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https://www.readbyqxmd.com/read/28317122/an-anthropomorphic-abdominal-phantom-for-deformable-image-registration-accuracy-validation-in-adaptive-radiation-therapy
#1
Yuliang Liao, Linjing Wang, Xiangdong Xu, Haibin Chen, Jiawei Chen, Guoqian Zhang, Huaiyu Lei, Ruihao Wang, Shuxu Zhang, Xuejun Gu, Xin Zhen, Linghong Zhou
PURPOSE: To design and construct a three-dimensional (3D) anthropomorphic abdominal phantom for geometric accuracy and dose summation accuracy evaluations of deformable image registration (DIR) algorithms for adaptive radiation therapy (ART). METHOD: Organ molds, including liver, kidney, spleen, stomach, vertebra and two metastasis tumors, were 3D printed using contours from an ovarian cancer patient. The organ molds were molded with deformable gels made of different mixtures of polyvinyl chloride (PVC) and the softener dioctyl terephthalate...
March 20, 2017: Medical Physics
https://www.readbyqxmd.com/read/28315152/bilateral-robotic-transabdominal-adrenalectomy-in-a-patient-with-intestinal-malrotation
#2
Zuliang Feng, Carmen C Solórzano
Bilateral adrenalectomy is the preferred surgical approach for patients with failed treatments for pituitary-based Cushing's syndrome. Intestinal malrotation (IM) is a rare congenital anatomic variant that rarely affects adults. The abnormal abdominal anatomy is concerning to surgeons planning elective procedures in such patients. Here, we describe a bilateral robotic transabdominal adrenalectomy (RTA) in a patient with IM. A 29-year-old female presented with refractory pituitary-based Cushing's syndrome and was found to have IM on preoperative CT scan...
March 17, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28303335/treatment-selection-for-urolithiasis-percutaneous-nephrolithomy-ureteroscopy-shock-wave-lithotripsy-and-active-monitoring
#3
Mahesh Desai, Yinghao Sun, Noor Buchholz, Andrew Fuller, Tadashi Matsuda, Brian Matlaga, Nicole Miller, Damien Bolton, Mohammad Alomar, Arvind Ganpule
Urolithiasis is a significant worldwide source of morbidity, constituting a common urological disease that affects between 10 and 15% of the world population. Recent technological and surgical advances have replaced the need for open surgery with less invasive procedures. The factors which determine the indications for percutaneous nephrolithotomy include stone factors (stone size, stone composition, and stone location), patient factors (habitus and renal anomalies), and failure of other treatment modalities (ESWL and flexible ureteroscopy)...
March 16, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28292386/histopathological-changes-in-arsenic-kushta-induced-nephrotoxicity-in-wistar-rats
#4
(no author information available yet)
OBJECTIVE: To determine the nephrotoxic effects of arsenic kushta (Kushta Sam-ul-Far) in Wistar rats. STUDY DESIGN: Experimental study. PLACE AND DURATION OF STUDY: Department of Morbid Anatomy and Histopathology, University of Health Sciences, Lahore from May to August 2014. METHODOLOGY: This experimental study was conducted on 48 healthy Wistar rats, each weighing 200 - 250 grams. The rats were randomly divided into 4 experimental groups each containing 12 rats...
February 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28292311/sonography-of-the-distal-urethra-in-lambs
#5
Ammar AlLugami, Kerstin von Pückler, Axel Wehrend, Marlene Sickinger
Sonography is a convenient, non-invasive diagnostic modality in small ruminants, often used in reproductive management, internal medicine, and surgery. Pregnancy diagnostics and imaging anatomy and pathology of organs, such as neoplasia, are major applications. Urolithiasis is one of the most common causes of death in male sheep and goats, for which sonography is the diagnostic modality of choice. Although ultrasound-imaging techniques for kidneys, ureters, and urinary bladder in small ruminants have been described previously, this study focuses on reporting the imaging technique of the extra-pelvic portion of the urethra, as nearly all the cases of obstructive urolithiasis result from urinary stones in this part...
