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Kidney anatomy

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https://www.readbyqxmd.com/read/29306507/immunogenicity-and-safety-of-a-novel-tetanus-toxoid-conjugated-anti-gastrin-vaccine-in-balb-c-mice
#1
Qing He, Hua Gao, Meng Gao, Shengmei Qi, Kun Yang, Yingqi Zhang, Junzhi Wang
The objective of this study is to determine the immunogenicity and safety of our novel anti-gastrin vaccine that is composed of the common amino-terminal portions of human carboxy-amidated gastrin-17 (G17) and glycine-extended gastrin-17 (gly-G17) as well as the common carboxy-terminal portion of the gastrin precursor progastrin (in a 50:50 mixture) all covalently linked to tetanus toxoid (TT) via peptide spacers. The vaccine, or immunogen, was injected intramuscularly into the legs of BALB/c mice, which produced high serum titres of specific IgG antibodies and IFN-γ in their spleen cells, identifiable by enzyme-linked immunosorbent assay (ELISA) and enzyme-linked immunospot assay (ELISPOT), respectively...
January 3, 2018: Vaccine
https://www.readbyqxmd.com/read/29273364/establishment-of-laparoscopic-live-donor-nephrectomy-in-a-porcine-model-techniques-and-outcomes-in-44-pigs
#2
Mark E Newman, Gabrielle C Musk, Bulang He
BACKGROUND: Laparoscopic live donor nephrectomy has replaced open donor nephrectomy in most patients due to numerous benefits. A live animal model is required to equip surgeons with the necessary skills to perform such a procedure with minimal risk of complications. The aim of this study was to establish the technique for laparoscopic live donor nephrectomy in a porcine (Sus scrofa) model. MATERIALS AND METHODS: This study was approved by the Animal Ethics Committee of the university...
February 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29241312/selective-clamping-during-laparoscopic-partial-nefrectomy-the-use-of-near-infrared-fluorescence-guidance
#3
Francesco Porpiglia, Cristian Fiori, Enrico Checcucci, Angela Pecoraro, Michele DI Dio, Riccardo Bertolo
BACKGROUND: Near infrared fluorescence (NIRF) is being investigated as a helpful tool to enhance segmental arterial clamping in robotics. Available experiences with NIRF during standard laparoscopy are anecdotal. The aim of the study was to perform a single-center feasibility and results analysis of laparoscopic partial nephrectomy (LPN) performed using NIRF-guided selective clamping. METHODS: May 2016-December 2016: 15 patients diagnosed with a renal mass suitable for nephron-sparing approach consecutively underwent LPN with NIRF-guidance technique...
December 14, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29226038/pencil-beam-scanning-proton-therapy-for-rhabdomyosarcoma-of-the-biliary-tract
#4
Luke Pater, Brian Turpin, Anthony Mascia
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood with 250-350 cases diagnosed annually in the United States. Biliary tract rhabdomyosarcoma is rare, representing <1% of the RMS cases. Due to its location, resection is clinically challenging, and functional complications exist and persist from biliary obstruction. The anatomical location of this tumor presents both opportunities and challenges for pencil beam scanning proton therapy. Proton therapy offers a dosimetric and clinical advantage by sparing the healthy liver, stomach, contra-lateral kidney and bowel...
October 5, 2017: Curēus
https://www.readbyqxmd.com/read/29222673/ureteric-entrapment-in-sacroiliac-joint-causing-hydroureter-and-ipsilateral-kidney-hypertrophy
#5
Yurie Otsuru, Chuichi Kondo, Shohei Hara, Hideo Takahashi, Kenjiro Matsuno
A unilateral megaureter was found in an elderly female cadaver during routine dissection. The left proximal ureter, which was thick and convolute, descended and entered into the pelvic cavity, where the distal ureter was attached to the posterior pelvic wall at the inlet level. Removal of connective tissue surrounding the attached region revealed ureteric entrapment in the sacroiliac joint. The ipsilateral kidney, from which the megaureter originated, showed no pelvicalyceal dilatation. In contrast, the left kidney was enlarged, weighing 24% more than the right kidney...
