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https://www.readbyqxmd.com/read/28814709/spindle-cell-oncocytoma-of-the-anterior-pituitary-presenting-with-an-acute-clinical-course-due-to-intraventricular-hemorrhage-a-case-report-and-review-of-literature
#1
Mostafa Osman, Andrew Wild
BACKGROUND Spindle cell oncocytoma (SCO) is a rare nonfunctioning neoplasm of the adenohypophysis, and was first described in 2002. SCO has been categorized as a separate entity by the 2007 World Health Organization (WHO) and is classified as a Grade 1 tumor of the central nervous system (CNS). Review of the literature has shown that 33 cases of SCO have been reported to date, and most of them presented with a mass effect or with panhypopituitarism. However, all reported cases have described the tendency of SCO to be hypervascular on imaging and histology...
August 17, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28810081/a-risk-analysis-approach-to-prioritizing-epidemics-ebola-virus-disease-in-west-africa-as-a-case-study
#2
Whenayon Simeon Ajisegiri, Abrar Ahmad Chughtai, C Raina MacIntyre
The 2014 Ebola virus disease (EVD) outbreak affected several countries worldwide, including six West African countries. It was the largest Ebola epidemic in the history and the first to affect multiple countries simultaneously. Significant national and international delay in response to the epidemic resulted in 28,652 cases and 11,325 deaths. The aim of this study was to develop a risk analysis framework to prioritize rapid response for situations of high risk. Based on findings from the literature, sociodemographic features of the affected countries, and documented epidemic data, a risk scoring framework using 18 criteria was developed...
August 15, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28791520/external-ventricular-drain-causes-brain-tissue-damage-an-imaging-study
#3
Fabrizio Ortolano, Marco Carbonara, Antonella Stanco, Vittorio Civelli, Giorgio Carrabba, Tommaso Zoerle, Nino Stocchetti
BACKGROUND: An external ventricular drain (EVD) is used to measure intracranial pressure (ICP) and to drain cerebrospinal fluid (CSF). The procedure is generally safe, but parenchymal sequelae are reported as a possible side effect, with variable incidence. We investigated the mechanical sequelae of EVD insertion and their clinical significance in acute brain-injured patients, with a special focus on hemorrhagic lesions. METHODS: Mechanical sequelae of EVD insertion were detected in patients by computed tomography (CT) and magnetic resonance imaging (MRI), performed for clinical purposes...
August 8, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28791241/ebola-virus-disease-essential-clinical-knowledge
#4
REVIEW
Mahmoud Tawfik Khalafallah, Omar Ali Aboshady, Shaban Ahmed Moawed, Menna Said Ramadan
Since its initial outbreak in 1976, Ebola virus disease (EVD) has affected thousands of people, causing severe illness with high mortality rates. In the absence of a vaccine or effective specific treatment, as well as the lack of early diagnostic and detective methods, the EVD outbreak has generated a significant worldwide health concern. Insufficient health-care system resources, deficient infection control measures, and the shortage of appropriate personal protective equipment acted as amplifiers of the outbreak extension, especially in poorly resourced and unprepared communities...
July 2017: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/28789958/diagnosis-of-ventriculostomy-related-infection-is-cerebrospinal-fluid-lactate-measurement-a-useful-tool
#5
Pedro Grille, Federico Verga, Alberto Biestro
OBJECTIVE: To evaluate the value of CSF lactate (LCSF) for the diagnosis of ventriculostomy related infections (VRI), and compare it with other CSF markers. METHODS: Prospective study of neurocritical patients admitted to Maciel Hospital and Clinicas Hospital ICUs in which an external ventricular drain (EVD) was inserted. In patients with clinical suspicion of VRI, a CSF sample was obtained through the EVD for CSF culture and markers analysis (glucose, protein, lactate and leukocytes)...