March 14, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28279720/stent-assisted-coil-embolization-of-a-symptomatic-renal-artery-aneurysm-at-a-bifurcation-point
#6
Naiem Nassiri, Lauren A Huntress
PURPOSE: Symptomatic renal artery aneurysms at bifurcation points present challenging clinical scenarios rarely amenable to endovascular repair due to concerns regarding parenchymal loss following intervention. Herein, we add to the scant body of literature describing successful endovascular repair of a saccular, symptomatic renal artery aneurysm situated at a bifurcation point. METHODS: A 52 year-old woman with a 2.5 cm extra-parenchymal, saccular, symptomatic left renal artery aneurysm underwent self-expanding stent-assisted detachable platinum microcoil embolization...
March 6, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28261636/safety-and-efficacy-of-a-high-performance-graphene-based-magnetic-resonance-imaging-contrast-agent-for-renal-abnormalities
#7
Shruti Kanakia, Jimmy Toussaint, Praveen Kukarni, Stephen Lee, Sayan Mullick Chowdhury, Slah Khan, Sandeep K Mallipattu, Kenneth R Shroyer, William Moore, Balaji Sitharaman
The etiology of renal insufficiency includes primary (e.g polycystic kidney disease) or secondary (e.g. contrast media, diabetes) causes. The regulatory restrictions placed on the use of contrast agents (CAs) for non-invasive imaging modalities such as X-ray computed tomography (CT) and magnetic resonance imaging (MRI) affects the clinical management of these patients. With the goal to develop a next-generation CA for unfettered use for renal MRI, here we report, in a rodent model of chronic kidney disease, the preclinical safety and efficacy of a novel nanoparticle CA comprising of manganese (Mn(2+)) ions intercalated graphene coated with dextran (hereafter called Mangradex)...
December 2016: Graphene Technol
https://www.readbyqxmd.com/read/28253274/planar-cell-polarity-genes-frizzled4-and-frizzled6-exert-patterning-influence-on-arterial-vessel-morphogenesis
#8
Rene Markovič, Julien Peltan, Marko Gosak, Denis Horvat, Borut Žalik, Benjamin Seguy, Remi Chauvel, Gregoire Malandain, Thierry Couffinhal, Cécile Duplàa, Marko Marhl, Etienne Roux
Quantitative analysis of the vascular network anatomy is critical for the understanding of the vasculature structure and function. In this study, we have combined microcomputed tomography (microCT) and computational analysis to provide quantitative three-dimensional geometrical and topological characterization of the normal kidney vasculature, and to investigate how 2 core genes of the Wnt/planar cell polarity, Frizzled4 and Frizzled6, affect vascular network morphogenesis. Experiments were performed on frizzled4 (Fzd4-/-) and frizzled6 (Fzd6-/-) deleted mice and littermate controls (WT) perfused with a contrast medium after euthanasia and exsanguination...
2017: PloS One
https://www.readbyqxmd.com/read/28237697/heart-transplantation-in-adults-with-congenital-heart-disease
#9
REVIEW
Lucile Houyel, Ngoc-Tram To-Dumortier, Yannick Lepers, Jérôme Petit, Régine Roussin, Mohamed Ly, Emmanuel Lebret, Elie Fadel, Jürgen Hörer, Sébastien Hascoët
With the advances in congenital cardiac surgery and postoperative care, an increasing number of children with complex congenital heart disease now reach adulthood. There are already more adults than children living with a congenital heart defect, including patients with complex congenital heart defects. Among these adults with congenital heart disease, a significant number will develop ventricular dysfunction over time. Heart failure accounts for 26-42% of deaths in adults with congenital heart defects. Heart transplantation, or heart-lung transplantation in Eisenmenger syndrome, then becomes the ultimate therapeutic possibility for these patients...
February 22, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28221144/-may-renal-lithiasis-be-really-prevented-new-trends-and-therapeutic-tools
#10
Félix Grases, Antonia Costa-Bauzá, Rafael M Prieto
Renal calculi are generally formed as a result of the combination of certain factors, some related to urine composition (concentration of lithogenic substances, deficiency of crystallization inhibitors, presence of heterogeneous nucleants) and others with renal morphology and anatomy (urinary tract stasis, low urodynamic efficiency cavities, morpho-anatomic deformations, renal papillary tissue lesions). In fact, the composition, macrostructure and microstructure of the calculus will clearly depend on the factors that have induced it...
