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https://www.readbyqxmd.com/read/28711401/performance-of-acoustic-radiation-force-impulse-ultrasound-imaging-for-carotid-plaque-characterization-with-histologic-validation
#1
Tomasz J Czernuszewicz, Jonathon W Homeister, Melissa C Caughey, Yue Wang, Hongtu Zhu, Benjamin Y Huang, Ellie R Lee, Carlos A Zamora, Mark A Farber, Joseph J Fulton, Peter F Ford, William A Marston, Raghuveer Vallabhaneni, Timothy C Nichols, Caterina M Gallippi
OBJECTIVE: Stroke is commonly caused by thromboembolic events originating from ruptured carotid plaque with vulnerable composition. This study assessed the performance of acoustic radiation force impulse (ARFI) imaging, a noninvasive ultrasound elasticity imaging method, for delineating the composition of human carotid plaque in vivo with histologic validation. METHODS: Carotid ARFI images were captured before surgery in 25 patients undergoing clinically indicated carotid endarterectomy...
July 13, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28706117/age-specific-sex-differences-in-magnetic-resonance-imaging-depicted-carotid-intraplaque-hemorrhage
#2
Navneet Singh, Alan R Moody, Bowen Zhang, Isabella Kaminski, Kush Kapur, Stephanie Chiu, Pascal N Tyrrell
BACKGROUND AND PURPOSE: Stroke rates are higher in men compared with women in the fourth through seventh decades of life, and higher rates may result from differences in carotid intraplaque hemorrhage (IPH), an unstable atherosclerotic plaque component. We report age-specific sex differences in the presence of magnetic resonance imaging-depicted carotid IPH. METHODS: Patients (n=1115) underwent magnetic resonance imaging for carotid IPH between 2005 and 2014. Low-grade carotid stenosis patients (n=906) without prior endarterectomy were eligible for this cross-sectional study...
August 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28670434/idiopathic-pulmonary-hemosiderosis-mimicking-iron-deficiency-anemia-a-delayed-diagnosis
#3
Sultan Aydin Koker, Salih Gözmen, Yeşim Oymak, Tuba Hilkay Karapinar, Demet Can, Sinan Genç, Raziye Canan Vergin
Idiopathic pulmonary hemosiderosis (IPH) is an uncommon chronic disorder in children. It is characterized by recurrent pulmonary hemorrhage and may result in hemoptysis and pulmonary insufficiency. The most common hematologic manifestation of IPH is iron deficiency anemia. The etiology of IPH is not known and its diagnosis may be difficult due to the variable clinical courses. The most helpful signs for identifying IPH are iron deficiency anemia and recurrent or chronic cough, hemoptysis, dyspnea, wheezing...
June 1, 2017: Hematology Reports
https://www.readbyqxmd.com/read/28669878/thresholds-for-volume-and-expansion-in-intraparenchymal-hemorrhage-predictors-of-neurologic-deterioration-and-mortality
#4
Darian R Esfahani, Caitlin A Radnis, Ahmed E Hussein, Sepideh Amin-Hanjani, Fady T Charbel, Ali Alaraj
OBJECTIVE: Spontaneous intraparenchymal hemorrhage (IPH) is a common neurosurgical emergency, with hemorrhage size and expansion associated with poor clinical outcomes. In this study, radiologic risk factors and specific IPH volume thresholds were calculated to identify heightened risk of neurologic deterioration and mortality. METHODS: A consecutive review of all nontraumatic IPH transfer patients to a tertiary academic neurosurgery service was performed over two years...
June 29, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28663143/oxygen-self-enriched-nanoparticles-functionalized-with-erythrocyte-membranes-for-long-circulation-and-enhanced-phototherapy
#5
Hao Ren, Jiaqi Liu, Yuqin Li, Haoran Wang, Sizhan Ge, Ahu Yuan, Yiqiao Hu, Jinhui Wu
In recent years, indocyanine green (ICG) encapsulated in different kinds of nano-carriers have been developed to overcome its short lifetime in vivo and non-selectivity in cancer cells. However, these nanoparticles are still easily recognized and captured by the reticuloendothelial system (RES) and the low singlet oxygen quantum (0.08) of ICG inevitably leads to a limited efficacy of phototherapy. To overcome these limitations, a novel oxygen self-enriched biomimetic red blood cell (RBC) was developed by cloaking albumin nanoparticles which contained ICG and perfluorocarbon (PFC) with RBC membranes...
