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https://www.readbyqxmd.com/read/28432019/feasibility-of-mini-tablets-as-a-flexible-drug-delivery-tool
#1
Biplob Mitra, Jessica Chang, Sy-Juen Wu, Chad N Wolfe, Robert L Ternik, Thomas Z Gunter, Michael C Victor
Mini-tablets have potential applications as a flexible drug delivery tool in addition to their generally perceived use as multi-particulates. That is, mini-tablets could provide flexibility in dose finding studies and/or allow for combination therapies in the clinic. Moreover, mini-tablets with well controlled quality attributes could be a prudent choice for administering solid dosage forms as a single unit or composite of multiple mini-tablets in patient populations with swallowing difficulties (e.g., pediatric and geriatric populations)...
April 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28431258/cage-and-linear-structured-polysiloxane-epoxy-hybrids-for-coatings-surface-property-and-film-permeability
#2
Yanli Ma, Ling He, Mengjun Jia, Lingru Zhao, Yanyan Zuo, Pingan Hu
Three polysiloxane/epoxy hybrids obtained by evolving cage- or linear-structured polysiloxane into poly glycidyl methacrylate (PGMA) matrix are compared used as coatings. One is the cage-structured hybrid of P(GMA/MA-POSS) copolymer obtained by GMA and methacrylisobutyl polyhedral oligomeric silsesquioxane (MA-POSS) via free radical polymerization, the other two are PGMA/NH2-POSS and PGMA/NH2-PDMS hybrids by cage-structured aminopropyllsobutyl POSS (NH2-POSS) or linear-structured diamino terminated poly(dimethylsiloxane) (NH2-PDMS) to cure PGMA...
April 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28425298/understanding-self-reported-difficulties-in-decision-making-by-people-with-autism-spectrum-disorders
#3
Lydia Vella, Howard A Ring, Mike Rf Aitken, Peter C Watson, Alexander Presland, Isabel Ch Clare
Autobiographical accounts and a limited research literature suggest that adults with autism spectrum disorders can experience difficulties with decision-making. We examined whether some of the difficulties they describe correspond to quantifiable differences in decision-making when compared to adults in the general population. The participants (38 intellectually able adults with autism spectrum disorders and 40 neurotypical adults) were assessed on three tasks of decision-making (Iowa Gambling Task, Cambridge Gamble Task and Information Sampling Task), which quantified, respectively, decision-making performance and relative attention to negative and positive outcomes, speed and flexibility, and information sampling...
April 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28425231/the-relationship-between-physical-fitness-and-falling-risk-and-fear-of-falling-in-community-dwelling-elderly-people-with-different-physical-activity-levels
#4
Mehmet Duray, Arzu Genç
BACKGROUND/AIM: The aim of this research was to determine the effects of physical activity level (PAL) and physical fitness on falling parameters in community-dwelling elderly people. MATERIALS AND METHODS: Seventy-six elderly people were grouped as low PAL group (group 1, n: 38) and high PAL (group 2, n: 38) according to their PAL scores. PAL was measured by the Physical Activity Scale for the Elderly and muscle strength, muscle endurance, aerobic endurance, and flexibility tests were applied; body mass index (BMI) was calculated for physical fitness measurement...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28420196/probe-sensor-using-nanostructured-multi-walled-carbon-nanotube-yarn-for-selective-and-sensitive-detection-of-dopamine
#5
Wed Al-Graiti, Zhilian Yue, Javad Foroughi, Xu-Feng Huang, Gordon Wallace, Ray Baughman, Jun Chen
The demands for electrochemical sensor materials with high strength and durability in physiological conditions continue to grow and novel approaches are being enabled by the advent of new electromaterials and novel fabrication technologies. Herein, we demonstrate a probe-style electrochemical sensor using highly flexible and conductive multi-walled carbon nanotubes (MWNT) yarns. The MWNT yarn-based sensors can be fabricated onto micro Pt-wire with a controlled diameter varying from 100 to 300 µm, and then further modified with Nafion via a dip-coating approach...
April 18, 2017: Sensors
https://www.readbyqxmd.com/read/28417630/self-healable-and-reprocessable-polysulfide-sealants-prepared-from-liquid-polysulfide-oligomer-and-epoxy-resin
#6
Wentong Gao, Mengyao Bie, Fu Liu, Pengshan Chang, Yiwu Quan
Polysulfide sealants have been commercially applied in many industrial fields. This paper studied the self-healing property of the epoxy resin cured polysulfide sealants for the first time. The obtained sealants showed a flexible range of the ultimate elongation from 157 to 478% and tensile strength from 1.02 to 0.75 MPa corresponding to different polysulfide oligomers. By taking advantage of the dynamic reversible exchange of disulfide bonds, the polysulfide sealants exhibited good self-healing ability under a moderate thermal stimulus...
