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https://www.readbyqxmd.com/read/29139254/-clinical-analysis-of-cervus-and-cucumis-polypeptide-injection-for-lumbar-vertebrae-diseases-based-on-real-world-hospital-information-system
#1
Ming-Yue Gao, Yan-Ming Xie, Yuan-Yuan Li, Yin Zhang, Yan Zhuang
To analyze the clinical drug use characteristics and medication rules of cervus and cucumis polypeptide injection (CCP injection) for the patients with lumbar vertebra diseases. Based on the electronic medical data of 6 990 patients with CCP injection for lumbar vertebra diseases from 25 first-class hospitals over the whole country from 2004, statistical analysis was conducted for their general information, diagnostic information, orders information, laboratory test information and treatment results. The results showed that the age distribution was highest in patients aged 45 to 64 (3 883, 55...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29123385/clostridium-difficile-infection-in-the-elderly-an-update-on-management
#2
REVIEW
Tomefa E Asempa, David P Nicolau
The burden of Clostridium difficile infection (CDI) is profound and growing. CDI now represents a common cause of health care-associated diarrhea, and is associated with significant morbidity, mortality, and health care costs. CDI disproportionally affects the elderly, possibly explained by the following risk factors: age-related impairment of the immune system, increasing antibiotic utilization, and frequent health care exposure. In the USA, recent epidemiological studies estimate that two out of every three health care-associated CDIs occur in patients 65 years or older...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29120541/-infection-of-chronic-wounds-in-elderly-patients
#3
Raphaël Masson, Hubert Vuagnat, Ilker Uçkay, Laurence Toutous-Trellu, Virginie Prendki
Chronic wounds infection in the elderly patients presents the risk of functional decompensation, or irreversible worsening of a wound. The diversity of clinical situations, the absence of data from clinical trials in the literature and a certain fatalism in view of the poor prognosis of these conditions should not be allowed to delay the early preparation of a patient-centred care plan (aiming at complete scarring, remission or symptomatic relief). Diagnostic and therapeutic strategies must be flexible, to take account not only of functional issues, constraints and special features relating to the patient but also of the resources and technical means available...
November 8, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29120481/medication-exposure-and-risk-of-recurrent-clostridium-difficile-infection-in-community-dwelling-older-people-and-nursing-home-residents
#4
John P Haran, Evan Bradley, Emily Howe, Xun Wu, Jennifer Tjia
BACKGROUND/OBJECTIVES: It is unclear how medication exposures differ in their association with recurrent Clostridium difficile infection (rCDI) in elderly nursing home (NH) residents and community-dwelling individuals. This study examined these exposures to determine whether the risk of rCDI differs according to living environment. DESIGN: Retrospective. SETTING: Academic and community healthcare settings. PARTICIPANTS: Individuals aged 65 and older with CDI (N = 616)...
November 9, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29119468/clinical-decision-support-and-optional-point-of-care-testing-of-renal-function-for-safe-use-of-antibiotics-in-elderly-patients-a-retrospective-study-in-community-pharmacy-practice
#5
Mette Heringa, Annemieke Floor-Schreudering, Peter A G M De Smet, Marcel L Bouvy
OBJECTIVE: The aim was to investigate the management of drug therapy alerts on safe use of antibiotics in elderly patients with (potential) renal impairment and the contribution of optional creatinine point of care testing (PoCT) in community pharmacy practice. METHODS: Community pharmacists used a clinical decision support system (CDSS) for seven antibiotics. Alerts were generated during prescription processing in the case of previously registered renal impairment and when no information on renal function was available for patients aged 70 and over...
