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Endocrine disruption chemical

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https://www.readbyqxmd.com/read/29778942/transcriptomic-and-methylomic-analysis-reveal-the-toxicological-effect-of-2-3-7-8-tetrachlorodibenzodioxin-on-human-embryonic-stem-cell
#1
Keng Po Lai, Jing Woei Li, Ting Fung Chan, Andy Chen, Cherie Yin Lau Lee, William Shu Biu Yeung, Chris Kong Chu Wong
Cumulating epidemiological studies demonstrated that environmental exposure to endocrine disrupting chemicals (EDCs) during the early stages of fetal development is associated with the increase in disease susceptibility in later life. The fetal developmental plasticity is considered as a protective mechanism against an undesirable prenatal environment. Dioxin is one of the environmental contaminants and is considered a diabetogenic factor. Experimental animal and human epidemiological studies have revealed that dioxin exposure was associated with insulin resistance and altered beta cell function...
May 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/29777853/investigation-of-the-potential-endocrine-effect-of-nitrate-in-zebrafish-danio-rerio-and-brown-trout-salmo-trutta
#2
Poul Bjerregaard, Karin Lund Kinnberg, Maria Pedersen Mose, Henrik Holbech
Nitrate has the potential to affect steroid production. Nitrate concentrations in streams in agricultural areas may exceed concentrations showing effects in laboratory studies. The effects of nitrate and/or nitrite on endocrine relevant endpoints were tested in zebrafish and brown trout. Zebrafish were exposed in two experiments to nitrate (8.8 to 89 mg NO3 - /L) and nitrite (3.6 to 19 mg NO2 - /L) during the period of sexual differentiation and sex ratios were determined. Vitellogenin concentrations were determined in the second experiment...
May 16, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29777495/ameliorative-effect-of-ginseng-extract-on-phthalate-and-bisphenol-a-reprotoxicity-during-pregnancy-in-rats
#3
Islam M Saadeldin, Mohamed A Hussein, Aida Hamid Suleiman, Mahmoud G Abohassan, Mona M Ahmed, Amr A Moustafa, Abdullah F Moumen, Ayman Abdel-Aziz Swelum
Phthalates (such as DEHP) and bisphenol A (BPA) are widely used chemicals in plastics manufacturing and exert public health concerns as endocrine disrupters. This study was designed to investigate the deleterious effect of DEHP and BPA on endocrine profile of pregnant female rats and the combined treatment with ginseng extract (Panax ginseng). Seventy-two pregnant rats were divided into six groups (control, ginseng, DEHP, BPA, Gin + DEHP, and Gin + BPA), 12 females per each group. The drugs were supplemented from pregnancy day 0 until day 20...
May 18, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29775944/alterations-of-cytochrome-p450-and-the-occurrence-of-persistent-organic-pollutants-in-tilapia-caged-in-the-reservoirs-of-the-igua%C3%A3-u-river
#4
F Y Yamamoto, G D Diamante, M S Santana, D R Santos, R Bombardeli, C C Martins, C A Oliveira Ribeiro, D Schlenk
Environmental chemicals originating from human activities, such as persistent organic pollutants (POPs), may interfere with the endocrine system of aquatic organisms. The effect of these chemicals on biota and human populations is of high public concern but remains poorly understood, especially in aquatic environments of South America. The aim of this study was to investigate the bioavailability of POPs and the related effects in caged male tilapia (Oreochromis niloticus) in four cascading reservoirs of the Iguaçu River, Southern Brazil...
May 15, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29772829/overview-of-cadmium-thyroid-disrupting-effects-and-mechanisms
#5
REVIEW
Aleksandra Buha, Vesna Matovic, Biljana Antonijevic, Zorica Bulat, Marijana Curcic, Elisavet A Renieri, Aristidis M Tsatsakis, Amie Schweitzer, David Wallace
Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland...