December 8, 2017: Anatomical Science International
https://www.readbyqxmd.com/read/29201520/transurethral-incision-of-ureteroceles-in-paediatric-age-group
#6
Hemanshi Shah, Charu Tiwari, Neha Sisodiya Shenoy, Pankaj Dwivedi, Suraj Gandhi
Objective: Ureteroceles are a great clinical challenge because of variations in anatomy and clinical presentations. We present our experience with primary transurethral incision of ureteroceles in children. Material and methods: Data of thirteen children managed for ureterocele from 2009 to 2016 was retrospectively analyzed with respect to age, sex, clinical presentation and symptomatology, type and localization of ureterocele, investigations, surgical management and follow-up...
December 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29198688/hanging-hepato-atrial-anastomosis-in-deceased-donor-liver-transplantation-for-budd-chiari-syndrome-with-extensive-vena-cava-obliteration-a-case-report
#7
S Y Hong, B-W Kim, H-J Wang, I-G Kim, X-G Hu
INTRODUCTION: Although outcomes of liver transplantation (LT) have improved as the result of progress in surgical procedures, a failure to restore sufficient graft outflow may yield fatal consequences including graft dysfunction and even graft loss to date. In particular, patients with pre-existing obliterated venous drainage, such as those with Budd-Chiari syndrome (BCS), are at high risk of having venous complications followed by conventional LT. In selected cases, the transplant surgeons are compelled to modify the surgical procedures of LT from the conventional procedure...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29181602/long-parallel-stent-grafts-for-the-treatment-of-complex-aortic-aneurysms
#8
Daniel Silverberg, Uri Rimon, Daniel Raskin, Moshe Halak
PURPOSE: To describe our experience with the chimney technique in endovascular aneurysm repair (ch-EVAR) using long parallel grafts (PGs) of 100 mm or more for the treatment of complex aortic aneurysms. MATERIALS AND METHODS: From 2009 to 2016, data were prospectively collected for patients who underwent ch-EVAR using long PGs. Data included patient demographics and aortic anatomy, technical success, patency and reintervention rate. RESULTS: A total of 29 long PGs were placed in 18 patients (males 16, average age 71 years)...
November 27, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29181522/inguinal-herniation-of-perinephric-tissue-case-report-and-review-of-the-literature
#9
Tara Nikonow Morgan, Jathin Bandari, Nathan Hale, Benjamin Davies
Inguinal hernias containing a kidney or perinephric tissue are extremely rare and usually related to cases involving a kidney positioned in the pelvis. We report the case of a 79-year-old man who presented with abdominal pain and scrotal swelling. He was found on imaging to have an inferiorly displaced kidney with an inguinal herniation of Gerota fascia, as well as an obstructing ureteral stone with an associated forniceal rupture. The unusual renal anatomy, as well as the management of a forniceal rupture, is discussed...
December 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29179563/clinical-outcomes-for-cystinuria-patients-with-unilateral-versus-bilateral-cystine-stone-disease
#10
Manint Usawachintachit, Benjamin Sherer, Matthew Hudnall, David T Tzou, Kazumi Taguchi, Ryan S Hsi, Marshall Stoller, Thomas Chi
<b>Introduction</b>: Cystinuria is a genetic disorder marked by elevated urinary cystine excretion and recurrent cystine nephrolithiasis. Interestingly, despite seemingly similar contralateral renal anatomy, a subset of cystinuric patients consistently form stones in only one kidney. The aim of this study is to evaluate clinical outcomes in unilateral versus bilateral cystine stone formers. <b>Methods</b>: We performed a retrospective case-control study of cystinuric patients evaluated and treated at the University of California, San Francisco between 1994 and 2015 and categorized patients as either unilateral or bilateral stone formers...
