Leon C D Smyth, Di Xu, Serhat V Okar, Taitea Dykstra, Justin Rustenhoven, Zachary Papadopoulos, Kesshni Bhasiin, Min Woo Kim, Antoine Drieu, Tornike Mamuladze, Susan Blackburn, Xingxing Gu, María I Gaitán, Govind Nair, Steffen E Storck, Siling Du, Michael A White, Peter Bayguinov, Igor Smirnov, Krikor Dikranian, Daniel S Reich, Jonathan Kipnis
The arachnoid barrier delineates the border between the central nervous system and dura mater. Although the arachnoid barrier creates a partition, communication between the central nervous system and the dura mater is crucial for waste clearance and immune surveillance1,2 . How the arachnoid barrier balances separation and communication is poorly understood. Here, using transcriptomic data, we developed transgenic mice to examine specific anatomical structures that function as routes across the arachnoid barrier...
February 7, 2024: Nature