June 26, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28631982/carotid-intraplaque-hemorrhage-on-vessel-wall-mri-does-not-correlate-with-tcd-emboli-monitoring-in-patients-with-recently-symptomatic-carotid-atherosclerosis
#6
Adam de Havenon, David Tirschwell, Jennifer J Majersik, Scott McNally, Gregory Stoddard, Anne Moore, Mahmud Mossa-Basha
Background Carotid intraplaque hemorrhage (IPH) seen on vessel wall MRI is associated with an increased risk of stroke or transient ischemic attack, as are microembolic signals (MES) detected by transcranial Doppler (TCD). We sought to examine the association between IPH and MES in acute stroke patients with symptomatic carotid atherosclerosis. Methods Through a retrospective chart review, we included patients from 2011 to 2013 with acute ischemic stroke due to carotid atherosclerosis of varying stenosis who had both 3D volumetric MRI of the neck and TCD emboli monitoring...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28629953/3d-black-blood-mr-angiography-of-the-carotid-arteries-a-simple-sequence-for-plaque-hemorrhage-and-stenosis-evaluation
#7
Monica Sigovan, Clément Bidet, Sébastien Bros, Loic Boussel, Laura Mechtouff, Philip M Robson, Zahi A Fayad, Antoine Millon, Philippe Douek
OBJECTIVES: To evaluate the diagnostic performance of a new three-dimensional T1-weighted turbo-spin-echo sequence (3D T1-w TSE) compared to 3D contrast-enhanced angiography (CE-MRA) for stenosis measurement and compared to 2D T1-w TSE for intra-plaque hemorrhage (IPH) detection. METHODS: Eighty three patients underwent carotid MRI, using a new elliptic-centric phase encoding T1-weighted 3D TSE sequence in addition to the clinical protocol. Two observers evaluated image quality, presence of flow artifacts, and presence of intra-plaque hemorrhage, and computed the NASCET degree of stenosis for CE-MRA and for the new sequence...
June 16, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28569134/incidence-and-outcome-of-severe-ante-partum-hemorrhage-at-the-teaching-hospital-yalgado-ou%C3%A3-draogo-in-burkina-faso
#8
Martin Lankoande, Papougnezambo Bonkoungou, Sosthène Ouandaogo, Marcelin Dayamba, Ali Ouedraogo, Francis Veyckmans, Nazinigouba Ouédraogo
BACKGROUND: Hemorrhage is the main cause of maternal death during pregnancy. This study aims to evaluate incidence and outcomes of Severe Ante Partum Hemorrhage (SAPH) during the third trimester of pregnancy prior to delivery. METHODS: Analytical cross-sectional study with prospective data collection during 12 months in Yalgado Ouedraogo Hospital, Ouagadougou, Burkina Faso. In this context SAPH is specifically referring to Ante Partum Hemorrhage (APH) and Intra Partum Hemorrhage (IPH) in the 3rd trimester...
May 31, 2017: BMC Emergency Medicine
https://www.readbyqxmd.com/read/28567488/early-rebleeding-of-intracranial-dural-arteriovenous-fistulas-after-an-intracranial-hemorrhage
#9
Jai Ho Choi, Kyung Il Jo, Keon Ha Kim, Pyoung Jeon, Je Young Yeon, Jong Soo Kim, Seung Chyul Hong
BACKGROUND: The aim of this study was to evaluate the clinical and angiographic characteristics of dural arteriovenous fistulas (DAVF) presenting with intracranial hemorrhage (ICH), with a focus on early rebleeding according to the initial hemorrhage type. METHOD: The clinical and radiologic features of 21 dAVFs that presented with intracranial hemorrhage were retrospectively reviewed. The hemorrhage type was classified as pure intraparenchymal hemorrhage (pIPH) and subarachnoid or subdural hemorrhage with IPH (non-pIPH)...
