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https://www.readbyqxmd.com/read/29704490/mathematical-modeling-of-atherosclerotic-plaque-destabilization-role-of-neovascularization-and-intraplaque-hemorrhage
#1
Muyi Guo, Yan Cai, Xinke Yao, Zhiyong Li
Observational studies have identified angiogenesis from the adventitial vasa vasorum and intraplaque hemorrhage (IPH) as critical factors in atherosclerotic plaque progression and destabilization. Here we propose a mathematical model incorporating intraplaque neovascularization and hemodynamic calculation with plaque destabilization for the quantitative evaluation of the role of neoangiogenesis and IPH in the vulnerable atherosclerotic plaque formation. An angiogenic microvasculature is generated by two-dimensional nine-point discretization of endothelial cell proliferation and migration from the vasa vasorum...
April 25, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29698879/use-of-pipeline%C3%A2-embolization-device-for-the-treatment-of-traumatic-intracranial-pseudoaneurysms-case-series-and-review-of-cases-from-literature
#2
Mairaj T Sami, Domenico A Gattozzi, Hesham M Soliman, Alan R Reeves, Christopher J Moran, Paul J Camarata, Koji C Ebersole
OBJECTIVE: Intracranial traumatic pseudoaneurysms (PSA) are a rare but dangerous subtype of cerebral aneurysm. Reports documenting use of flow-diverting stents to treat traumatic intracranial PSAs are few and lack long-term follow-up. To our knowledge, this is the largest case-series to date demonstrating use of Pipeline Endovascular Device (PED) for traumatic intracranial PSAs. PATIENTS AND METHODS: Retrospective review of 8 intracranial traumatic PSAs in 7 patients treated using only PED placement...
June 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29695254/atherosclerosis-t1-weighted-characterization-catch-evaluation-of-the-accuracy-for-identifying-intraplaque-hemorrhage-with-histological-validation-in-carotid-and-coronary-artery-specimens
#3
Wen Liu, Yibin Xie, Chuan Wang, Yanni Du, Christopher Nguyen, Zhenjia Wang, Zhaoyang Fan, Li Dong, Yi Liu, Xiaoming Bi, Jing An, Chengxiong Gu, Wei Yu, Debiao Li
BACKGROUND: Coronary high intensity plaques (CHIPs) detected using cardiovascular magnetic resonance (CMR) coronary atherosclerosis T1-weighted characterization with integrated anatomical reference (CATCH) have been shown to be positively associated with high-risk morphology observed on intracoronary optical coherence tomography (OCT). This study sought to validate whether CHIPs detected on CATCH indicate the presence of intraplaque hemorrhage (IPH) through ex vivo imaging of carotid and coronary plaque specimens, with histopathology as the standard reference...
April 26, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29672788/neutrophil-extracellular-traps-participate-in-all-different-types-of-thrombotic-and-haemorrhagic-complications-of-coronary-atherosclerosis
#4
Kartika R Pertiwi, Allard C van der Wal, Dara R Pabittei, Claire Mackaaij, Marinus B van Leeuwen, Xiaofei Li, Onno J de Boer
Acute coronary syndromes can be initiated by either atherosclerotic fibrous cap ruptures, superficial plaque erosions or intraplaque haemorrhages (IPHs). Since neutrophil extracellular traps (NETs) display pro-inflammatory and pro-thrombotic properties, we investigated the presence, extent and distribution of neutrophils and NETs in different types of plaque complications in relation to the age of overlying thrombus mass or haemorrhage. Sixty-four paraffin-embedded coronary plaque segments of 30 acute myocardial infarction patients were retrieved from the autopsy archives, which contained 44 complicated plaques (17 IPHs, 9 erosions and 18 ruptures) and 20 intact plaques...
April 19, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29671187/suicide-and-additional-homicides-associated-with-intimate-partner-homicide-north-carolina-2004-2013
#5
Sierra Smucker, Rose E Kerber, Philip J Cook
Intimate partner homicide (IPH) is a critical public health and safety issue in the USA. In this study, we determine the prevalence and correlates of perpetrator suicide and additional homicides following intimate partner homicide (IPH) in a large, diverse state with high quality data. We extract IPHs from the North Carolina Violent Death Reporting System for 2004-2013 and identify suicides and other homicides that were part of the same incidents. We analyze the likelihood (in odds ration form) of perpetrator suicide and additional homicides using logistic regression analysis...
