSE OF REVIEW: The purpose of this review was to summarise current evidence that some environmental chemicals may be able to interfere in the endocrine regulation of energy metabolism and adipose tissue structure. RECENT FINDINGS: Recent findings demonstrate that such endocrine-disrupting chemicals, termed "obesogens", can promote adipogenesis and cause weight gain. This includes compounds to which the human population is exposed in daily life through their use in pesticides/herbicides, industrial and household products, plastics, detergents, flame retardants and as ingredients in personal care products...
February 15, 2017: Current Obesity Reports
https://www.readbyqxmd.com/read/28199414/direct-and-transgenerational-effects-of-low-doses-of-perinatal-di-2-ethylhexyl-phthalate-dehp-on-social-behaviors-in-mice
#4
Kayla M Quinnies, Erin P Harris, Rodney W Snyder, Susan S Sumner, Emilie F Rissman
Di-(2-ethylhexyl) phthalate (DEHP) is an endocrine disrupting chemical commonly used as a plasticizer in medical equipment, food packaging, flooring, and children's toys. DEHP exposure during early development has been associated with adverse neurobehavioral outcomes in children. In animal models, early exposure to DEHP results in abnormal development of the reproductive system as well as altered behavior and neurodevelopment. Based on these data, we hypothesized that developmental exposure to DEHP would decrease social interactions and increase anxiety-like behaviors in mice in a dose-dependent manner, and that the effects would persist over generations...
2017: PloS One
https://www.readbyqxmd.com/read/28196854/hypothalamic-transcriptomic-alterations-in-male-and-female-california-mice-peromyscus-californicus-developmentally-exposed-to-bisphenol-a-or-ethinyl-estradiol
#5
Sarah A Johnson, William G Spollen, Lindsey K Manshack, Nathan J Bivens, Scott A Givan, Cheryl S Rosenfeld
Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) prevalent in many household items. Rodent models and human epidemiological studies have linked this chemical to neurobehavior impairments. In California mice, developmental exposure to BPA results in sociosexual disorders at adulthood, including communication and biparental care deficits, behaviors that are primarily regulated by the hypothalamus. Thus, we sought to examine the transcriptomic profile in this brain region of juvenile male and female California mice offspring exposed from periconception through lactation to BPA or ethinyl estradiol (EE, estrogen present in birth control pills and considered a positive estrogen control for BPA studies)...
February 2017: Physiological Reports
https://www.readbyqxmd.com/read/28184387/controllable-preparation-of-core-shell-magnetic-covalent-organic-framework-nanospheres-for-efficient-adsorption-and-removal-of-bisphenols-in-aqueous-solution
#6
Yang Li, Cheng-Xiong Yang, Xiu-Ping Yan
We herein report a monomer-mediated in situ growth strategy for the controllable construction of porous nanospheres with a magnetic core and a tunable COF shell. The composite exhibits high stability and excellent performance for the removal of a typical class of endocrine-disrupting chemicals, bisphenol chemicals, in aqueous solution.
February 10, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28181406/endocrine-disrupting-effects-of-methylparaben-on-the-adult-gerbil-prostate
#7
Janaína R Costa, Mônica S Campos, Rodrigo F Lima, Liana S Gomes, Mara R Marques, Sebastião R Taboga, Manoel F Biancardi, Pedro V A Brito, Fernanda C A Santos
Parabens are xenoestrogens widely employed in cosmetics, foodstuffs, and pharmaceutical products. These chemicals are known to disrupt hormone-dependent organs, due to their binding affinity for hormonal receptors. Although recent studies have evaluated the endocrine-disrupting potential of parabens in several reproductive organs, few have investigated the effects of these chemicals in the prostate. The aim of this work was to evaluate the effects of oral exposure to methylparaben (500 mg/kg/day) for 3, 7, and 21 days on male and female adult gerbil prostate...
February 9, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28181297/induction-of-oxidative-stress-by-bisphenol-a-and-its-pleiotropic-effects
#8
REVIEW
Natalie R Gassman
Bisphenol A (BPA) has become a target of intense public scrutiny since concerns about its association with human diseases such as obesity, diabetes, reproductive disorders, and cancer have emerged. BPA is a highly prevalent chemical in consumer products, and human exposure is thought to be ubiquitous. Numerous studies have demonstrated its endocrine disrupting properties and attributed exposure with cytotoxic, genotoxic, and carcinogenic effects; however, the results of these studies are still highly debated and a consensus about BPA's safety and its role in human disease has not been reached...