November 8, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/29115367/bahng-score-predictive-model-for-detection-of-subjects-with-the-oropharynx-colonized-by-uncommon-microorganisms
#6
J González-Del Castillo, J Teja-Marina, F J Candel, J Barberán, A Moreno-Cuervo, F Chiarella, L López-González, P Ramos-Cordero, F J Martín-Sánchez
OBJECTIVE: Pneumonia is most frequently produced by the microaspiration of flora that colonizes the oropharynx. Etiological diagnosis of pneumonia is infrequent in clinical practise and empirical treatment should be prescribed. The aims of the present study were to determine the factors associated with oropharynx colonization by uncommon microorganisms (UM) and to develop a predictive model. METHODS: A cross-sectional study that included all pa-tients living in one long-term care facilities was developed...
November 6, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29107417/osteoarticular-and-skin-and-soft-tissue-infections-caused-by-streptococcus-agalactiae-in-elderly-patients-are-frequently-associated-with-bacteremia
#7
Corinne Ruppen, Julia Notter, Carol Strahm, Beat Sonderegger, Parham Sendi
Older persons (≥65 years) are at risk for invasive group B streptococcal (GBS) infections. The most frequent clinical syndromes in 174 infection episodes were osteoarticular (40%) and skin and soft-tissue infections (30%). In 36% of episodes, a companion microorganism was isolated, and in 45%, blood culture results were positive. Antibiotics were streamlined after species identification in 29% of monomicrobial infections. These findings have clinical and therapeutic implications for GBS infections in the elderly...
September 19, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29102205/a-multi-institutional-cohort-study-confirming-the-risks-of-clostridium-difficile-infection-associated-with-prolonged-antibiotic-prophylaxis
#8
Katherine A Kirkwood, Brian C Gulack, Alexander Iribarne, Michael E Bowdish, Giampaolo Greco, Mary Lou Mayer, Karen O'Sullivan, Annetine C Gelijns, Nishit Fumakia, Ravi K Ghanta, Jesse M Raiten, Anuradha Lala, Joseph S Ladowski, Eugene H Blackstone, Michael K Parides, Alan J Moskowitz, Keith A Horvath
OBJECTIVES: The incidence and severity of Clostridium difficile infection (CDI) have increased rapidly over the past 2 decades, particularly in elderly patients with multiple comorbidities. This study sought to characterize the incidence and risks of these infections in cardiac surgery patients. METHODS: A total of 5158 patients at 10 Cardiothoracic Surgical Trials Network sites in the US and Canada participated in a prospective study of major infections after cardiac surgery...
September 28, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29089174/clinical-outcomes-of-elderly-patients-with-bloodstream-infections-due-to-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-in-an-italian-internal-medicine-ward
#9
Simone Meini, Raffaele Laureano, Carlo Tascini, Fabio Arena, Lucia Fani, Anna Frullini, Maria Teresa Passaleva, Anna Teresa Roberts, Dario Mannini, Francesco Sbrana, Andrea Ripoli, Gian Maria Rossolini
PURPOSE: Infections caused by ESBL-producing Enterobacteriaceae (ESBL-EB) are a major health problem, but data regarding elderly patients is lacking. METHODS: We performed a retrospective observational study quantifying the effects of antimicrobial treatment and primary infection site on clinical outcomes in an historical case series of 42 patients aged 80.7±10years admitted to an Internal Medicine ward in Italy for ESBL-EB bloodstream infections (BSI). RESULTS: At multivariate risk analysis, we found that urinary tract as primary infection site (RR=0...
October 28, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29078905/sphingosine-rescues-aged-mice-from-pulmonary-pseudomonas-infection
#10
Teresa C Rice, Amanda M Pugh, Aaron P Seitz, Erich Gulbins, Vanessa Nomellini, Charles C Caldwell
BACKGROUND: Bacterial lung infection is a leading cause of death for those 65 y or older, often requiring intensive care unit admission and mechanical ventilation, which consumes considerable health care resources. Although administration of antibiotics is the standard of care for bacterial pneumonia, its overuse has led to the emergence of multidrug resistant organisms. Therefore, alternative strategies to help minimize the effects of bacterial pneumonia in the elderly are necessary...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29065395/life-threatening-atypical-case-of-acute-generalized-exanthematous-pustulosis
#11
Azadeh Tajmir-Riahi, Petra Wörl, Thomas Harrer, Stefan Schliep, Gerold Schuler, Miklos Simon
Antibiotics are known to cause severe cutaneous adverse reactions, such as the rare acute generalized exanthematous pustulosis (AGEP). Unlike Stevens-Johnson syndrome or toxic epidermal necrolysis, AGEP is rarely life-threatening. Systemic involvement is not typical, and if present usually coincides with a mild elevation of the hepatic enzymes and a decrease in renal function. Hence, AGEP is known to have a good prognosis and to be life-threatening only in elderly patients or patients with chronic diseases...