April 18, 2018: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/29669957/association-of-age-and-size-of-carotid-artery-intraplaque-hemorrhage-and-minor-fibrous-cap-disruption-a-high-resolution-magnetic-resonance-imaging-study
#6
Yuanyuan Cui, Huiyu Qiao, Lu Ma, Mingming Lu, Jiafei Yang, Guoen Yao, Jianming Cai, Xihai Zhao
AIM: To investigate the association between the volumes of different aging intraplaque hemorrhage (IPH) and minor fibrous cap disruption (MFCD) in carotid arteries. METHODS: Patients with cerebrovascular symptoms and carotid atherosclerotic plaques determined by ultrasound were recruited and underwent multi-contrast magnetic resonance (MR) vessel wall imaging for carotid arteries. Carotid plaques with IPH on MR imaging were included in the analysis. The age (fresh or recent) and the volume of IPH for each plaque were evaluated...
April 17, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29658768/idiopathic-portal-hypertension-with-regard-to-thiopurine-treatment
#7
Salvador Machlab, Mireia Miquel, Mercedes Vergara
Idiopathic portal hypertension (IPH) is an infrequent adverse reaction to the use of thiopurines that tends to be overlooked. Herein, we present a patient with ileocolic Crohn's disease treated with azathioprine who presented ascites, esophageal varices and splenomegaly without any signs of liver cirrhosis. A portal hemodynamics study revealed a normal portosystemic gradient compatible with presinusoidal portal hypertension. Finally, IPH was diagnosed after a liver biopsy. IPH secondary to thiopurines is due to a 6-thioguanine nucleotide (6-TGN)-dependent reaction and occurs predominantly between three months and three years after the start of treatment...
April 16, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29626682/patterns-predictors-and-outcomes-of-post-procedure-delayed-hemorrhage-following-flow-diversion-for-intracranial-aneurysm-treatment
#8
A C White, D A Kumpe, C D Roark, D E Case, J Seinfeld
PURPOSE: To evaluate patterns, predictors, and outcomes of post procedure delayed hemorrhage (PPDH) following flow diversion therapy for intracranial aneurysm. METHODS: 50 patients with 52 aneurysms were treated from 2012-2016 with the Pipeline Embolization Device (PED; Medtronic, Minneapolis, MN). PED placement was performed as a standalone therapy or with adjunctive coil embolization. Patients underwent dual antiplatelet therapy (DAT) for 6 months following treatment...
April 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29571754/carotid-intraplaque-hemorrhage-in-patients-with-embolic-stroke-of-undetermined-source
#9
Navneet Singh, Alan R Moody, Val Panzov, David J Gladstone
BACKGROUND: Many embolic strokes are of undetermined source (ESUS). Carotid artery intraplaque hemorrhage (IPH), an unstable component of atherosclerosis, may be an under-recognized etiology in patients with ESUS. We investigated the prevalence of carotid IPH detected noninvasively by magnetic resonance imaging (MRI). METHODS: This pilot study analyzed data from a prospective cohort of patients with a recent ESUS who underwent MRI for carotid IPH assessment. All patients had carotid artery stenosis of less than 50%...
March 20, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29570003/economic-evaluation-of-global-endometrial-ablation-versus-inpatient-and-outpatient-hysterectomy-for-treatment-of-abnormal-uterine-bleeding-us-commercial-and-medicaid-payer-perspectives
#10
Jeffrey D Miller, Machaon M Bonafede, Qian Cai, Scott K Pohlman, Kathleen A Troeger, Aarathi Cholkeri-Singh
Every year, abnormal uterine bleeding (AUB) exacts a heavy toll on women's health and leads to high costs for the US health care system. The literature shows that endometrial ablation results in fewer complications, shorter recovery and lower costs than more commonly performed hysterectomy procedures. The objective of this study was to model clinical-economic outcomes, budget impact, and cost-effectiveness of global endometrial ablation (GEA) versus outpatient hysterectomy (OPH) and inpatient hysterectomy (IPH) procedures...
