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https://www.readbyqxmd.com/read/28938797/revisiting-the-safety-of-aspartame
#1
Arbind Kumar Choudhary, Etheresia Pretorius
Aspartame is a synthetic dipeptide artificial sweetener, frequently used in foods, medications, and beverages, notably carbonated and powdered soft drinks. Since 1981, when aspartame was first approved by the US Food and Drug Administration, researchers have debated both its recommended safe dosage (40 mg/kg/d) and its general safety to organ systems. This review examines papers published between 2000 and 2016 on both the safe dosage and higher-than-recommended dosages and presents a concise synthesis of current trends...
September 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28938795/lipid-lowering-nutraceuticals-in-clinical-practice-position-paper-from-an-international-lipid-expert-panel
#2
Arrigo F G Cicero, Alessandro Colletti, Gani Bajraktari, Olivier Descamps, Dragan M Djuric, Marat Ezhov, Zlatko Fras, Niki Katsiki, Michel Langlois, Gustavs Latkovskis, Demosthenes B Panagiotakos, Gyorgy Paragh, Dimitri P Mikhailidis, Olena Mitchenko, Bernhard Paulweber, Daniel Pella, Christos Pitsavos, Željko Reiner, Kausik K Ray, Manfredi Rizzo, Amirhossein Sahebkar, Maria-Corina Serban, Laurence S Sperling, Peter P Toth, Dragos Vinereanu, Michal Vrablík, Nathan D Wong, Maciej Banach
In recent years, there has been growing interest in the possible use of nutraceuticals to improve and optimize dyslipidemia control and therapy. Based on the data from available studies, nutraceuticals might help patients obtain theraputic lipid goals and reduce cardiovascular residual risk. Some nutraceuticals have essential lipid-lowering properties confirmed in studies; some might also have possible positive effects on nonlipid cardiovascular risk factors and have been shown to improve early markers of vascular health such as endothelial function and pulse wave velocity...
September 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28938731/the-importance-of-genetic-parenthood-for-infertile-men-and-women
#3
S Hendriks, K Peeraer, H Bos, S Repping, E A F Dancet
STUDY QUESTION: Do men and women beginning to attend a fertility clinic prefer genetic over non-genetic parenthood? SUMMARY ANSWER: Nearly, all infertile men and women prefer genetic parenthood. WHAT IS KNOWN ALREADY: Clinicians assume that all infertile couples prefer genetic parenthood over non-genetic parenthood and, therefore, consider treatments with donor gametes an option of last resort. Previous studies of the desire for parenthood identified 30 motivations for genetic parenthood, and 51 motivations for which having a genetically related child is not strictly necessary but might be deemed required...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938712/invited-commentary-the-need-for-cognitive-science-in-methodology
#4
Sander Greenland
There is no complete solution for the problem of abuse of statistics, but methodological training needs to cover cognitive biases and other psychosocial factors affecting inferences. The present paper discusses 3 common cognitive distortions: 1) dichotomania, the compulsion to perceive quantities as dichotomous even when dichotomization is unnecessary and misleading, as in inferences based on whether a P value is "statistically significant"; 2) nullism, the tendency to privilege the hypothesis of no difference or no effect when there is no scientific basis for doing so, as when testing only the null hypothesis; and 3) statistical reification, treating hypothetical data distributions and statistical models as if they reflect known physical laws rather than speculative assumptions for thought experiments...
September 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28938216/efficient-removal-of-priority-hazardous-priority-and-emerging-pollutants-with-prunus-armeniaca-functionalized-biochar-from-aqueous-wastes-experimental-optimization-and-modeling
#5
Maja Turk Sekulić, Sabolč Pap, Zoran Stojanović, Nikola Bošković, Jelena Radonić, Tatjana Šolević Knudsen
This paper investigates the ability of the phosphoric acid functionalized Prunus armeniaca stones biochar (AsPhA) prepared by thermochemical activation to remove lead (Pb(2+)), cadmium (Cd(2+)), nickel (Ni(2+)), naproxen and chlorophenols from aqueous wastes. The engineered biochar was characterized using the Scanning Electron Microscopy, Energy-dispersive X-ray Spectroscopy, Fourier Transform Infrared Spectroscopy and Brunauer, Emmett and Teller technique. The batch studies were performed by varying the initial pH of the solution (2-9), adsorbent dosage (0...
September 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28938212/the-problem-of-identifying-arsenic-anomalies-in-the-basin-of-sahand-dam-through-risk-based-soft-modelling
#6
Ata Allah Nadiri, Fariba Sadeghi Aghdam, Rahman Khatibi, Asghar Asghari Moghaddam
An investigation is undertaken to identify arsenic anomalies at the complex of Sahand dam, East Azerbaijan, northwest Iran. The complex acts as a system, in which the impounding reservoir catalyses system components related to Origin-Source-Pathways-Receptor-Consequence (OSPRC) viewed as a risk system. This 'conceptual framework' overlays a 'perceptual model' of the physical system, in which arsenic with geogenic origins diffused into the formations through extensive fractures swept through the region during the Miocene era...
