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https://www.readbyqxmd.com/read/28937063/a-mini-epidemic-of-anti-glomerular-basement-membrane-disease-clinical-and-epidemiological-study
#1
Umesh Lingaraj, Shivaprasad Sasivehalli Mallappa, Rajiv Elkal Neminah, Satishkumar Madakala Mohan, Leelavathi Venkatesh, Sreedhara Chikkanayakanahalli Gurusiddaiah, Niranjan Manibally Rachaiah
Acute glomerulonephritis due to anti-glomerular basement membrane (anti-GBM) antibody disease is rare, estimated to occur in fewer than one case per million population and accounts for less than 20% of rapidly progressive glomerulonephritis. The prevalence among patients evaluated for potential glomerular disease is lower. It accounts for fewer than 3% of all kidney biopsies done with crescentic glomerulonephritis. Cases of anti-GBM disease occurring in a cluster have rarely been reported. All biopsy proven anti-GBM disease cases were collected from January 2015 to March 2015 at our Institute...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28936815/-current-clinical-variables-in-schizophrenia-cases-with-suicide-attempt-history
#2
Demet Sağlam Aykut, Filiz Civil Arslan, Evrim Özkorumak Karagüzel, Serdar Karakullukçu, Ahmet Tiryaki
OBJECTIVE: High suicide risk was shown to be related with depression and low quality of life in studies investigating clinical variables related to suicidal behavior. The aim of this study was to investigate the effects of a suicide attempt on clinical presentation by comparing sociodemographic variables, clinical signs, symptoms of depression, quality of life, social functionality, and reported adverse drug reactions in schizophrenic patients with and without suicide. METHOD: Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale (CDS), Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), Social Functioning Scale (SFS), and Udvalg for Kliniske Undersøgelser Side Effect Rating Scale (UKU) were administered to 115 patients with schizophrenia...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28936375/hand-hygiene-practices-among-indian-medical-undergraduates-a-questionnaire-based-survey
#3
Pranav D Modi, Pooja Kumar, Rajavi Solanki, Janhavi Modi, Srinath Chandramani, Niharika Gill
Background and objectives To prevent the spread of infections in all healthcare settings, hand hygiene must be routinely practiced. Appropriate hand hygiene techniques can go a long way in reducing nosocomial infections, cross-transmission of microorganisms and the risk of occupational exposure to infectious diseases. World Health Organisation (WHO) has taken an incredible approach called "My Five Moments for Hand Hygiene" which defines the key moments when health-care workers should perform hand hygiene. We thus carried out a survey to assess knowledge of hand hygiene practices among undergraduate medical students...
July 12, 2017: Curēus
https://www.readbyqxmd.com/read/28935247/seroepidemiology-and-risk-factors-of-crimean-congo-hemorrhagic-fever-among-butchers-and-slaughterhouse-workers-in-southeastern-iran
#4
Ehsan Mostafavi, Behzad Pourhossein, Saber Esmaeili, Fahimeh Bagheri Amiri, Sahar Khakifirouz, Nariman Shah-Hosseini, Seyed Mehdi Tabatabaei
OBJECTIVE: Crimean-Congo Haemorrhagic Fever (CCHF) is a viral zoonotic disease. Butchers and slaughterhouse workers are considered to be high risk occupational groups for the disease. Sistan and Baluchistan province is an area in southeastern Iran, where is endemic for CCHF and the most confirmed cases of the disease are reported from this province. The aim of this study was to investigate the seroprevalence of CCHF and risk factors for seropositivity among them in Sistan and Baluchistan province in 2011...
September 18, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28933701/a-cross-sectional-descriptive-study-of-medication-use-among-persons-with-a-gastrointestinal-stoma
#5
Bianca Augusta Pereira de Paula, Geisa Cristina da Silva Alves, Álvaro PercÍnio, Mariana Linhares Pereira, Juliano Teixeira Moraes, Cristina Sanches
Research on the use of medications in people with intestinal stomas is lacking, creating gaps in knowledge of pharmacoepidemiology in these patients. A cross-sectional, descriptive study was conducted over a period of 4 months in Divinópolis, Brazil to describe the profile of medication use among people enrolled in the Health Support Service for People with Stoma - Level II (SSPS II) of a municipality in the state of Minas Gerais, Brazil. All patients from SSPS II with a colostomy or ileostomy were invited by phone to participate; those with incomplete registration data and/or who were <18 years old, hospitalized for any reason, or had their stoma reversed were excluded from participation...
September 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28933618/novel-cns-drug-discovery-and-development-approach-model-based-integration-to-predict-neuro-pharmacokinetics-and-pharmacodynamics
#6
Elizabeth C M de Lange, Willem van den Brink, Yumi Yamamoto, Wilhelmus E A de Witte, Yin Cheong Wong
CNS drug development has been hampered by inadequate consideration of CNS pharmacokinetic (PK), pharmacodynamics (PD) and disease complexity (reductionist approach). Improvement is required via integrative model-based approaches. Areas covered: The authors summarize factors that have played a role in the high attrition rate of CNS compounds. Recent advances in CNS research and drug discovery are presented, especially with regard to assessment of relevant neuro-PK parameters. Suggestions for further improvements are also discussed...
