Niroj Shrestha, Klaus Zorn-Pauly, Pietro Mesirca, Chintan N Koyani, Gerald Wölkart, Valentina Di Biase, Eleonora Torre, Petra Lang, Astrid Gorischek, Wolfgang Schreibmayer, Robert Arnold, Heinrich Maechler, Bernd Mayer, Dirk von Lewinski, Angelo G Torrente, Matteo E Mangoni, Brigitte Pelzmann, Susanne Scheruebel
Sepsis has emerged as a global health burden associated with multiple organ dysfunction and 20% mortality rate in patients. Numerous clinical studies over the past two decades have correlated the disease severity and mortality in septic patients with impaired heart rate variability (HRV), as a consequence of impaired chronotropic response of sinoatrial node (SAN) pacemaker activity to vagal/parasympathetic stimulation. However, the molecular mechanism(s) downstream to parasympathetic inputs have not been investigated yet in sepsis, particularly in the SAN...
July 11, 2023: Proceedings of the National Academy of Sciences of the United States of America