February 9, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/28159858/transcriptomic-alterations-in-the-brain-of-painted-turtles-chrysemys-picta-developmentally-exposed-to-bisphenol-a-or-ethinyl-estradiol
#9
Lindsey K Manshack, Caroline M Conard, Sara J Bryan, Sharon L Deem, Dawn K Holliday, Nathan J Bivens, Scott A Givan, Cheryl Susan Rosenfeld
Developmental exposure of turtles and other reptiles to endocrine disrupting chemicals (EDCs), including bisphenol A (BPA) and ethinyl estradiol (EE), can stimulate partial to full gonadal sex-reversal in males. We have also recently shown that in ovo exposure to either EDC can induce similar sex-dependent behavioral changes typified by improved spatial learning and memory or possibly feminized brain responses. Observed behavioral changes are presumed to be due to BPA- and EE-induced brain transcriptomic alterations during development...
February 3, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/28159674/extranuclear-initiated-estrogenic-actions-of-endocrine-disrupting-chemicals-is-there-toxicology-beyond-paracelsus
#10
Angel Nadal, Esther Fuentes, Cristina Ripoll, Sabrina Villar-Pazos, Manuel Castellano-Muñoz, Sergi Soriano, Juan Martinez-Pinna, Ivan Quesada, Paloma Alonso-Magdalena
Endocrine Disrupting Chemicals (EDCs), including bisphenol-A (BPA) do not act as traditional toxic chemicals inducing massive cell damage or death in an unspecific manner. EDCs can work upon binding to hormone receptors, acting as agonists, antagonists or modulators. Bisphenol-A displays estrogenic activity and, for many years it has been classified as a weak estrogen, based on the classic transcriptional action of estrogen receptors serving as transcription factors. However, during the last two decades our knowledge about estrogen signaling has advanced considerably...
January 31, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28154885/endocrine-disruption-and-in-vitro-ecotoxicology-recent-advances-and-approaches
#11
Martin Wagner, Cornelia Kienle, Etiënne L M Vermeirssen, Jörg Oehlmann
Endocrine-disrupting chemicals (EDCs) are man-made compounds interfering with hormone signaling. Omnipresent in the environment, they can cause adverse effects in a wide range of wildlife. Accordingly, Endocrine Disruption is one focal area of ecotoxicology. Because EDCs induce complex response patterns in vivo via a wide range of mechanisms of action, in vitro techniques have been developed to reduce and understand endocrine toxicity. In this review we revisit the evidence for endocrine disruption in diverse species and the underlying molecular mechanisms...
February 3, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/28153235/fabrication-of-a-polymeric-ionic-liquid-based-adsorbent-for-multiple-monolithic-fiber-solid-phase-microextraction-of-endocrine-disrupting-chemicals-in-complicated-samples
#12
Miao Pei, Zirui Zhang, Xiaojia Huang, Yuanfei Wu
A multiple monolithic fiber solid-phase microextraction (MMF-SPME) utilizing polymeric ionic liquid-based adsorbent was prepared. The adsorbent was obtained by in situ copolymerization of an ionic liquid, 1-trimethyl-(4-vinylbenzyl) aminium chloride and dual cross-linkers (divinylbenzene and ethylenedimethacrylate). The effect of preparation conditions including the content of ionic liquid and porogen in the polymerization mixture on extraction performance was studied in detail. Infrared spectroscopy, elemental analysis, scanning electron microscopy and mercury intrusion porosimetry were used to inspect the physicochemical properties of the new adsorbent...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28152656/the-role-of-healthcare-professionals-in-environmental-health-and-fertility-decision-making
#13
Ellen Sweeney
There is increasing evidence that raises specific concerns about prenatal exposures to toxic substances which makes it necessary to consider everyday exposures to industrial chemicals and toxic substances in consumer products, including endocrine disrupting chemicals. Pregnant women have measurable levels of numerous toxic substances from exposures in their everyday environments, including those which are associated with adverse developmental and reproductive health outcomes. As a result, environmental contexts have begun to influence the decisions women make related to fertility, as well as the formal guidelines and advice provided by healthcare professionals...
January 1, 2017: New Solutions: a Journal of Environmental and Occupational Health Policy: NS
https://www.readbyqxmd.com/read/28152472/exposure-to-phthalates-is-associated-with-lipid-profile-in-peripubertal-mexican-youth
#14
Wei Perng, Deborah J Watkins, Alejandra Cantoral, Adriana Mercado-García, John D Meeker, Martha Maria Téllez-Rojo, Karen E Peterson
Animal models indicate that endocrine disrupting chemicals (EDCs) affect circulating lipid concentrations by interfering with hepatic fatty acid oxidation. Little is known of the relationship between EDC exposure and lipid profile in humans. We measured bisphenol A (BPA) and 9 phthalate metabolites in maternal urine collected at up to three time points during pregnancy as a measure of in utero exposure, and in the child's urine at 8-14 years as a measure of concurrent, peripubertal exposure among 248 participants of a Mexico City pre-birth cohort...