April 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28417599/high-dielectric-performances-of-flexible-and-transparent-cellulose-hybrid-films-controlled-by-multidimensional-metal-nanostructures
#7
Sangyoon Ji, Jiuk Jang, Eunjin Cho, Si-Hoon Kim, Eun-Seok Kang, Jihoon Kim, Han-Ki Kim, Hoyoul Kong, Sun-Kyung Kim, Ju-Young Kim, Jang-Ung Park
Various wearable electronic devices have been developed for extensive outdoor activities. The key metrics for these wearable devices are high touch sensitivity and good mechanical and thermal stability of the flexible touchscreen panels (TSPs). Their dielectric constants (k) are important for high touch sensitivities. Thus, studies on flexible and transparent cover layers that have high k with outstanding mechanical and thermal reliabilities are essential. Herein, an unconventional approach for forming flexible and transparent cellulose nanofiber (CNF) films is reported...
April 18, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28415456/osteoinductive-composite-coatings-for-flexible-intramedullary-nails
#8
E N Bolbasov, A V Popkov, D A Popkov, E N Gorbach, I A Khlusov, A S Golovkin, A Sinev, V M Bouznik, S I Tverdokhlebov, Y G Anissimov
This work presents composite coatings based on a copolymer of vinylidene fluoride with tetrafluoroethylene (VDF-TeFE) and hydroxyapatite (HA) for flexible intramedullary nails (FIN). The effect of the proportion of VDF-TeFE (100-25% wt.) on physicochemical and biological properties of the composite coatings was investigated. It was shown that a decrease of VDF-TeFE in the coating hinders its crystallization in β and γ forms which have piezoelectric properties. The decrease also reduces an adhesive strength to 9...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28414333/dynamic-hidden-states-underlying-working-memory-guided-behavior
#9
Michael J Wolff, Janina Jochim, Elkan G Akyürek, Mark G Stokes
Recent theoretical models propose that working memory is mediated by rapid transitions in 'activity-silent' neural states (for example, short-term synaptic plasticity). According to the dynamic coding framework, such hidden state transitions flexibly configure memory networks for memory-guided behavior and dissolve them equally fast to allow forgetting. We developed a perturbation approach to measure mnemonic hidden states in an electroencephalogram. By 'pinging' the brain during maintenance, we show that memory-item-specific information is decodable from the impulse response, even in the absence of attention and lingering delay activity...
April 17, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28412818/transparent-ethenylene-bridged-polymethylsiloxane-aerogels-mechanical-flexibility-and-strength-and-availability-for-addition-reaction
#10
Taiyo Shimizu, Kazuyoshi Kanamori, Ayaka Maeno, Hironori Kaji, Cara M Doherty, Kazuki Nakanishi
Transparent, low-density ethenylene-bridged polymethylsiloxane (Ethe-BPMS, O2/2(CH3)Si-CH=CH-Si(CH3)O2/2) aerogels from 1,2-bis(methyldiethoxysilyl)ethene have successfully been synthesized via sol-gel. A two-step sol-gel process composed of hydrolysis under acidic conditions and polycondensation under basic conditions in a liquid surfactant has produced homogeneous pore structure based on crosslinked nano-sized colloidal particles. Visible-light transmittance of the aerogels varies with the concentration of base catalyst, and reaches as high as 87 % (at wavelength of 550 nm for a 10 mm-thick sample)...
April 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28409595/exercise-prescriptions-in-older-adults
#11
Pearl Guozhu Lee, Elizabeth A Jackson, Caroline R Richardson
Regular physical activity and exercise are important for healthy aging and are beneficial for chronic disease management. Exercise prescriptions for older adults should account for the individual's health status and functional capacity. Any amount of exercise is better than being sedentary, even if health status prevents a person from achieving recommended goals. For most health outcomes, more benefits occur with physical activity performed at higher intensity, greater frequency, or longer duration. Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity or 75 minutes of vigorous-intensity aerobic activity and at least two days of muscle-strengthening activities per week...
April 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28409509/fitness-can-be-a-determinant-of-arterial-stiffness-in-healthy-adult-men-a-cross-sectional-study
#12
Jin-Wook Chung, Mi-Lyang Kim, Youngsoo Jin, Yonghwan Kim, Jeeyoung Hong
BACKGROUND: Fitness is known to influence arterial stiffness. This study aimed to assess differences in cardiorespiratory endurance, muscular strength, and flexibility according to arterial stiffness, based on sex and age. METHODS: We enrolled 1,590 healthy adults (men: 1,242, women: 348) who were free of metabolic syndrome. We measured cardiorespiratory endurance in an exercise stress test on a treadmill, muscular strength by a grip test, and flexibility by upper body forward-bends from a standing position...
April 13, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28406104/institutionalized-physical-activity-curriculum-benefits-of-medical-students-in-colombia
#13
Gustavo Tovar, Gabriel López, Milcíades Ibáñez, Ricardo Alvarado, Felipe Lobelo, John Duperly
BACKGROUND: Health authorities internationally have recommended implementing physical activity and exercise for health training programs within the curriculum of medical schools. The purpose of this evaluation was to determine the changes in physical fitness and health (Fitnessgram criteria) of a sports medicine and physical activity course implemented for 3rd year students in a private medical school in Bogotá, Colombia. METHODS: Intervention was targeted to 13 medical student cohorts...
