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https://www.readbyqxmd.com/read/29667742/genetic-association-and-expression-analyses-of-the-phosphatidylinositol-4-phosphate-5-kinase-pip5k1c-gene-in-alcohol-use-disorder-relevance-for-pain-signaling-and-alcohol-use
#1
Ji Soo Lee, Jill L Sorcher, Allison D Rosen, Ruslan Damadzic, Hui Sun, Melanie Schwandt, Markus Heilig, John Kelly, Kelsey L Mauro, Audrey Luo, Daniel Rosoff, Christine Muench, Jeesun Jung, Zachary A Kaminsky, Falk W Lohoff
BACKGROUND: The gene encoding Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) has been recently implicated in pain regulation. Interestingly, a recent cross-tissue and cross-phenotypic epigenetic analysis identified the same gene in alcohol use disorder (AUD). Given the high comorbidity between AUD and chronic pain, we hypothesized that genetic variation in PIP5K1C might contribute to susceptibility to AUD. METHODS: We conducted a case-control association study of genetic variants in PIP5K1C...
April 18, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29667645/genotoxic-effects-of-exposure-to-gasoline-fumes-on-petrol-pump-workers
#2
Amrin Shaikh, Darshana Barot, Divya Chandel
BACKGROUND: Petrol pump workers are occupationally exposed to gasoline and its fumes consisting of several mutagenic chemicals. OBJECTIVE: To evaluate the genotoxic effects of exposure to gasoline fumes on petrol pump workers. METHODS: The study groups included 70 petrol pump workers (exposed group) and 70 healthy age-matched individuals with no known exposure (comparison group). Buccal micronucleus cytome assay (BMCyt) was performed to check the genotoxicity caused due to inhalation of gasoline fumes...
April 2018: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29667303/mir-146a-regulates-pm-1-induced-inflammation-via-nf-%C3%AE%C2%BAb-signaling-pathway-in-beas-2b-cells
#3
Limin Liu, Chong Wan, Wei Zhang, Longfei Guan, Guoxiong Tian, Fang Zhang, Wenjun Ding
Exposure to particulate matter (PM) leads to kinds of cardiopulmonary diseases, such as asthma, COPD, arrhythmias, lung cancer, etc., which are related to PM-induced inflammation. We have found that PM2.5 (aerodynamics diameter <2.5 µm) exposure induces inflammatory response both in vivo and in vitro. Since the toxicity of PM is tightly associated with its size and components, PM1 (aerodynamics diameter <1.0 µm) is supposed to be more toxic than PM2.5 . However, the mechanism of PM1 -induced inflammation is not clear...
April 18, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29667054/connecting-gastrointestinal-cancer-risk-to-cadmium-and-lead-exposure-in-the-chaoshan-population-of-southeast-china
#4
Xueqiong Lin, Lin Peng, Xijin Xu, Yanrong Chen, Yuling Zhang, Xia Huo
Cadmium (Cd) and lead (Pb) pose a serious threat to human health because of its carcinogenicity. China ranks first according to the Global Cancer Report for 2014 in newly diagnosed gastrointestinal cancers and cancer deaths. The aim of the present study was to evaluate the association of Cd and Pb burden with the risk of gastrointestinal cancers in a hospital-based case-control study from southern regions of China, Chaoshan area. A total of 279 hospitalized patients were recruited in this study, of which 167 were gastrointestinal cancer cases (70 esophageal cancer, 51 gastric cancer, and 46 colorectal cancer), and 112 controls were recruited from two hospitals in the Chaoshan area of southeast China...
April 17, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29666879/-muscle-injuries-in-professional-football-treatment-and-rehabilitation
#5
REVIEW
H Riepenhof, R Del Vescovo, J-N Droste, S McAleer, A Pietsch
BACKGROUND: Muscle injuries are common in professional sports, especially in football. Recent epidemiological studies showed that muscle injuries account for more than 30% of professional football injuries (1.8-2.2/1000 h exposure); however, even though there are significant differences within a European comparison, a single professional football team diagnosed on average 12 muscle injuries per season, corresponding to more than 300 availability days lost. OBJECTIVE: The aim of this work is to present the diagnosis, general treatment and comprehensive management of muscle injuries in professional football...