May 31, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28544644/%C3%AE-cell-function-in-postmenopausal-women-with-isolated-post-challenge-hyperglycemia
#10
Chii-Min Hwu, Yi-Chun Lin, Kuan-Hung Lin
BACKGROUND: Isolated post-challenge hyperglycemia (IPH) is an early stage of type 2 diabetes mellitus (T2DM), with fasting glucose <126 mg/dL and 2-h glucose ≥200 mg/dL. Observations of insulin secretion profile in subjects with IPH may provide an insight into the pathogenesis of T2DM in older women. METHODS: We recruited 555 naturally postmenopausal women without a history of T2DM to the present study. All participants received a 75-g oral glucose tolerance test to determine whether they had IPH...
May 22, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28540013/infantile-periocular-hemangioma
#11
REVIEW
Mehdi Tavakoli, Saeid Yadegari, Mahnaz Mosallaei, Maryam Aletaha, Hossein Salour, Wendy W Lee
Infantile periocular hemangiomas (IPH) are common benign vascular tumors that present early in childhood. They typically show a rapid nonlinear growth pattern a few weeks after birth during a proliferative phase, then continue with an involution phase and may result in serious ocular or systemic complications. Theses tumors may present in a range of small isolated lesions to multiple, diffuse involvements. Understanding the nature of the disease, the natural course, complications, indications for intervention, and treatment modalities would be helpful for ophthalmologists, who will likely be consulted for periocular cases...
April 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28538637/factors-associated-with-intimate-partner-homicide-in-illinois-2005-2010-findings-from-the-illinois-violent-death-reporting-system
#12
Sana Yousuf, Suzanne McLone, Maryann Mason, Lisa Snow, Carol Gall, Karen Sheehan
BACKGROUND: Critical elements in intimate partner homicides (IPH) often go undocumented. Previous studies have highlighted precipitating causes, but few have examined the place of injury that led to the victim's death. We sought to describe IPH cases in Illinois, and in particular to examine factors surrounding the location of injury that led to the victim's death. METHODS: We analyzed data collected in the Illinois Violent Death Reporting System (IVDRS) to assess victim demographics, perpetrator characteristics, the victim/perpetrator relationship, and circumstances surrounding the location of injury that led to the victim's death...
May 22, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28450297/association-between-carotid-atherosclerotic-plaque-calcification-and-intraplaque-hemorrhage-a-magnetic-resonance-imaging-study
#13
Ruolan Lin, Shuo Chen, Gaifen Liu, Yunjing Xue, Xihai Zhao
OBJECTIVE: Carotid intraplaque hemorrhage (IPH) is associated with cardiovascular events. Calcification, which frequently accompanies IPH, may play a role in IPH occurrence. In this study, we aimed to investigate the associations between calcification characteristics and IPH in carotid plaques. APPROACH AND RESULTS: One hundred seventeen patients with cerebrovascular symptoms and carotid plaques detected by ultrasound were recruited and underwent multicontrast magnetic resonance imaging...
June 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28412421/change-in-carotid-plaque-components-a-4-year-follow-up-study-with-serial-mr-imaging
#14
Laura Pletsch-Borba, Mariana Selwaness, Aad van der Lugt, Albert Hofman, Oscar H Franco, Meike W Vernooij
OBJECTIVES: The goal of this study was to determine how carotid plaque components (e.g., intraplaque hemorrhage [IPH], calcification, lipid core) change over time and which cardiovascular risk factors are associated with the development of each component. BACKGROUND: Carotid atherosclerotic plaque components are important markers of plaque vulnerability. How these components change and which factors lead to the development and changes in the components remain unclear...
