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https://www.readbyqxmd.com/read/29053626/a-systematic-review-of-computational-drug-discovery-development-and-repurposing-for-ebola-virus-disease-treatment
#1
REVIEW
James Schuler, Matthew L Hudson, Diane Schwartz, Ram Samudrala
Ebola virus disease (EVD) is a deadly global public health threat, with no currently approved treatments. Traditional drug discovery and development is too expensive and inefficient to react quickly to the threat. We review published research studies that utilize computational approaches to find or develop drugs that target the Ebola virus and synthesize its results. A variety of hypothesized and/or novel treatments are reported to have potential anti-Ebola activity. Approaches that utilize multi-targeting/polypharmacology have the most promise in treating EVD...
October 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29033398/intensive-education-of-health-care-workers-improves-the-outcome-of-ebola-virus-disease-lessons-learned-from-the-2014-outbreak-in-sierra-leone
#2
Tracey Elizabeth Claire Jones-Konneh, Aya Murakami, Hiroyuki Sasaki, Shinichi Egawa
The rare and deadly Ebola virus disease (EVD) is caused by Ebola virus (EBOV) infection. The 2014-2015 EVD outbreak in West Africa was unprecedented. Person-to-person transmission of EBOV by direct contact with the body or bodily fluids of an infected person through broken skin or unprotected mucous membrane caused rapid outbreak in communities. Nosocomial infection was the cause of death of many health care workers (HCWs). This paper aims to reveal the importance and effect of intensive education of HCWs when combating an outbreak such as EVD...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29033375/intraprocedural-arterial-perforation-during-neuroendovascular-therapy-preliminary-result-of-a-dual-trained-endovascular-neurosurgeon-in-the-neurosurgical-hybrid-operating-room
#3
Yuang-Seng Tsuei, Chih-Hsiang Liao, Chung-Hsin Lee, Yea-Jiuan Liang, Wen-Hsien Chen, Shun-Fa Yang
BACKGROUND: Intraprocedural arterial perforation (IPAP) is a potentially dismal complication of neuroendovascular therapy with high mortality and morbidity rates. The management of IPAP with the techniques described has been well established, but rescue results from the dual-trained endovascular neurosurgeon in the neurosurgical hybrid operating room (OR) are rarely reported. Here, we report five cases of successful rescue of IPAP in the neurosurgical hybrid OR and compare them with other series...
October 12, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29020589/phase-2-placebo-controlled-trial-of-two-vaccines-to-prevent-ebola-in-liberia
#4
RANDOMIZED CONTROLLED TRIAL
Stephen B Kennedy, Fatorma Bolay, Mark Kieh, Greg Grandits, Moses Badio, Ripley Ballou, Risa Eckes, Mark Feinberg, Dean Follmann, Birgit Grund, Swati Gupta, Lisa Hensley, Elizabeth Higgs, Krisztina Janosko, Melvin Johnson, Francis Kateh, James Logue, Jonathan Marchand, Thomas Monath, Martha Nason, Tolbert Nyenswah, François Roman, Eric Stavale, Julian Wolfson, James D Neaton, H Clifford Lane
BACKGROUND: The safety and efficacy of vaccines to prevent Ebola virus disease (EVD) were unknown when the incidence of EVD was peaking in Liberia. METHODS: We initiated a randomized, placebo-controlled, phase 3 trial of the chimpanzee adenovirus 3 vaccine (ChAd3-EBO-Z) and the recombinant vesicular stomatitis virus vaccine (rVSV∆G-ZEBOV-GP) in Liberia. A phase 2 subtrial was embedded to evaluate safety and immunogenicity. Because the incidence of EVD declined in Liberia, the phase 2 component was expanded and the phase 3 component was eliminated...
October 12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29019800/academic-medical-support-to-the-ebola-virus-disease-outbreak-in-liberia
#5
Patricia A McQuilkin, Michelle Niescierenko, Ann Marie Beddoe, Jarod Goentzel, Elinor A Graham, Patricia C Henwood, Lise Rehwaldt, Sisay Teklu, Janis Tupesis, Roseda Marshall
During the Ebola Virus Disease (EVD) epidemic in West Africa (2014-2016), many faculty, staff, and trainees from U.S. academic medical centers (i.e., teaching hospitals and their affiliated medical schools; AMCs) wished to contribute to the response to the outbreak, but many barriers prevented their participation. Here, the authors describe a successful long-term academic collaboration in Liberia that facilitated participation in the EVD response. This Perspective outlines the role the authors played in the response (providing equipment and training, supporting the return of medical education), the barriers they faced (logistical and financial), and elements that contributed to their success (partnering and coordinating their response with both U...
