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https://www.readbyqxmd.com/read/28094208/multidisciplinary-assessment-of-post-ebola-sequelae-in-guinea-postebogui-an-observational-cohort-study
#1
Jean-François Etard, Mamadou Saliou Sow, Sandrine Leroy, Abdoulaye Touré, Bernard Taverne, Alpha Kabinet Keita, Philippe Msellati, N'Fally Magassouba, Sylvain Baize, Hervé Raoul, Suzanne Izard, Cécé Kpamou, Laura March, Ibrahima Savane, Moumié Barry, Eric Delaporte
BACKGROUND: The high number of survivors from the 2013-16 west African outbreak of Ebola virus disease (EVD) has raised several new issues: long-term clinical complications, psychosocial consequences, risks of EVD reactivation, and secondary transmission due to viral persistence in body fluids. We aimed to assess long-term clinical, psychosocial, and viral outcomes in EVD survivors in Guinea. METHODS: In this multidisciplinary observational cohort study, we recruited patients aged 1 year or more in four sites in Guinea (Donka National Hospital, Conakry; Macenta Prefectoral Hospital, Macenta; N'zérékoré Regional Hospital, N'zérékoré; and Forécariah Prefectoral Hospital, Forécariah) following discharge from any Ebola treatment centre in Guinea...
January 13, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28089808/stress-induced-hyperglycemia-after-spontaneous-subarachnoid-hemorrhage-and-its-role-in-predicting-cerebrospinal-fluid-diversion
#2
Bappaditya Ray, Ayumi Ludwig, Lori K Yearout, David M Thompson, Bradley N Bohnstedt
BACKGROUND: Stress induced hyperglycemia (SIH) after acute cerebrovascular disease is common and is associated with adverse clinical outcomes. Incidence of SIH after spontaneous subarachnoid hemorrhage (SAH) and its role in shunt placement has not been systematically investigated. Present study is designed to investigate the incidence of SIH after spontaneous SAH and its determinants. Role of SIH and premorbid hyperglycemia (using glycated hemoglobin, HbA1c) in predicting external ventricular drainage (EVD) and ventriculoperitoneal shunt (VPS) placement is also investigated...
January 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28065333/preparedness-planning-and-care-of-patients-under-investigation-for-or-with-ebola-virus-disease-a-survey-of-physicians-in-north-america
#3
Jessica D Lewis, Kyle B Enfield, Trish M Perl, Costi D Sifri
The West African Ebola virus disease (EVD) epidemic of 2014-2015 required North American hospitals to undertake comprehensive planning and training for the potential need to care for patients with EVD. Here we describe physician contributions to EVD preparedness planning and the care of persons under investigation for or patients with EVD.
January 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28061463/prevalence-of-psychological-symptoms-among-ebola-survivors-and-healthcare-workers-during-the-2014-2015-ebola-outbreak-in-sierra-leone-a-cross-sectional-study
#4
Dong Ji, Ying-Jie Ji, Xue-Zhang Duan, Wen-Gang Li, Zhi-Qiang Sun, Xue-Ai Song, Yu-Hua Meng, Hong-Mei Tang, Fang Chu, Xiao-Xia Niu, Guo-Feng Chen, Jin Li, Hui-Juan Duan
The 2014-2015 Ebola epidemic was considered to be the largest and most complex outbreak, which caused 11,310 reported deaths. The epidemic disease can cause a mental health crisis, however, there is only a small amount of scientific literature available related to this health issue so far. We evaluated the psychological symptoms of 161 participants including Ebola survivors and healthcare workers in Sierra Leone, analyzed the impact of job classification, education level on psychological status. We found that the order of total general severity index (GSI) scores from high to low was EVD survivors, SL medical staff, SL logistic staff, SL medical students, and Chinese medical staff...
January 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28059659/antiplatelet-therapy-for-the-prevention-of-peri-coiling-thromboembolism-in-high-risk-patients-with-ruptured-intracranial-aneurysms
#5
Nancy J Edwards, Wesley H Jones, Aditya Sanzgiri, Juan Corona, Mark Dannenbaum, Peng Roc Chen
OBJECTIVE The most frequent procedural complication of the endovascular treatment of intracranial aneurysms is a thromboembolic event (TEE); in a subset of patients, such events will cause permanent neurological disability. In patients with unruptured aneurysms, increasing evidence supports the use of periprocedural antiplatelet therapy to prevent TEEs. The object of this study was to evaluate whether patients with ruptured aneurysms and subarachnoid hemorrhage would also benefit from periprocedural antiplatelet therapy...
