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Multiple sclerosis, vitamin d

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https://www.readbyqxmd.com/read/29131543/hla-class-ii-polymorphism-in-saudi-patients-with-multiple-sclerosis
#1
M Al Jumah, S Kojan, A M Al Shehri, M Al Balwi, I Al Abdulkarim, E M Masuadi, Y Alhaidan, A Alabdulrahman, H M Fakhoury, A H Hajeer
Several studies have investigated the association of different HLA antigens with multiple sclerosis (MS). However, only few studies have considered the association of high resolution HLA type and MS, with none yet from Saudi Arabia. The aim of this study was to investigate the association of HLA class II alleles with MS in the Saudi population. We used next generation sequencing to investigate HLA association with MS. This study was conducted at King Abdulaziz Medical City in Riyadh, Saudi Arabia. We found that several HLA-DRB1 and DQB1 alleles were associated with MS...
November 13, 2017: HLA
https://www.readbyqxmd.com/read/29110148/association-between-vdr-polymorphisms-and-multiple-sclerosis-systematic-review-and-updated-meta-analysis-of-case-control-studies
#2
Yan-Jie Zhang, Li Zhang, Shan-Yu Chen, Guo-Jun Yang, Xiao-Lei Huang, Yu Duan, Li-Juan Yang, Dong-Qing Ye, Jing Wang
Vitamin D receptor (VDR) polymorphisms have been inconsistently investigated in multiple sclerosis (MS). However, published studies demonstrated differences concerning design and effect size. A meta-analysis is necessary to determine the magnitude of the association between VDR polymorphisms and MS risk. The aim of the current study was to quantify the magnitude of the association between BsmI, FokI, ApaI, and TaqI VDR polymorphisms and MS risk. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a systematic search and meta-analysis of the VDR gene polymorphisms and the risk of MS...
November 6, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29074827/-update-on-recent-progress-in-vitamin-d-research-the-effects-of-vitamin-d-in-autoinflammatory-diseases
#3
Tomoka Ao, Junichi Kikuta, Masaru Ishii
Various kinds of immune cells -including dendritic cells, macrophages, T cells and B cells- express the vitamin D receptor and 1α-hydroxylase(CYP27B1). In vitro studies have shown the anti-inflammatory effect of 1,25-dihydroxyvitamin D:the active form of vitamin D. As vitamin D deficiency spread in our society, epidemiological studies have established the association between vitamin D deficiency and incidence or progression of several inflammatory diseases, including rheumatoid arthritis(RA), systemic lupus erythematosus(SLE), and multiple sclerosis(MS)...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29072967/association-of-vdr-gene-polymorphisms-with-risk-of-relapsing-remitting-multiple-sclerosis-in-an-iranian-kurdish-population
#4
Rasoul Abdollah Zadeh, Parisa Moradi Pordanjani, Farideh Rahmani, Fatemeh Mashayekhi, Asaad Azarnezhad, Yaser Mansoori
Vitamin D receptor (VDR) polymorphisms have been reported to be associated with multiple sclerosis (MS). The purpose of this study was to evaluate the association of VDR Apa-I, Bsm-I, Fok-I, Taq-I polymorphisms with MS risk in an Iranian Kurdish population. A population including of 118 patients affected with MS and 124 healthy matched controls were recruited to the study. DNA was extracted from blood and genotyping of single nucleotide polymorphisms (SNPs) was accomplished using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...
October 26, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29068493/managing-epstein-barr-virus-and-other-risk-factors-in-ms-future-perspectives
#5
REVIEW
P Sundström
Here, we discuss the rationale and feasibility of treatment directed against the modifiable risk factors in multiple sclerosis. The established environmental risk factors vitamin D insufficiency, cigarette smoke exposure, adolescence overweight, and Epstein-Barr virus infection are reviewed. Already available measures to target these risk factors are discussed.