September 2016: Education for Health: Change in Training & Practice
https://www.readbyqxmd.com/read/28403029/secular-trends-in-the-physical-fitness-of-united-states-army-recruits-on-entry-to-service-1975-2013
#14
Joseph Knapik, Marilyn Sharp, Ryan A Steelman
A systematic literature search was conducted to identify and analyze articles that reported on physical fitness of new United States (US) Army recruits. The National Library of Medicine's PubMed and the Defense Technical Information Center, were searched using the keywords {military personnel OR trainee OR recruit OR soldier} AND {physical fitness OR strength OR endurance OR flexibility OR balance OR coordination OR muscle contraction OR running OR exercise OR physical conditioning}. Reference lists of obtained articles and contact with authors enhanced the search...
April 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28400748/short-term-exposure-of-paddy-soil-microbial-communities-to-salt-stress-triggers-different-transcriptional-responses-of-key-taxonomic-groups
#15
Jingjing Peng, Carl-Eric Wegner, Werner Liesack
Soil salinization due to seawater intrusion along coastal areas is an increasing threat to rice cultivation worldwide. While the detrimental impact on rice growth and yield has been thoroughly studied, little is known about how severe salinity affects structure and function of paddy soil microbial communities. Here, we examined their short-term responses to half- and full-strength seawater salinity in controlled laboratory experiments. Slurry microcosms were incubated under anoxic conditions, with rice straw added as carbon source...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28399621/aerobic-synergized-exercises-may-improve-fall-related-physical-fitness-in-older-adults
#16
Yu-Chen Chang, Jung-Der Wang, Ho-Cheng Chen, Susan C Hu
BACKGROUND: The purpose of the present study was to determine whether a synergistic exercise model based on aerobics with additional fall-preventive components could provide extra benefits compared with the same duration of aerobic-synergistic exercise alone. METHODS: A total of 102 adults aged 65 years and over from three geographically separated communities were assigned to three groups: the general aerobic exercise (GAE) group (N.=44), the GAE plus ball game group (BG group; N...
May 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28399076/effects-of-a-10-day-intensive-health-promotion-program-combining-diet-and-physical-activity-on-body-composition-physical-fitness-and-blood-factors-of-young-adults-a-randomized-pilot-study
#17
Kyoung Soon Lee, Jae Koo Lee, Young Ran Yeun
BACKGROUND A lifestyle characterized by poor eating habits and physical inactivity is a risk factor for multiple lifestyle diseases in young adults. This study assessed the effects of implementing an intensive 10-day health promotion program combining diet and physical activities on body composition, physical fitness, and biochemical parameters of young adults. MATERIAL AND METHODS In this randomized pilot study, 30 female undergraduate students were randomly allocated to an intervention and a control group...
April 11, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28397903/exceptional-room-temperature-plasticity-in-amorphous-alumina-nanotubes-fabricated-by-magnetic-hard-anodisation
#18
Amir Sajad Esmaeily, Shaun Mills, J M D Coey
Crystalline aluminum oxide is a brittle ceramic material. Here we show that individual alumina nanotubes with internal and external radii of ∼15 nm and ∼50 nm, respectively and lengths of the order of 100 μm can be readily separated from amorphous alumina membranes fabricated by a hard anodisation process under a magnetic field of up to 1.5 T. The ceramic nanotubes are extremely flexible and exhibit an exceptional plasticity of ±70% at room temperature without breaking. Elastic properties investigated by the double clamped beam method include a tensile strength of 4...
April 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28397862/a-robust-salt-tolerant-superoleophobic-alginate-graphene-oxide-aerogel-for-efficient-oil-water-separation-in-marine-environments
#19
Yuqi Li, Hui Zhang, Mizi Fan, Peitao Zheng, Jiandong Zhuang, Lihui Chen
Marine pollution caused by frequent oil spill accidents has brought about tremendous damages to marine ecological environment. Therefore, the facile large-scale preparation of three-dimensional (3D) porous functional materials with special wettability is in urgent demand. In this study, we report a low-cost and salt-tolerant superoleophobic aerogel for efficient oil/seawater separation. The aerogel is prepared through incorporating graphene oxide (GO) into alginate (ALG) matrix by using a facile combined freeze-drying and ionic cross-linking method...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28396634/morphological-properties-of-mass-spring-networks-for-optimal-locomotion-learning
#20
Gabriel Urbain, Jonas Degrave, Benonie Carette, Joni Dambre, Francis Wyffels
Robots have proven very useful in automating industrial processes. Their rigid components and powerful actuators, however, render them unsafe or unfit to work in normal human environments such as schools or hospitals. Robots made of compliant, softer materials may offer a valid alternative. Yet, the dynamics of these compliant robots are much more complicated compared to normal rigid robots of which all components can be accurately controlled. It is often claimed that, by using the concept of morphological computation, the dynamical complexity can become a strength...
2017: Frontiers in Neurorobotics
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