March 2018: Population Health Management
https://www.readbyqxmd.com/read/29567026/serum-tumor-necrosis-factor-%C3%AE-levels-are-associated-with-new-ischemic-brain-lesions-after-carotid-artery-stenting
#11
Changpo Lin, Xiao Tang, Zhenyu Shi, Lu Zhang, Dong Yan, Cong Niu, Min Zhou, Lixin Wang, Weiguo Fu, Daqiao Guo
OBJECTIVE: New diffusion-weighted imaging (DWI) lesions on magnetic resonance imaging (MRI) after carotid artery stenting (CAS) are associated with an increased risk of future cerebrovascular events. Therefore, we evaluated the association between the expression levels of serum inflammatory markers and new DWI lesions after CAS and the presence of intraplaque hemorrhage (IPH). We also explored the mechanisms underlying this association. METHODS: A total of 225 inpatients with severe carotid artery stenosis were consecutively enrolled in this cohort study...
March 19, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29541474/early-diagnosis-of-idiopathic-pulmonary-haemosiderosis-increased-haemosiderin-laden-macrophages-in-repeat-bronchoscopy
#12
Yuichi Mukai, Toshihiko Agatsuma, Gen Ideura
Idiopathic pulmonary haemosiderosis (IPH) is a diagnosis of exclusion, which is characterized by persistent or recurrent episodes of alveolar haemorrhage. Early diagnosis of IPH, especially in the case of first-time manifestation, is challenging because previous episodes of alveolar haemorrhage are often difficult to prove. Repeated episodes of alveolar haemorrhage can result in chronic iron-deficient anaemia and irreversible interstitial fibrosis; thus, early recognition and intervention are desirable in terms of clinical outcome...
April 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29512056/quantitative-t-1-and-t-2-carotid-atherosclerotic-plaque-imaging-using-a-three-dimensional-multi-echo-phase-sensitive-inversion-recovery-sequence-a-feasibility-study
#13
Yasuhiro Fujiwara, Hirotoshi Maruyama, Kanako Toyomaru, Yuri Nishizaka, Masahiro Fukamatsu
Magnetic resonance imaging (MRI) is widely used to detect carotid atherosclerotic plaques. Although it is important to evaluate vulnerable carotid plaques containing lipids and intra-plaque hemorrhages (IPHs) using T1 -weighted images, the image contrast changes depending on the imaging settings. Moreover, to distinguish between a thrombus and a hemorrhage, it is useful to evaluate the iron content of the plaque using both T1 -weighted and T2 *-weighted images. Therefore, a quantitative evaluation of carotid atherosclerotic plaques using T1 and T2 * values may be necessary for the accurate evaluation of plaque components...
March 6, 2018: Radiological Physics and Technology
https://www.readbyqxmd.com/read/29479763/diagnostic-accuracy-of-a-clinical-carotid-plaque-mr-protocol-using-a-neurovascular-coil-compared-to-a-surface-coil-protocol
#14
Waleed Brinjikji, J Kevin DeMarco, Robert Shih, Giuseppe Lanzino, Alejandro A Rabinstein, Christopher A Hilditch, Patrick J Nicholson, John Huston
BACKGROUND: Carotid plaque imaging with MRI is becoming more commonplace, but practical challenges exist in performing plaque imaging with surface coils. PURPOSE: To compare the diagnostic performance of a carotid plaque MRI protocol using a standard neurovascular coil (Neurovascular Coil Protocol) to a higher-resolution carotid plaque MRI using carotid surface coils (Surface Coil Protocol) in characterizing carotid plaque. STUDY TYPE: Prospective study comparing two MR techniques in plaque characterization...
February 25, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29476390/spontaneous-intracranial-hemorrhage-in-pregnancy-a-systematic-review-of-the-literature
#15
Luis C Ascanio, Georgios A Maragkos, Brett C Young, Myles D Boone, Ekkehard M Kasper
Stroke in pregnant women has a mortality rate of 1.4 deaths per 100,000 deliveries. Vascular malformations are the most common cause of hemorrhagic stroke in this population; preeclampsia and other risk factors have been identified. However, nearly a quarter of strokes have an undeterminable cause. Spontaneous intracranial hemorrhage (ICH) is less frequent but results in significant morbidity. The main objective of this study is to review the literature on pregnant patients who had a spontaneous ICH. A systematic review of the literature was conducted on PubMed and the Cochrane library from January 1992 to September 2016 following the PRISMA guidelines...