November 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29067566/diet-gut-microbiota-and-vitamins-d-%C3%A2-a-in-multiple-sclerosis
#6
REVIEW
Paolo Riccio, Rocco Rossano
Central to the understanding of the relationships between diet, gut microbiota, and vitamins D and A in multiple sclerosis is low-grade inflammation, which is involved in all chronic inflammatory diseases and is influenced by each of the above effectors. We show that food components have either proinflammatory or anti-inflammatory effects and influence both the human metabolism (the "metabolome") and the composition of gut microbiota. Hypercaloric, high-animal-fat Western diets favor anabolism and change gut microbiota composition towards dysbiosis...
October 24, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29055437/season-of-infectious-mononucleosis-as-a-risk-factor-for-multiple-sclerosis-a-uk-primary-care-case-control-study
#7
Christina Downham, Elizabeth Visser, Mark Vickers, Carl Counsell
BACKGROUND: Infectious mononucleosis (IM) and vitamin D deficiency are both risk factors for multiple sclerosis (MS). OBJECTIVE: We wished to establish if IM in the winter months when vitamin D levels are low may be a greater risk factor for MS than IM in the summer months. METHODS: We identified all patients with MS diagnosed aged 16-60 in a large primary care database in the United Kingdom and matched each by age, sex, general practice and observation period with up to six controls...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29055009/in-search-of-regulatory-circuits-that-control-the-biological-activity-of-vitamin-d
#8
REVIEW
Sylvia Christakos
Although the cytochrome P450 CYP27B1 plays a critical role in vitamin D biology, the molecular mechanisms involved in regulation of CYP27B1 have remained undefined. A new study has identified a kidney-specific control module distal to the Cyp27b1 gene that mediates the basal activity and hormonal regulation of Cyp27b1 This work provides a novel mechanism indicating differential regulation of Cyp27b1 in renal and non-renal cells and has implications for vitamin D biology in multiple sclerosis and perhaps other autoimmune diseases as well...
October 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29030863/hotair-but-not-anril-long-non-coding-rna-contributes-to-the-pathogenesis-of-multiple-sclerosis
#9
Majid Pahlevan Kakhki, Abbas Nikravesh, Zeinab Shirvani Farsani, Mohammad Ali Sahraian, Mehrdad Behmanesh
Different studies have revealed that dysregulation in gene expression is one of the main aspects of multiple sclerosis (MS) pathogenesis. Although the molecular pathways underlying the immunomodulatory role of vitamin D (VD) in MS is not completely elucidated, VD has more recently become a topic of interest in immune regulation and is widely administrated to MS patients as an immunomodulatory supplement. Long non-coding RNAs (lncRNAs) are known to play important roles in regulation of gene expression via different mechanisms...
October 14, 2017: Immunology
https://www.readbyqxmd.com/read/28993476/contribution-of-dietary-intake-to-relapse-rate-in-early-paediatric-multiple-sclerosis
#10
Saeedeh Azary, Teri Schreiner, Jennifer Graves, Amy Waldman, Anita Belman, Bianca Weinstock Guttman, Gregory Aaen, Jan-Mendelt Tillema, Soe Mar, Janace Hart, Jayne Ness, Yolanda Harris, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Tanuja Chitnis, John Rose, Lisa F Barcellos, Tim Lotze, Suzan L Carmichael, Shelly Roalstad, Charles T Casper, Emmanuelle Waubant
OBJECTIVE: The role of diet in multiple sclerosis (MS) course remains largely unknown. Children with MS have a higher relapse rate compared with MS in adults. Thus, studying the effect of diet on relapse rate in this age group is likely to provide more robust answers. METHODS: This is a multicentre study done at 11 paediatric MS centres in the USA. Patients with relapsing-remitting MS (RRMS) or clinically isolated syndrome (CIS) with disease onset before 18 years of age and duration of less than 4 years were included in this study...