November 27, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29169444/urinary-diversion-in-renal-transplantation
#11
REVIEW
Mohamed Eltemamy, Alice Crane, David A Goldfarb
Renal transplantation involving anatomically or functionally altered recipient urinary reservoirs is a challenging procedure. Initial reports discouraged kidney transplantation in patients with urinary diversion due to inferior outcomes. However, more recent studies have shown that although there are more infectious complications, patients with urinary diversions have comparable long-term graft survival with those with native anatomy. Careful preoperative assessment of these candidates is mandatory. Unique technical and surgical concepts must be considered before embarking on transplanting this specific cohort of kidney transplantation candidates...
February 2018: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29149982/marrow-mesenchymal-stem-cells-effectively-reduce-histologic-changes-in-a-rat-model-of-chronic-renal-allograft-rejection
#12
P Yu, Z Wang, Y Liu, Z Xiao, Y Guo, M Li, M Zhao
BACKGROUND: Chronic allograft rejection remains as the leading cause of the chronic renal grafts loss post-transplantation. No therapy has been found really effective to prevent and treat chronic allograft rejection. Mesenchymal stem cells (MSCs) have characteristics of immunomodulation and are expected to be used for inducing graft immune tolerance in organ transplantation. We investigated the efficacy and safety of early infusion of donor-derived marrow MSCs in a rat model of chronic renal allograft rejection...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149952/financial-impact-of-incidental-radiologic-findings-during-living-kidney-donor-evaluation
#13
A Mutneja, L Saling, M Yano, A Vijayan
Living kidney donor (LKD) transplantation is an important alternative for the end-stage renal disease population and is preferred due to superior outcomes when compared with dialysis or deceased donor transplantation. LKD evaluation includes a computed tomography angiogram (CTA) for assessment of renal and renovascular anatomy. Incidental nonrenal findings are frequently noted during the CTAs, and these may have variable clinical significance. These incidental findings lead to further testing, procedures, and referrals, which incur additional cost...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29145401/anatomically-specific-intratubular-and-interstitial-biominerals-in-the-human-renal-medullo-papillary-complex
#14
Ling Chen, Ryan S Hsi, Feifei Yang, Benjamin A Sherer, Marshall L Stoller, Sunita P Ho
Limited information exists on the anatomically-specific early stage events leading to clinically detectable mineral aggregates in the renal papilla. In this study, quantitative multiscale correlative maps of structural, elemental and biochemical properties of whole medullo-papillary complexes from human kidneys were developed. Correlative maps of properties specific to the uriniferous and vascular tubules using high-resolution X-ray computed tomography, scanning and transmission electron microscopy, energy dispersive X-ray spectroscopy, and immunolocalization of noncollagenous proteins (NCPs) along with their association with anatomy specific biominerals were obtained...
2017: PloS One
https://www.readbyqxmd.com/read/29119295/treatment-of-hip-fracture-of-pope-innocent-xii-by-marcello-malpighi-with-bed-rest
#15
REVIEW
Marco Bigoni, Giovanni Zatti, Nicolò Zanchi, Filippo Maria Anghilieri, Michele A Riva
Marcello Malpighi (1628-1694), who is referred to as the father of microscopical anatomy, histology, physiology and embryology was an Italian biologist and physician, well known for his discoveries on microscopical anatomy of kidney, circulating and lymphatic systems. As well as being a brilliant anatomist, Malpighi was also a valued physician so far as to became the personal physician of Pope Innocent XII (1615-1700). On 23 August 1691, one month after his election, the Pope fell to the ground hitting his left hip...
