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https://www.readbyqxmd.com/read/29783192/interaction-of-dna-and-mononucleotides-with-theophylline-investigated-using-electrochemical-biosensors-and-biosensing
#1
Katarína Nemčeková, Ján Labuda, Viktor Milata, Jana Blaškovičová, Jozef Sochr
The understanding of DNA-drug interaction mechanism is among the important aspects of biological studies for drug design, discovery and pharmaceutical development processes. Published rather detailed FTIR and UV-visible spectroscopic studies on the interactions of theophylline, theobromine and caffeine with calf thymus DNA have shown effective binding of these methylxanthine derivatives to DNA and RNA involving H-bonds. However, to our knowledge, there is no such investigation using electrochemical approach...
May 3, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29782893/quantity-based-analysis-of-household-food-consumption-patterns-and-drivers-the-case-of-israel
#2
Yuval Damari, Meidad Kissinger
The interest in better understanding the characteristics and drivers of food consumption by individuals and social groups has grown in recent years, because of various social, environmental, health and economic issues. Most analyses have focused either on the macro or national scale, using food balance/disappearance data, or on the micro scale, focusing on nutrition analysis in limited groups of individual consumers. While various household characteristics are expected to influence food-purchasing habits, the scope and methodology of most previous studies limited their ability to relate to multiple factors, and integrate all into specific consumption patterns...
May 18, 2018: Appetite
https://www.readbyqxmd.com/read/29782815/reprint-of-initial-uncertainty-impacts-statistical-learning-in-sound-sequence-processing
#3
Juanita Todd, Alexander Provost, Lisa Whitson, Daniel Mullens
This paper features two studies confirming a lasting impact of first learning on how subsequent experience is weighted in early relevance-filtering processes. In both studies participants were exposed to sequences of sound that contained a regular pattern on two different timescales. Regular patterning in sound is readily detected by the auditory system and used to form "prediction models" that define the most likely properties of sound to be encountered in a given context. The presence and strength of these prediction models is inferred from changes in automatically elicited components of auditory evoked potentials...
May 18, 2018: Neuroscience
https://www.readbyqxmd.com/read/29782796/resolution-measurement-from-a-single-reconstructed-cryo-em-density-map-with-multi-scale-spectral-analysis
#4
Yu-Jiao Yang, Shuai Wang, Biao Zhang, Hong-Bin Shen
As a relatively new technology to solve the 3D structure of a protein or protein complex, the Single-Particle Reconstruction (SPR) of cryo-EM images shows much superiority and is in a rapidly developing stage. Resolution measurement in SPR, which evaluates the quality of a reconstructed 3D density map, plays a critical role for promoting methodology development of SPR and structural biology. Due to there is no benchmark map in a new structure generation, how to realize the resolution estimation of a new map is still an open problem...
May 21, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29782582/surfaces-from-the-visual-past-recovering-high-resolution-terrain-data-from-historic-aerial-imagery-for-multitemporal-landscape-analysis
#5
Christopher Sevara, Geert Verhoeven, Michael Doneus, Erich Draganits
Historic aerial images are invaluable sources of aid to archaeological research. Often collected with large-format photogrammetric quality cameras, these images are potential archives of multidimensional data that can be used to recover information about historic landscapes that have been lost to modern development. However, a lack of camera information for many historic images coupled with physical degradation of their media has often made it difficult to compute geometrically rigorous 3D content from such imagery...
2018: Journal of archaeological method and theory
https://www.readbyqxmd.com/read/29782504/measurement-agreement-of-the-self-administered-questionnaire-of-the-belgian-health-interview-survey-paper-and-pencil-versus-web-based-mode
#6
Elise Braekman, Finaba Berete, Rana Charafeddine, Stefaan Demarest, Sabine Drieskens, Lydia Gisle, Geert Molenberghs, Jean Tafforeau, Johan Van der Heyden, Guido Van Hal
Before organizing mixed-mode data collection for the self-administered questionnaire of the Belgian Health Interview Survey, measurement effects between the paper-and-pencil and the web-based questionnaire were evaluated. A two-period cross-over study was organized with a sample of 149 employees of two Belgian research institutes (age range 22-62 years, 72% female). Measurement agreement was assessed for a diverse range of health indicators related to general health, mental and psychosocial health, health behaviors and prevention with kappa coefficients and intraclass correlation (ICC)...
2018: PloS One
https://www.readbyqxmd.com/read/29782490/an-optimized-digital-watermarking-algorithm-in-wavelet-domain-based-on-differential-evolution-for-color-image
#7
Xinchun Cui, Yuying Niu, Xiangwei Zheng, Yingshuai Han
In this paper, a new color watermarking algorithm based on differential evolution is proposed. A color host image is first converted from RGB space to YIQ space, which is more suitable for the human visual system. Then, apply three-level discrete wavelet transformation to luminance component Y and generate four different frequency sub-bands. After that, perform singular value decomposition on these sub-bands. In the watermark embedding process, apply discrete wavelet transformation to a watermark image after the scrambling encryption processing...