October 10, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29018586/sex-practices-and-awareness-of-ebola-virus-disease-among-male-survivors-and-their-partners-in-guinea
#6
Mandy Kader Kondé, Moustapha Keita Diop, Marie Yvonne Curtis, Abdoulaye Barry, Saidou Kouyaté, Ludovica Ghilardi, Sékou Kouyaté, Aissatou Malal Diallo, N'faly Magassouba, Isadora Quick, Mory Keïta, Miles W Carroll, Josep Jansa, Lorenzo Subissi
INTRODUCTION: Towards the end of the 2013-2016 West African outbreak, sexually-transmitted Ebola virus re-emerged from Ebola virus disease (EVD) survivors in all three hardest hit countries. We explore sex practices and awareness of the risk of Ebola virus transmission among EVD survivors and their partners. METHODS: In this cross-sectional study, we recruited a convenience sample of study participants aged >15 years who were male EVD survivors, their sexual partners and a comparison group...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29017364/can-patients-safely-be-admitted-to-a-ward-after-craniotomy-for-resection-of-intra-axial-brain-tumors
#7
Farhan A Mirza, Catherine Wang, Thomas Pittman
OBJECTIVE: We reviewed the safety of our practice of admitting patients who have undergone a craniotomy for resection of an intra-axial brain tumor to a floor bed instead of an ICU. We also tried to quantify the risk that patients electively admitted to the ICU would develop a problem that could not have been effectively managed on the ward. METHODS: A retrospective chart review was performed of both adult and pediatric patients who underwent craniotomy by the senior author for resection of an intra-axial brain tumor between January 2012 and December 2015...
October 11, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28991915/analysing-published-global-ebola-virus-disease-research-using-social-network-analysis
#8
Christiane Hagel, Felix Weidemann, Stephan Gauch, Suzanne Edwards, Peter Tinnemann
INTRODUCTION: The 2014/2015 West African Ebola Virus Disease (EVD) outbreak attracted global attention. Numerous opinions claimed that the global response was impaired, in part because, the EVD research was neglected, although quantitative or qualitative studies did not exist. Our objective was to analyse how the EVD research landscape evolved by exploring the existing research network and its communities before and during the outbreak in West Africa. METHODS/ PRINCIPAL FINDINGS: Social network analysis (SNA) was used to analyse collaborations between institutions named by co-authors as affiliations in publications on EVD...
October 9, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28989043/cerebrospinal-fluid-leak-at-percutaneous-exit-of-ventricular-catheter-as-crucial-risk-factor-for-external-ventricular-drainage-related-infection-in-adult-neurosurgical-patients
#9
Jaechan Park, Yeon-Ju Choi, Boram Ohk, Hyun-Ha Chang
OBJECTIVE: The placement of a ventricular catheter for temporary cerebrospinal fluid (CSF) diversion is associated with a considerable risk of CSF infection. The authors investigated the effect of a CSF leak on CSF-related infection and the predisposing factors for a CSF leak. METHODS: Fifty-two patients who underwent external ventricular drainage (EVD) for acute hydrocephalus associated with a subarachnoid hemorrhage (SAH) or intraventricular hemorrhage (IVH) were enrolled in this prospective study...
October 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28987840/endovascular-treatment-of-ruptured-vertebrobasilar-dissecting-aneurysms-using-flow-diversion-embolization-devices-single-institution-experience
#10
Waldo R Guerrero, Santiago Ortega-Gutierrez, Minako Hayakawa, Colin P Derdeyn, James D Rossen, David Hasan, Edgar A Samaniego
OBJECTIVE: Treatment of ruptured posterior circulation dissecting aneurysms is technically challenging with potentially high morbidity and mortality. We sought to assess the safety and feasibility of using a flow diversion devices (FDD) and a specific acute antiplatelet aggregation protocol in the management of ruptured dissecting aneurysms. METHODS: Subjects with ruptured dissecting aneurysms treated during a three-year period were retrospectively identified from a prospective registry...