November 8, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29118534/pure-retroperitoneoscopic-donor-nephrectomy-in-duplication-of-inferior-vena-cava-a-series-of-four-cases
#16
Bipin Chandra Pal, Pranjal R Modi, Syed Jamal Rizvi, Rohit Chauhan, Suresh Kumar, Shruti P Gandhi, Vivek B Kute, Hargovind L Trivedi
Aim: Complex vascular anatomy poses a major challenge to the donor surgeon. Here, we have described the technical nuances in retroperitoneoscopic living donor nephrectomy for the left kidney in the situations of a rare vascular anomaly of duplication of inferior vena. Materials and Methods: Between September 2005 and June 2016, 1460 retroperitoneoscopic living donor nephrectomy were carried out in single surgical unit of our institution. Out of these four donors were found to have duplication of inferior vena cava (IVC)...
October 2017: Urology Annals
https://www.readbyqxmd.com/read/29114109/frequency-of-acccessory-renal-arteries-diagnosed-by-computerized-tomography
#17
Sabina Prevljak, Edin Prelevic, Salih Mesic, Odey Ali Abud, Spomenka Kristic, Sandra Vegar-Zubovic
Introduction: Accessory renal arteries play a significant role in kidney and abdominal aorta surgery, and renovascular hypertension. In the published literature, the frequency varies considerably, depending on the size of the sample, the method of examination and the ethnic group. Materials and Methods: The aim of this study is to determine the general frequency of accessory renal arteries, their frequency in relation to gender, the origin and the vascularization area, and to determine the differences in left-right and bilateral distribution...
September 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/29106471/kidney-function-modifies-the-selection-of-treatment-strategies-and-long-term-survival-in-stable-ischemic-heart-disease-insights-from-the-alberta-provincial-project-for-outcomes-assessment-in-coronary-heart-disease-approach-registry
#18
Jay S Shavadia, Danielle A Southern, Matthew T James, Robert C Welsh, Kevin R Bainey
Aims: Patients with chronic kidney disease (CKD) have been under-represented in stable ischemic heart disease (SIHD) trials despite their heightened risk of cardiovascular mortality. We examine associations between kidney disease, treatment selection, and long-term survival in patients with SIHD. Methods and Results: SIHD patients with angiographically significant stenosis (≥70%) were categorized by renal function (dialysis-dependent, severe CKD [eGFR<30], mild-moderate CKD [eGFR30-59] and no CKD [eGFR≥60]), and by treatment groups (revascularization ≤ 3 months of angiogram [CABG or PCI] versus medical therapy)...
November 2, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29102666/a-90-day-subchronic-gavage-toxicity-study-in-fischer-344-rats-with-3-methylfuran
#19
S Gill, M Kavanagh, W Cherry, C Bourque, D Caldwell, G Wang, G Bondy
A 90-day gavage study was conducted with 0.0, 0.02, 0.075, 0.25, 1.0 and 4.0 mg/kg bw/day dose groups of 3-methylfuran to identify a no-observed adverse effect level for hepatotoxicity and to characterize non-neoplastic effects including changes in gross anatomy, histopathology, clinical biochemistry and hematology. There were significant changes in the serum clinical biochemistry markers related to liver injury where males were more affected than the females for most parameters analysed. The serum liver injury marker γ-glutamyltransferase, alanine and aspartate aminotransferases were significantly increased in males in the 4...
November 1, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29078159/challenging-case-of-horseshoe-kidney-double-fracture
#20
Francesco Cortese, Pietro Fransvea, Roberto Marcello, Alessandra Saputelli, Luca Lepre, Aldo Gioffrè, Gabriele Sganga
INTRODUCTION: Renal injuries occur in 10% of blunt abdominal traumas, 7% of these occur in kidneys with congenital or acquired disorders. Trauma of horseshoe kidney is an uncommon finding. PRESENTATION OF A CASE: We present the case of 31 year-old caucasian man with no remarkable personal records, who was brought to our Trauma Unit soon after being involved in a motorcycle collision. A Contrast Enhanced - Multi Detector Computed Tomography (ce-MDCT) revealed a double disconnection of a horseshoe kidney...
October 10, 2017: International Journal of Surgery Case Reports
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