October 9, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28991684/vitamin-d-deficiency-is-associated-with-disability-and-disease-progression-in-multiple-sclerosis-patients-independently-of-oxidative-and-nitrosative-stress
#11
Sayonara R Oliveira, Andréa N C Simão, Daniela Frizon Alfieri, Tamires Flauzino, Ana Paula Kallaur, Leda Mezzaroba, Marcell Alysson B Lozovoy, Beatriz Sardinha Sabino, Katerine Panichi Zanin Ferreira, Wildea L C J Pereira, Damacio R Kaimen-Maciel, Isaias Dichi, Edna M V Reiche
The aim of this study was to assess vitamin D status in patients with multiple sclerosis (MS) and to evaluate whether it was associated with oxidative and nitrosative stress (O&NS) markers and disability. This study included 137 patients with MS and 218 healthy controls. The markers evaluated were serum levels of 25-hydroxyvitamin D, lipid hydroperoxides, advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), and total radical-trapping antioxidant parameter TRAP/UA. Patients with 25(OH)D<20ng/mL showed higher EDSS (p=0...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28980606/-modern-conception-of-the-pathogenesis-of-neurodegenerative-diseases-and-therapeutic-strategy
#12
I V Litvinenko, I V Krasakov, G N Bisaga, D I Skulyabin, I D Poltavsky
Here we discuss the pathogenesis of the inflammatory and degenerative nervous system disorders on the example of Parkinson's disease, Alzheimer's disease, multiple sclerosis. Common mechanisms of neurodegeneration in these diseases are reviewed. The role of neurodegeneration as the main process leading to the resistant disability of patients with multiple sclerosis is discussed. The authors consider a contribution of inflammatory process and chronic infection to the manifestation and progressing of a neurodegenerative disease and discuss the use of treatment not usually indicated including interferon, anti-inflammatory drugs, statin, vitamin D, monoclonal antibodies, correction of the intestinal microbiota in Parkinson's disease and Alzheimer's disease...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28979796/the-genetics-of-multiple-sclerosis-in-latin-america
#13
REVIEW
Verónica Rivas Alonso, José de Jesús Flores Rivera, Yamel Rito García, Teresa Corona
BACKGROUND: In today's globalised world, the heterogeneity of diseases such as multiple sclerosis has been studied since it has been suggested that ethnic differences, in conjunction with geographical and environmental factors, influence its incidence and prevalence. AIM: Based on this, an attempt has been made to identify the genetic factors that may confer risk or protection, not only for developing multiple sclerosis but also for determining the course of its evolution...
July 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28978801/metabolic-alterations-in-multiple-sclerosis-and-the-impact-of-vitamin-d-supplementation
#14
Pavan Bhargava, Kathryn C Fitzgerald, Peter A Calabresi, Ellen M Mowry
BACKGROUND: Our goal was to identify changes in the metabolome in multiple sclerosis (MS) and how vitamin D supplementation alters metabolic profiles in MS patients and healthy controls. METHODS: We applied global untargeted metabolomics to plasma from a cross-sectional cohort of age- and sex-matched MS patients and controls and a second longitudinal cohort of MS patients and healthy controls who received 5,000 IU cholecalciferol daily for 90 days. We applied partial least squares discriminant analysis, weighted correlation network analysis (WGCNA), and pathway analysis to the metabolomics data...
October 5, 2017: JCI Insight
https://www.readbyqxmd.com/read/28975580/vitamin-d-and-disability-in-relapsing-remitting-multiple-sclerosis-in-patients-with-a-mexican-background
#15
Yamel Rito, Jesus Flores, Angeles Fernández-Aguilar, Carmen Escalante-Membrillo, Miguel A Barboza, Lilyana Amezcua, Teresa Corona
Previous studies of multiple sclerosis (MS) patients have reported an inverse correlation between disability, the number of relapses and vitamin D levels in mostly white patients. It is unclear if this relationship has the same behavior in individuals with Hispanic backgrounds. To determine the relationship between vitamin D serum levels and disability in a sample of Hispanics of a Mexican background with relapsing-remitting multiple sclerosis (RRMS). A cross-sectional study was conducted on 50 RRMS individuals of Mexican background...