October 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28977500/monitoring-of-returnees-from-ebola-affected-areas-lessons-learned-based-on-the-experience-of-french-armed-forces-deployed-in-guinea-2015
#11
Ghislain Manet, Gabriel Bédubourg, Guillaume Velut, Franck de Laval, Aurélie Mayet, Aissata Dia, Franck Berger, Benoît Quentin, Jean-Baptiste Meynard, Rémy Michel, Sandrine Duron
Introduction: During the 2014-15 Ebola virus disease (EVD) outbreak in West Africa, French armed forces were involved in the treatment and management of Ebola patients in Guinea. The constant flow of military personnel returning from their deployment posed a risk of secondary dissemination of the Ebola virus. Our objective was to describe the follow-up of returning service members that was implemented to prevent this risk of dissemination in France. Method: For the French military, a specific complementary follow-up was added to the national monitoring to take into account the need for a detailed record for follow-up of returning military personnel and to keep the military chain of command informed...
August 31, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28970766/hand-hygiene-practices-post-ebola-virus-disease-outbreak-in-a-nigerian-teaching-hospital
#12
S O Martins, A O Osiyemi
INTRODUCTION: Ebola virus disease (EVD) is a highly contagious viral infection that requires a high risk perception and practice of good hand hygiene by regular hand washing or use of hand sanitizers for infection control at all time. The declaration of Nigeria as an Ebola-free country by the World Health Organization on the 20th of October, 2014 has prompted many Nigerians, including healthcare workers, to discontinue the regular practice of good hand hygiene which was commonplace during the EVD outbreak...
June 2017: Annals of Ibadan Postgraduate Medicine
https://www.readbyqxmd.com/read/28964945/validation-of-a-predictive-scoring-system-for-ventriculoperitoneal-shunt-insertion-following-aneurysmal-subarachnoid-hemorrhage
#13
Raghav Gupta, Luis C Ascanio, Alejandro Enriquez-Marulanda, Christoph J Griessenauer, Anu Chinnadurai, Ray Jhun, Abdulrahman Alturki, Christopher S Ogilvy, Ajith J Thomas, Justin M Moore
INTRODUCTION: Hydrocephalus is a frequently encountered complication in the context of aneurysmal subarachnoid hemorrhage (aSAH). Here, we performed an external validation of the recently proposed Post-Subarachnoid Shunt Scoring (PS3) system, which aims to stratify patients presenting with aSAH based on their relative risk of requiring ventriculoperitoneal (VP) shunt insertion. MATERIALS AND METHODS: A retrospective review of all patients presenting with aSAH to our institution between July 2007 and December 2016, who underwent CT imaging at the time of hospital admission, was performed...
September 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28963177/infant-feeding-policy-and-programming-during-the-2014-2015-ebola-virus-disease-outbreak-in-sierra-leone
#14
Amelia Brandt, Óscar Serrano Oria, Mustapha Kallon, Alessandra N Bazzano
Optimal breastfeeding is of vital importance to infant and child health and has been adopted by countries as a standard recommendation. However, in the context of an infectious disease outbreak, especially when the disease is poorly understood, policy makers must balance the benefits of breastfeeding against the risk of disease transmission through breastfeeding. During the 2014-2015 Ebola Virus Disease (EVD) outbreak in Sierra Leone, the development of correct and consistent messaging about infant feeding and nutrition programming was considerably delayed by numerous challenges...
September 27, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28958444/a-pilot-survey-of-the-u-s-medical-waste-industry-to-determine-training-needs-for-safely-handling-highly-infectious-waste
#15
Aurora B Le, Selin Hoboy, Anne Germain, Hal Miller, Richard Thompson, Jocelyn J Herstein, Katelyn C Jelden, Elizabeth L Beam, Shawn G Gibbs, John J Lowe
BACKGROUND: The recent Ebola outbreak led to the development of Ebola virus disease (EVD) best practices in clinical settings. However, after the care of EVD patients, proper medical waste management and disposal was identified as a crucial component to containing the virus. Category A waste-contaminated with EVD and other highly infectious pathogens-is strictly regulated by governmental agencies, and led to only several facilities willing to accept the waste. METHODS: A pilot survey was administered to determine if U...