2018: PloS One
https://www.readbyqxmd.com/read/29782158/fluorescigenic-magnetofluids-based-on-gadolinium-terbium-and-dysprosium-containing-imidazolium-salts
#8
Kun-Lun Cheng, Wen-Li Yuan, Ling He, Ning Tang, Hong-Mei Jian, Ying Zhao, Song Qin, Guo-Hong Tao
Multistimuli responsive soft materials are urgently needed in many different fields, such as anticounterfeiting technology and microdroplet manipulation. Herein, the straightforward preparation of fluorescigenic magnetofluids by the introduction of the paramagnetic metal ions Gd3+ , Tb3+ , and Dy3+ into alkylimidazolium-based ionic liquids (ILs) is reported. Bright visible fluorescence was observed under UV irradiation for Tb- and Dy-containing ILs. Either pure samples or papers coated with these ILs exhibited pronounced magnetic responses...
May 21, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29782145/stackable-lab-on-paper-device-with-all-in-one-au-electrode-for-high-efficiency-photoelectrochemical-cyto-sensing
#9
Hongmei Yang, Yan Zhang, Lina Zhang, Kang Cui, Shenguang Ge, Jiadong Huang, Jinghua Yu
Highly conductive, robust, and multifunctional integrated paper-supported electrodes are requisite to fulfill the promise of paper-based analytical application. Herein, an all-in-one Au electrode comprising of detection zone, waterproof electronic bridge, and signal output contactor was engineered via combining the double-sided growth method with the secondary wax-printing. Benefiting from the strongly omnidirectional conductivity and desirably mechanical robustness of the as-prepared electrode, a stackable lab-on-paper cyto-device integrated with high-efficiency photoelectrochemical strategy was developed for the MCF-7 cells assay...
May 21, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29782067/sublingual-immunotherapy-for-pediatric-allergic-conjunctivitis-a-meta-analysis-of-randomized-controlled-trials
#10
Jie Yang, Li Zhang, Zhixiang Zhao, Shiyu Liao
BACKGROUND: Allergic conjunctivitis (AC) is a common chronic condition, especially in children. Ocular symptoms are often overlooked during treatment of allergic rhinoconjunctivitis (ARC). Pediatric ARC can be effectively treated using sublingual immunotherapy (SLIT), which is a guideline-recommended safe treatment approach. However, the therapeutic efficacy of SLIT in terms of ameliorating eye symptoms has not been effectively evaluated. METHODS: We performed a meta-analysis of randomized controlled trials (RCTs) evaluating the use of SLIT for infants, children, and adolescents (aged from 3 to 18 years) with AC or ARC...
May 21, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29782045/revisiting-the-table-2-fallacy-a-motivating-example-examining-preeclampsia-and-preterm-birth
#11
Gretchen Bandoli, Kristin Palmsten, Christina D Chambers, Laura L Jelliffe-Pawlowski, Rebecca J Baer, Caroline A Thompson
BACKGROUND: A "Table Fallacy," as coined by Westreich and Greenland, reports multiple adjusted effect estimates from a single model. This practice, which remains common in published literature, can be problematic when different types of effect estimates are presented together in a single table. The purpose of this paper is to quantitatively illustrate this potential for misinterpretation with an example estimating the effects of preeclampsia on preterm birth. METHODS: We analysed a retrospective population-based cohort of 2 963 888 singleton births in California between 2007 and 2012...
May 21, 2018: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/29782029/a-technique-for-a-nano-textured-gapless-microlens-array-using-self-formation-characteristics-of-anodic-alumina
#12
Yong Min Park, Woong Ki Jang, Tae Hwan Shin, Byeong Hee Kim, Young Ho Seo
This paper presents a method to utilize the growth properties of anodic alumina possessing self-formation characteristics to fabricate a nano-textured microstructure and also introduces an application technique of the proposed method. The growth rate of anodic alumina, fabricated on aluminum surfaces, has a strong dependence on the intensity of the applied current density or electric field. The uniformity of the thickness of anodic alumina is determined by its electrical distribution characteristics. Accordingly, microscale structures can be fabricated using the growth rate deviation of anodic alumina...
May 21, 2018: Nanoscale
https://www.readbyqxmd.com/read/29781986/measuring-the-carotid-to-femoral-pulse-wave-velocity-cf-pwv-to-evaluate-arterial-stiffness
#13
Hongwei Ji, Jing Xiong, Shikai Yu, Chen Chi, Bin Bai, Jiadela Teliewubai, Yuyan Lu, Yi Zhang, Yawei Xu
For the elderly, arterial stiffening is a good marker for aging evaluation and it is recommended that the arterial stiffness be determined noninvasively by the measurement of carotid to femoral pulse wave velocity (cf-PWV) (Class I; Level of Evidence A). In literature, numerous community-based or disease-specific studies have reported that higher cf-PWV is associated with increased cardiovascular risk. Here, we discuss strategies to evaluate arterial stiffness with cf-PWV. Following the well-defined steps detailed here, e...
