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https://www.readbyqxmd.com/read/28433109/pathogenesis-of-wilson-disease
#1
Ivo Florin Scheiber, Radan Brůha, Petr Dušek
Wilson disease is an autosomal-recessive disorder originating from a genetic defect in the copper-transporting ATPase ATP7B that is required for biliary copper secretion and loading of ceruloplasmin with copper. Impaired ATP7B function in Wilson disease results in excessive accumulation of copper in liver, brain, and other tissues. Toxic copper deposits may induce oxidative stress, modify expression of genes, directly inhibit proteins, and impair mitochondrial function, leading to hepatic, neuropsychiatric, renal, musculoskeletal, and other symptoms...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28423016/evaluating-the-utility-of-two-gestural-discomfort-evaluation-methods
#2
Minseok Son, Jaemoon Jung, Woojin Park
Evaluating physical discomfort of designed gestures is important for creating safe and usable gesture-based interaction systems; yet, gestural discomfort evaluation has not been extensively studied in HCI, and few evaluation methods seem currently available whose utility has been experimentally confirmed. To address this, this study empirically demonstrated the utility of the subjective rating method after a small number of gesture repetitions (a maximum of four repetitions) in evaluating designed gestures in terms of physical discomfort resulting from prolonged, repetitive gesture use...
2017: PloS One
https://www.readbyqxmd.com/read/28419751/clinical-characteristics-of-fibromyalgia-in-a-chronic-pain-population
#3
Mark Gostine, Fred Davis, Bradley Roberts, Rebecca Risko, Michael Asmus, Joseph C Cappelleri, Alesia Sadosky
OBJECTIVE: To compare fibromyalgia (FM) characteristics among patients identified in a community-based chronic pain cohort based on traditional International Classification of Diagnoses Ninth Revision, ICD-9 diagnostic coding, with that of patients identified using a novel predictive model. METHODS: This retrospective study used data collected from July 1999 to February 17, 2015 in multiple chronic pain clinics in the United States. Patients were assigned to the FM case group based on specific inclusion criteria using ICD-9 codes or, separately, from results of a novel FM predictive model that was developed using random forest and logistic regression techniques...
April 18, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28416996/the-relationship-between-the-development-of-musculoskeletal-disorders-body-mass-index-and-academic-stress-in-bahraini-university-students
#4
Sayed A Tantawy, Asma Abdul Rahman, Maryam Abdul Ameer
BACKGROUND: There are many mechanisms in which stress can lead to weight gain thus high a BMI. The endocrine and inflammatory pathway can directly increase abdominal adiposity. Another way in which stress leads to weight gain is through changes in health behaviors. The study aimed to investigate the prevalence of musculoskeletal disorders (MSDs) among healthy students of Ahlia University, and to determine the relationship between the development of MSDs and academic stressors and body mass index...
April 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/28413672/whole-body-magnetic-resonance-imaging-in-the-diagnosis-and-follow-up-of-multicentric-infantile-myofibromatosis-a-case-report
#5
Sergio Salerno, Maria Chiara Terranova, Mario Rossello, Maria Piccione, Ottavio Ziino, Giuseppe Lo Re
Myofibromatosis is an uncommon disorder of infancy, characterized by proliferation of myofibroblasts in solitary or multiple nodules. The clinical characteristics depend on the involved sites: Myofibromatosis may develop as a musculoskeletal form, with non-painful swellings and eventual mass effect symptoms, or as a generalized form with visceral involvement and organ failure. Prognosis and therapy vary between the abovementioned patterns. When there is no visceral involvement, the tumors may regress spontaneously; however, the visceral form may represent a lifethreatening condition with poor outcome and it requires aggressive management...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28413599/rare-features-associated-with-mobius-syndrome-report-of-two-cases
#6
Rumela Ghosh, Vikram Shetty, Shruthi Hegde, G Subhas Babu, Vidya Ajila, Nanda Kishore P, Mithula Nair
Mobius syndrome is a rare congenital disorder with the preliminary diagnostic criteria of congenital facial and abducent nerve palsy. Involvement of other cranial nerves, too, is common. Prevalence rate of this syndrome is approximately 1 in 100,000 neonates. It is of unknown etiology with sporadic occurrence. However, data regarding the occurrence rate in India is limited. Features such as orofacial malformations, limb defects, and musculoskeletal, behavioral, and cognitive abnormalities might be associated...
2017: Journal of Dental Research, Dental Clinics, Dental Prospects
https://www.readbyqxmd.com/read/28413025/biochemical-and-biological-attributes-of-matrix-metalloproteinases
#7
Ning Cui, Min Hu, Raouf A Khalil
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are involved in the degradation of various proteins in the extracellular matrix (ECM). Typically, MMPs have a propeptide sequence, a catalytic metalloproteinase domain with catalytic zinc, a hinge region or linker peptide, and a hemopexin domain. MMPs are commonly classified on the basis of their substrates and the organization of their structural domains into collagenases, gelatinases, stromelysins, matrilysins, membrane-type (MT)-MMPs, and other MMPs...
