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https://www.readbyqxmd.com/read/27917541/fish-pollutants-mehg-and-aroclor-cause-permanent-structural-damage-in-male-gonad-and-kidney-after-prepubertal-exposure
#1
Mariana S Garcia, Dulce Helena J Constantino, Ana P G Silva, Juliana E Perobelli
This study investigated whether or not prepubertal exposure to the fish contaminants methylmercury (MeHg) and the polychlorinated bisphenol Aroclor in low doses interferes with the histomorphometry of the testes, epididymis, liver and kidneys in rats. Wistar male rats, 21 days old, were allocated into the following: control (n = 17, received corn oil), MeHg (n = 17, received MeHg at 0.5 mg/kg/day), Aroclor (n = 17, received Aroclor at 1.0 mg/kg/day), low mix (n = 18, received MeHg at 0.05 mg/kg/day and Aroclor at 0...
December 5, 2016: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/27916918/subchronic-toxicities-of-hz1006-a-hydroxamate-based-histone-deacetylase-inhibitor-in-beagle-dogs-and-sprague-dawley-rats
#2
Xiaofang Zhang, Xiaodong Zhang, Bojun Yuan, Lijun Ren, Tianbao Zhang, Guocai Lu
Histone deacetylase inhibitors (HDACIs), such as vorinostat and panobinostat, have been shown to have active effects on many hematologic malignancies, including multiple myeloma and cutaneous T-cell lymphoma. Hydroxamate-based (Hb) HDACIs have very good toxicity profiles and are currently being tested in phases I and II clinical trials with promising results in selected neoplasms, such as bladder carcinoma. One of the Hb-HDACIs, HZ1006, has been demonstrated to be a promising drug for clinical use. The aim of our study was to determine the possible target of toxicity and to identify a non-toxic dose of HZ1006 for clinical use...
November 30, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27916575/circannual-and-circadian-rhythms-of-hypothalamic-dna-methyltransferase-and-histone-deacetylase-expression-in-male-siberian-hamsters-phodopus-sungorus
#3
Tyler J Stevenson
Precise timing of gene transcription is a fundamental component of many biological rhythms. DNA methylation and histone acetylation are two epigenetic modifications that can affect the probability of gene transcription and RNA expression. Enzymes involved in DNA methylation (dnmts) have been shown to exhibit photoperiodic rhythms in expression in the hypothalamus, which coincide with hypothalamic expression of deiodinase type III (dio3), a gene involved in the photoperiodic regulation of reproduction. It is currently unknown whether enzymes involved in histone deacetylation (hdacs) also vary in response to photoperiod, nor have seasonal changes in the circadian waveforms of methylation and/or acetylation enzymes been examined...
December 1, 2016: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27914954/molecular-cloning-characterization-and-expression-profile-of-kisspeptin1-and-kisspeptin1-receptor-at-brain-pituitary-gonad-bpg-axis-of-golden-mahseer-tor-putitora-hamilton-1822-during-gonadal-development
#4
Neetu Shahi, Atul Kumar Singh, Monalisa Sahoo, Sumanta Kumar Mallik, Dimpal Thakuria
Complete cDNA sequences of kiss1 (gmkiss1) and its receptor kiss1r (gmkiss1r) were cloned and characterized from brain tissue of adult golden mahseer (Tor putitora). Thereafter, quantification of gmkiss1 and gmkiss1r mRNA expression in brain-pituitary-gonad (BPG) axis of male and female golden mahseer was carried out using quantitative real-time (qRT)-PCR assay during an annual reproductive cycle, at different gonadal development stages. The gmkiss1 cDNA was 508bp, with 330bp open reading frame (ORF), encoding a precursor protein of 109 amino acids, whereas gmkiss1r cDNA was 1383bp with an ORF of 1004bp, which encodes a 334 amino acid protein residue...
