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flexibility and strength

Ivo D Shterev, David B Dunson, Cliburn Chan, Gregory D Sempowski
High-throughput screening of compounds (chemicals) is an essential part of drug discovery, involving thousands to millions of compounds, with the purpose of identifying candidate hits. Most statistical tools, including the industry standard B-score method, work on individual compound plates and do not exploit cross-plate correlation or statistical strength among plates. We present a new statistical framework for high-throughput screening of compounds based on Bayesian nonparametric modeling. The proposed approach is able to identify candidate hits from multiple plates simultaneously, sharing statistical strength among plates and providing more robust estimates of compound activity...
June 22, 2018: Scientific Reports
Kosuke Takeuchi, Masahiro Takemura, Masatoshi Nakamura, Fumiko Tsukuda, Shumpei Miyakawa
Takeuchi, K, Takemura, M, Nakamura, M, Tsukuda, F, and Miyakawa, S. Effects of active and passive warm-ups on range of motion, strength, and muscle passive properties in ankle plantarflexor muscles. J Strength Cond Res XX(X): 000-000, 2018-The purpose of this study was to examine the effects of active and passive warm-ups on flexibility and strength of calf muscles. Fourteen healthy males (age: 23.1 ± 2.6 years, height: 172.7 ± 5.6 cm, and body mass: 64.5 ± 7.0 kg) performed 3 types of warm-ups respectively for 10 minutes in a random order: an active warm-up by pedaling a cycling ergometer, an active warm-up doing repeated isometric contractions, and a passive warm-up in a hot water bath...
June 21, 2018: Journal of Strength and Conditioning Research
Michelle A Rodrigues, Emily R Boeving
Despite similar dispersal patterns, models of Pan sociality emphasize sex differences in social bonding between the two species. Such disparities are attributed to hypothesized differences in environmental selective pressures that structure association patterns. However, recent research documents greater within-species variation in social bonds in both species. Here, we examine grooming networks in captive chimpanzees at the North Carolina Zoo, and captive bonobos at the Columbus Zoo. We hypothesized that male-female grooming relationships would be the strongest in both species, but that males and females of both species would not significantly differ between centrality, strength, or clustering...
June 21, 2018: Primates; Journal of Primatology
Kirsti Malterud, Aase Aamland, Kristina Riis Iden
BACKGROUND: Research often fails to impose substantial shifts in clinical practice. Evidence-based health care requires implementation of documented interventions, with implementation research as a science-informed strategy to identify core experiences from the process and share preconditions for achievement. Evidence developed in hospital contexts is often neither relevant nor feasible for primary care. Different evidence types may constitute a point of departure, stretching and testing the transferability of the intervention by piloting it in primary care...
June 21, 2018: BMC Family Practice
Jeffrey H Mettler, Robert Shapiro, Michael B Pohl
Mettler, JH, Shapiro, R, and Pohl, MB. Effects of a hip flexor stretching program on running kinematics in individuals with limited passive hip extension. J Strength Cond Res XX(X): 000-000, 2018-Tightness of the hip flexor muscle group may theoretically contribute to altered kinematics of the lumbo-pelvic-hip (LPH) complex during dynamic movements. Therefore, the purpose of this study was to analyze the effects of a 3-week home-based stretching program on passive hip extension and sagittal plane kinematics of the LPH complex when running...
June 20, 2018: Journal of Strength and Conditioning Research
Santiago Sanz-Quinto, Raúl López-Grueso, Gabriel Brizuela, Andrew A Flatt, Manuel Moya-Ramón
Sanz-Quinto, S, López-Grueso, R, Brizuela, G, Flatt, AA, and Moya-Ramón, M. Influence of training models at 3,900-m altitude on the physiological response and performance of a professional wheelchair athlete: A case study. J Strength Cond Res XX(X): 000-000, 2018-This case study compared the effects of two training camps using flexible planning (FP) vs. inflexible planning (IP) at 3,860-m altitude on physiological and performance responses of an elite marathon wheelchair athlete with Charcot-Marie-Tooth disease (CMT)...
June 20, 2018: Journal of Strength and Conditioning Research
T van den Boom, R R F Stevens, T Delhaas, F N van de Vosse, W Huberts
A benchmark study by Boileau et al. tested six commonly used numerical schemes for 1D wave propagation, for their ability to capture the main features of pressure, flow, and area waveforms in large arteries. While all numerical schemes showed good agreement in pressure and flow waveforms for smaller arterial networks, the Simplified Trapezium-rule Method proposed by Kroon et al. showed an overestimation for the systolic pressure of 1% in proximal regions and an underestimation of 3% in distal regions in comparison with the five other schemes when using a larger arterial network, published as the ADAN56 model...