2017: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/28411738/implementing-powered-stretcher-and-load-systems-was-a-cost-effective-intervention-to-reduce-the-incidence-rates-of-stretcher-related-injuries-in-a-paramedic-service
#8
Daniel P Armstrong, Richard Ferron, Cindi Taylor, Brent McLeod, Steve Fletcher, Renée S MacPhee, Steven L Fischer
Paramedic services are considering moving towards the use of powered stretcher and load systems to reduce stretcher related injuries, but cost is perceived as a barrier. This study compared injury incidence rates, days lost, and compensation costs between Niagara Emergency Medical Service (NEMS) and Hamilton Paramedic Service (HPS) pre- (four years) and post- (one year) implementation of powered stretcher and load systems in NEMS. Prior to the intervention stretcher related musculoskeletal disorder (MSD) incidence rates averaged 20...
July 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28411720/inter-and-intra-observer-reliability-of-risk-assessment-of-repetitive-work-without-an-explicit-method
#9
Kristina Eliasson, Peter Palm, Teresia Nyman, Mikael Forsman
A common way to conduct practical risk assessments is to observe a job and report the observed long term risks for musculoskeletal disorders. The aim of this study was to evaluate the inter- and intra-observer reliability of ergonomists' risk assessments without the support of an explicit risk assessment method. Twenty-one experienced ergonomists assessed the risk level (low, moderate, high risk) of eight upper body regions, as well as the global risk of 10 video recorded work tasks. Intra-observer reliability was assessed by having nine of the ergonomists repeat the procedure at least three weeks after the first assessment...
July 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28411487/the-relationship-of-corticospinal-excitability-with-pain-motor-performance-and-disability-in-subjects-with-chronic-wrist-hand-pain
#10
René Pelletier, Johanne Higgins, Daniel Bourbonnais
There is a growing body of evidence of changes in corticospinal excitability associated with musculoskeletal disorders, however there is a lack of knowledge of how these changes relate to measures of pain, motor performance and disability. An exploratory study was performed utilizing Transcranial Magnetic Stimulation to investigate differences in corticospinal excitability in the Abductor Pollicis Brevis (APB) between 15 pain-free subjects and 15 subjects with chronic wrist/hand pain and to determine how corticospinal excitability was associated with measures of pain (visual analog scale, AUSCAN™), hand motor performance (isometric and key pinch strength, Purdue Pegboard Test), disability (AUSCAN™), and spinal motoneuronal excitability...
April 7, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28410005/meeting-report-of-the-2016-bone-marrow-adiposity-meeting
#11
Bram van der Eerden, André van Wijnen
There is considerable interest in the physiology and pathology, as well as the cellular and molecular biology, of bone marrow adipose tissue (BMAT). Because bone marrow adiposity is linked not only to systemic energy metabolism, but also to both bone marrow and musculoskeletal disorders, this biologic compartment has become of major interest to investigators from diverse disciplines. Bone marrow adiposity represents a virtual multi-tissue endocrine organ, which encompasses cells from multiple developmental lineages (e...
April 5, 2017: Adipocyte
https://www.readbyqxmd.com/read/28409765/effects-of-patient-handling-and-individual-factors-on-the-prevalence-of-low-back-pain-among-nursing-personnel
#12
Seyed Ehsan Samaei, Maryam Mostafaee, Hasanali Jafarpoor, Majid Bagheri Hosseinabadi
BACKGROUND: Patient transfer is one of the main tasks of nursing personnel; it imposes compressive and shear forces on nurses' lower spine. The aim of this study was to determine the prevalence of Low Back Pains (LBPs), risk factors in the incidence of such disorders, and patient transfer risk assessment among nursing personnel. METHODS: This study was carried out on 243 randomly selected nursing personnel who played a role in transferring the patients (58 wards)...
April 12, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28409763/work-related-musculoskeletal-disorders-among-jordanian-dental-technicians-prevalence-and-associated-factors
#13
Zeid Al-Hourani, Mohammad Nazzal, Yousef Khader, Khader Al Mhdawi, Abdel Rahim Bibars
BACKGROUND: Dental technology is a profession that requires precise manual skills and dexterous handling of small tools. There is an abundance research on work-related musculoskeletal disorders (WMSDs) affecting dentists, dental hygienists and dental assistants, yet very few articles investigated WMSDs among dental technicians. OBJECTIVES: This study aimed to determine the prevalence of WMSDs among Jordanian dental technicians and their associated factors. METHODS: A cross-sectional design was conducted...
April 12, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28408656/is-job-rotation-effective-for-prevention-of-work-related-musculoskeletal-disorders-and-sick-leave
#14
EDITORIAL
Charlotte Diana Nørregaard Rasmussen
No abstract text is available yet for this article.