November 30, 2016: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/27914857/imidacloprid-induces-various-toxicological-effects-related-to-the-expression-of-3%C3%AE-hsd-nr5a1-and-ogg1-genes-in-mature-and-immature-rats
#5
Amany Abdel-Rahman Mohamed, Wafaa A M Mohamed, Safaa I Khater
This study aimed to evaluate the adverse effects of the insecticide imidacloprid (IMI) on male spermatogenesis, steroidogenesis, and DNA damage in sexually mature and immature rats. Forty male rats (mature and immature) were equally divided into four groups: two mature and two immature groups. IMI groups of both ages were orally administered IMI in corn oil at a concentration of 1 mg/mL for kg BW/day, whereas their respective controls were orally administered corn oil only (1 mL/kg of body weight) daily for 65 days...
November 30, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27914708/generation-and-phenotypic-analysis-of-mice-lacking-all-urea-transporters
#6
Tao Jiang, Yingjie Li, Anita T Layton, Weiling Wang, Yi Sun, Min Li, Hong Zhou, Baoxue Yang
Urea transporters (UT) are a family of transmembrane urea-selective channel proteins expressed in multiple tissues and play an important role in the urine concentrating mechanism of the mammalian kidney. UT inhibitors have diuretic activity and could be developed as novel diuretics. To determine if functional deficiency of all UTs in all tissues causes physiological abnormality, we established a novel mouse model in which all UTs were knocked out by deleting an 87 kb of DNA fragment containing most parts of Slc14a1 and Slc14a2 genes...
November 30, 2016: Kidney International
https://www.readbyqxmd.com/read/27910854/the-genetic-basis-and-fitness-consequences-of-sperm-midpiece-size-in-deer-mice
#7
Heidi S Fisher, Emily Jacobs-Palmer, Jean-Marc Lassance, Hopi E Hoekstra
An extensive array of reproductive traits varies among species, yet the genetic mechanisms that enable divergence, often over short evolutionary timescales, remain elusive. Here we examine two sister-species of Peromyscus mice with divergent mating systems. We find that the promiscuous species produces sperm with longer midpiece than the monogamous species, and midpiece size correlates positively with competitive ability and swimming performance. Using forward genetics, we identify a gene associated with midpiece length: Prkar1a, which encodes the R1α regulatory subunit of PKA...
December 2, 2016: Nature Communications
https://www.readbyqxmd.com/read/27908417/biphasic-action-of-iodine-in-excess-at-different-doses-on-ovary-in-adult-rats
#8
Dakshayani Mahapatra, Amar K Chandra
Iodine consumption in excess of its recommended levels over a prolonged period of time is well known to cause thyroid disorders. The thyroid hormones on the other hand are responsible in maintenance of the physiology of the reproductive system. Excess iodine intake affects male reproductive physiology. However, the effects of excess iodine on the ovarian structure and function is yet to be established. The present study has thus been undertaken to investigate the effect of excess iodine on the ovarian physiology...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27907106/brain-transcriptional-profiles-of-male-alternative-reproductive-tactics-and-females-in-bluegill-sunfish
#9
Charlyn G Partridge, Matthew D MacManes, Rosemary Knapp, Bryan D Neff
Bluegill sunfish (Lepomis macrochirus) are one of the classic systems for studying male alternative reproductive tactics (ARTs) in teleost fishes. In this species, there are two distinct life histories: parental and cuckolder, encompassing three reproductive tactics, parental, satellite, and sneaker. The parental life history is fixed, whereas individuals who enter the cuckolder life history transition from sneaker to satellite tactic as they grow. For this study, we used RNAseq to characterize the brain transcriptome of the three male tactics and females during spawning to identify gene ontology (GO) categories and potential candidate genes associated with each tactic...