February 23, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29467356/endogenous-interleukin-1%C3%AE-is-implicated-in-intraplaque-hemorrhage-in-apolipoprotein-e-gene-null-mice
#16
Etsu Suzuki, Hiroyuki Imuta, Daishi Fujita, Masao Takahashi, Shigeyoshi Oba, Arihiro Kiyosue, Hiroaki Nishimatsu
BACKGROUND: Intraplaque hemorrhage (IPH) has been implicated in plaque instability and rupture in atherosclerotic lesions, although the mechanisms by which IPH progresses remain largely unknown. In this study, apolipoprotein E-deficient mice with carotid artery ligation and cuff placement around the artery were used, and pro-inflammatory cytokines that are implicated in IPH were analyzed.Methods and Results:The expression of interleukin-1β (IL-1β) increased significantly following cuff placement compared with mice with carotid artery ligation alone...
March 23, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29464506/idiopathic-portal-hypertension-and-extrahepatic-portal-venous-obstruction
#17
REVIEW
Rajeev Khanna, Shiv Kumar Sarin
BACKGROUND: Idiopathic portal hypertension (IPH) and extrahepatic portal venous obstruction (EHPVO) are non-cirrhotic vascular causes of portal hypertension (PHT). Variceal bleed and splenomegaly are the commonest presentations. AIM: The present review is intended to provide the existing literature on etiopathogenesis, clinical profile, diagnosis, natural history and management of IPH and EHPVO. RESULTS: IPH and EHPVO are both characterized by normal hepatic venous pressure gradient, moderate to massive splenomegaly with preserved liver synthetic functions...
February 2018: Hepatology International
https://www.readbyqxmd.com/read/29417155/diagnosing-neoplastic-hematoma-role-of-mr-perfusion
#18
Jai Jai Shiva Shankar, Namita Sinha
BACKGROUND: The imaging appearance of neoplastic hematoma can be complicated by the presence of a large hematoma, even on magnetic resonance imaging (MRI). We describe the role of MR perfusion (MRP) in detecting neoplastic hematomas in patients with intraparenchymal hematoma (IPH). MATERIAL AND METHODS: A retrospective review was performed for consecutive patients with IPH, where MRP was performed. Routine, post-gadolinium MRI and MRP were analyzed. All patients were either operated on for evacuation of IPH or followed up on imaging...
February 7, 2018: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29409186/medial-and-lateral-exostoses-of-the-distal-phalanx-of-the-hallux-a-potentially-painful-bunion-like-structure-part-1-incidence-and-clinical-application
#19
V Montiel, M Alfonso, C Villas, A Valentí
BACKGROUND: Exostoses at the base of the distal phalanx of the great toe are usually asymptomatic. The literature has not generally considered them as the origin of a possible problem resulting from a pressure conflict between hallux and shoe (medial aspect) or second toe (lateral aspect) nor a potential complication of surgical correction of hallux valgus deformity. No studies, to our knowledge, have evaluated its possible correlation with other foot disorders. When one of these neglected exostoses became painful after surgical correction of hallux valgus, we decided to start a study to determine their possible origin, prevalence in daily practice and histo-pathological morphology...
November 13, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29400432/all-inorganic-perovskite-nanowires-ingazno-heterojunction-for-high-performance-ultraviolet-visible-photodetectors
#20
Mengxing Sun, Qiyi Fang, Zhepeng Zhang, Dan Xie, Yilin Sun, Jianlong Xu, Weiwei Li, Tianling Ren, Yanfeng Zhang
Inorganic cesium lead halide perovskites have attracted intense interest in optoelectronic applications due to the relatively stable performance in air. However, most reported inorganic perovskite-based optoelectronic devices exhibit low photosensitivity, which greatly hinders their further applications. Here, we first demonstrate a hybrid optical structure, which combines the n-type thin-film InGaZnO and the all-inorganic perovskite nanowires of CsPbBr3 together. By this way, excellent optical and electrical properties such as a low dark current of 10-10 A (at -5 V), a high Iph /Idark of 1...
February 28, 2018: ACS Applied Materials & Interfaces
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