January 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28057165/current-and-future-diagnostic-tests-for-ebola-virus-disease
#6
Bharti Singh, Advaita Ganguly, Hoon H Sunwoo
Ebola virus disease (EVD) is a major public health concern with a high mortality rate in infected individuals. Outbreaks of Ebola have been widespread-there is no rapid, sensitive, specific, and affordable diagnostic test for the virus, nor there is any treatment for the disease. Overlapping symptoms of other endemic diseases, such as malaria and cholera, make it difficult to diagnose EVD. For clinical management, outbreak investigation, and proper surveillance, EVD requires a detection system, which should be fast, sensitive, specific, efficient, affordable, and user-friendly with in-country staff...
October 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28050444/review-of-the-management-of-peroral-extrusion-of-ventriculoperitoneal-shunt-catheter
#7
REVIEW
Rajendra Kumar Ghritlaharey
INTRODUCTION: Peroral extrusion of peritoneal part of Ventriculoperitoneal Shunt (VPS) catheter is an extremely rare complication following VPS implantation. AIM: To review the options available for the management of peroral extrusion of VPS catheter. MATERIALS AND METHODS: PubMed, Medline, PMC (PubMed Central), Embase, Google scholar databases search was performed to retrieve the published/available data relating to the peroral extrusion of VPS catheter...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28042619/beating-the-odds-successful-establishment-of-a-phase-ii-iii-clinical-research-trial-in-resource-poor-liberia-during-the-largest-ever-ebola-outbreak
#8
J Doe-Anderson, B Baseler, P Driscoll, M Johnson, J Lysander, L McNay, W S Njoh, M Smolskis, L Wehrlen, J Zuckerman
It has been argued that a country such as Liberia, not fully recovered from the devastation of decades of civil unrest, lacked the appropriate ethical and regulatory framework, basic human and health care services, and infrastructure to carry out clinical trials according to international standards of quality during a public health emergency. However, as Liberia, Sierra Leone, and Guinea were being ravaged by the largest and most devastating Ebola Virus Disease (EVD) outbreak ever recorded, the topic of conducting clinical trials of experimental vaccine and treatment candidates in these resource-poor countries generated the keen interest and concern of scientists, researchers, physicians, bioethicists, philanthropists, and even politicians...
December 15, 2016: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/28042365/variations-in-strategies-to-prevent-ventriculostomy-related-infections-a-practice-survey
#9
Ariane Lewis, Barry M Czeisler, Aaron S Lord
BACKGROUND AND PURPOSE: The ideal strategy to prevent infections in patients with external ventricular drains (EVDs) is unclear. METHODS: We conducted a cross-sectional survey of members of the Neurocritical Care Society on infection prevention practices for patients with EVDs between April and July 2015. RESULTS: The survey was completed by 52 individuals (5% response rate). Catheter selection, use of prolonged prophylactic systemic antibiotics (PPSAs), cerebrospinal fluid (CSF) collection policies, location of EVD placement, and performance of routine EVD exchanges varied...
January 2017: Neurohospitalist
https://www.readbyqxmd.com/read/28042016/spontaneous-intraventricular-hemorrhage-a-rare-presentation-of-a-skull-base-mesenchymal-chondrosarcoma
#10
Altaf Ali Laghari, Gohar Javed, Muhammad Faheem Khan, Syed Ijlal Ahmed, Karim Rizwan Nathani, Riyasat Ahmed
INTRODUCTION: Chondrosarcomas (CSA) are very rare malignant slow growing tumors which develop in or near the petroclival region of the brain. We report our experience of a very rare case in which the tumor originated from left petrous bone and induced intraventricular hemorrhage (IVH) leading to an acute comatose presentation. CASE DESCRIPTION: A 28 year old male initially presented in outpatient department (OPD) with a 1 month history of headache, vomiting, vertigo and left facial numbness...