April 17, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29666814/digital-chest-tomosynthesis-the-2017-updated-review-of-an-emerging-application
#6
REVIEW
Arianna Ferrari, Luca Bertolaccini, Piergiorgio Solli, Paola Oriana Di Salvia, David Scaradozzi
Lung cancer is the leading cause of cancer death and second most common cancer among both men and women, but most of them are detected when patients become symptomatic and in late-stage. Chest radiography (CR) is a basic technique for the investigation of lung cancer and has the benefit of convenience and low radiation dose, but detection of malignancy is often difficult. The introduction of computed tomography (CT) for screening has increased the proportion of lung cancer detected but with higher exposure dose and higher costs...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666782/new-perspectives-on-diagnosis-and-therapy-of-malignant-pleural-mesothelioma
#7
REVIEW
Marika Rossini, Paola Rizzo, Ilaria Bononi, Anthony Clementz, Roberto Ferrari, Fernanda Martini, Mauro G Tognon
Malignant pleural mesothelioma (MPM) is a rare, but severe form of cancer, with an incidence that varies significantly within and among different countries around the world. It develops in about one to two persons per million of the general population, leading to thousands of deaths every year worldwide. To date, the MPM is mostly associated with occupational asbestos exposure. Asbestos represents the predominant etiological factor, with approximately 70% of cases of MPM with well-documented occupational exposure to asbestos, with the exposure time, on average greater than 40 years...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29666544/efficiency-of-selected-food-ingredients-on-protein-efficiency-ratio-glycemic-index-and-in-vitro-digestive-properties
#8
M B Anusha, Naveen Shivanna, G Phani Kumar, K R Anilakumar
The human body on exposure to high-altitude, undergoes many physiological challenges. The cardiopulmonary reserves are favoured against the digestive system. Hence, the efficiency of digestion is compromised to a great extent, which leads to anorexia, hypophagia, epigastralgia, dyspepsia, nausea, and peptic ulcers. The present study was focused on in vitro digestive influence of selected food ingredients viz. cardamom, carom, cumin, coriander, fennel, fenugreek, ginger, pepper, star anise, turmeric, papaya, orange, pineapple, liquorice, valerian, and tarragon on the activities of digestive enzymes of rat pancreas, duodenum, and small intestine...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29666304/strategic-therapeutic-targeting-to-overcome-venetoclax-resistance-in-aggressive-b-cell-lymphomas
#9
Lan V Pham, Shengjian Huang, Hui Zhang, Jun Zhang, Taylor Bell, Shouhao Zhou, Elizabeth Pogue, Zhiyong Ding, Laura Lam, Jason R Westin, R Eric Davis, Ken H Young, L Jeffrey Medeiros, Richard J Ford, Krystle Nomie, Liang Zhang, Michael Wang
PURPOSE: B-cell lymphoma-2 (BCL-2), an anti-apoptotic protein often dysregulated in B-cell lymphomas, promotes cell survival and provides protection from stress. A recent Phase I first-in-human study of the BCL-2 inhibitor venetoclax in non-Hodgkin lymphoma showed an overall response rate of 44%. These promising clinical results prompted our examination of the biological effects and mechanism of action underlying venetoclax activity in aggressive B-cell lymphoma, including mantle cell lymphoma (MCL) and diffuse large B cell lymphoma (DLBCL)...