2016: PloS One
https://www.readbyqxmd.com/read/27906670/stag3-regulates-microtubule-stability-to-maintain-euploidy-during-mouse-oocyte-meiotic-maturation
#10
Mianqun Zhang, Xiaoxin Dai, Yalu Sun, Yajuan Lu, Changyin Zhou, Yilong Miao, Ying Wang, Bo Xiong
Stag3, a meiosis-specific subunit of cohesin complex, has been demonstrated to function in both male and female reproductive systems in mammals. However, its roles during oocyte meiotic maturation have not been fully defined. In the present study, we report that Stag3 uniquely accumulates on the spindle apparatus and colocalizes with microtubule fibers during mouse oocyte meiotic maturation. Depletion of Stag3 by gene-targeting morpholino disrupts normal spindle assembly and chromosome alignment in oocytes...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27904014/male-infertility-related-molecules-involved-in-sperm-oocyte-fusion
#11
Lisha Mou, Ni Xie
Male infertility has become a very serious problem in the human reproduction system, but the molecular mechanism of infertility remains largely unknown. Fertilization is the phenomenon in which a sperm and oocyte find each other, interact, and fuse. Sperm-oocyte fusion-related factors on the sperm side play crucial roles in male infertility. For example, IZUMO1 is well-known as a sperm protein essential for fusion of a sperm and oocyte, but its dysfunction or mutation can result in male infertility. Recent studies showed a novel sperm protein named Bactericidal/permeability-increasing protein (BPI), which takes part in the sperm-oocyte fusion process...
December 1, 2016: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/27903868/allee-effect-in-polar-bears-a-potential-consequence-of-polychlorinated-biphenyl-contamination
#12
Viola Pavlova, Jacob Nabe-Nielsen, Rune Dietz, Christian Sonne, Volker Grimm
Polar bears (Ursus maritimus) from East Greenland and Svalbard exhibited very high concentrations of polychlorinated biphenyls (PCBs) in the 1980s and 1990s. In Svalbard, slow population growth during that period was suspected to be linked to PCB contamination. In this case study, we explored how PCBs could have impacted polar bear population growth and/or male reproductive success in Svalbard during the mid-1990s by reducing the fertility of contaminated males. A dose-response relationship linking the effects of PCBs to male polar bear fertility was extrapolated from studies of the effects of PCBs on sperm quality in rodents...
November 30, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/27902778/an-insecticide-further-enhances-experience-dependent-increased-behavioural-responses-to-sex-pheromone-in-a-pest-insect
#13
Antoine Abrieux, Amel Mhamdi, Kaouther K Rabhi, Julie Egon, Stéphane Debernard, Line Duportets, Hélène Tricoire-Leignel, Sylvia Anton, Christophe Gadenne
Neonicotinoid insecticides are widely used to protect plants against pest insects, and insecticide residues remaining in the environment affect both target and non-target organisms. Whereas low doses of neonicotinoids have been shown to disturb the behaviour of pollinating insects, recent studies have revealed that a low dose of the neonicotinoid clothianidin can improve behavioural and neuronal sex pheromone responses in a pest insect, the male moth Agrotis ipsilon, and thus potentially improve reproduction...
2016: PloS One
https://www.readbyqxmd.com/read/27902451/vitamin-d-and-male-reproductive-system
#14
Pablo R Costanzo, Pablo Knoblovits
Vitamin D deficiency is a highly prevalent worldwide condition and affects people of all ages. The most important role of vitamin D is the regulation of intestinal calcium absorption and metabolism of calcium and phosphorus to maintain muscle and bone homeostasis. Furthermore, in recent years it has been discovered that the vitamin D receptor (VDR) is widely distributed in many organs and tissues where vitamin D can perform other actions that include the modulation of the immune response, insulin secretion, anti-proliferative effect on cells of vascular smooth muscle, modulation of the renin-angiotensin-aldosterone system and regulates cell growth in several organs...
December 1, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27901500/spatial-variation-in-the-parasitic-isopod-load-of-the-japanese-halfbeak-in-western-japan
#15
R Kawanishi, A Sogabe, R Nishimoto, H Hata
Cymothoid isopods (family Cymothoidae) are commonly found parasitizing diverse fishes, including commercial species. However, the effects of these parasites on host body condition are still poorly known. Here we investigated the spatial variation of the effects of parasite infection on host body condition, using the parasitic load of the cymothoid Mothocya parvostis on the Japanese halfbeak Hyporhamphus sajori at 4 sampling sites in western Japan. M. parvostis prevalence at each site (41.6-74.4%) was higher than that known for other fish host-cymothoid systems (usually less than 30%)...