December 29, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28034809/trends-in-ventriculostomy-associated-infections-and-mortality-in-aneurysmal-subarachnoid-hemorrhage-data-from-the-nationwide-inpatient-sample
#11
Roy Poblete, Ling Zheng, Ranjita Raghavan, Steven Cen, Arun Amar, Nerses Sanossian, William Mack, May Kim-Tenser
BACKGROUND: Patients with aneurysmal subarachnoid hemorrhage (aSAH) are susceptible to various medical complications, including ventriculostomy-associated infections (VAIs) in those who undergo external ventricular drain (EVD) placement. Many VAI preventative strategies have been utilized over the last 20 years, but their overall effect is unknown. Using the Nationwide (National) Inpatient Sample (NIS), this study examines trends in VAI rates and mortality over a recent 12-year period in the aSAH population...
December 26, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28030717/pathologic-evaluation-of-skin-tumors-with-ex-vivo-dermoscopy-with-derm-dotting
#12
Marc Haspeslagh, Isabelle Hoorens, Nele Degryse, Ine De Wispelaere, Annemarie Degroote, Sarah Van Belle, Jan Verboven, Katrien Vossaert, Fabio Facchetti, Jo Van Dorpe, Sofie De Schepper, Lieve Brochez
Importance: Ex vivo dermoscopy (EVD) with derm dotting (DD) improves clinicopathologic correlation and the quality of diagnosis in skin tumors. Objective: To compare the diagnostic performance of the standard method of skin biopsy processing with the practice of EVD with DD. Design, Setting, and Participants: This retrospective study compares the diagnostic performance in 6526 skin biopsy specimens examined from 2008 to 2010 with a standard method of processing with 8584 biopsy specimens examined in 2015 with EVD and DD...
December 28, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/28029089/perception-of-measures-for-dealing-with-ebola-disease-in-primary-care
#13
Carme Roca Saumell, Anna Aguilar Margalejo, Silvia Barro Lugo, Dolors Sànchez Collado
BACKGROUND: An epidemic of Ebola virus disease (EVD) occurred in West Africa in 2014. In Catalonia, primary care is the first level of healthcare so it has a key role in the detection and initial management of possible cases of EVD and in identifying contacts. AIM: This study aimed to find out how the staff of primary care centers perceived the measures for dealing with EVD. METHOD: An online questionnaire was distributed to all primary care workers in Catalonia during the period February-March 2015...
December 28, 2016: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28024977/external-ventricular-drain-related-infection-in-spontaneous-intracerebral-hemorrhage
#14
Samir Cezimbra Dos Santos, Telmo Tiburcio Fortes Lima, Luciano Werle Lunardi, Marco Antonio Stefani
OBJECTIVE: To analyze infection rates in a series of patients with spontaneous intracranial hemorrhage who underwent surgical external ventricular drain (EVD) placement. METHODS: This prospective study included patients who required EVD for spontaneous intracranial hemorrhage at the Neurosurgery Department of Hospital Cristo Redentor (HCR), Porto Alegre, Rio Grande do Sul, Brazil. Overall, 94 consecutive patients were included. RESULTS: The mean duration of EVD use was 7 days...
December 23, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28024952/real-time-dynamic-modelling-for-the-design-of-a-cluster-randomized-phase-3-ebola-vaccine-trial-in-sierra-leone
#15
A Camacho, R M Eggo, N Goeyvaerts, A Vandebosch, R Mogg, S Funk, A J Kucharski, C H Watson, T Vangeneugden, W J Edmunds
BACKGROUND: Declining incidence and spatial heterogeneity complicated the design of phase 3 Ebola vaccine trials during the tail of the 2013-16 Ebola virus disease (EVD) epidemic in West Africa. Mathematical models can provide forecasts of expected incidence through time and can account for both vaccine efficacy in participants and effectiveness in populations. Determining expected disease incidence was critical to calculating power and determining trial sample size. METHODS: In real-time, we fitted, forecasted, and simulated a proposed phase 3 cluster-randomized vaccine trial for a prime-boost EVD vaccine in three candidate regions in Sierra Leone...