September 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28938198/differentiation-of-black-writing-ink-on-paper-using-luminescence-lifetime-by-time-resolved-luminescence-spectroscopy
#7
Mototsugu Suzuki, Norimitsu Akiba, Kenji Kurosawa, Yoshinori Akao, Yoshiyasu Higashikawa
The time-resolved luminescence spectra and the lifetimes of eighteen black writing inks were measured to differentiate pen ink on altered documents. The spectra and lifetimes depended on the samples. About half of the samples only exhibited short-lived luminescence components on the nanosecond time scale. On the other hand, the other samples exhibited short- and long-lived components on the microsecond time scale. The samples could be classified into fifteen groups based on the luminescence spectra and dynamics...
September 11, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28938126/the-need-for-theory-evaluation-in-global-citizenship-programmes-the-case-of-the-gcsa-programme
#8
Sarah Goodier, Carren Field, Suki Goodman
Many education programmes lack a documented programme theory. This is a problem for programme planners and evaluators as the ability to measure programme success is grounded in the plausibility of the programme's underlying causal logic. Where the programme theory has not been documented, conducting a theory evaluation offers a foundational evaluation step as it gives an indication of whether the theory behind a programme is sound. This paper presents a case of a theory evaluation of a Global Citizenship programme at a top-ranking university in South Africa, subsequently called the GCSA Programme...
August 24, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28938073/transfer-learning-from-markov-models-leads-to-efficient-sampling-of-related-systems
#9
Mohammad Muneeb Sultan, Vijay S Pande
We recently showed that the time-structure based independent component analysis method from Markov state model literature provided a set of variationally optimal slow collective variables for Metadynamics (tICA-Metadynamics). In this paper, we extend the methodology towards efficient sampling of related mutants by borrowing ideas from transfer learning methods in machine learning. Our method explicitly assumes that a similar set of slow modes and metastable states are found in both the wild type (base line) and its mutants...
September 22, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28938011/a-novel-hazard-assessment-method-for-biomass-gasification-stations-based-on-extended-set-pair-analysis
#10
Fang Yan, Kaili Xu, Deshun Li, Zhikai Cui
Biomass gasification stations are facing many hazard factors, therefore, it is necessary to make hazard assessment for them. In this study, a novel hazard assessment method called extended set pair analysis (ESPA) is proposed based on set pair analysis (SPA). However, the calculation of the connection degree (CD) requires the classification of hazard grades and their corresponding thresholds using SPA for the hazard assessment. In regard to the hazard assessment using ESPA, a novel calculation algorithm of the CD is worked out when hazard grades and their corresponding thresholds are unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28937913/dietary-euphorbia-hirta-extract-improved-the-resistance-of-african-catfish-clarias-gariepinus-to-aeromonas-hydrophila
#11
Atefeh Sheikhlar, Goh Yong Meng, Razak Alimon, Nicholas Romano, Mahdi Ebrahimi
Aqueous and methanol extracts of lemon (Citrus lemon) peel, Euphorbia hirta (aerial parts) and fenugreek (Trigonella foenum-graecum) seeds were tested for their in vitro antimicrobial activities against the bacterium Aeromonas hydrophila. A swab paper disk method showed the methanol extract of E. hirta (EHE) had the largest inhibition zone and the lowest minimal inhibitory concentration compared to all other herbal extracts. Based on these results, EHE was included in the diets of African catfish (Clarias gariepinus) at 0 (control), 2, 5 or 7 g/kg diet (experiment 1)...
September 22, 2017: Journal of Aquatic Animal Health
https://www.readbyqxmd.com/read/28937778/-changes-of-the-who-classification-of-myeloid-neoplasms-in-the-context-of-the-2016-revision
#12
Juraj Marcinek, Tomáš Balhárek, Lukáš Plank
Continual progress of knowleges in hematopathology and genetics of hematologic tumors requires actualisation of widely accepted and presently used WHO classification of myeloid neoplasms published 8 years ago. However, the basic principles of this classification remain unchanged, therefore the authors of new WHO classification mention the "revision" of previous and not the introduction o new classification. The aim of this paper is to outline the most important changes of myeloid neoplasm diagnostics to pathologists, hematologists and other clinicians in Czech Republic and Slovakia...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/28937659/assessing-the-allocation-of-special-elderly-nursing-homes-in-tokyo-japan
#13
Ninglong You, Zhenjiang Shen, Tatsuya Nishino
Social welfare and public health departments require reliable assessments to enhance the rationality of phased construction of special elderly nursing homes (SENHs). This paper aims to assess the allocation of SENHs based on a beds-needed index for SENHs (BNIS). This may help departments determine the priority for approving locations of SENHs more accurately with a limited budget. Traditional assessments in Tokyo use the sphere of welfare, ward, and sphere of daily life as spatial units for estimating beds-to-elderly population ratios...