August 5, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28781914/will-clinical-parameters-reliably-predict-external-ventricular-drain-associated-ventriculitis-is-frequent-routine-cerebrospinal-fluid-surveillance-necessary
#6
Omid Hariri, Saman Farr, Shokry Lawandy, Bailey Zampella, Dan Miulli, Javed Siddiqi
BACKGROUND: The placement of an external ventricular drain (EVD) for monitoring and treatment of increased intracranial pressure is not without risk, particularly for the development of associated ventriculitis. The goal of this study was to investigate whether changes in cerebrospinal fluid (CSF), serum, or clinical parameters are correlated with the development of ventriculitis before it occurs, allowing for the determination of optimal timing of CSF collection. METHODS: An observational retrospective study was conducted between January 2006 and May 2012...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28780838/-retrospective-analysis-of-the-discharge-outcome-of-external-ventricular-drainage-and-conservative-treatment-in-patients-with-severe-intraventricular-hemorrhage
#7
Y F Liu, H C Qiu, G F Zhao, J L Yang, G L Lü, J Lü, W M Kang, B Yan, J Liu, S M Zhao, W J Jiang
Objective: To investigate the discharge outcome of external ventricular drainage(EVD) and conservative treatment in patients with severe intraventricular hemorrhage (SeIVH). Methods: From January 2011 to December 2016, patients with SeIVH admitted to the General Hospital of the PLA Rocket Force and the Army General Hospital received EVD treatment and were classified as the treatment group. According to intraventricular hemorrhage volume and age, patients received conservative treatment were pair matched and classified as control group...
August 1, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28771956/knowledge-risk-perception-and-mitigation-measures-towards-ebola-virus-disease-by-potentially-exposed-bushmeat-handlers-in-north-central-nigeria-any-critical-gap
#8
N B Alhaji, S Yatswako, E Y Oddoh
The bushmeat industry has been a topic of increasing importance among public health officials for its influence on zoonotic diseases transmission, such as Ebola virus disease (EVD), a rare and severe infectious disease of humans and non-human primates. This survey assessed knowledge/awareness, risk perceptions and mitigation practices towards EVD among bushmeat handlers in north-central Nigeria. These characteristics are premise to level of preparedness against appropriate risk prevention and control. A questionnaire-based cross-sectional study was conducted between January and December 2015 on 395 bushmeat handlers...
August 3, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28768904/mapping-the-clinical-outcomes-and-genetic-evolution-of-ebola-virus-in-sierra-leone
#9
Tao Li, Hong-Wu Yao, Di Liu, Hong-Guang Ren, Yi Hu, David Kargbo, Yue Teng, Yong-Qiang Deng, Hui-Jun Lu, Xiong Liu, Kun Liu, Li-Qun Fang, Nian-Zhi Ning, Gary Wong, Foday Dafae, Abdul Kamara, AiPing Wu, Tai-Jiao Jiang, Zhan Li, Jie Huang, Yu Sun, Jun Qian, Brima Kargbo, Jia-Fu Jiang, Hui Wang, Wu-Chun Cao
Sierra Leone was the most severely affected country in Western Africa during the 2013-2016 outbreak of Ebola virus disease (EVD). Previous genome surveillance studies have revealed the origin, diversity, and evolutionary dynamics of the Ebola virus (EBOV); however, the information regarding EBOV sequences is insufficient, especially the clinical outcomes, given that the correlation between the clinical outcomes and the genetic evolution of EBOV is still not clear. Here, we collected and curated a comprehensive data set that includes 514 EBOV genome sequences from patients with confirmed EVD (including 60 sequences not previously studied), >87...
August 3, 2017: JCI Insight
https://www.readbyqxmd.com/read/28765409/the-uk-s-multidisciplinary-response-to-an-ebola-epidemic
#10
Sian Reece, Colin S Brown, Jake Dunning, Meera A Chand, Maria C Zambon, Michael Jacobs
The West African Ebola virus disease (EVD) epidemic was the largest and most devastating outbreak of EVD the world has ever seen. Its impact was felt far from the shores of Guinea, Liberia and Sierra Leone, with public health systems and clinicians across the globe confronted with an international response both in the affected region and within their own borders. The UK had a prominent role in response efforts, particularly in Sierra Leone. This article highlights how UK academic, health service, military, commercial and public health professionals all played a significant role both at home and abroad...