January 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28218361/arteriovenous-fistula-maturation-in-patients-with-permanent-access-created-prior-to-or-after-hemodialysis-initiation
#11
Juan C Duque, Laisel Martinez, Marwan Tabbara, Denise Dvorquez, Sushil K Mehandru, Arif Asif, Roberto I Vazquez-Padron, Loay H Salman
INTRODUCTION: Multiple factors and comorbidities have been implicated in the ability of arteriovenous fistulas (AVF) to mature, including vessel anatomy, advanced age, and the presence of coronary artery disease or peripheral vascular disease. However, little is known about the role of uremia on AVF primary failure. In this study, we attempt to evaluate the effect of uremia on AVF maturation by comparing AVF outcomes between pre-dialysis chronic kidney disease (CKD) stage five patients and those who had their AVF created after hemodialysis (HD) initiation...
February 15, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28205351/functional-assessment-of-the-kidneys-in-a-10%C3%A2-month-old-child-with-renal-artery-stenosis-by-intravoxel-incoherent-motion
#12
Jochen Herrmann, Harald Ittrich, Michael Gerhard Kaul, Michael Groth, Magdalini Tozakidou, Martin Blohm, Jun Oh, Gerhard Adam
Renovascular stenosis is an important cause for arterial hypertension in childhood. We report a 10-month-old girl with arterial hypertension caused by right-sided renal artery stenosis detected by Doppler ultrasound. Magnetic resonance imaging (MRI) was performed before renal artery angioplasty to depict vascular anatomy in detail and to retrieve additional functional information of the kidneys by analysis of intravoxel incoherent motion (IVIM). The value of quantitative diffusion weighted imaging of the kidneys prior to percutaneous transluminal renal angioplasty (PTRA) is discussed...
March 2017: Nephrology
https://www.readbyqxmd.com/read/28197028/gross-morphological-study-of-the-renal-pelvicalyceal-patterns-in-human-cadaveric-kidneys
#13
T S R Anjana, Elangovan Muthian, Sivakami Thiagarajan, Sumathi Shanmugam
INTRODUCTION: The knowledge of detailed calyceal anatomy is essential for performing urologic procedures such as percutaneous nephrolithotomy, percutaneous nephrostomy, flexible ureterorenoscopy, endopyelotomy, and retrograde renal surgery. This study was performed to analyze the various patterns of pelvicalyceal system in the South Indian population, and compare these with previously published studies in different populations. METHODS: The study was conducted in 100 kidney specimens...
January 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28197027/comparison-of-computed-tomographic-angiography-and-noncontrast-magnetic-resonance-angiography-in-preoperative-evaluation-of-living-renal-donors
#14
Abhijit Dnyandeo Patil, K Shailage, Jeyaseelan Nadarajah, P Harigovind, R Krishna Mohan
INTRODUCTION: The computed tomographic angiography (CTA) renal donor protocol is an established method of preoperative renal vascular pedicle evaluation in prospective renal donors. However, CTA is associated with significant radiation exposure and intravenous contrast administration. The newer noncontrast-enhanced magnetic resonance angiography (NCE-MRA) techniques, especially arterial spin labeling (ASL) with steady-state free precession (SSFP) hold promise as an effective alternative...
January 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28196661/pediatric-medical-device-development-by-surgeons-via-capstone-engineering-design-programs
#15
Bryan S Sack, Rodolfo A Elizondo, Gene O Huang, Nicolette Janzen, Jimmy Espinoza, Magdalena Sanz-Cortes, Jennifer E Dietrich, Julie Hakim, Eric Richardson, Maria Oden, John Hanks, Balakrishna Haridas, James F Hury, Chester J Koh
BACKGROUND: There is a need for pediatric medical devices that accommodate the unique physiology and anatomy of pediatric patients that is increasingly receiving more attention. However, there is limited literature on the programs within children's hospitals and academia that can support pediatric device development. We describe our experience with pediatric device design utilizing collaborations between a children's hospital and two engineering schools. METHODS: Utilizing the academic year as a timeline, unmet pediatric device needs were identified by surgical faculty and matched with an engineering mentor and a team of students within the Capstone Engineering Design programs at two universities...
