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https://www.readbyqxmd.com/read/29227420/us-state-public-health-departments-special-pathogen-planning
#1
Jocelyn J Herstein, Paul D Biddinger, Shawn G Gibbs, Aurora B Le, Katelyn C Jelden, Angela L Hewlett, John J Lowe
CONTEXT: US state public health departments played key roles in planning for and responding to confirmed and suspected cases of Ebola virus disease (EVD) during the 2014-2016 outbreak, including designating select hospitals as high-level isolation units (HLIUs) for EVD treatment in conjunction with the Centers for Disease Control and Prevention. OBJECTIVE: To identify existing guidelines and perspectives of state health departments pertaining to the management and transport of patients with EVD and other highly hazardous communicable diseases (HHCDs)...
December 7, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29210303/treatment-focused-ebola-trials-supportive-care-and-future-of-filovirus-care
#2
Maryam Keshtkar-Jahromi, Karen A O Martins, Anthony Cardile, Ronald Reisler, George W Christopher, Sina Bavari
During the 2014-2016 Ebolavirus (EBOV) outbreak, several candidate therapeutics were used in EBOV-infected patients in clinical trials and under expanded access for emergency use. This review will focus briefly on medications used during the outbreak. We will discuss current therapeutic candidates and their status and will then turn to a related and essential topic: supportive care and the standard of care for filovirus infected patients. Potential benefits and pitfalls of combination therapies for filoviruses will be discussed...
December 6, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29208326/a-review-on-the-antagonist-ebola-a-prophylactic-approach
#3
REVIEW
Fatima Nazish Khan, Sahar Qazi, Khushnuma Tanveer, Khalid Raza
Ebola virus (EBOV), a member of Filoviridae virus family under the genus Ebolavirus, has emerged as a dangerous and potential threat to human health globally. It causes a severe and deadly hemorrhagic fever in humans and other mammals, called Ebola Virus Disease (EVD). In recent outbreaks of EVD, there has been loss of large numbers of individual's life. Therefore, EBOV has attracted researchers and increased interests in developing new models for virus evolution, and therapies. The EBOV interacts with the immune system of the host which led to understand how the virus functions and effects immune system behaviour...
December 2, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29206076/assessment-of-the-ability-of-v920-recombinant-vesicular-stomatitis-zaire-ebolavirus-vaccine-to-replicate-in-relevant-arthropod-cell-cultures-and-vector-species
#4
Nicholas A Bergren, Megan R Miller, Thomas P Monath, Rebekah C Kading
V920, rVSVΔG-ZEBOV-GP, is a recombinant vesicular stomatitis-Zaire ebolavirus vaccine which has shown an acceptable safety profile and provides a protective immune response against Ebola virus disease (EVD) induced by Zaire ebolavirus in humans. The purpose of this study was to determine whether the V920 vaccine is capable of replicating in arthropod cell cultures of relevant vector species and of replicating in live mosquitoes. While the V920 vaccine replicated well in Vero cells, no replication was observed in Anopheles or Aedes mosquito, Culicoides biting midge, or Lutzomyia sand fly cells, nor in live Culex or Aedes mosquitoes following exposure through intrathoracic inoculation or feeding on a high-titer infectious blood meal...
December 5, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29202089/the-role-of-risk-perception-in-willingness-to-respond-to-the-2014-2016-west-african-ebola-outbreak-a-qualitative-study-of-international-health-care-workers
#5
Stephanie Gee, Morten Skovdal
Background: The 2014-2016 West Africa Ebola Virus Disease (EVD) outbreak was an unprecedented public health event, and in addition to claiming over 11,000 lives, it resulted in the deaths of more healthcare workers than any outbreak in recent history. While a cadre of willing and able health workers is essential for an effective epidemic response, health workforce capacity in times of crisis may be significantly impacted by how risks are perceived by health staff. This study aimed to explore how risk perceptions influenced healthcare workers' willingness to respond during this outbreak...
2017: Global Health Research and Policy
https://www.readbyqxmd.com/read/29190713/operational-evaluation-of-rapid-diagnostic-testing-for-ebola-virus-disease-in-guinean-laboratories
#6
Amanda VanSteelandt, Josephine Aho, Kristyn Franklin, Jacques Likofata, Jean Baptiste Kamgang, Sakoba Keita, Lamine Koivogui, N'Faly Magassouba, Lise D Martel, Anicet George Dahourou
BACKGROUND: Rapid Diagnostic Tests (RDTs) for Ebola Virus Disease (EVD) at the point of care have the potential to increase access and acceptability of EVD testing and the speed of patient isolation and secure burials for suspect cases. A pilot program for EVD RDTs in high risk areas of Guinea was introduced in October 2015. This paper presents concordance data between EVD RDTs and PCR testing in the field as well as an assessment of the acceptability, feasibility, and quality assurance of the RDT program...