January 30, 2017: Environmental Research
https://www.readbyqxmd.com/read/28143888/divergent-mechanisms-leading-to-signaling-dysfunction-in-embryonic-muscle-by-bisphenol-a-and-tetrabromobisphenol-a
#15
Rui Zhang, Isaac N Pessah
Bisphenol A (BPA) and its brominated derivative tetrabromobisphenol A (TBBPA) are high production volume chemicals utilized in the manufacture of various consumer products. Although regarded as endocrine disruptors, these chemicals are suspected to exert non-genomic actions on muscle function that are not well understood. Using skeletal muscle microsomes, we examined the effects of BPA and TBBPA on ryanodine receptor type 1 (RyR1), dihydropyridine receptor (DHPR), and sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA)...
January 31, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28131741/structural-aspects-of-thyroid-hormone-binding-to-proteins-and-competitive-interactions-with-natural-and-synthetic-compounds
#16
Ulrich Schweizer, Holly Towell, Allegra Vit, Alfonso Rodriguez-Ruiz, Clemens Steegborn
Thyroid hormones and their metabolites constitute a vast class of related iodothyronine compounds that contribute to the regulation of metabolic activity and cell differentiation. They are in turn transported, transformed and recognized as signaling molecules through binding to a variety of proteins from a wide range of evolutionary unrelated protein families, which renders these proteins and their iodothyronine binding sites an example for extensive convergent evolution. In this review, we will briefly summarize what is known about iodothyronine binding sites in proteins, the modes of protein/iodothyronine interaction, and the ligand conformations...
January 25, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28129936/assessment-of-parabens-and-ultraviolet-filters-in-human-placenta-tissue-by-ultrasound-assisted-extraction-and-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#17
F Vela-Soria, M E Gallardo-Torres, O Ballesteros, C Díaz, J Pérez, A Navalón, M F Fernández, N Olea
Increasing concerns have been raised over recent decades about human exposure to Endocrine Disrupting Chemicals (EDCs), especially about their possible effects on embryo, foetus, newborn, and child. Parabens (PBs) and ultraviolet filters (UV-filters) are prevalent EDCs widely used as additives in cosmetics and personal care products (PCPs). The objective of this study was to determine the presence of four PBs and ten UV-filters in placental tissue samples using a novel analytical method based on ultrasound-assisted extraction (UAE) and ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)...
January 18, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28129617/computational-study-involving-identification-of-endocrine-disrupting-potential-of-herbicides-its-implication-in-tds-and-cancer-progression-in-crpc-patients
#18
Md Irshad Ahmad, Afia Usman, Masood Ahmad
Several environmental pollutants, including herbicides, act as endocrine disrupting chemicals (EDCs). They can cause cancer, diabetes, obesity, metabolic diseases and developmental problems. Present study was conducted to screen 608 herbicides for evaluating their endocrine disrupting potential. The screening was carried out with the help of endocrine disruptome docking program, http://endocrinedisruptome.ki.si (Kolsek et al., 2013). This program screens the binding affinity of test ligands to 12 major nuclear receptors...
January 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/28115241/poly-and-perfluorinated-compounds-activate-human-pregnane-x-receptor
#19
Yi-Ming Zhang, Xiao-Yu Dong, Li-Juan Fan, Zhi-Lei Zhang, Qian Wang, Nan Jiang, Xu-Shu Yang
Poly- and perfluorinated compounds (PFCs), which have been detected worldwide in human blood, surface water and house dust, are suspected to induce potential endocrine-disrupting hormonal effects. In this study, cell-based reporter gene assays were used to determine the activity of a variety of PFCs against the human pregnane X receptor (hPXR) to identify the critical structural feature of PFCs related to their hPXR activity. Molecular docking studies combined with site-directed mutagenesis were employed to investigate the mechanism by which PFCs interact with and activate hPXR...
January 20, 2017: Toxicology
https://www.readbyqxmd.com/read/28111253/atrazine-exposure-elicits-copy-number-alterations-in-the-zebrafish-genome
#20
Sara E Wirbisky, Jennifer L Freeman
Atrazine is an agricultural herbicide used throughout the Midwestern United States that frequently contaminates potable water supplies resulting in human exposure. Using the zebrafish model system, an embryonic atrazine exposure was previously reported to decrease spawning rates with an increase in progesterone and ovarian follicular atresia in adult females. In addition, alterations in genes associated with distinct molecular pathways of the endocrine system were observed in brain and gonad tissue of the adult females and males...
January 19, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
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