October 25, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29044643/fidaxomicin-versus-vancomycin-as-a-first-line-treatment-for-clostridium-difficile-associated-diarrhea-cdad-in-specific-patient-populations-a-pharmacoeconomic-evaluation
#12
Kelly R Reveles, Jennifer L Backo, Frank A Corvino, Marko Zivkovic, Kelly C Broderick
OBJECTIVES: The reduction in recurrent Clostridium difficile-associated diarrhea (CDAD) with fidaxomicin therapy may reduce hospital readmissions and lead to lower overall CDAD costs. However, studies assessing the cost-effectiveness of fidaxomicin as first-line therapy from the United States (US) hospital perspective are lacking. This study evaluated the costs associated with utilizing fidaxomicin or vancomycin as a first-line therapy for CDAD in specific patient populations from a US hospital perspective...
October 17, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29042390/effect-of-point-of-care-susceptibility-testing-in-general-practice-on-appropriate-prescription-of-antibiotics-for-patients-with-uncomplicated-urinary-tract-infection-a-diagnostic-randomised-controlled-trial
#13
Anne Holm, Gloria Cordoba, Tina Møller Sørensen, Lisbeth Rem Jessen, Niels Frimodt-Møller, Volkert Siersma, Lars Bjerrum
OBJECTIVES: To investigate the effect of adding point-of-care (POC) susceptibility testing to POC culture on appropriate use of antibiotics as well as clinical and microbiological cure for patients with suspected uncomplicated urinary tract infection (UTI) in general practice. DESIGN: Open, individually randomised controlled trial. SETTING: General practice. PARTICIPANTS: Women with suspected uncomplicated UTI, including elderly patients above 65, patients with recurrent UTI and patients with diabetes...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29037481/surgical-outcomes-among-elderly-women-with-endometrial-cancer%C3%A2-treated-by-laparoscopic-hysterectomy-a-nrg-gynecologic-oncology-group-study
#14
Erin A Bishop, James J Java, Kathleen N Moore, Nick M Spirtos, Michael L Pearl, Oliver Zivanovic, David M Kushner, Floor Backes, Chad A Hamilton, Melissa A Geller, Jean Hurteau, Cara Mathews, Robert M Wenham, Pedro T Ramirez, Susan Zweizig, Joan L Walker
OBJECTIVE: Tolerance of and complications caused by minimally invasive hysterectomy and staging in the older endometrial cancer population is largely unknown despite the fact that this is the most rapidly growing age group in the United States. The objective of this retrospective review was to compare operative morbidity by age in patients on the Gynecologic Oncology Group Laparoscopic Surgery or Standard Surgery in Treating Patients With Endometrial Cancer or Cancer of the Uterus (LAP2) trial...
October 14, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29035774/facial-dog-bite-injuries-in-children-a-case-report
#15
Alessandro Leite Cavalcanti, Edgleys Porto, Bruno Ferreira Dos Santos, Christiane Leite Cavalcanti, Alidianne Fábia Cabral Cavalcanti
INTRODUCTION: Dog bites are common and can affect victims of different ages, from children to the elderly. Injuries are usually located in different body regions, including head and face. The treatment of choice for injuries is the suture of the lesion, accompanied by antibiotic therapy and tetanus and anti-rabies vaccination. PRESENTATION OF CASE: An 11-year-old male black patient was admitted to the Surgery and Maxillo-Facial Traumatology Service, on an urgent basis, victim of domestic animal aggression (dog biting)...