2017: PloS One
https://www.readbyqxmd.com/read/29188127/enhancing-ebola-virus-disease-surveillance-and-prevention-in-counties-without-confirmed-cases-in-rural-liberia-experiences-from-sinoe-county-during-the-flare-up-in-monrovia-april-to-june-2016
#7
Vera Darling Weah, John S Doedeh, Samson Q Wiah, Emmanuel Nyema, Siafa Lombeh, Jeremias Naiene
Introduction: During the flare-ups of Ebola virus disease (EVD) in Liberia, Sinoe County reactivated the multi-sectorial EVD control strategy in order to be ready to respond to the eventual reintroduction of cases. This paper describes the impacts of the interventions implemented in Sinoe County during the last flare-up in Monrovia, from April 1 to June 9, 2016, using the resources provided during the original outbreak that ended a year ago. Methods: We conducted a descriptive study to describe the key interventions implemented in Sinoe County, the capacity available, the implications for the reactivation of the multi-sectoral EVD control strategy, and the results of the same...
November 9, 2017: PLoS Currents
https://www.readbyqxmd.com/read/29170019/evaluation-of-a-rapid-and-sensitive-rt-qpcr-assay-for-the-detection-of-ebola-virus
#8
M Biava, F Colavita, A Marzorati, D Russo, D Pirola, A Cocci, A Petrocelli, M Guanti Delli, G Cataldi, T A Kamara, A S Kamara, K Konneh, A Cannas, S Coen, S Quartu, S Meschi, M B Valli, A Mazzarelli, C Venditti, G Grassi, G Rozera, C Castilletti, A Mirazimi, M R Capobianchi, G Ippolito, R Miccio, A Di Caro
BACKGROUND: The 2013-2016 Ebola virus disease (EVD) outbreak showed a lack of diagnostic point-of-care methods. Currently, EBOV diagnosis relies on quantitative reverse-transcription-PCR (RT- qPCR), highly specific and sensitive, but requiring skilled personnel and well-equipped laboratories. In field settings, these factors and others, such as samples' time of collection and transportation, determine a prolonged turnaround-time to final results. In outbreak scenarios, a rapid and transportable method could eliminate issues of cohorting suspected and actual EVD patients for lack of diagnostic certainty...
November 20, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/29168445/strengthened-ebola-surveillance-in-france-during-a-major-outbreak-in-west-africa-march-2014-january-2016
#9
A Mailles, H Noel, D Pannetier, C Rapp, Y Yazdanpanah, S Vandentorren, P Chaud, J M Philippe, B Worms, M Bruyand, M Tourdjman, M Nahon, E Belchior, E Lucas, J Durand, M Zurbaran, S Vaux, B Coignard, H DE Valk, S Baize, S Quelet, F Bourdillon
Introduction An unprecedented outbreak of Ebola virus diseases (EVD) occurred in West Africa from March 2014 to January 2016. The French Institute for Public Health implemented strengthened surveillance to early identify any imported case and avoid secondary cases. METHODS: Febrile travellers returning from an affected country had to report to the national emergency healthcare hotline. Patients reporting at-risk exposures and fever during the 21st following day from the last at-risk exposure were defined as possible cases, hospitalised in isolation and tested by real-time polymerase chain reaction...
November 23, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29164612/seizures-csf-neurofilament-light-and-tau-in-patients-with-subarachnoid-haemorrhage
#10
I Halawa, P Vlachogiannis, Å Amandusson, K Elf, E-R Engström, H Zetterberg, E Kumlien
OBJECTIVES: Patients with severe subarachnoid haemorrhage (SAH) often suffer from complications with delayed cerebral ischaemia (DCI) due to vasospasm that is difficult to identify by clinical examination. The purpose of this study was to monitor seizures and to measure cerebrospinal fluid (CSF) concentrations of neurofilament light (NFL) and tau, and to see whether they could be used for predicting preclinical DCI. METHODS: We prospectively studied 19 patients with aneurysmal SAH who underwent treatment with endovascular coiling...