September 21, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28933159/hemoglobin-adducts-and-urinary-metabolites-of-arylamines-and-nitroarenes
#7
Gabriele Sabbioni
Arylamines and nitroarenes are intermediates in the production of pharmaceuticals, dyes, pesticides, and plastics and are important environmental and occupational pollutants. N-Hydroxyarylamines are the toxic common intermediates of arylamines and nitroarenes. N-Hydroxyarylamines and their derivatives can form adducts with hemoglobin (Hb-adducts), albumin, DNA, and tissue proteins in a dose-dependent manner. Most of the arylamine Hb-adducts are labile and undergo hydrolysis in vitro, by mild acid or base, to form the arylamines...
September 21, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28932331/retraction-notice-lack-of-relationship-between-occupational-workload-and-microscopic-alterations-in-lumbar-intervertebral-disc-disease
#8
Gerald Huschak, Hans-Jürgen Holzhausen, Andre Beier, Hans Jörg Meisel, Thomas Hoell
[This retracts the article on p. 242 in vol. 8.].
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28932330/is-male-rheumatoid-arthritis-an-occupational-disease-a-review
#9
Dan Murphy, David Hutchinson
BACKGROUND: Rheumatoid arthritis (RA) is a systemic, inflammatory disease with an estimated global prevalence of 0.3-1.0%. An unexplained association exists between low formal education and the development of RA independent of smoking. It is established that RA is initiated in the lungs and that various occupations associated with dust, fume and metal inhalation can increase the risk of RA development. OBJECTIVE: The objective of this review is to evaluate published clinical reports related to occupations associated with RA development...
2017: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28931789/metabolic-syndrome-over-4-years-before-the-onset-of-cardiovascular-disease%C3%A3-nested-case-control-study
#10
Huanhuan Hu, Tohru Nakagawa, Toru Honda, Shuichiro Yamamoto, Akiko Nanri, Maki Konishi, Hiroko Okazaki, Keisuke Kuwahara, Ai Hori, Chihiro Nishiura, Ikuko Kashino, Teppei Imai, Akiko Nishihara, Shamima Akter, Toshiaki Miyamoto, Naoko Sasaki, Takayuki Ogasawara, Akihiko Uehara, Makoto Yamamoto, Taizo Murakami, Makiko Shimizu, Masafumi Eguchi, Takeshi Kochi, Satsue Nagahama, Kentaro Tomita, Isamu Kabe, Tetsuya Mizoue, Tomofumi Sone, Seitaro Dohi
BACKGROUND: We investigated the risk of cardiovascular disease (CVD) with duration of metabolic syndrome (MetS) for the past 4 years before the CVD event.Methods and Results:We performed a nested case-control study within the Japan Epidemiology Collaboration on Occupational Health Study. A total of 139 registered cases of CVD and 561 self-reported cases of CVD were identified and matched individually on age, sex, and worksite with 695 and 2,803 controls, respectively. MetS was defined by the Joint Interim Statement definition...
September 21, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28930375/occupation-and-chronic-obstructive-pulmonary-disease-in-minsk-tractor-plant-workers
#11
Denis Vinnikov, Sergey Semizhon, Tatsyana Rybina, Ludmila Savich, Vicktor Scherbitsky, Igor Manichev
BACKGROUND: The aim of this study was to measure the association of exposure to dust at workplace with COPD using objective methods of exposure and outcome classification. METHODS: Forced expiratory volume in one second (FEV1 ) to forced vital capacity (FVC) <70%; FVC below LLN, and FEV1 below LLN from the annual screening of Minsk Tractor Plant workers (N = 458) were tested for predictors in an adjusted logistic regression model. RESULTS: In a regression model, adjusted for pack-years of smoking, age, sex, and work duration, work in highly exposed workplaces was associated with FEV1 /FVC<70% (odds ratio (OR) 2...
September 20, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28928296/strengthening-occupational-medicine-to-address-challenges-of-occupational-diseases-a-priority
#12
EDITORIAL
Pankaja Raghav
No abstract text is available yet for this article.
July 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28926803/distribution-of-chromosome-breakpoints-in-benzene-exposed-and-unexposed-aml-patients
#13
Patrick J Kerzic, Richard D Irons
Results of laboratory studies and investigations of occupationally exposed healthy individuals have been used to develop a mode of action for benzene-induced leukemia that mirrors disease following treatment with chemotherapeutic agents. Recently we have described series of AML and MDS cases with benzene exposure history, and have provided cytogenetic, molecular, and pathologic evidence that these cases differ significantly in many features from therapy-related disease. Here we have extended this work, and describe chromosome breakpoints across 441 identifiable regions, in terms of gains or losses, in 710 AML cases collected during the Shanghai Health Study, which include 75 with a history of benzene exposure...