April 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28400153/spatiotemporal-diversification-of-intrapatient-genomic-clones-and-early-drug-development-concepts-realize-the-roadmap-of-precision-cancer-medicine
#15
REVIEW
Dimitrios H Roukos
The unmet clinical needs of high relapse and cancer-related death rates are reflected by the poor understanding of the genome-wide mutational landscape and molecular mechanisms orchestrating therapeutic resistance. Emerging potential solutions to this challenge include the exploration of cancer genome dynamic evolution in time and space. Breakthrough next-generation sequencing (NGS) applications including multiregional NGS for intratumor heterogeneity identification, repeated cell-free DNA/circulating tumor DNA-NGS for detecting circulating genomic subclones and their comparison to reveal intrapatient heterogeneity (IPH) could identify the dynamic emergence of resistant subclones in the neoadjuvant, adjuvant and metastatic setting...
April 8, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28385479/opportunity-to-reduce-transfer-of-patients-with-mild-traumatic-brain-injury-and-intracranial-hemorrhage-to-a-level-1-trauma-center
#16
Brian J Yun, Benjamin A White, H Benjamin Harvey, Anand M Prabhakar, Jonathan D Sonis, McKinley Glover, Emily Vallillo, Sun Choi, Pierre Borczuk, Ali S Raja
OBJECTIVE: Current guidelines do not address the disposition of patients with mild traumatic brain injury (TBI) and resultant intracranial hemorrhage (ICH). Emergency medicine clinicians working in hospitals without neurosurgery coverage typically transfer patients with both to a trauma center with neurosurgery capability. Evidence is accruing which demonstrates that the risk of neurologic decompensation depends on the type of ICH and as a result, not every patient may need to be transferred...
March 30, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28372696/effectiveness-of-active-and-passive-warming-for-the-prevention-of-inadvertent-hypothermia-in-patients-receiving-neuraxial-anesthesia-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#17
Clarissa A Shaw, Victoria M Steelman, Jennifer DeBerg, Marin L Schweizer
OBJECTIVE: Perioperative hypothermia is a common complication of anesthesia that can result in negative outcomes. The purpose of this review is to answer the question: Does the type of warming intervention influence the frequency or severity of inadvertent perioperative hypothermia (IPH) in surgical patients receiving neuraxial anesthesia? DESIGN: Systematic review and meta-analysis. SETTING: Perioperative care areas. PATIENTS: Adults undergoing surgery with neuraxial anesthesia...
May 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28276591/postprocedure-subarachnoid-hemorrhage-after-endovascular-treatment-for-acute-ischemic-stroke
#18
Adnan I Qureshi, Muhammad A Saleem, Emrah Aytac
BACKGROUND: The rate of occurrence and associated outcomes of subarachnoid hemorrhage (SAH) in acute ischemic stroke patients following endovascular treatment is not well studied. METHODS: We analyzed data from subjects treated with intravenous recombinant tissue plasminogen activator followed by endovascular treatment in the Interventional Management of Stroke III trial. The baseline and 24 (±6) hours postrandomization computed tomographic scans were interpreted centrally for presence, type, and location of intracranial hemorrhages (ICHs) including SAH...
March 9, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28247771/poems-syndrome-and-idiopathic-portal-hypertension-a-possible-association
#19
Sara Campos, Cláudia Agostinho, Maria Augusta Cipriano
A 48-year old female patient was admitted to the emergency department with upper gastrointestinal bleeding. Endoscopy showed large esophageal varices that were treated with band ligation. She had been treated with cyclophosphamide, melphalan, lenalidomide and corticosteroids for POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy or edema, M protein, skin changes). She had no other risk factors for chronic liver disease. Laboratory and radiological examinations could not confirm the etiology of portal hypertension...
March 1, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28211002/factors-that-influence-effective-perioperative-temperature-management-by-anesthesiologists-a-qualitative-study-using-the-theoretical-domains-framework
#20
Sylvain Boet, Andrea M Patey, Justine S Baron, Karim Mohamed, Ashlee-Ann E Pigford, Gregory L Bryson, Jamie C Brehaut, Jeremy M Grimshaw
PURPOSE: Inadvertent perioperative hypothermia (IPH) is associated with a range of adverse outcomes. Safe and effective warming techniques exist to prevent IPH; however, IPH remains common. This study aimed to identify factors that anesthesiologists perceive may influence temperature management during the perioperative period. METHODS: After Research Ethics Board approval, semi-structured interviews were conducted with staff anesthesiologists at a Canadian academic hospital...
February 16, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
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