May 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29767714/comparing-postnatal-development-of-gonadal-hormones-and-associated-social-behaviors-in-rats-mice-and-humans
#6
Margaret R Bell
Postnatal development includes dramatic changes in gonadal hormones and the many social behaviors they help regulate, both in rodents and humans. Parental care-seeking is the most salient social interaction in neonates and infants, play and pro-social behaviors are commonly studied in juveniles, and the development of aggression and sexual behavior begins in peripubertal stages but continues through late adolescence into adulthood. While parental behaviors are shown after reproductive success in adulthood, alloparenting behaviors are actually high in juveniles as well...
May 14, 2018: Endocrinology
https://www.readbyqxmd.com/read/29763883/impact-of-common-environmental-chemicals-bisphenol-a-and-bisphenol-s-on-the-physiology-of-lumbriculus-variegatus
#7
Victoria Vought, Hong-Sheng Wang
Bisphenol A (BPA) is a component of polycarbonate plastics and a near ubiquitous environmental endocrine disrupting chemical. Bisphenol S (BPS), a substitute of BPA, is also hormonally active. This study examines the effects of aqueous exposure to BPA and BPS on the freshwater annelids Lumbriculus variegatus, a keystone species in shallow water ecosystems. Both BPA and BPS, at both low dose (10-9 M) and high dose (10-6 M), retarded the initial phase of body regrowth after cutting/fragmentation, which is the main mode of reproduction of L...
May 8, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29763587/mice-exposed-to-bisphenol-a-exhibit-depressive-like-behavior-with-neurotransmitter-and-neuroactive-steroid-dysfunction
#8
Frances Xin, Erin Fischer, Christopher Krapp, Elizabeth N Krizman, Yemin Lan, Clementina Mesaros, Nathaniel W Snyder, Amita Bansal, Michael B Robinson, Rebecca A Simmons, Marisa S Bartolomei
Fetal exposure to endocrine disrupting chemicals (EDCs) has been associated with adverse neurobehavioral outcomes across the lifespan and can persist across multiple generations of offspring. However, the underlying mechanisms driving these changes are not well understood. We investigated the molecular perturbations associated with EDC-induced behavioral changes in first (F1) and second (F2) filial generations, using the model EDC bisphenol A (BPA). C57BL/6J dams were exposed to BPA from preconception until lactation through the diet at doses (10 μg/kg bw/d-lower dose or 10 mg/kg bw/d-upper dose) representative of human exposure levels...
May 12, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29763383/eb-2017-article-soy-protein-isolate-feeding-does-not-result-in-reproductive-toxicity-in-the-pre-pubertal-rat-testis
#9
Martin Jj Ronis, Horacio Gomez-Acevedo, Kartik Shankar, Neha Sharma, Michael Blackburn, Rohit Singhal, Kelly E Mercer, Thomas M Badger
The isoflavone phytoestrogens found in the soy protein isolate used in soy infant formulas have been shown to have estrogenic actions in the developing male reproductive tract resulting in reproductive toxicity. However, few studies have examined potential estrogenicity of soy protein isolate as opposed to that of pure isoflavones. In this study, we fed weanling male Sprague-Dawley rats a semi-purified diet with casein or soy protein isolate as the sole protein source from postnatal day 21 to 33. Additional groups were fed casein or soy protein isolate and treated s...
May 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29760680/disruption-in-thyroid-signaling-pathway-a-mechanism-for-the-effect-of-endocrine-disrupting-chemicals-on-child-neurodevelopment
#10
REVIEW
Akhgar Ghassabian, Leonardo Trasande
Thyroid hormones are crucial in normal brain development. Transient and mild thyroid hormone insufficiency in pregnancy is also associated with impaired neurodevelopment in the offspring (e.g., 3-4 IQ score loss in association with maternal free thyroxine in the lowest fifth percentile). While inadequate iodine intake remains the most common underlying cause of mild thyroid hormone insufficiency in vulnerable populations including pregnant women, other factors such as exposure to environmental contaminants have recently attracted increasing attention, in particular in interaction with iodine deficiency...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29756578/endocrine-disrupting-chemical-induced-pollution-of-metabolic-pathways-a-case-of-shifting-paradigms-with-implications-for-vascular-diseases
#11
Rajiv Janardhanan
The latter half of the twentieth century has witnessed a humongous spurt in the use of synthetic chemicals in a wide variety of industrial and agricultural applications are leading to niche specific perturbations affecting every trophic level of the ecosystems due to unmitigated environmental contamination. Despite the incremental usefulness of endocrine disrupting chemicals (EDCs) such as pesticides and plasticizers, their statutory impact on environmental health is assuming worrisome proportions. The EDCs can disrupt physiological homeostasis resulting in developmental and reproductive abnormalities...