February 6, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28117559/anatomic-study-of-renal-arterial-vasculature-and-its-potential-implication-on-partial-nephrectomy
#16
Veronica Macchi, Alessandro Crestani, Andrea Porzionato, Maria Martina Sfriso, Aldo Morra, Marta Rossanese, Giacomo Novara, Raffaele De Caro, Vincenzo Ficarra
BACKGROUND AND OBJECTIVES: A detailed understanding of surgical anatomy is an essential requisite to maximize perioperative and functional outcomes of partial nephrectomy. The objectives of this study were 1) to validate the Graves classification and 2) to verify the real absence of collateral arterial blood-supply between different renal segments. MATERIAL AND METHODS: The study was performed on 15 normal kidneys sampled from 8 un-embalmed cadavers. Kidneys with the surrounding perirenal fat tissue were removed en bloc with the abdominal segment of the aorta...
January 24, 2017: BJU International
https://www.readbyqxmd.com/read/28116780/r1-autonomic-nervous-system-in-acute-kidney-injury
#17
REVIEW
Dagmara Hering, Pawel J Winklewski
Acute kidney injury (AKI) is a rapid loss of kidney function resulting in accumulation of end metabolic products and associated abnormalities in fluid, electrolyte and acid-base homeostasis. The pathophysiology of AKI is complex and multifactorial involving numerous vascular, tubular and inflammatory pathways. Neurohumoral activation with heightened activity of the sympathetic nervous system and renin-angiotensin-aldosterone system play a critical role in this scenario. Inflammation and/or local renal ischaemia are underlying mechanisms triggering renal tissue hypoxia and resultant renal microcirculation dysfunction; a common feature of AKI occurring in numerous clinical conditions leading to a high morbidity and mortality rate...
February 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28112399/estimating-organ-doses-from-tube-current-modulated-ct-examinations-using-a-generalized-linear-model
#18
Maryam Bostani, Kyle McMillan, Peiyun Lu, Grace Hyun J Kim, Dianna Cody, Gary Arbique, S Bruce Greenberg, John J DeMarco, Chris H Cagnon, Michael F McNitt-Gray
PURPOSE: Currently available Computed Tomography dose metrics are mostly based on fixed tube current Monte Carlo (MC) simulations and/or physical measurements such as the size specific dose estimate (SSDE). In addition to not being able to account for Tube Current Modulation (TCM), these dose metrics do not represent actual patient dose. The purpose of this study was to generate and evaluate a dose estimation model based on the Generalized Linear Model (GLM) which extends the ability to estimate organ dose from tube current modulated examinations by incorporating regional descriptors of patient size, scanner output and other scan-specific variables as needed...
January 23, 2017: Medical Physics
https://www.readbyqxmd.com/read/28077268/development-of-high-resolution-3d-hyperpolarized-carbon-13-mr-molecular-imaging-techniques
#19
Eugene Milshteyn, Cornelius von Morze, Galen D Reed, Hong Shang, Peter J Shin, Zihan Zhu, Hsin-Yu Chen, Robert Bok, Andrei Goga, John Kurhanewicz, Peder E Z Larson, Daniel B Vigneron
The goal of this project was to develop and apply techniques for T2 mapping and 3D high resolution (1.5mm isotropic; 0.003cm(3)) (13)C imaging of hyperpolarized (HP) probes [1-(13)C]lactate, [1-(13)C]pyruvate, [2-(13)C]pyruvate, and [(13)C,(15)N2]urea in vivo. A specialized 2D bSSFP sequence was implemented on a clinical 3T scanner and used to obtain the first high resolution T2 maps of these different hyperpolarized compounds in both rats and tumor-bearing mice. These maps were first used to optimize timings for highest SNR for single time-point 3D bSSFP acquisitions with a 1...
May 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28048032/su-f-j-63-abdominal-diameter-changes-in-children-during-volumetric-modulated-arc-therapy-vmat-is-re-planning-needed
#20
F Guerreiro, G Janssens, E Seravalli, B Raaymakers
PURPOSE: To investigate the dosimetric impact of daily changes in patient's diameter, due to weight gain/loss and air in the bowel, based on CBCT information during radiotherapy treatment of pediatric abdominal tumors. METHODS: 10 pediatric patients with neuroblastoma (n=6) and Wilms' (n=4) tumors were included. Available CBCTs were affinely registered to the planning CT for daily set-up variations corrections. A density override approach assigning air-density to the random air pockets and water-density to the remaining anatomy was used to determine the CBCT and CT dose...
June 2016: Medical Physics
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