April 13, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28407683/the-effects-of-high-glucose-on-tendon-derived-stem-cells-implications-of-the-pathogenesis-of-diabetic-tendon-disorders
#15
Yu-Cheng Lin, Ying-Juan Li, Yun-Feng Rui, Guang-Chun Dai, Liu Shi, Hong-Liang Xu, Ming Ni, Song Zhao, Hui Chen, Chen Wang, Gang Li, Gao-Jun Teng
Patients with diabetes are at great risk to suffer many musculoskeletal disorders, such as tendinopathy, tendon rupture and impaired tendon healing. However, the pathogenesis of these tendon disorders still remains unclear. In this study, we aimed to investigate the effects of high glucose on cell proliferation, cell apoptosis and tendon-related markers expression of tendon-derived stem cells (TDSCs) in vitro. These findings might provide new insights into the pathogenesis of diabetic tendon disorders. The cell proliferative ability and apoptosis rate of TDSCs in different groups were evaluated by MTT assay and Annexin V-FITC/PI staining assay...
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28405546/arthropathy-in-dermatology-a-comprehensive-review
#16
REVIEW
Soumya Jagadeesan, Padmanabha Shenoy
Dermatology and rheumatology are two specialties that deal with significant overlap. In this context, it is important that the dermatologists acquaint themselves with conditions presenting with arthropathy. As the first step, it is essential to know whether the origin of musculoskeletal symptom is articular or extra-articular; inflammatory or noninflammatory; acute or chronic; oligo- or poly-articular. This will help in narrowing down the differential diagnoses as well as in better correlation with the cutaneous symptoms...
March 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28404613/risk-factors-of-non-specific-neck-pain-and-low-back-pain-in-computer-using-office-workers-in-china-a-cross-sectional-study
#17
Sunyue Ye, Qinglei Jing, Chen Wei, Jie Lu
OBJECTIVES: Several studies have found that inappropriate workstations are associated with musculoskeletal disorders. The present cross-sectional study aimed to identify the risk factors of non-specific neck pain (NP) and low back pain (LBP) among computer-using workers. DESIGN: Observational study with a cross-sectional sample. SETTING: This study surveyed 15 companies in Zhejiang province, China. PARTICIPANTS: After excluding participants with missing variables, 417 office workers, including 163 men and 254 women, were analyzed...
April 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28403669/use-of-videoconferencing-for-physical-therapy-in-people-with-musculoskeletal-conditions-a-systematic-review
#18
Stacey Lovo Grona, Brenna Bath, Angela Busch, Thomas Rotter, Catherine Trask, Elizabeth Harrison
Background Physical therapists are key players in the management of musculoskeletal conditions, which are common in rural and remote communities. There are few physical therapists in rural regions compared to potential need, so care is either not provided or must be sought in urban centers, requiring travel and time away from work and family to access services. Telerehabilitation strategies, such as real-time videoconferencing, are emerging as possible solutions to address shortages in rural physical therapy services...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28403205/spontaneous-diseases-in-captive-ratites-struthioniformes-in-northwestern-germany-a-retrospective-study
#19
Aimara Bello, Samuel Frei, Martin Peters, Anne Balkema-Buschmann, Wolfgang Baumgärtner, Peter Wohlsein
A retrospective study was carried out to define the spectrum of spontaneous diseases in ostriches and few other captive ratites, order Struthioniformes, in northwestern Germany. The investigation included 71 ratites necropsied between 1968 and 2014. They consisted of 54 ostriches, 5 emus, and 12 rheas with 37 adults, 23 juveniles and 11 neonates and embryonated eggs. Necropsy reports were reviewed, histologic preparations were re-examined and additional histochemical and immunohistochemical stains were carried out in selected cases...
2017: PloS One
https://www.readbyqxmd.com/read/28401441/effect-of-inpatient-multicomponent-occupational-rehabilitation-versus-less-comprehensive-outpatient-rehabilitation-on-sickness-absence-in-persons-with-musculoskeletal-or-mental-health-disorders-a-randomized-clinical-trial
#20
Lene Aasdahl, Kristine Pape, Ottar Vasseljen, Roar Johnsen, Sigmund Gismervik, Vidar Halsteinli, Nils Fleten, Claus Vinther Nielsen, Marius Steiro Fimland
Purpose To assess effects of an inpatient multicomponent occupational rehabilitation program compared to less comprehensive outpatient rehabilitation on sickness absence in persons with musculoskeletal- or mental health disorders. Methods Randomized clinical trial with parallel groups. Participants were individuals 18-60 years old on sick-leave for 2-12 months with a sick-leave diagnosis within the musculoskeletal, psychological or general and unspecified chapters of ICPC-2, identified in a national register...
April 11, 2017: Journal of Occupational Rehabilitation
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