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Multiple sclerosis, vitamin d

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https://www.readbyqxmd.com/read/28320120/seasonal-variations-of-25-oh-vitamin-d-serum-levels-are-associated-with-clinical-disease-activity-in-multiple-sclerosis-patients
#1
Christina Hartl, Viola Obermeier, Lisa Ann Gerdes, Mathias Brügel, Rüdiger von Kries, Tania Kümpfel
Low 25-hydroxy vitamin D (25-[OH]-D) serum concentrations have been associated with higher disease activity in multiple sclerosis (MS) patients. In a large cross-sectional study we assessed the vitamin D status in MS patients in relation to seasonality and relapse rate. 415 MS-patients (355 relapsing-remitting MS and 60 secondary-progressive, 282 female, mean age 39.1years) of whom 25-(OH)-D serum concentrations were determined at visits between 2010 and 2013 were included in the study. All clinical data including relapse at visit and expanded disability status scale were recorded in a standardized manner by an experienced neurologist...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28292961/modeling-month-season-of-birth-as-a-risk-factor-in-mouse-models-of-chronic-disease-from-multiple-sclerosis-to-autoimmune-encephalomyelitis
#2
Jacob D Reynolds, Laure K Case, Dimitry N Krementsov, Abbas Raza, Rose Bartiss, Cory Teuscher
Month-season of birth (M-SOB) is a risk factor in multiple chronic diseases, including multiple sclerosis (MS), where the lowest and greatest risk of developing MS coincide with the lowest and highest birth rates, respectively. To determine whether M-SOB effects in such chronic diseases as MS can be experimentally modeled, we examined the effect of M-SOB on susceptibility of C57BL/6J mice to experimental autoimmune encephalomyelitis (EAE). As in MS, mice that were born during the M-SOB with the lowest birth rate were less susceptible to EAE than mice born during the M-SOB with the highest birth rate...
March 14, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28284354/vitamin-d-binding-protein-gene-polymorphisms-are-not-associated-with-ms-risk-in-an-italian-cohort
#3
Cristina Agliardi, Franca Rosa Guerini, Milena Zanzottera, Elisabetta Bolognesi, Andrea Saul Costa, Mario Clerici
Vitamin D binding protein (DBP) gene encodes for Gc, an α2 globulin that transports vitamin D metabolites in serum. Given the role of vitamin D in MS onset and disease progression we analyzed the frequencies of three polymorphisms (rs7041, rs4588 and rs2282679) within DBP gene in 701 Italian multiple sclerosis (MS) patients and 831 healthy controls (HC). None of the polymorphisms showed any association with MS onset and progression. Our results suggest that DBP is not involved in the pathogenesis of MS in Italians...
April 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28283108/higher-prevalence-of-restless-legs-syndrome-willis-ekbom-disease-in-multiple-sclerosis-patients-is-related-to-spinal-cord-lesions
#4
M Minár, D Petrleničová, P Valkovič
BACKGROUND: Multiple sclerosis (MS) is connected with higher prevalence of secondary restless legs syndrome/Willis-Ekbom disease (RLS/WED). Aim of this study was to determine risk factor for developing symptoms of RLS in MS patients. METHODS: In cross-sectional study we examined 200 random MS patients. After obtaining informed consents, patients undervent a structured interview based on RLS and MS symptoms and characteristics, demographic, and health-related data...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28282804/ifnar1-expression-level-in-iranian-multiple-sclerosis-patients-treated-with-ifn-b
#5
Arezou Sayad, Mohsen Khakzad Kelarijani, Elham Sajjadi, Mohammad Taheri
BACKGROUND: Multiple sclerosis (MS) as an auto-immune disease is an inflammatory, demyelinating disease of the central nervous system. Certain genes have shown to be involved in the initiation of MS but the specific role of some of them, e.g. IFNAR1 has not been identified in certain populations yet. OBJECTIVE: The IFNAR1 as a type I membrane protein shapes one of the two chains of a receptor for interferons alpha and beta. METHODS: To find out how IFNAR1 functions in the Iranian population, the researchers compared the expression level of this gene in relapsing-remitting MS (RR-MS) samples with normal individuals...