November 21, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29161839/the-potential-impact-of-a-prophylactic-vaccine-for-ebola-in-sierra-leone
#11
Erin N Bodine, Connor Cook, Mikayla Shorten
The 2014 outbreak of Ebola virus disease (EVD) in West Africa was multinational and of an unprecedented scale primarily affecting the countries of Guinea, Liberia, and Sierra Leone. One of the qualities that makes EVD of high public concern is its potential for extremely high mortality rates (up to 90%). A prophylactic vaccine for ebolavirus (rVSV-ZEBOV) has been developed, and clinical trials show near-perfect efficacy. We have developed an ordinary differential equations model that simulates an EVD epidemic and takes into account (1) transmission through contact with infectious EVD individuals and deceased EVD bodies, (2) the heterogeneity of the risk of becoming infected with EVD, and (3) the increased survival rate of infected EVD patients due to greater access to trained healthcare providers...
April 1, 2018: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/29161826/modeling-ebola-virus-disease-transmissions-with-reservoir-in-a-complex-virus-life-ecology
#12
Tsanou Berge, Samuel Bowong, Jean Lubuma, Martin Luther Mann Manyombe
We propose a new deterministic mathematical model for the transmission dynamics of Ebola Virus Disease (EVD) in a complex Ebola virus life ecology. Our model captures as much as possible the features and patterns of the disease evolution as a three cycle transmission process in the two ways below. Firstly it involves the synergy between the epizootic phase (during which the disease circulates periodically amongst non-human primates populations and decimates them), the enzootic phase (during which the disease always remains in fruit bats population) and the epidemic phase (during which the EVD threatens and decimates human populations)...
February 1, 2018: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/29156248/the-symbolic-violence-of-outbreak-a-mixed-methods-quasi-experimental-impact-evaluation-of-social-protection-on-ebola-survivor-wellbeing
#13
Eugene T Richardson, J Daniel Kelly, Osman Sesay, Michael D Drasher, Ishaan K Desai, Raphael Frankfurter, Paul E Farmer, Mohamed Bailor Barrie
Despite over 28,000 reported cases of Ebola virus disease (EVD) in the 2013-16 outbreak in West Africa, we are only beginning to trace the complex biosocial processes that have promoted its spread. Important questions remain, including the effects on survivors of clinical sequelae, loss of family and livelihood, and other psychological and social trauma. Another poorly understood question is what effect social protection and job creation programs have had on survivors' wellbeing. Several clinical and social protection programs have been developed to respond to the needs of EVD survivors; however, little in the way of impact evaluation has taken place...
November 11, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29154748/cdc-safety-training-course-for-ebola-virus-disease-healthcare-workers
#14
Rupa Narra, Jeremy Sobel, Catherine Piper, Deborah Gould, Nahid Bhadelia, Mary Dott, Anthony Fiore, William A Fischer, Mary Jo Frawley, Patricia M Griffin, Douglas Hamilton, Barbara Mahon, Satish K Pillai, Emily F Veltus, Robert Tauxe, Michael Jhung
Response to sudden epidemic infectious disease emergencies can demand intensive and specialized training, as demonstrated in 2014 when Ebola virus disease (EVD) rapidly spread throughout West Africa. The medical community quickly became overwhelmed because of limited staff, supplies, and Ebola treatment units (ETUs). Because a mechanism to rapidly increase trained healthcare workers was needed, the US Centers for Disease Control and Prevention developed and implemented an introductory EVD safety training course to prepare US healthcare workers to work in West Africa ETUs...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29154144/multi-platform-omics-analysis-of-human-ebola-virus-disease-pathogenesis
#15
Amie J Eisfeld, Peter J Halfmann, Jason P Wendler, Jennifer E Kyle, Kristin E Burnum-Johnson, Zuleyma Peralta, Tadashi Maemura, Kevin B Walters, Tokiko Watanabe, Satoshi Fukuyama, Makoto Yamashita, Jon M Jacobs, Young-Mo Kim, Cameron P Casey, Kelly G Stratton, Bobbie-Jo M Webb-Robertson, Marina A Gritsenko, Matthew E Monroe, Karl K Weitz, Anil K Shukla, Mingyuan Tian, Gabriele Neumann, Jennifer L Reed, Harm van Bakel, Thomas O Metz, Richard D Smith, Katrina M Waters, Alhaji N'jai, Foday Sahr, Yoshihiro Kawaoka
The pathogenesis of human Ebola virus disease (EVD) is complex. EVD is characterized by high levels of virus replication and dissemination, dysregulated immune responses, extensive virus- and host-mediated tissue damage, and disordered coagulation. To clarify how host responses contribute to EVD pathophysiology, we performed multi-platform 'omics analysis of peripheral blood mononuclear cells and plasma from EVD patients. Our results indicate that EVD molecular signatures overlap with those of sepsis, imply that pancreatic enzymes contribute to tissue damage in fatal EVD, and suggest that Ebola virus infection may induce aberrant neutrophils whose activity could explain hallmarks of fatal EVD...