November 22, 2016: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/27901187/interactions-between-prolactin-and-kisspeptin-to-control-reproduction
#16
Jose Donato, Renata Frazão
Prolactin is best known for its effects of stimulating mammary gland development and lactogenesis. However, prolactin is a pleiotropic hormone that is able to affect several physiological functions, including fertility. Prolactin receptors (PRLRs) are widely expressed in several tissues, including several brain regions and reproductive tract organs. Upon activation, PRLRs may exert prolactin's functions through several signaling pathways, although the recruitment of the signal transducer and activator of transcription 5 causes most of the known effects of prolactin...
November 24, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27901106/the-role-of-pim1-pim2-kinases-in-tumors-of-the-male-reproductive-system
#17
Manuel Pedro Jiménez-García, Antonio Lucena-Cacace, María José Robles-Frías, Maja Narlik-Grassow, Carmen Blanco-Aparicio, Amancio Carnero
The PIM family of serine/threonine kinases has three highly conserved isoforms (PIM1, PIM2 and PIM3). PIM proteins are regulated through transcription and stability by JAK/STAT pathways and are overexpressed in hematological malignancies and solid tumors. The PIM kinases possess weak oncogenic abilities, but enhance other genes or chemical carcinogens to induce tumors. We generated conditional transgenic mice that overexpress PIM1 or PIM2 in male reproductive organs and analyzed their contribution to tumorigenesis...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27890950/healthcare-seeking-preferences-of-patients-with-sexually-transmitted-infection-attending-a-tertiary-care-center-in-south-kerala
#18
Sabeena Jayapalan
BACKGROUND: Sexually transmitted infections (STIs) are a major public health problem in developing countries. These diseases are associated with increased risk of transmission of human immunodeficiency virus as well as adverse outcomes on pregnancy and reproductive health. Sexual behavior and healthcare-seeking behavior are identified as the true risk factors of STIs. METHODS: Hospital-based cross-sectional study design was adopted. Eighty-five STI patients were studied regarding the inappropriate treatment-seeking behavior, the nature of the first point of contact with the health care, the appropriateness of treatment and the concerns of the patient regarding the services rendered by government health-care facilities...
July 2016: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27887945/kisspeptin-system-in-pejerrey-fish-odontesthes-bonariensis-characterization-and-gene-expression-pattern-during-early-developmental-stages
#19
M Oswaldo Tovar Bohórquez, Alejandro S Mechaly, Lily C Hughes, Daniela Campanella, Guillermo Ortí, Luis F Canosa, Gustavo M Somoza
In vertebrates, kisspeptins and their receptors are known to be related to puberty onset and gonadal maturation, however, there are few studies concerning their role in early development. Here, we characterize the kisspeptin system in the pejerrey, Odontesthes bonariensis, a fish with strong temperature-dependent sex determination. We reconstructed the phylogenetic history of the two ligands (kiss1 and kiss 2) and two receptors (kissr2 and kissr3) in pejerrey in the context of recent classifications of bony fishes, determined their tissue distribution and documented the early expression pattern of these ligands and receptors...
November 23, 2016: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/27883363/sexual-selection-shapes-development-and-maturation-rates-in-drosophila
#20
Brian Hollis, Laurent Keller, Tadeusz J Kawecki
Explanations for the evolution of delayed maturity usually invoke trade-offs mediated by growth, but processes of reproductive maturation continue long after growth has ceased. Here, we tested whether sexual selection shapes the rate of posteclosion maturation in the fruit fly Drosophila melanogaster. We found that populations maintained for more than 100 generations under a short generation time and polygamous mating system evolved faster posteclosion maturation and faster egg-to-adult development of males, when compared to populations kept under short generations and randomized monogamy that eliminated sexual selection...
November 7, 2016: Evolution; International Journal of Organic Evolution
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