March 3, 2017: Human Antibodies
https://www.readbyqxmd.com/read/28275670/data-characterizing-the-zmiz1-molecular-phenotype-of-multiple-sclerosis
#6
N Fewings, P N Gatt, F C McKay, G P Parnell, S D Schibeci, J Edwards, M A Basuki, A Goldinger, M J Fabis-Pedrini, A G Kermode, C P Manrique, J L McCauley, D Nickles, S E Baranzini, T Burke, S Vucic, G J Stewart, D R Booth
The data presented in this article are related to the research article entitled "The autoimmune risk gene ZMIZ1 is a vitamin D responsived marker of a molecular phenotype of multiple sclerosis" Fewings et al. (2017) [1]. Here we identify the set of genes correlated with ZMIZ1 in multiple cohorts, provide phenotypic details on those cohorts, and identify the genes negatively correlated with ZMIZ1 and the cells predominantly expressing those genes. We identify the metabolic pathways in which the molecular phenotype genes are over-represented...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28239520/association-of-vitamin-d-status-and-clinical-and-radiological-outcomes-in-a-treated-ms-population-in-poland
#7
Sławomir Wawrzyniak, Emilia Mikołajewska, Ewelina Kuczko-Piekarska, Anna Niezgodzińska-Maciejek, Aleksander Goch
BACKGROUND: Vitamin D influences the immune system significantly. Previous studies have found that vitamin D deficiency in adolescence can play a significant role in increasing the risk of developing autoimmune diseases including multiple sclerosis. The aim of this study was to investigate the relationship between the vitamin D status in serum and clinical and radiological outcomes in a treated population in Poland. METHODS: Inclusion criteria met 83 adult patients aged 20-61 years with diagnosis of relapsing-remitting multiple sclerosis, who underwent immunomodulatory treatment which lasted at least 12 months...
February 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28236843/multiple-sclerosis-and-air-pollution-exposure-mechanisms-toward-brain-autoimmunity
#8
Sayed Esmaeil Mousavi, Pouria Heydarpour, Jacques Reis, Masoud Amiri, Mohammad Ali Sahraian
The association between neurodegenerative diseases and environmental exposures, in particular air pollution, has been noticed in the last two decades, but the importance of this environmental factor in multiple sclerosis (MS) pathogenesis has not been considered extensively. However, recent evidence suggests that major mechanisms involved in MS pathogenesis, such as inflammatory factors expression, free radicals overproduction, the blood brain barrier (BBB) breakdown, neuroinflammation, vitamin D deficiency and mitochondrial dysfunction could also occur due to exposure to air pollutants...
March 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28229097/pediatric-hypovitaminosis-d-molecular-perspectives-and-clinical-implications
#9
Rafiu Ariganjoye
Vitamin D, a secosteroid, is essential for the development and maintenance of healthy bone in both the adult and pediatric populations. Low level of 25-hydroxy vitamin D (25-(OH)-D) is highly prevalent in children worldwide and has been linked to various adverse health outcomes including rickets, osteomalacia, osteomalacic myopathy, sarcopenia, and weakness, growth retardation, hypocalcemia, seizure and tetany, autism, cardiovascular diseases, diabetes mellitus, cancers (prostate, colon, breast), infectious diseases (viral, tuberculosis), and autoimmune diseases, such as multiple sclerosis and Hashimoto's thyroiditis...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28214921/vitamin-d-administration-during-pregnancy-as-prevention-for-pregnancy-neonatal-and-postnatal-complications
#10
REVIEW
Carol L Wagner, Bruce W Hollis, Kalliopi Kotsa, Hana Fakhoury, Spyridon N Karras
Pregnancy represents a time of rapid bodily change, which includes physical proportions, physiology and responsibility. At this context, maternal vitamin D stores have been the objective of extensive scientific research during the last decades, focusing on their potential effects on maternal an neonatal health. A growing body of observational studies indicated that maternal hypovitaminosis D (as defined by maternal 25-hydroxyvitamin D [25(OH)D] levels <20 ng/ml or <50 nmol/l) is a significant risk factor for adverse neonatal outcomes including asthma, multiple sclerosis and other neurological disorders...
February 18, 2017: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28208641/temporal-trends-in-satellite-derived-erythemal-uvb-and-implications-for-ambient-sun-exposure-assessment
#11
Marvin Langston, Leslie Dennis, Charles Lynch, Denise Roe, Heidi Brown
Ultraviolet radiation (UVR) has been associated with various health outcomes, including skin cancers, vitamin D insufficiency, and multiple sclerosis. Measurement of UVR has been difficult, traditionally relying on subject recall. We investigated trends in satellite-derived UVB from 1978 to 2014 within the continental United States (US) to inform UVR exposure assessment and determine the potential magnitude of misclassification bias created by ignoring these trends. Monthly UVB data remotely sensed from various NASA satellites were used to investigate changes over time in the United States using linear regression with a harmonic function...