October 3, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28975037/effects-of-vitamin-d3-in-clinically-isolated-syndrome-and-healthy-control-participants-a-double-blind-randomised-controlled-trial
#16
Karen O'Connell, Jamal Sulaimani, Sharee A Basdeo, Katie Kinsella, Sinead Jordan, Orla Kenny, Siobhan B Kelly, David Murphy, Eric Heffernan, Ronan P Killeen, Keith Mulready, Marguerite MacMahon, Jennifer J Brady, Carmel McKenna, Ciaran Muldowney, Lorraine Cassidy, Cathal Walsh, Killian O'Rourke, Niall Tubridy, Chris McGuigan, Jean M Fletcher, Michael Hutchinson
BACKGROUND: Lowserum vitamin D levels are associated with susceptibility to, and severity of, multiple sclerosis. High dose vitamin D has been proposed as a potential immunomodulator in multiple sclerosis. OBJECTIVES: We performed a single centre, investigator-led, exploratory, double-blind, randomised, placebo controlled, trial of vitamin D3 in clinically isolated syndrome and healthy control participants to assess its immunological effects. Secondary end-points included clinical and magnetic resonance imaging outcomes and safety...
July 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28951256/serum-25-hydroxyvitamin-d-levels-in-multiple-sclerosis-patients-from-the-north-of-portugal
#17
Andreia Bettencourt, Daniela Boleixa, Henrique Reguengo, Raquel Samões, Ernestina Santos, José Carlos Oliveira, Berta Silva, Paulo Pinho Costa, Ana Martins da Silva
Increasing evidence has shown that individuals with Multiple Sclerosis (MS) have lower 25-hydroxyvitamin D [25(OH)D] levels compared to healthy controls. There is no information regarding 25(OH)D levels and MS in Portugal. Therefore the aim of the current study was to examine the levels of 25(OH)D in a group of patients with MS and in healthy matched controls, as well as the association of 25(OH)D levels with disease course, disability and severity. A group of 244 unrelated Portuguese patients, with a definitive diagnosis of MS, and 198 ethnically matched healthy controls were included in the study...
September 22, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28949008/vitamin-d-deficiency-accelerates-ageing-and-age-related-diseases-a-novel-hypothesis
#18
Michael J Berridge
Ageing can occur at different rates, but what controls this variable rate is unknown. Here I have developed a hypothesis that vitamin D may act to control the rate of ageing. The basis of this hypothesis emerged from studyng the various cellular processes that control ageing. These processes such as autophagy, mitochondrial dysfunction, inflammation, oxidative stress, epigenetic changes, DNA disorders and alterations in Ca(2+) and reactive oxygen species (ROS) signalling are all known to be regulated by vitamin D...
November 15, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28947637/vitamin-d-supplementation
#19
EDITORIAL
Ruth Dobson, Hannah R Cock, Peter Brex, Gavin Giovannoni
Vitamin D testing and supplementation is of great interest to neurologists and their patients. Recommended nutritional intakes of vitamin D in the UK remain focused on bone health, despite increasing evidence for a role outside this area. Here we discuss how neurologists might approach vitamin D testing and supplementation, focusing on two conditions associated with vitamin D deficiency that have an increased risk of downstream complications resulting from these: multiple sclerosis and epilepsy. We set out a rationale for testing serum 25-hydroxyvitamin D concentrations and discuss our personal practice in terms of supplementation, with evidence where available...
September 25, 2017: Practical Neurology
https://www.readbyqxmd.com/read/28946518/comparison-of-25-hidroksi-vitamin-d-serum-concentrations-in-patients-with-psoriasis-and-psoriatic-arthritis
#20
Mustafa Serdar Sağ, Sinem Sağ, İbrahim Tekeoğlu, Berna Solak, Ayhan Kamanlı, Kemal Nas, Halil Harman, Mine Kantar
BACKGROUND AND OBJECT: Rheumatoid arthritis (RA), insulin-dependent diabetes mellitus (IDDM), inflammatory bowel disease, systemic lupus erythematosus (SLE) and multiple sclerosis (MS) are some of the autoimmune diseases related to the decreases in Vitamin D levels. The same immunological properties as psoriasis, such as Th1/Th2 dysregulation, are seen in all of them. This study aims to compare 25-hidroksi Vitamin D (25-OHD) serum concentrations in patients with psoriasis and psoriatic arthritis...
September 8, 2017: Journal of Back and Musculoskeletal Rehabilitation
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