September 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28937647/identification-of-dna-binding-proteins-using-mixed-feature-representation-methods
#14
Kaiyang Qu, Ke Han, Song Wu, Guohua Wang, Leyi Wei
DNA-binding proteins play vital roles in cellular processes, such as DNA packaging, replication, transcription, regulation, and other DNA-associated activities. The current main prediction method is based on machine learning, and its accuracy mainly depends on the features extraction method. Therefore, using an efficient feature representation method is important to enhance the classification accuracy. However, existing feature representation methods cannot efficiently distinguish DNA-binding proteins from non-DNA-binding proteins...
September 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28937632/design-and-analysis-of-a-low-latency-deterministic-network-mac-for-wireless-sensor-networks
#15
Prasan Kumar Sahoo, Sudhir Ranjan Pattanaik, Shih-Lin Wu
The IEEE 802.15.4e standard has four different superframe structures for different applications. Use of a low latency deterministic network (LLDN) superframe for the wireless sensor network is one of them, which can operate in a star topology. In this paper, a new channel access mechanism for IEEE 802.15.4e-based LLDN shared slots is proposed, and analytical models are designed based on this channel access mechanism. A prediction model is designed to estimate the possible number of retransmission slots based on the number of failed transmissions...
September 22, 2017: Sensors
https://www.readbyqxmd.com/read/28937629/tracking-of-maneuvering-complex-extended-object-with-coupled-motion-kinematics-and-extension-dynamics-using-range-extent-measurements
#16
Lifan Sun, Baofeng Ji, Jian Lan, Zishu He, Jiexin Pu
The key to successful maneuvering complex extended object tracking (MCEOT) using range extent measurements provided by high resolution sensors lies in accurate and effective modeling of both the extension dynamics and the centroid kinematics. During object maneuvers, the extension dynamics of an object with a complex shape is highly coupled with the centroid kinematics. However, this difficult but important problem is rarely considered and solved explicitly. In view of this, this paper proposes a general approach to modeling a maneuvering complex extended object based on Minkowski sum, so that the coupled turn maneuvers in both the centroid states and extensions can be described accurately...
September 22, 2017: Sensors
https://www.readbyqxmd.com/read/28937615/sfol-pulse-a-high-accuracy-dme-pulse-for-alternative-aircraft-position-and-navigation
#17
Euiho Kim, Jiwon Seo
In the Federal Aviation Administration's (FAA) performance based navigation strategy announced in 2016, the FAA stated that it would retain and expand the Distance Measuring Equipment (DME) infrastructure to ensure resilient aircraft navigation capability during the event of a Global Navigation Satellite System (GNSS) outage. However, the main drawback of the DME as a GNSS back up system is that it requires a significant expansion of the current DME ground infrastructure due to its poor distance measuring accuracy over 100 m...
September 22, 2017: Sensors
https://www.readbyqxmd.com/read/28937462/instability-in-thoracolumbar-trauma-is-a-new-definition-warranted
#18
Salman Abbasi Fard, Jesse Skoch, Mauricio J Avila, Apar S Patel, Kamran V Sattarov, Christina M Walter, Ali A Baaj
STUDY DESIGN: Review of the articles. OBJECTIVE: The objective of this study was to review all articles related to spinal instability to determine a consensus statement for a contemporary, practical definition applicable to thoracolumbar injuries. SUMMARY OF BACKGROUND DATA: Traumatic fractures of the thoracolumbar spine are common. These injuries can result in neurological deficits, disability, deformity, pain, and represent a great economic burden to society...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28936831/-real-world-analysis-to-explore-xiyanping-injection-combined-with-other-drugs-for-hand-foot-mouth-disease
#19
Zhi-Fei Wang, Hai-Wei Fan, Yan-Ming Xie
Integrated network analysis was used in this paper to analyze Xiyanping injection combined therapy for hand-foot-mouth disease based on the registered research data of 3 204 cases. It was found that the drug combination therapy was almost consistent with the guidelines for the diagnosis and treatment of hand foot mouth disease, but there were some problems to be noticed: there were too many applications of antibiotics, more than the need in preventing secondary infection; and ribavirin was not necessary for use...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28936797/peer-victimization-and-adjustment-in-young-adulthood-introduction-to-the-special-section
#20
Mara Brendgen
A substantive number of children and adolescents are bullied by their peers, with serious risks for the victims' emotional, behavioral, physical, and academic adjustment. However, while the immediate and short-term consequences of peer victimization in childhood and adolescence are very well documented, knowledge about the potential long-term consequences for victims' functioning once they reach adulthood is only slowly emerging. Based on prospective, longitudinal data from different countries, the 4 papers in this special section investigate the association between peer victimization suffered in childhood and adolescence and victims' developmental outcomes in late adolescence/early adulthood...
September 22, 2017: Journal of Abnormal Child Psychology
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