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https://www.readbyqxmd.com/read/27710869/plasma-proteomics-in-cml-patients-before-and-after-initiation-of-tyrosine-kinase-inhibitor-therapy-reveals-induced-th1-immunity-and-loss-of-angiogenic-stimuli
#1
Stina Söderlund, Lisa Christiansson, Inger Persson, Henrik Hjorth-Hansen, Johan Richter, Bengt Simonsson, Satu Mustjoki, Ulla Olsson-Strömberg, Angelica Loskog
BACKGROUND AND AIMS: The simultaneous measurement of many proteins is now possible using multiplex assays. In this pilot study we investigated a total of 124 proteins in plasma from chronic myeloid leukemia (CML) patients with the purpose of identifying proteins that are differently expressed at diagnosis and after tyrosine kinase inhibitor (TKI) treatment initiation. METHODS: Samples were taken from 14 CML patients at diagnosis and after three months of TKI treatment (imatinib or dasatinib)...
September 27, 2016: Leukemia Research
https://www.readbyqxmd.com/read/27533451/serum-protein-fingerprinting-by-pea-immunoassay-coupled-with-a-pattern-recognition-algorithms-distinguishes-mgus-and-multiple-myeloma
#2
Petra Schneiderova, Tomas Pika, Petr Gajdos, Regina Fillerova, Pavel Kromer, Milos Kudelka, Jiri Minarik, Tomas Papajik, Vlastimil Scudla, Eva Kriegova
Serum protein fingerprints associated with MGUS and MM and their changes in MM after autologous stem cell transplantation (MM-ASCT, day 100) remain unexplored. Using highly-sensitive Proximity Extension ImmunoAssay on 92 cancer biomarkers (Proseek Multiplex, Olink), enhanced serum levels of Adrenomedullin (ADM, Pcorr= .0004), Growth differentiation factor 15 (GDF15, Pcorr= .003), and soluble Major histocompatibility complex class I-related chain A (sMICA, Pcorr= .023), all prosurvival and chemoprotective factors for myeloma cells, were detected in MM comparing to MGUS...
August 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27383427/anti-inflammatory-effect-of-exclusive-enteral-nutrition-in-patients-with-juvenile-idiopathic-arthritis
#3
Lillemor Berntson, Iris Hedlund-Treutiger, Kjell Alving
OBJECTIVES: There is extensive evidence for an influence of gut microbiota on the immune system, which has consequences for inflammatory diseases. Exclusive enteral nutrition (EEN), which may change the gut microbiota, is an effective anti-inflammatory treatment for Crohn's disease in children. We wanted to explore the immediate anti-inflammatory effect of EEN in children with juvenile idiopathic arthritis (JIA). METHODS: Thirteen patients with JIA (7-17 years of age), in a disease flare-up, were included in the study...
September 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/26475405/associations-between-circulating-proteins-and-corresponding-genes-expressed-in-coronary-thrombi-in-patients-with-acute-myocardial-infarction
#4
Ragnhild Helseth, Thomas W Weiss, Trine Baur Opstad, Agneta Siegbahn, Svein Solheim, Matthias K Freynhofer, Kurt Huber, Harald Arnesen, Seljeflot Seljeflot
INTRODUCTION: Several genes are expressed in aspirated coronary thrombi in acute myocardial infarction (AMI), exhibiting dynamic changes along ischemic time. Whether soluble biomarkers reflect the local gene environment and ischemic time is unclear. We explored whether circulating biomarkers were associated with corresponding coronary thrombi genes and total ischemic time. MATERIAL AND METHODS: In 33 AMI patients undergoing percutaneous coronary intervention (PCI), blood samples were collected within 6-24h for markers related to plaque rupture (metalloproteinase 9, tissue inhibitor of metalloproteinases 1), platelet and endothelial cell activation (P-selectin, CD40 ligand, PAR-1), hemostasis (tissue factor, tissue plasminogen activator, plasminogen activator inhibitor 1, free and total tissue factor pathway inhibitor, D-dimer, prothrombin fragment 1+2), inflammation (interleukin 8 and 18, fractalkine, monocyte chemoattractant protein 1 (MCP-1), CXCL1, pentraxin 3, myeloperoxidase) and galectin 3, caspase 8 and epidermal growth factor (EGF)...
December 2015: Thrombosis Research
https://www.readbyqxmd.com/read/26204497/use-of-a-proximity-extension-assay-proteomics-chip-to-discover-new-biomarkers-for-human-atherosclerosis
#5
Lars Lind, Johan Ärnlöv, Bertil Lindahl, Agneta Siegbahn, Johan Sundström, Erik Ingelsson
BACKGROUND AND AIMS: We used a proteomics array to simultaneously measure multiple proteins that have been suggested to be associated with atherosclerosis and related them to plaque prevalence in carotid arteries in a human population-based study. METHODS: In the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS; n = 931, 50% women, all aged 70 years), the number of carotid arteries with plaques was recorded by ultrasound. Levels of 82 proteins were assessed in plasma by a proximity extension assay (Proseek Multiplex CVD, Olink Bioscience, Uppsala, Sweden) and related to carotid measures in a regression framework...
September 2015: Atherosclerosis
https://www.readbyqxmd.com/read/25987887/a-novel-multiplexed-immunoassay-identifies-cea-il-8-and-prolactin-as-prospective-markers-for-dukes-stages-a-d-colorectal-cancers
#6
Sadia Mahboob, Seong Beom Ahn, Harish R Cheruku, David Cantor, Emma Rennel, Simon Fredriksson, Gabriella Edfeldt, Edmond J Breen, Alamgir Khan, Abidali Mohamedali, Md Golam Muktadir, Shoba Ranganathan, Sock-Hwee Tan, Edouard Nice, Mark S Baker
BACKGROUND: Current methods widely deployed for colorectal cancers (CRC) screening lack the necessary sensitivity and specificity required for population-based early disease detection. Cancer-specific protein biomarkers are thought to be produced either by the tumor itself or other tissues in response to the presence of cancers or associated conditions. Equally, known examples of cancer protein biomarkers (e.g., PSA, CA125, CA19-9, CEA, AFP) are frequently found in plasma at very low concentration (pg/mL-ng/mL)...
2015: Clinical Proteomics
https://www.readbyqxmd.com/read/19040730/proseek-a-web-server-for-mlpa-probe-design
#7
Lorena Pantano, Lluís Armengol, Sergi Villatoro, Xavier Estivill
BACKGROUND: The technological evolution of platforms for detecting genome-wide copy number imbalances has allowed the discovery of an unexpected amount of human sequence that is variable in copy number among individuals. This type of human variation can make an important contribution to human diversity and disease susceptibility. Multiplex Ligation-dependent Probe Amplification (MLPA) is a targeted method to assess copy number differences for up to 40 genomic loci in one single experiment...
2008: BMC Genomics
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