May 14, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29751654/biodegradation-of-di-2-ethylhexyl-phthalate-by-rhodococcus-ruber-yc-yt1-in-contaminated-water-and-soil
#12
Ting Yang, Lei Ren, Yang Jia, Shuanghu Fan, Junhuan Wang, Jiayi Wang, Ruth Nahurira, Haisheng Wang, Yanchun Yan
Di-(2-ethylehxyl) phthalate (DEHP) is one of the most broadly representative phthalic acid esters (PAEs) used as a plasticizer in polyvinyl chloride (PVC) production, and is considered to be an endocrine-disrupting chemical. DEHP and its monoester metabolites are responsible for adverse effects on human health. An efficient DEHP-degrading bacterial strain Rhodococcus ruber YC-YT1, with super salt tolerance (0⁻12% NaCl), is the first DEHP-degrader isolated from marine plastic debris found in coastal saline seawater...
May 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29748642/gestational-oral-low-dose-estradiol-17%C3%AE-induces-altered-dna-methylation-of-cdkn2d-and-psat1-in-embryos-and-adult-offspring
#13
Vera A van der Weijden, Veronika L Flöter, Susanne E Ulbrich
Endocrine disrupting chemicals (EDC) interfere with the natural hormone balance and may induce epigenetic changes through exposure during sensitive periods of development. In this study, the effects of short-term estradiol-17β (E2) exposure on various tissues of pregnant sows (F0 ) and on day 10 blastocysts (F1 ) were assessed. Intergenerational effects were investigated in the liver of 1-year old female offspring (F1 ). During gestation, sows were orally exposed to two low doses and a high dose of E2 (0.05, 10, and 1000 µg/kg body weight/day)...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29744538/endocrine-disrupting-chemicals-and-risk-of-diabetes-an-evidence-based-review
#14
REVIEW
P Monica Lind, Lars Lind
The purpose of this study was to review the epidemiological and experimental evidence linking background exposure to a selection of environmental endocrine-disrupting chemicals (EDCs) with diabetes and impaired glucose metabolism. The review summarises the literature on both cross-sectional and prospective studies in humans, as well as experimental in vivo and in vitro studies. The findings were subjected to evidence grading according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) classification...
May 9, 2018: Diabetologia
https://www.readbyqxmd.com/read/29743443/bisphenol-af-as-an-activator-of-human-estrogen-receptor-%C3%AE-1-er%C3%AE-1-in-breast-cancer-cell-lines
#15
Hiroyuki Okazaki, Masayo Hirao-Suzuki, Shuso Takeda, Yukimi Takemoto, Ramu Mizunoe, Koichi Haraguchi, Kazuhito Watanabe, Masufumi Takiguchi, Hironori Aramaki
Bisphenol AF (BPAF) is now recognized as one of the replacements for bisphenol A (BPA). Although considerable experimental evidence suggests that BPA is an endocrine-disrupting chemical, the toxicological profile of BPAF has been investigated in less detail than that of BPA, even at the in vitro level. BPAF has been established as an activator of estrogen receptor α (ERα) in many cell lines; however, controversy surrounds its effects on the other isoform, ERβ (i.e., whether it functions as a stimulator)...