September 25, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28956308/bedside-transcranial-sonography-monitoring-in-a-patient-with-hydrocephalus-post-subarachnoid-hemorrhage
#16
Ahmed Najjar, André Y Denault, Michel W Bojanowski
BACKGROUND: Development of hydrocephalus can occur after subarachnoid hemorrhage (SAH). Typically, it is diagnosed with computed tomography, CT, scan. However, transcranial sonography (TCS) can be used particularly in patients with craniotomy which removes the acoustic interference of the skull and allows a closer up visualization of brain structures through the skin. CASE PRESENTATION: We report a 73-year-old woman who was hospitalized for SAH and developed acute hydrocephalus requiring an external ventricular drain (EVD)...
September 27, 2017: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/28951472/ebola-virus-binding-to-tim-1-on-t-lymphocytes-induces-a-cytokine-storm
#17
Patrick Younan, Mathieu Iampietro, Andrew Nishida, Palaniappan Ramanathan, Rodrigo I Santos, Mukta Dutta, Ndongala Michel Lubaki, Richard A Koup, Michael G Katze, Alexander Bukreyev
Ebola virus (EBOV) disease (EVD) results from an exacerbated immunological response that is highlighted by a burst in the production of inflammatory mediators known as a "cytokine storm." Previous reports have suggested that nonspecific activation of T lymphocytes may play a central role in this phenomenon. T-cell immunoglobulin and mucin domain-containing protein 1 (Tim-1) has recently been shown to interact with virion-associated phosphatidylserine to promote infection. Here, we demonstrate the central role of Tim-1 in EBOV pathogenesis, as Tim-1(-/-) mice exhibited increased survival rates and reduced disease severity; surprisingly, only a limited decrease in viremia was detected...
September 26, 2017: MBio
https://www.readbyqxmd.com/read/28939358/recrudescence-of-ebola-virus-disease-outbreak-in-west-africa-2014-2016
#18
Hyojung Lee, Hiroshi Nishiura
OBJECTIVES: There have been errors in determining the end of the Ebola virus disease (EVD) epidemic when adhering to the criteria of the World Health Organization. The present study aimed to review and learn from all known recrudescence events in West Africa occurring in 2014-2016. METHODS: Background mechanisms of five erroneous declarations in Guinea, Liberia, and Sierra Leone during 2014-2016 were reviewed. RESULTS: Three cases of recrudescence were suspected to have been caused by sexual contact with survivors, one to be due to international migration, and one was linked to a potentially immunocompromised mother...
September 20, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28937795/using-mystery-patient-drills-to-assess-hospital-ebola-preparedness-in-new-york-city-2014-2015
#19
Mary Foote, Roshni Daver, Celia Quinn
In response to the Ebola virus disease (EVD) outbreak in West Africa, rapid measures were taken to ensure readiness at frontline New York City (NYC) healthcare facilities, including mandating monthly EVD mystery patient drills to test screening protocols. This study analyzed after-action reports to describe the use of mystery patient drills to test rapid identification and isolation of potential EVD cases in NYC emergency departments. NYC hospitals were required to develop protocols for EVD screening and isolation, and to conduct drills with an actor presenting to the emergency department with symptoms suggestive of EVD...
September 22, 2017: Health Security
https://www.readbyqxmd.com/read/28932714/evaluation-of-clinicians-reporting-proficiency-and-their-risk-perceptions-of-ebola-virus-disease-in-ebonyi-state-nigeria
#20
Nnennaya Anthony Ajayi, Chiedozie Kingsley Ojide, Immanuel Anthony Ajayi, Kingsley Nnanna Ukwaja
INTRODUCTION: Ebola virus disease (EVD) is a highly contagious infection with a high case fatality rate. Thus, there is a crucial need for early detection and reporting of any individual suspected to have EVD in order to facilitate containment strategies. The aim of our study was to evaluate clinicians' reporting proficiency and their risk perceptions of EVD in Ebonyi State, Nigeria. METHODS: We performed a descriptive cross-sectional study conducted among clinicians...
September 2017: Germs
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