February 10, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28196884/functional-genomics-analysis-of-vitamin-d-effects-on-cd4-t-cells-in-vivo-in-experimental-autoimmune-encephalomyelitis-%C3%A2
#12
Manuel Zeitelhofer, Milena Z Adzemovic, David Gomez-Cabrero, Petra Bergman, Sonja Hochmeister, Marie N'diaye, Atul Paulson, Sabrina Ruhrmann, Malin Almgren, Jesper N Tegnér, Tomas J Ekström, André Ortlieb Guerreiro-Cacais, Maja Jagodic
Vitamin D exerts multiple immunomodulatory functions and has been implicated in the etiology and treatment of several autoimmune diseases, including multiple sclerosis (MS). We have previously reported that in juvenile/adolescent rats, vitamin D supplementation protects from experimental autoimmune encephalomyelitis (EAE), a model of MS. Here we demonstrate that this protective effect associates with decreased proliferation of CD4+ T cells and lower frequency of pathogenic T helper (Th) 17 cells. Using transcriptome, methylome, and pathway analyses in CD4+ T cells, we show that vitamin D affects multiple signaling and metabolic pathways critical for T-cell activation and differentiation into Th1 and Th17 subsets in vivo...
February 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28188842/vitamin-d-supplementation-during-pregnancy-improvements-in-birth-outcomes-and-complications-through-direct-genomic-alteration
#13
REVIEW
Bruce W Hollis, Carol L Wagner
Pregnancy represents a time of rapid change, including dramatic shifts in vitamin D metabolism. Circulating concentrations of the active form of vitamin D-1,25(OH)2D skyrocket early in pregnancy to levels that would be toxic to a nonpregnant adult, signaling a decoupling of vitamin D from the classic endocrine calcium metabolic pathway, likely serving an immunomodulatory function in the mother and her developing fetus. In this review, we summarize the unique aspects of vitamin D metabolism and the data surrounding vitamin D requirements during this important period...
February 7, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28167940/narrowband-uvb-phototherapy-for-clinically-isolated-syndrome-a-trial-to-deliver-the-benefits-of-vitamin-d-and-other-uvb-induced-molecules
#14
Prue H Hart, Robyn M Lucas, David R Booth, William M Carroll, David Nolan, Judith M Cole, Anderson P Jones, Allan G Kermode
Low vitamin D and insufficient sun exposure are additive independent risk factors for the development of multiple sclerosis (MS). The usual measure of vitamin D status, serum 25-hydroxy vitamin D [25(OH)D], is also a marker of recent exposure to the UVB rays of sunshine. The main evidence for a protective effect for MS development of higher 25(OH)D comes from observational studies, but this study design cannot separate out whether 25(OH)D is acting as a marker of vitamin D status, sun exposure, or both. In light of a lack of definitive outcomes in MS patients after trials of vitamin D supplementation and the ability of narrowband UVB to induce vitamin D, as well as other immune-regulatory molecules in skin, the Phototherapy for Clinically Isolated Syndrome (PhoCIS) trial was established to investigate the benefits of narrowband UVB, in addition to supplemented vitamin D, on MS development in individuals with Clinically Isolated Syndrome...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28165135/multiple-sclerosis-associated-retrovirus-epstein-barr-virus-and-vitamin-d-status-in-patients-with-relapsing-remitting-multiple-sclerosis
#15
Aliehossadat Mostafa, Somayeh Jalilvand, Zabihollah Shoja, Ahmad Nejati, Shohreh Shahmahmoodi, Mohammad Ali Sahraian, Sayed Mahdi Marashi
The relationship between infections and autoimmune diseases is complex and there are several reports highlighting the role of human endogenous retroviruses (HERVs) in these patients. The levels of multiple sclerosis-associated retrovirus (MSRV)-type DNA of Env gene was measured in peripheral blood mononuclear cells from 52 patients with relapsing-remitting multiple sclerosis (RRMS) and 40 healthy controls using specific quantitative PCR (qPCR) analysis. Furthermore, we analyzed the status of HERV-W/MSRV in these patients with regards to both EBV (DNA load and anti-EBNA1 IgG antibody) and vitamin D concentration...