2018: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29734751/a-novel-action-of-endocrine-disrupting-chemicals-on-wildlife-ddt-and-its-derivatives-have-remained-in-the-environment
#16
REVIEW
Ayami Matsushima
Huge numbers of chemicals are released uncontrolled into the environment and some of these chemicals induce unwanted biological effects, both on wildlife and humans. One class of these chemicals are endocrine-disrupting chemicals (EDCs), which are released even though EDCs can affect not only the functions of steroid hormones but also of various signaling molecules, including any ligand-mediated signal transduction pathways. Dichlorodiphenyltrichloroethane (DDT), a pesticide that is already banned, is one of the best-publicized EDCs and its metabolites have been considered to cause adverse effects on wildlife, even though the exact molecular mechanisms of the abnormalities it causes still remain obscure...
May 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29732168/endocrine-disrupting-chemicals-epigenetics-and-skeletal-system-dysfunction-exploration-of-links-using-bisphenol-a-as-a-model-system
#17
Frances Xin, Lauren M Smith, Martha Susiarjo, Marisa S Bartolomei, Karl J Jepsen
Early life exposures to endocrine-disrupting chemicals (EDCs) have been associated with physiological changes of endocrine-sensitive tissues throughout postnatal life. Although hormones play a critical role in skeletal growth and maintenance, the effects of prenatal EDC exposure on adult bone health are not well understood. Moreover, studies assessing skeletal changes across multiple generations are limited. In this article, we present previously unpublished data demonstrating dose-, sex-, and generation-specific changes in bone morphology and function in adult mice developmentally exposed to the model estrogenic EDC bisphenol A (BPA) at doses of 10 μg (lower dose) or 10 mg per kg bw/d (upper dose) throughout gestation and lactation...
April 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29731175/identifying-the-gaps-resources-and-perspectives-on-the-use-of-nuclear-receptor-based-assays-to-improve-hazard-assessment-of-emerging-contaminants
#18
M M Santos, R Ruivo, A Capitão, E Fonseca, L F C Castro
Biological control of key processes, such as development and reproduction, is largely ascribed to a superfamily of ligand-dependent and independent transcription factors named Nuclear Receptors (NRs). Given their ability to accommodate ligands, NRs are prime targets of man-made compounds that mimic or antagonise the action of endogenous ligands. Accordingly, NRs occupy a prominent role in OECD and EPA guidelines for testing and assessment of Endocrine disrupting chemicals (EDCs). Although NR assays are already a key instrument in the OECD Conceptual Framework for Testing and Assessment of EDCs, the focus is mostly on vertebrate NRs...
April 30, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29727133/identifying-vulnerable-periods-of-neurotoxicity-to-triclosan-exposure-in-children
#19
Medina S Jackson-Browne, George D Papandonatos, Aimin Chen, Antonia M Calafat, Kimberly Yolton, Bruce P Lanphear, Joseph M Braun
BACKGROUND: Exposure to triclosan, an endocrine disrupting chemical, may affect thyroid hormone homeostasis and adversely affect neurodevelopment. OBJECTIVE: Using a longitudinal pregnancy and birth cohort, we investigated associations between triclosan exposures during different time windows, and cognitive test scores at 8 y of age in 198 children from the HOME Study. METHODS: We quantified triclosan in urine samples from mother-child pairs up to nine times between the second trimester of gestation and 8 y of age...
May 2, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29725723/occurrence-and-ecological-risk-assessment-of-eight-endocrine-disrupting-chemicals-in-urban-river-water-and-sediments-of-south-china
#20
Cong Huang, Liu-Hong Wu, Guo-Qiang Liu, Lei Shi, Ying Guo
Chemicals in the water of urban areas are representative of the occurrence of these chemicals in the city surrounding water systems and reflect recent human or industrial usage of those chemicals in the sampling areas. In this study, the levels of eight endocrine-disrupting chemicals [including bisphenol analogues, parabens, and triclosan (TCS)] were determined in urban river water and sediments in Guangzhou, South China, and their related ecological risks were evaluated. The eight target chemicals were frequently detected in our samples, with concentrations ranging from not detected (ND) to 65,600 ng/L and from ND to 492 ng/g dw in river water and sediments, respectively...
May 3, 2018: Archives of Environmental Contamination and Toxicology
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