April 17, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29666259/shared-epitope-aryl-hydrocarbon-receptor-crosstalk-underlies-the-mechanism-of-gene-environment-interaction-in-autoimmune-arthritis
#10
Jiaqi Fu, Sarah V Nogueira, Vincent van Drongelen, Patrick Coit, Song Ling, Edward F Rosloniec, Amr H Sawalha, Joseph Holoshitz
The susceptibility to autoimmune diseases is affected by genetic and environmental factors. In rheumatoid arthritis (RA), the shared epitope (SE), a five-amino acid sequence motif encoded by RA-associated HLA-DRB1 alleles, is the single most significant genetic risk factor. The risk conferred by the SE is increased in a multiplicative way by exposure to various environmental pollutants, such as cigarette smoke. The mechanism of this synergistic interaction is unknown. It is worth noting that the SE has recently been found to act as a signal transduction ligand that facilitates differentiation of Th17 cells and osteoclasts in vitro and in vivo...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29665647/mir-362-3p-regulates-cell-proliferation-migration-and-invasion-of-trophoblastic-cells-under-hypoxia-through-targeting-pax3
#11
Nan Wang, Yaling Feng, Jianjuan Xu, Jinfang Zou, Minghua Chen, Yue He, Huan Liu, Min Xue, Yanfang Gu
Preeclampsia (PE), a common obstetrical disorder, is one of the leading causes of pregnancy associated death. PE is closely linked with impaired migration and invasion ability of trophoblastic cells. miR-362-3p recently received our particular attention due not only to its aberrant expression in the placentas of patients with PE, but also to its important roles in regulating migration and invasion of various cells. This study was thus conducted to investigate the roles of miR-362-3p in PE and the related mechanism...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29665622/existing-regulatory-approaches-to-reducing-exposures-to-chemical-and-product-based-risk-and-their-applicability-to-diet-related-chronic-disease
#12
Deborah A Cohen, Debra S Knopman
We aimed to identify and categorize the types of policies that have been adopted to protect Americans from harmful exposures that could also be relevant for addressing diet-related chronic diseases. This article examines and categorizes the rationales behind government regulation. Our interest in the historical analysis is to inform judgments about how best to address newly emergent risks involving diet-related chronic disease within existing regulatory and information-based frameworks. We assessed exemplars of regulation with respect to harmful exposures from air, water, and food, as well as regulations that are intended to modify voluntary behaviors...
April 17, 2018: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29665547/lead-and-cadmium-levels-in-raw-bovine-milk-and-dietary-risk-assessment-in-areas-near-petroleum-extraction-industries
#13
Reza Norouzirad, Jose-Ramiro González-Montaña, Felipe Martínez-Pastor, Hedayat Hosseini, Ali Shahrouzian, Mehdi Khabazkhoob, Fardin Ali Malayeri, Haniyeh Moallem Bandani, Mohsen Paknejad, Behrouz Foroughi-Nia, Atefeh Fooladi Moghaddam
Oil fields are a source of heavy metal pollution, but few studies have evaluated its impact on the intake of these contaminants through milk, an important food especially for children. From February 2015 to 2016, 118 samples of raw cow's milk, 14 of fodder and 8 of water in Southwest Iran were collected from farms close to oil fields or related industries. Lead (Pb) and cadmium (Cd) levels were evaluated by graphite furnace atomic absorption spectrometry. Mean±SE in milk and fodder were 47.0±3.9 and 54.0±6...
April 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29665491/methamphetamine-use-and-future-risk-for-parkinson-s-disease-evidence-and-clinical-implications
#14
REVIEW
Julia M Lappin, Shane Darke, Michael Farrell
BACKGROUND: Methamphetamine use has been posited to be a risk factor for the development of Parkinson's disease (PD) and parkinsonism. The clinical implications of a potential association between methamphetamine use and PD are considered. METHODS: A review of methamphetamine and PD and parkinsonism was conducted, including evidence from animal models, clinical and population studies. RESULTS: There is biological plausibility to a link between methamphetamine use and PD...
April 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29665414/silver-nanoparticle-mediated-cellular-responses-in-isolated-primary-sertoli-cells-in-vitro
#15
Khaled Habas, M H Brinkworth, D Anderson
The present study explored the mechanism of cytotoxic and genotoxic effects of AgNPs on a primary culture of mouse Sertoli cells in vitro. To understand the possible molecular mechanisms of testicular lesions following exposure to AgNPs, isolated Sertoli cells were exposed to 5, 10, or 15 μg/ml. DNA damage in the Comet assay and apoptosis in the TUNEL assay were evaluated. The mRNA expression of p53 and bcl-2 genes and their proteins involved in apoptosis was also investigated. The antioxidant status of treated Sertoli cells was determined by measuring catalase (CAT), glutathione peroxidase (GPX-1) and superoxide dismutase (SOD-1) using qPCR...