June 21, 2018: International Journal for Numerical Methods in Biomedical Engineering
Nan Wang, Majid Kabiri Samani, Hu Li, Lan Dong, Zhongwei Zhang, Peng Su, Shujing Chen, Jie Chen, Shirong Huang, Guangjie Yuan, Xiangfan Xu, Baowen Li, Klaus Leifer, Lilei Ye, Johan Liu
Due to substantial phonon scattering induced by various structural defects, the in-plane thermal conductivity (K) of graphene films (GFs) is still inferior to the commercial pyrolytic graphite sheet (PGS). Here, the problem is solved by engineering the structures of GFs in the aspects of grain size, film alignment, and thickness, and interlayer binding energy. The maximum K of GFs reaches to 3200 W m-1 K-1 and outperforms PGS by 60%. The superior K of GFs is strongly related to its large and intact grains, which are over four times larger than the best PGS...
June 21, 2018: Small
Basant Chitara, Assaf Ya'akobovitz
Gallium sulphide (GaS), gallium selenide (GaSe), and gallium telluride (GaTe), belonging to the group-III monochalcogenide family, have shown promising optoelectronic performance over graphene and monolayer molybdenum disulphide (MoS2). However, to date, the mechanical properties of these materials have not been investigated, which hinders their utilisation in flexible electronics and optomechanics. Here, we characterize the elastic properties and breaking strengths of suspended two-dimensional (2D) nanosheets of GaS, GaSe, and GaTe, using atomic force microscopy...
June 20, 2018: Nanoscale
Suzanne Broadbent, Sonja Coetzee, Rosalind Beavers
PURPOSE: This pilot pre-and post-intervention study investigated the effects of a short-term aquatic exercise programme on physiological outcomes, symptoms and exercise capacity in women with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). METHODS: Eleven women (54.8 ± 12.4 year) volunteered for the 5-week program; an initial 20-min aquatic exercise session then two self-paced 20-min sessions per week for 4 weeks. Pre- and post-intervention outcomes were physiological measures, 6 min Walk Test (6MWT), perceived exertion (RPE), hand grip strength, Sit-to-Stand, Sit-Reach test, Apley's shoulder test, FACIT questionnaire, and 24-h post-test tiredness and pain scores (0-10 visual analogue scale)...
June 19, 2018: European Journal of Applied Physiology
Katrina M Long, Fiona McDermott, Graham N Meadows
BACKGROUND: The healthcare system has proved a challenging environment for innovation, especially in the area of health services management and research. This is often attributed to the complexity of the healthcare sector, characterized by intersecting biological, social and political systems spread across geographically disparate areas. To help make sense of this complexity, researchers are turning towards new methods and frameworks, including simulation modeling and complexity theory...
June 20, 2018: BMC Medicine
Muhammed Şeref Yıldırım, Filiz Tuna, Derya Demirbağ Kabayel, Necdet Süt
Background: Decreased hamstring flexibility is associated with many pathological conditions. For this reason, hamstrings are one of the most frequently evaluated muscle groups for flexibility in the lower extremity. Muscle flexibility is evaluated indirectly by measuring adjacent joint range of motion. Passive and active knee extension angle values are used as an indirect indicator of hamstring flexibility. But the results of the active knee extension test are claimed to be influenced by subject’s quadriceps strength...
June 19, 2018: Balkan Medical Journal
Chao Sun, Jie Zhang, Shanglin Gao, Nan Zhang, Yijun Zhang, Jian Zhuang, Ming Liu, Xiaohui Zhang, Wei Ren, Hua Wu, Zuo-Guang Ye
The interphase between fiber and matrix plays an essential role in the performance of composites. Therefore, the ability to design or modify the interphase is a key technology needed to manufacture stronger and smarter composite. Recently, depositing nano-materials onto the surface of the fiber has become a promising approach to optimize the interphase and composites. But, the modified composites have not reached the highest strength yet, because the determining parameters, such as thickness of the nano-layer, are hardly controlled by the mentioned methods in reported works...
June 18, 2018: ACS Applied Materials & Interfaces
Hector Guillen-Ahlers, Prahlad K Rao, Danu S Perumalla, Maria J Montoya, Avinash Y L Jadhav, Michael R Shortreed, Lloyd M Smith, Michael Olivier
The hybridization capture of chromatin-associated proteins for proteomics (HyCCAPP) technology was initially developed to uncover novel DNA-protein interactions in yeast. It allows analysis of a target region of interest without the need for prior knowledge about likely proteins bound to the target region. This, in theory, allows HyCCAPP to be used to analyze any genomic region of interest, and it provides sufficient flexibility to work in different cell systems. This method is not meant to study binding sites of known transcription factors, a task better suited for Chromatin Immunoprecipitation (ChIP) and ChIP-like methods...