May 3, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781781/gene-expression-microarray-analysis-reveals-prognostic-markers-of-survival-in-high-grade-astrocytomas
#14
Jun Yang, Ziming Hou, Changjiang Wang, Hao Wang, Hongbing Zhang
OBJECTIVE: High grade astrocytoma (HGA) as an aggressive brain tumor, is always correlated with poor prognosis. In this paper, we aimed to explore the genetic prognostic biomarkers for HGA. METHODS: The genome-wide expression profile of 26 brain tumor samples obtained from 26 patients with HGA was downloaded from Gene Expression Omnibus. The risk genes for prognosis of HGA were identified and verified by the data in TCGA database. Protein-protein interaction (PPI) network of risk factor genes was constructed and significant module was screened...
May 21, 2018: Neurological Research
https://www.readbyqxmd.com/read/29781714/happy-life-expectancy-and-correlates-of-happiness-among-older-adults-in-south-africa
#15
Witness Chirinda, Nancy Phaswana-Mafuya
OBJECTIVES: This paper examines factors associated with happiness and to estimate happy life expectancy for older people in South Africa. METHODS: The study uses data from the first wave of the Study on Ageing and Adult Health (SAGE) survey, which is a nationally representative population-based survey with a sample of 3,840 individuals aged 50 years and above. The Sullivan method and multivariate linear regression analysis were used in the analysis. RESULTS: The prevalence of happiness was the same for men (55...
May 21, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29781618/field-detection-of-citrus-huanglongbing-associated-with-candidatus-liberibacter-asiaticus-by-recombinese-polymerase-amplification-within-15-min
#16
Wenjuan Qian, Ying Lu, Youqing Meng, Zunzhong Ye, Liu Wang, Rui Wang, Qiqi Zheng, Jian Wu
Candidatus Liberibacter asiaticus(Las)is the most prevalent bacterium associated with Huanglongbing which is one of the most destructive diseases of citrus. In this paper, an extremely rapid and simple method for field detection of Las from leaf samples based on recombinase polymerase amplification (RPA) is developed. Three RPA primer pairs were designed and evaluated. RPA amplification was optimized so that it could be accomplished within 10 min. In combination with DNA crude extraction by 50-fold diluting after 1 min of grinding in 0...
May 21, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29781450/music-brain-plasticity-and-the-resilience-the-pillars-of-new-receptive-therapy
#17
Helena Dukić
This paper describes a new type of receptive music therapy which aims to build the patients' psychological resilience by increasing the levels of dopamine, serotonin and oxytocin in order to increase standard psychopharmacological treatment efficiency. Previous research concerning the musically induced production of the two neurotransmitters and a hormone is discussed and reviewed. Based upon the existent studies concerning the influence of music on dopamine, serotonin and oxytocin induction, a new design of specific music features for this purpose is proposed and elaborated upon...
April 2018: Psychiatria Danubina
https://www.readbyqxmd.com/read/29781321/metoprolol-in-the-treatment-of-cardiovascular-disease-a-critical-reappraisal
#18
Guido Grassi
Extensive clinical experience on metoprolol has been gained in different cardiovascular conditions. In this paper, we discuss the use of metoprolol, with a focus on the extended-release formulation, in clinical practice in the light of existing evidence and current recommendations. This is a narrative review based on existing evidence and clinical experience of the Author. Evidence on the use of metoprolol in heart failure, ischemic artery disease, arterial hypertension and atrial fibrillation is well-established...
May 21, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29781047/a-survey-on-coronary-atherosclerotic-plaque-tissue-characterization-in-intravascular-optical-coherence-tomography
#19
REVIEW
Alberto Boi, Ankush D Jamthikar, Luca Saba, Deep Gupta, Aditya Sharma, Bruno Loi, John R Laird, Narendra N Khanna, Jasjit S Suri
PURPOSE OF REVIEW: Atherosclerotic plaque deposition within the coronary vessel wall leads to arterial stenosis and severe catastrophic events over time. Identification of these atherosclerotic plaque components is essential to pre-estimate the risk of cardiovascular disease (CVD) and stratify them as a high or low risk. The characterization and quantification of coronary plaque components are not only vital but also a challenging task which can be possible using high-resolution imaging techniques...
May 21, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29780767/effectiveness-of-a-multicomponent-school-based-intervention-to-reduce-bullying-among-adolescents-in-chandigarh-north-india-a-quasi-experimental-study-protocol
#20
Monica Rana, Madhu Gupta, Prahbhjot Malhi, Sandeep Grover, Manmeet Kaur
Background: Bullying perpetration and victimization is associated with significant academic, psychosocial and health related problems among adolescents. There is a need to develop effective interventions to prevent bullying among adolescents, especially in low and middle income countries. This paper presents the study protocol to develop, and evaluate the effect of multi-component school based prevention program for bullying in India. Design: Quasi-experimental study...
February 5, 2018: Journal of Public Health Research
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