February 6, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28156186/polyunsaturated-fatty-acids-and-the-risk-of-multiple-sclerosis
#16
Kjetil Bjørnevik, Tanuja Chitnis, Alberto Ascherio, Kassandra L Munger
BACKGROUND: Results from previous studies on polyunsaturated fatty acid (PUFA) intake and multiple sclerosis (MS) risk are conflicting. OBJECTIVE: To prospectively investigate the association between dietary intake of PUFA and MS risk. METHODS: We followed 80,920 women from Nurses' Health Study (1984-2004) and 94,511 women from Nurses' Health Study II (1991-2009) who reported on diet using a validated food frequency questionnaire every 4 years and identified 479 incident MS cases during follow-up...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28151074/a-systematic-review-of-the-effects-of-modifiable-risk-factor-interventions-on-the-progression-of-multiple-sclerosis
#17
Susanne Hempel, Glenn D Graham, Ning Fu, Elena Estrada, Annie Y Chen, Isomi Miake-Lye, Jeremy N V Miles, Roberta Shanman, Paul G Shekelle, Jessica M Beroes, Mitchell T Wallin
BACKGROUND: Several risk factors are associated with multiple sclerosis (MS) progression and may be amenable to intervention. OBJECTIVE: To systematically review the evidence for interventions targeting risk factors for MS progression. METHODS: We searched six databases and existing reviews till March 2015 and consulted with experts to identify randomized controlled trials (RCTs) of interventions targeting MS risk factors (PROSPERO 2015:CRD42015016461)...
April 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28151053/a-systematic-review-of-modifiable-risk-factors-in-the-progression-of-multiple-sclerosis
#18
Susanne Hempel, Glenn D Graham, Ning Fu, Elena Estrada, Annie Y Chen, Isomi Miake-Lye, Jeremy N V Miles, Roberta Shanman, Paul G Shekelle, Jessica M Beroes, Mitchell T Wallin
BACKGROUND: The presenting symptoms and rate of progression of multiple sclerosis (MS) are very heterogeneous. The diverse clinical manifestations and the clinical course of the disease may vary with modifiable risk factors. OBJECTIVE: To systematically review modifiable risk factors and exposures associated with MS progression. METHODS: We searched six databases till March 2015, reference-mined reviews, and consulted with experts (PROSPERO 2015:CRD42015016461)...
April 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28134233/-the-role-of-diet-in-multiple-sclerosis
#19
REVIEW
Karolina Brzostek, Anna Ukleja
Multiple sclerosis is a chronic demyelinating disease of the central nervous system. The aim of this study was to present the relationship between nutrition and the occurrence and course of the disease. The work on the basis of the literature demonstrated the adverse effect of high intake of saturated fatty acids and salt on the development and course of multiple sclerosis. Also in the paper we demonstrat a correlation between favorable adequate supply of omega-3, vitamin D, B12 and folic acid and the risk of exacerbation and symptoms of MS...
January 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28099554/no-correlation-was-observed-between-vitamin-d-levels-and-disability-of-patients-with-multiple-sclerosis-between-latitudes-18%C3%A2-and-30%C3%A2-south
#20
Yara Dadalti Fragoso, Tarso Adoni, Soniza Vieira Alves-Leon, Samira L Apostolos-Pereira, Walter Oleschko Arruda, Joseph B Bidin Brooks, Henrique S Rodrigues Cal, Carlos A Albuquerque Damasceno, Paulo Diniz Gama, Marcus V Magno Goncalves, Carlos A da Silva de Jesus, Suzana C Nunes Machado, Letícia Fezer Mansur, Andre P da Cunha Matta, Maria Fernanda Mendes, Rogerio Rizo Morales, Adaucto Wanderley da Nobrega-Jr, Monica K Fiuza Parolin, Mario Pietro Peres, Marlise de Castro Ribeiro, Heloisa Helena Ruocco, Simone Scherpenhuijzen, Fabio Siquinelli, Patrick N Stoney, Daniel Lima Varela, Audred Cristina Biondo Eboni, Caroline Vieira Spessotto, Elisa Teixeira da Rocha, Pamela Emanuele Lacerda
Objective: Vitamin D has taken center stage in research and treatment of multiple sclerosis (MS). The objective of the present study was to assess the serum vitamin D levels of a large population of patients with MS and controls living in a restricted tropical area. Methods: Data from 535 patients with MS and 350 control subjects were obtained from 14 cities around the Tropic of Capricorn. Results: The mean serum 25-OH vitamin D level was 26...
January 2017: Arquivos de Neuro-psiquiatria
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