April 14, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29665273/butylidenephthalide-abrogates-the-myofibroblasts-activation-and-mesenchymal-transdifferentiation-in-oral-submucous-fibrosis
#16
Tzu-Rong Su, Yi-Wen Liao, Pei-Ling Hsieh, Lo-Lin Tsai, Chih-Yuan Fang, Taichen Lin, Yu-Hsien Lee, Horng-Jyh Harn, Cheng-Chia Yu
Oral submucous fibrosis (OSF) is a premalignant disorder in the oral cavity, and areca nut chewing habit has been implicated in the persistent activation of myofibroblasts and the subsequent fibrosis. Therefore, it is critical to ameliorate the excessive activities of myofibroblasts prior to the malignant transformation of OSF. In the current study, we evaluated the cytotoxicity of butylidenephthalide (BP), a major phthalide ingredient of Angelica sinensis, in fibrotic buccal mucosal fibroblasts (fBMFs) as well as various myofibroblast hallmarks, including the phenotypical characteristics and fibrosis-related markers...
April 17, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29665093/the-mapk-activator-protein-1-signaling-regulates-changes-in-lung-tissue-of-rat-exposed-to-hypobaric-hypoxia
#17
Mrinalini Singh, Seema Yadav, Meetul Kumar, Shweta Saxena, Deepika Saraswat, Anju Bansal, Shashi B Singh
This study reports the role of MAPKs (JNK, ERK, and p38), and activator protein-1 (AP-1) transcription factor in the hypobaric hypoxia induced change in lung tissue. Healthy male Sprague-Dawley rats were exposed to hypobaric hypoxia for 6, 12, 24, 48, 72, and 120 hr. Hypoxia resulted in significant increase in reactive oxygen species (ROS), vascular endothelial growth factor (VEGF) and decreased nitric oxide (NO), these act as signaling molecules for activation of MAPK and also contribute in development of vascular leakage (an indicator of pulmonary edema) as confirmed by histological studies...
April 17, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29665002/three-dimensional-collagenous-niche-and-azacytidine-selectively-promote-time-dependent-cardiomyogenesis-from-human-bone-marrow-derived-msc-spheroids
#18
Jyotsna Joshi, Gautam Mahajan, Chandrasekhar R Kothapalli
Endogenous adult cardiac regenerative machinery is not capable of replacing the lost cells following myocardial infarction, often leading to permanent alterations in structure-function-mechanical properties. Regenerative therapies based on delivering autologous stem cells within an appropriate 3D milieu could meet such demand, by enabling homing and directed differentiation of the transplanted cells into lost specialized cell populations. Since type I collagen is the predominant cardiac tissue matrix protein, we here optimized the 3D niche which could promote time-dependent evolution of cardiomyogenesis from human bone marrow-derived mesenchymal stem cells (BM-MSC)...
April 17, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29664715/late-infection-related-mortality-in-asplenic-survivors-of-childhood-cancer-a-report-from-the-childhood-cancer-survivor-study
#19
Brent R Weil, Arin L Madenci, Qi Liu, Rebecca M Howell, Todd M Gibson, Yutaka Yasui, Joseph P Neglia, Wendy M Leisenring, Susan A Smith, Emily S Tonorezos, Danielle N Friedman, Louis S Constine, Christopher L Tinkle, Lisa R Diller, Gregory T Armstrong, Kevin C Oeffinger, Christopher B Weldon
Purpose Infection-related outcomes associated with asplenia or impaired splenic function in survivors of childhood cancer remains understudied. Methods Late infection-related mortality was evaluated in 20,026 5-year survivors of childhood cancer (diagnosed < 21 years of age from 1970 to 1999; median age at diagnosis, 7.0 years [range, 0 to 20 years]; median follow-up, 26 years [range, 5 to 44 years]) using cumulative incidence and piecewise-exponential regression models to estimate adjusted relative rates (RRs)...
April 17, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29663891/flipped-learning-can-rheumatology-lead-the-shift-in-medical-education
#20
Yasser El Miedany, Maha El Gaafary, Nadia El Aroussy, Sally Youssef
OBJECTIVE: To: 1. implement flipped classroom rheumatology teaching for undergraduate education. 2. Evaluate outcomes of teaching using OSCE assessment and student perceived effectiveness and satisfaction survey. METHODS: The flipped classroom education was conducted in 3 phases. Phase 1: carried out in the students' own time. Web links were emailed to assist exposure of the instructional part of the lesson online. Phase 2: interactive in-class activity to share personal reflection and reinforce the key aspects...
April 16, 2018: Current Rheumatology Reviews
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