November 15, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/29149432/ebola-in-the-netherlands-2014-2015-costs-of-preparedness-and-response
#16
Anita W M Suijkerbuijk, Corien M Swaan, Marie-Josee J Mangen, Johan J Polder, Aura Timen, Wilhelmina L M Ruijs
The recent epidemic of Ebola virus disease (EVD) resulted in countries worldwide to prepare for the possibility of having an EVD patient. In this study, we estimate the costs of Ebola preparedness and response borne by the Dutch health system. An activity-based costing method was used, in which the cost of staff time spent in preparedness and response activities was calculated based on a time-recording system and interviews with key professionals at the healthcare organizations involved. In addition, the organizations provided cost information on patient days of hospitalization, laboratory tests, personal protective equipment (PPE), as well as the additional cleaning and disinfection required...
November 17, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/29148368/lack-of-secondary-transmission-of-ebola-virus-from-healthcare-worker-to-238-contacts-united-kingdom-december-2014
#17
Paul Crook, Alison Smith-Palmer, Helen Maguire, Noel McCarthy, Hilary Kirkbride, Bruce Court, Sanch Kanagarajah, Deborah Turbitt, Syed Ahmed, Paul Cosford, Isabel Oliver
In December 2014, Ebola virus disease (EVD) was diagnosed in a healthcare worker in the United Kingdom after the worker returned from an Ebola treatment center in Sierra Leone. The worker flew on 2 flights during the early stages of disease. Follow-up of 238 contacts showed no evidence of secondary transmission of Ebola virus.
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29141743/prognostic-and-predictive-factors-of-ebola-virus-disease-outcome-in-elderly-people-during-the-2014-outbreak-in-guinea
#18
Mahamoud Sama Cherif, Shyam Prakash Dumre, Diénaba Kassé, Fatoumata Cherif, Facély Camara, Alpha Koné, Mandiou Diakité, Mohamed Cisse, Mamadou Pathé Diallo, Edouard Le Gall, Juntra Karbwang, Kenji Hirayama
Elderly people occupy a prominent position in African societies; however, their potential linkage to high case fatality rate (CFR) in Ebola virus disease (EVD) was often overlooked. We describe the predictive factors for EVD lethality in the elderly. A total of 2,004 adults and 309 elderly patients with confirmed EVD were included in the analysis. The median age (interquartile range) was 35 years (23-44) in adults and 65 years (60-70) in the elderly. The proportion of funeral participation was significantly higher in the elderly group than in the adult group...
October 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29140769/addressing-maternal-health-during-cdc-s-ebola-response-in-the-united-states
#19
Sascha Ellington, Mirna Perez, Diane Morof, Marianne E Zotti, William Callaghan, Dana Meaney-Delman, Maleeka Glover, Quynh-Chau Ha, Denise J Jamieson
Previous outbreaks suggest that pregnant women with Ebola virus disease (EVD) are at increased risk for severe disease and death. Healthcare workers who treat pregnant women with EVD are at increased risk of body fluid exposure. Despite the absence of pregnant women with EVD in the United States, CDC activated the Maternal Health Team (MHT), a functional unit dedicated to emergency preparedness and response issues, on October 18, 2014. We describe major activities of the MHT. A high-priority MHT activity was to publish guiding principles early in the response...
November 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29138016/the-challenges-of-detecting-and-responding-to-a-lassa-fever-outbreak-in-an-ebola-affected-setting
#20
E L Hamblion, P Raftery, A Wendland, E Dweh, G S Williams, R N C George, L Soro, V Katawera, P Clement, A N Gasasira, E Musa, T K Nagbe
OBJECTIVES: Lassa fever(LF), a priority emerging pathogen likely to cause major epidemics, is endemic in much of West Africa and difficult to distinguish from other viral haemorrhagic fevers including Ebola virus disease(EVD). Definitive diagnosis requires laboratory confirmation not widely available in affected settings. We report the public health action to contain a LF outbreak and challenges encountered in an EVD-affected setting. METHODS: In February 2016 a rapid response team was deployed in Liberia in response to a cluster of LF cases...
November 11, 2017: International Journal of Infectious Diseases: IJID
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