September 1, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28924313/tobacco-use-among-serving-army-personnel-an-epidemiological-study
#14
Atul Puthia, A K Yadav, Atul Kotwal
BACKGROUND: India has consequential burden of tobacco related disease and death. Though there are surveys conducted at national and regional level yet the information about tobacco consumption among army personnel is scarce. Thus an epidemiological study was conducted to estimate the prevalence and assess determinants of tobacco consumption amongst army personnel. METHODS: A community based cross sectional study was conducted using simple random sampling to enroll 380 personnel...
April 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28921583/associations-of-alcohol-intake-smoking-physical-activity-and-obesity-with-survival-following-colorectal-cancer-diagnosis-by-stage-anatomic-site-and-tumor-molecular-subtype
#15
Harindra Jayasekara, Dallas R English, Andrew Haydon, Allison M Hodge, Brigid M Lynch, Christophe Rosty, Elizabeth J Williamson, Mark Clendenning, Melissa C Southey, Mark A Jenkins, Robin Room, John L Hopper, Roger L Milne, Daniel D Buchanan, Graham G Giles, Robert J MacInnis
The influence of lifestyle factors on survival following a diagnosis of colorectal cancer (CRC) is not well established. We examined associations between lifestyle factors measured before diagnosis and CRC survival. The Melbourne Collaborative Cohort Study collected data on alcohol intake, cigarette smoking and physical activity, and body measurements at baseline (1990-94) and wave 2 (2003-07). We included participants diagnosed to 31 August 2015 with incident stage I-III CRC within 10-years post exposure assessment...
September 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28920966/-prevention-of-cardiovascular-diseases-prophylactic-program-in-a-selected-enterprise
#16
Jadwiga Siedlecka, Elżbieta Gadzicka, Agata Szyjkowska, Patryk Siedlecki, Wiesław Szymczak, Teresa Makowiec-Dąbrowska, Alicja Bortkiewicz
BACKGROUND: In Poland cardiovascular diseases (CVD), classified as work-related diseases, are responsible for 25% of disability and cause 50% of all deaths, including 26.9% of deaths in people aged under 65 years. The aim of the study was to analyze employee expectations regarding CVD- oriented prophylactic activities in the selected enterprise. MATERIAL AND METHODS: A questionnaire, developed for this study, consists of: socio-demographic data, job characteristics, occupational factors, and questions about the respondents' expectations concerning the prevention program...
September 18, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28920440/unrestricted-mass-spectrometric-data-analysis-for-identification-localization-and-quantification-of-oxidative-protein-modifications
#17
Martin Rykær, Birte Svensson, Michael J Davies, Per Hägglund
Oxidation generates multiple diverse post-translational modifications resulting in changes in protein structure and function, associated with a wide range of diseases. Of these modifications, carbonylations have often been used as hallmarks of oxidative damage. However, accumulating evidence supports the hypothesis that other oxidation products may be quantitatively more important under physiological conditions. To address this issue we have developed a holistic mass spectrometry-based approach for simultaneous identification, localization and quantification of a broad range of oxidative modifications based on so-called 'dependent peptides'...
September 18, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28920072/associations-between-neighborhood-socioeconomic-environment-and-physical-activity-in-cuban-immigrants
#18
Olivia Affuso, Chelsea R Singleton, Scott C Brown, Tatiana Perrino, Shi Huang, José Szapocznik
Physical inactivity is a major public health concern because it is a determinant of obesity and obesity-related chronic diseases. Few longitudinal studies have examined the association between neighborhood socioeconomic (SES) environment and change in physical activity behaviors. Additionally, few studies have examined this association in immigrant groups or Hispanic subgroups such as Cubans. This research aimed to determine if neighborhood SES is associated with longitudinal change in moderate-to-vigorous physical activity (MVPA) among Cuban immigrants who participate in the Cuban Health Study in Miami, Florida...
December 2016: SSM—Population Health
https://www.readbyqxmd.com/read/28919597/quality-of-life-in-children-with-asthma-in-bangladesh
#19
M R Hassan, S Kabir, A E Basher, M A Rahman, M A Islam, M K Khan, M S Basher
Asthma is a public health problem that adversely affects different aspects of quality of life. Childhood asthma is common in Bangladesh affecting their lifestyle. The objective of the study was to assess health-related quality of life in children with bronchial asthma. A descriptive, cross-sectional study was carried out from January 2014 to December 2014 at the Outpatient Department of National Asthma Centre, Mohakhali, Dhaka among hundred sixty-two purposively selected children of both sexes with bronchial asthma aged from 7 to 17 years...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28919119/global-regional-and-national-comparative-risk-assessment-of-84-behavioural-environmental-and-occupational-and-metabolic-risks-or-clusters-of-risks-1990-2016-a-systematic-analysis-for-the-global-burden-of-disease-study-2016
#20
(no author information available yet)
BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of risk factor exposure and attributable burden of disease. By providing estimates over a long time series, this study can monitor risk exposure trends critical to health surveillance and inform policy debates on the importance of addressing risks in context. METHODS: We used the comparative risk assessment framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2016...
September 16, 2017: Lancet
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