July 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28763151/supramolecular-architecture-of-substituted-tetraphenyl-carbo-benzenes-from-the-energetic-viewpoint
#11
Svitlana V Shishkina, Viktoriya V Dyakonenko, Oleg V Shishkin, Valérie Maraval, Remi Chauvin
The use of DFT-calculated energy-vector diagrams (EVDs) featuring the topology of pairwise intermolecular interaction energies is applied to crystals of carbo-benzenes. A homogeneous set of six ideally centrosymmetric tetraphenyl-carbo-benzenes is selected, with various substituents R in para positions: R=4-anisyl, 1-ethyl-2-phenyl-1H-indol-3-yl, 2-chloro-2-(1-ethyl-2-phenyl-1H-indol-3-yl)ethenyl, tetradecyl, and 9,9-dihexyl-9H-fluoren-2-yl, 2-(9,9-dihexyl-9H-fluoren-2-yl)ethynyl. The basic structural motifs (BSMs) of the crystals vary from layers to columns, depending on the size and shape of the substituents R...
August 1, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28761574/repurposed-therapeutic-agents-targeting-the-ebola-virus-a-systematic-review
#12
Hussein Sweiti, Obinna Ekwunife, Thomas Jaschinski, Stefan K Lhachimi
BACKGROUND: The Ebola virus has been responsible for numerous outbreaks since the 1970s, with the most recent outbreak taking place between 2014 and 2016 and causing an international public health emergency. Ebola virus disease (EVD) has a high mortality rate and no approved targeted treatment exists to date. A number of established drugs are being considered as potential therapeutic agents for the treatment of EVD. OBJECTIVE: We aimed to identify potential drug repositioning candidates and to assess the scientific evidence available on their efficacy...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28751468/overcoming-operational-challenges-to-ebola-case-investigation-in-sierra-leone
#13
Samuel T Boland, Erin Polich, Allison Connolly, Adam Hoar, Tom Sesay, Ahn-Minh A Tran
The Ebola virus disease (EVD) epidemic that hit West Africa in 2013 was the worst outbreak of EVD in recorded history. While much has been published regarding the international and national-level EVD responses, there is a dearth of literature on district-level coordination and operational structures, successes, and failures. This article seeks to understand how the EVD response unfolded at the district level, namely the challenges to operationalizing EVD surveillance over the course of the outbreak in Port Loko and Kambia districts of Sierra Leone...
July 27, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28748776/knowledge-attitudes-and-practices-among-members-of-households-actively-monitored-or-quarantined-to-prevent-transmission-of-ebola-virus-disease-margibi-county-liberia-february-march-2015
#14
Jason A Wilken, Paran Pordell, Brant Goode, Rachel Jarteh, Zayzay Miller, Benjamin G Saygar, Leroy Maximore, Watta M Borbor, Moses Carmue, Gregory W Walker, Adolphus Yeiah
BACKGROUND: In early 2015, a patient from a cluster of cases of Ebola Virus Disease (EVD) in Monrovia, Liberia traveled to a rural village in Margibi County, potentially exposing numerous persons. The patient died in the village and post-mortem testing confirmed Ebola Virus infection. Problem The Margibi County Health Team (CHT; Kakata, Margibi, Liberia) needed to prevent further transmission of EVD within and outside of the affected villages, and they needed to better understand the factors that support or impede compliance with measures to stop the spread of EVD...
July 27, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28741225/conversion-of-external-ventricular-drainage-to-ventriculo-peritoneal-shunt-to-change-or-not-to-change-the-proximal-catheter
#15
Jehuda Soleman, Haggai Benvenisti, Shlomi Constantini, Jonathan Roth
PURPOSE: In this study, we investigate the occurrence rate of early shunt infection and malfunction in pediatric patients after converting an external ventricular drainage (EVD) to a ventriculo-peritoneal shunt (VPS) without replacing the ventricular catheter. METHODS: Data was retrospectively reviewed for 17 pediatric patients (11 male (64.7%), mean age 7.5 years, range 0.25-15 years) who underwent 18 consecutive direct conversions of tunneled EVD to VPS without replacing the ventricular catheter between 2008 and 2017...