October 10, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29029665/mohs-micrographic-surgery-key-pharmacologic-considerations
#16
Diana Fischer, Patricia Orlando, Laura Shane-McWhorter
OBJECTIVE: To describe Mohs micrographic surgery and evaluate whether direct oral anticoagulants should be withheld in patients with atrial fibrillation (Afib) prior to the procedure and to consider what type of antibiotic prophylaxis should be used. SETTING: A community setting in which an elderly patient is living independently at home. PRACTICE DESCRIPTION: Academic-affiliated internal medicine clinic that cares for adult patients of all ages, including elderly patients living independently in their own home...
August 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29026893/descending-necrotizing-mediastinitis-after-a-trigger-point-injection
#17
Jae Young Choe, Jong Kun Kim, Dong Eun Lee, Kang Suk Seo, Jung Bae Park, Mi Jin Lee, Hyun Wook Ryoo, Jae Yun Ahn, Sungbae Moon
Descending necrotizing mediastinitis (DNM) is a rare form of mediastinal infection. Most cases are associated with esophageal rupture. DNM after a trigger point injection in the upper trapezius has not been described previously. We present a case of DNM after a trigger point injection in the upper trapezius. A 70-year-old man visited the emergency department with chest discomfort and fever after a trigger point injection in the left upper trapezius. Chest computed tomography showed evidence of DNM, and antibiotic therapy was immediately administered intravenously...
September 2017: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/29020290/implementing-antimicrobial-stewardship-in-long-term-care-settings-an-integrative-review-using-a-human-factors-approach
#18
Morgan J Katz, Ayse P Gurses, Pranita D Tamma, Sara E Cosgrove, Melissa A Miller, Robin L P Jump
Implementing effective antimicrobial stewardship in long-term care facilities (LTCFs) is associated with challenges distinct from those faced by hospitals. LTCFs generally care for elderly populations who are vulnerable to infection, have prescribers who are often off-site, and have limited access to timely diagnostic testing. Identification of feasible interventions in LTCFs is important, particularly given the new requirement for stewardship programs by the Centers for Medicare and Medicaid Services (CMS)...
June 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020203/empirical-antibiotic-treatment-does-not-improve-outcomes-in-catheter-associated-urinary-tract-infection-prospective-cohort-study
#19
Tanya Babich, Oren Zusman, Michal Elbaz, Haim Ben-Zvi, Mical Paul, Leonard Leibovici, Tomer Avni
Background: Catheter associated urinary tract infection (CAUTI) is the most common healthcare-associated acquired infection. We aimed to describe the short- and long-term survival of patients with CAUTI and the impact of the empirical antibiotic treatment on survival rates. Methods: In this prospective observational study we included consecutive adult patients with a chronic indwelling catheter-associated UTI and sepsis hospitalized in medical departments. The primary outcomes were 30-days all-cause mortality and long-term survival at end of the follow-up...
August 2, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020171/comparison-of-the-impact-of-pcv10-or-pcv13-on-invasive-pneumococcal-disease-in-equivalent-populations
#20
Pontus Naucler, Ilias Galanis, Eva Morfeldt, Jessica Darenberg, Åke Örtqvist, Birgitta Henriques-Normark
Background: Conjugated pneumococcal vaccines, PCV10 or PCV13, are used in childhood immunization programs worldwide, but direct comparisons of impacts against invasive pneumococcal disease (IPD) in equivalent populations have not been performed. We used the unique opportunity in Sweden, where the 21 counties use either PCV10 or PCV13 (introduced 2009-2010), to compare the vaccines (pre-vaccination 2007-2009 versus post-vaccination 2013-2016). Methods: All IPD episodes (n=16992) were recorded in Sweden during 2005-2016...
August 3, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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