December 23, 2016: Vaccine
https://www.readbyqxmd.com/read/28018915/ebola-virus-infection-among-western-healthcare-workers-unable-to-recall-the-transmission-route
#16
REVIEW
Stefano Petti, Carmela Protano, Giuseppe Alessio Messano, Crispian Scully
Introduction. During the 2014-2016 West-African Ebola virus disease (EVD) outbreak, some HCWs from Western countries became infected despite proper equipment and training on EVD infection prevention and control (IPC) standards. Despite their high awareness toward EVD, some of them could not recall the transmission routes. We explored these incidents by recalling the stories of infected Western HCWs who had no known directly exposures to blood/bodily fluids from EVD patients. Methodology. We carried out conventional and unconventional literature searches through the web using the keyword "Ebola" looking for interviews and reports released by the infected HCWs and/or the healthcare organizations...
2016: BioMed Research International
https://www.readbyqxmd.com/read/28012890/a-simple-infection-control-protocol-durably-reduces-external-ventricular-drain-infections-to-near-zero-levels
#17
Alexander C Flint, Shahed Toossi, Sheila L Chan, Vivek A Rao, William Sheridan
OBJECTIVE: External ventricular drains (EVDs) historically have a high rate of infection, and EVD infections are a cause of significant morbidity and mortality. We have previously shown that a simple infection control protocol reduced the rate of EVD infections over a 3-year period, and the present study examines whether infection rates were durably reduced over an additional 4 years. METHODS: Retrospective analysis of EVDs placed in the ICU of a tertiary Neurosurgical center over an additional 4 year follow-up period...
December 21, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28011610/characteristics-and-outcomes-of-pediatric-patients-with-ebola-virus-disease-admitted-to-treatment-units-in-liberia-and-sierra-leone-a-retrospective-cohort-study
#18
Michael A Smit, Ian C Michelow, Justin Glavis-Bloom, Vanessa Wolfman, Adam C Levine
BACKGROUND: The clinical and virologic characteristics of Ebola virus disease (EVD) in children have not been thoroughly documented. METHODS: Consecutive children aged <18 years with real-time polymerase chain reaction (RT-PCR)-confirmed EVD were enrolled retrospectively in 5 Ebola treatment units in Liberia and Sierra Leone in 2014/2015. Data collection and medical management were based on standardized International Medical Corps protocols. We performed descriptive statistics, multivariate logistic regression, and Kaplan-Meier survival analyses...
February 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28003349/assessment-and-optimization-of-the-genexpert-diagnostic-platform-for-detection-of-ebola-virus-rna-in-seminal-fluid
#19
James Pettitt, Elizabeth Higgs, Mosoka Fallah, Martha Nason, Eric Stavale, Jonathan Marchand, Cavan Reilly, Kenneth Jensen, Bonnie Dighero-Kemp, Kaylie Tuznik, James Logue, Fatorma Bolay, Lisa Hensley
Recent studies have suggested that Ebola virus (EBOV) RNA potentially present in the semen of a large number of survivors of Ebola virus disease (EVD) in Western Africa may contribute to sexual transmission of EVD and generate new clusters of cases in regions previously declared EBOV free. These findings drive the immediate need for a reliable, rapid, user-friendly assay for detection of EBOV RNA in semen that is deployable to multiple sites across Western Africa. In this study, we optimized the Xpert EBOV assay for semen samples by adding dithiothreitol...
December 21, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28000129/management-of-external-ventricular-drains-after-subarachnoid-hemorrhage-a-multi-institutional-survey
#20
David Y Chung, Thabele M Leslie-Mazwi, Aman B Patel, Guy A Rordorf
BACKGROUND: Patients with aneurysmal subarachnoid hemorrhage (SAH) often develop hydrocephalus requiring an external ventricular drain (EVD). The best available evidence suggests that a rapid EVD wean and intermittent CSF drainage is safe, reduces complications, and shortens ICU and hospital length of stay as compared to a gradual wean and continuous drainage. However, optimal EVD management remains controversial and the baseline practice among neurological ICUs is unclear. Therefore, we sought to determine current institutional practices of EVD management for patients with aneurysmal SAH...
December 20, 2016: Neurocritical Care
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