July 24, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28740846/the-transmission-chain-analysis-of-2014-2015-ebola-virus-disease-outbreak-in-koinadugu-district-sierra-leone-an-observational-study
#16
Ifeanyi-Stanley Muoghalu, Francis Moses, Ishata Conteh, Patrick Swaray, Anthonia Ajudua, Anders Nordström
INTRODUCTION: Sierra Leone experienced an unprecedented Ebola virus disease (EVD) outbreak in all its districts. Koinadugu District was the last to report an EVD case. Several outbreak response strategies were implemented. As part of lessons learnt, we conducted an observational study to describe the transmission chain in the district and the impact of the control measures implemented to contain the outbreak. METHODS: We reconstructed the transmission chain, positioning both confirmed and probable cases, described the distribution of the EVD confirmed cases in the context of the routes of transmission (Community, Funeral or Health facility setting) and assessed the impact of control measures using the surveillance data collected during the outbreak...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28732038/analysis-of-patient-data-from-laboratories-during-the-ebola-virus-disease-outbreak-in-liberia-april-2014-to-march-2015
#17
Yuki Furuse, Mosoka Fallah, Hitoshi Oshitani, Ling Kituyi, Nuha Mahmoud, Emmanuel Musa, Alex Gasasira, Tolbert Nyenswah, Bernice Dahn, Luke Bawo
An outbreak of Ebola virus disease (EVD) in Liberia began in March 2014 and ended in January 2016. Epidemiological information on the EVD cases was collected and managed nationally; however, collection and management of the data were challenging at the time because surveillance and reporting systems malfunctioned during the outbreak. EVD diagnostic laboratories, however, were able to register basic demographic and clinical information of patients more systematically. Here we present data on 16,370 laboratory samples that were tested between April 4, 2014 and March 29, 2015...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28726603/clinical-laboratory-values-as-early-indicators-of-ebola-virus-infection-in-nonhuman-primates
#18
Ronald B Reisler, Chenggang Yu, Michael J Donofrio, Travis K Warren, Jay B Wells, Kelly S Stuthman, Nicole L Garza, Sean A Vantongeren, Ginger C Donnelly, Christopher D Kane, Mark G Kortepeter, Sina Bavari, Anthony P Cardile
The Ebola virus (EBOV) outbreak in West Africa during 2013-2016 demonstrated the need to improve Ebola virus disease (EVD) diagnostics and standards of care. This retrospective study compared laboratory values and clinical features of 3 nonhuman primate models of lethal EVD to assess associations with improved survival time. In addition, the study identified laboratory values useful as predictors of survival, surrogates for EBOV viral loads, and triggers for initiation of therapeutic interventions in these nonhuman primate models...
August 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28723900/the-natural-history-of-acute-ebola-virus-disease-among-patients-managed-in-five-ebola-treatment-units-in-west-africa-a-retrospective-cohort-study
#19
Kelly Skrable, Reshma Roshania, Michaela Mallow, Vanessa Wolfman, Matthew Siakor, Adam C Levine
INTRODUCTION: Previous studies of Ebola Virus Disease (EVD) have focused on clinical symptoms and Ebola virus (EBOV) cycle threshold (CT) values recorded at patient triage. Our study explores EVD symptoms and EBOV CT values from onset of illness to recovery or death in a diverse population of patients. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed clinical care data from EBOV positive patients admitted to five Ebola treatment units in West Africa from 2014-2015. Prevalence of clinical signs/symptoms and CT values were explored using descriptive statistics...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28722621/health-care-access-during-the-ebola-virus-epidemic-in-liberia
#20
Patricia A McQuilkin, Kanagasabai Udhayashankar, Michelle Niescierenko, Louise Maranda
The Ebola virus disease (EVD) epidemic, which began in West Africa in December 2013, claimed more than 11,000 lives, with more than 4,800 of these deaths occurring in Liberia. The epidemic had an additional effect of paralyzing the health-care systems in affected countries, which led to even greater mortality and morbidity. Little is known about the impact that the epidemic had on the provision of basic health care. During the period from March to May 2015, we undertook a nationwide, community-based survey to learn more about health-care access during the EVD epidemic in Liberia...
July 10, 2017: American Journal of Tropical Medicine and Hygiene
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