June 1, 2018: Journal of Visualized Experiments: JoVE
Erick D Richman, Brian M Tyo, Clayton R Nicks
Richman, ED, Tyo, BM, and Nicks, CR. Combined effects of self-myofascial release and dynamic stretching on range of motion, jump, sprint, and agility performance. J Strength Cond Res XX(X): 000-000, 2018-Massage has been used as both a pre- and post-exercise modality with purported benefits to flexibility and athletic performance. This study was designed to determine the effect of a 6-minute protocol of self massage known as self-myofascial release (SMR) using a foam rolling device in conjunction with a general warm-up and sport-specific dynamic stretching (DS) session on flexibility and explosive athletic performance in a sample of 14 female collegiate athletes...
June 14, 2018: Journal of Strength and Conditioning Research
Anthony Caterisano, Randolph Hutchison, Clarence Parker, Scott James, Stephen Opskar
Caterisano, A, Hutchison, R, Parker, C, James, S, and Opskar, S. Improved functional power over a 5-week period: Comparison of combined weight training with flexible barbell training. J Strength Cond Res XX(X): 000-000, 2018-Previous studies demonstrated increased power development with various resistance-training modes over short training periods of 4-7 weeks through neuromuscular adaptations. The purpose of this study was to compare 2 different power-training regimens over a 5-week period: combined weight training program (CT) using speed-lifts and plyometrics vs...
June 14, 2018: Journal of Strength and Conditioning Research
Luis Eduardo Garrido, Juan Ramón Barrada, José Armando Aguasvivas, Agustín Martínez-Molina, Víctor B Arias, Hudson F Golino, Eva Legaz, Gloria Ferrís, Luis Rojo-Moreno
During the present decade a large body of research has employed confirmatory factor analysis (CFA) to evaluate the factor structure of the Strengths and Difficulties Questionnaire (SDQ) across multiple languages and cultures. However, because CFA can produce strongly biased estimations when the population cross-loadings differ meaningfully from zero, it may not be the most appropriate framework to model the SDQ responses. With this in mind, the current study sought to assess the factorial structure of the SDQ using the more flexible exploratory structural equation modeling approach...
June 1, 2018: Assessment
Maksym Golub, Leonid Rusevich, Klaus-Dieter Irrgang, Joerg Pieper
Dynamics-function correlations are usually inferred when molecular mobility and protein function are simultaneously impaired at characteristic temperatures or hydration levels. In this sense, excitation energy transfer in the photosynthetic light-harvesting complex II (LHC II) is an untypical example, because it remains fully functional even at cryogenic temperatures relying mainly on interactions of electronic states with protein vibrations. Here, we study the vibrational and conformational protein dynamics of monomeric and trimeric light-harvesting complex II (LHC II) from spinach using inelastic neutron scattering (INS) in the temperature range between 20 and 305 K...
June 16, 2018: Journal of Physical Chemistry. B
Min Gong, Cheng Chi, Jingjing Ye, Meihong Liao, Wenqi Xie, Chengai Wu, Rui Shi, Liqun Zhang
Due to the significant role of the periosteum in bone regeneration, we hypothesised that using a specially engineered artificial periosteum could lead to an enhancement in osteogenesis in bone grafts. Herein, we describe our work aimed at fabricating an electrospun fibrous membrane as an artificial periosteum that exhibits flexibility, permeability and osteoinduction. This membrane was designed to cover the complex surface of bone grafts to facilitate and accelerate bone regeneration. The traditional Chinese medicine icariin (ICA) was subsequently introduced into poly (ε-caprolactone) (PCL) /gelatin nanofibers to fabricate an artificial periosteum for the first time...
June 14, 2018: Colloids and Surfaces. B, Biointerfaces
Ravi Pant, Siva Shakthi A, Anjali B Yelikar
Wideband excitation and control of Fano resonance and electromagnetically induced transparency (EIT), both of which rely on coherent interaction between two excitation paths, is challenging. It requires precise control and tuning of interacting resonances or coupling between different resonant structures over a wide frequency range. Gain (Stokes) and absorption (anti-Stokes) resonances associated with the stimulated Brillouin scattering (SBS) process can be excited and controlled over a wide frequency range by tuning the pump frequency, its power and profile...
June 15, 2018: Scientific Reports
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