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A González-Castro, M Ortiz-Lasa, J C Rodriguez-Borregan, E Rodrigo Calabia, J C Ruiz San Millan, T Dierssen Soto
BACKGROUND: The hyperchloremic metabolic acidosis triggered by the infusion of normal saline (NS) significantly increases the level of extracellular potassium. In this study we assessed the influence of proportion of NS administered in the perioperative period of renal transplantation on potassium levels in usual clinical practice. METHODS: This study was a retrospective cohort analysis of patients undergoing renal transplantation during a 24-month period (2015-2016)...
March 2018: Transplantation Proceedings
Matthieu Legrand, Pierre-Olivier Ludes, Ziad Massy, Patrick Rossignol, Jiri Parenica, Jin-Joo Park, Shiro Ishihara, Khalid F AlHabib, Aldo Maggioni, Òscar Miró, Naoki Sato, Alain Cohen-Solal, Enrique Fairman, Johan Lassus, Veli-Pekka Harjola, Christian Mueller, Franck W Peacock, Dong-Ju Choi, Patrick Plaisance, Jindřich Spinar, Mikhail Kosiborod, Alexandre Mebazaa, Etienne Gayat
BACKGROUND: The interaction between chronic medications on admission and the association between serum potassium level and outcome in patients with acute heart failure (AHF) are unknown. METHODS: Observational intercontinental study of patients admitted with AHF. 15954 patients were included from 12 cohorts in 4 continents. Main outcome was 90-day mortality. Clinical presentation (medication use, hemodynamics, comorbidities), demographic, echocardiographic, and biochemical data on admission were recorded prospectively in each cohort, with prospective adjudication of outcomes...
March 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Carmen Falcone, Leonida Compostella, Antonella Camardo, Li Van Stella Truong, Francesco Centofanti
PURPOSE: During treatment of bone and joint infections (BJIs) with multiple antibiotic therapy, hypokalemia has been reported as a rare side effect. The aim of this study was to evaluate incidence and risk factors for hypokalemia in a cohort of patients treated with multidrug therapy for BJIs, in a single center. METHODS: We retrospectively reviewed 331 clinical files of 150 consecutive patients (65% males; median age 59 years, 95% CI 55-62) admitted repeatedly to our Osteomyelitis Department for treatment of chronic BJIs...
April 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Félicite Kamdem, Fernando Kemta Lekpa, Marie Solange Doualla, Yvette Ngo Nouga, Olivier Donfack Sontsa, Elvis Temfack, Samuel Kingue
Chronic kidney disease (CKD) has emerged as a worldwide problem and is a major cause for comorbidity in hypertensive patients. In an attempt to enhance awareness and to help in establishing preventive measures and care, it is necessary to describe CKD among newly diagnosed and untreated hypertensive patients. We conducted a cross-sectional study to describe the characteristics of CKD among newly diagnosed, treatment naïve, hypertensive patients in four health-care centers in the city of Douala, Cameroon. Sociodemographic and biological data were collected and serum creatinine was measured by enzymatic - colorimetric methods...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
Hai Li, Jianbin Liu, Xiujuan Feng, Liehua Liu, Guohong Wei, Xiaopei Cao, Yanbing Li
PURPOSE: To test the efficacy of a strategy based on CT imaging and clinical characteristics on lateralizing origin of excess aldosterone secretion in primary aldosteronism. PATIENTS AND METHODS: Consecutive patients with diagnosed primary hyperaldosteronism from June 2006 to July 2012 in our center underwent adrenal surgeries without pre-operational adrenal venous sampling (AVS) if all the three criteria were met: (1) round- or oval-shaped occupational lesion of low density after contrast enhancement with diameter >1 cm on CT scan was located in one adrenal gland; (2) unequivocally normal contralateral adrenal gland; (3) serum potassium level lower than 3...
December 2017: International Urology and Nephrology
Davide Ferrazzoli, Annarita Sabetta, Grazia Palamara, Luca Caremani, Marina Capobianco, Pietro Balbi, Giuseppe Frazzitta
OBJECTIVE: To report a rare case of hypokalemic rhabdomyolysis induced by the heavy and prolonged ingestion of cola-based beverages, and its uneventful recovery after kalemia normalization. METHODS: We report a 38-year-old Caucasian male presented in our emergency room with a recent and progressive weakness of the lower limbs proximal muscles. RESULTS: A dietary history revealed a prolonged ingestion of cola-based beverages. Blood tests showed severe hypokalemia and marked increase in serum creatine phosphokinase...
2017: SAGE Open Medical Case Reports
Anne Blanchard, Emmanuel Curis, Tiphaine Guyon-Roger, Diana Kahila, Cyrielle Treard, Véronique Baudouin, Etienne Bérard, Gérard Champion, Pierre Cochat, Julie Dubourg, Renaud de la Faille, Olivier Devuyst, Georges Deschenes, Michel Fischbach, Jérôme Harambat, Pascal Houillier, Alexandre Karras, Bertrand Knebelmann, Marie-Pierre Lavocat, Chantal Loirat, Elodie Merieau, Patrick Niaudet, François Nobili, Robert Novo, Rémi Salomon, Tim Ulinski, Xavier Jeunemaître, Rosa Vargas-Poussou
Dent disease classically combines low-molecular-weight proteinuria, hypercalciuria with nephrocalcinosis, and renal failure. Nephrotic range proteinuria, normal calciuria, and hypokalemia have been rarely reported. It is unknown whether the changes in phenotype observed over time are explained by a decrease in glomerular filtration rate (GFR) or whether there is any phenotype-genotype relationship. To answer this we retrospectively analyzed data from 109 male patients with CLCN5 mutations (Dent-1) and 9 patients with mutation of the OCRL gene (Dent-2)...
August 2016: Kidney International
C Noilhan, M Barigou, L Bieler, J Amar, B Chamontin, B Bouhanick
OBJECTIVE: To study the prevalence of different causes of hypertension in young adults referred to a hypertension center in the south west of France. METHODS: We conducted a retrospective overview of patients younger than 40years old hospitalized consecutively in the Hypertension department of Toulouse University Hospital between 2012 and 2014. Clinical data about gender, age, anthropomorphic parameters and blood pressure measurement by 24h Ambulatory Blood Pressure Monitoring (ABPM) were recorded...
June 2016: Annales de Cardiologie et D'angéiologie
Jean-Philippe Bertocchio, Coralie Barbe, Sylvie Lavaud, Olivier Toupance, Pierre Nazeyrollas, Frederic Jaisser, Philippe Rieu
BACKGROUND: Animal studies have highlighted the role of vascular mineralocorticoid receptor during Cyclosporine A-induced nephrotoxicity. Mineralocorticoid receptor antagonists could improve kidney survival but are not commonly used during renal impairment and in association with several immunosuppressive drugs due to a supposed higher risk of adverse events. We tested the tolerance of eplerenone according to its expected adverse events: hyperkalemia, metabolic acidosis, hypotension, acute kidney failure, or any other adverse event...
2016: PloS One
W Grira, F Chaker, M Yazidi, C Denguir, M Tebib, M Chihaoui, H Slimane
OBJECTIFS: L'hyperaldostéronisme primaire est la première cause d'HTA endocrinienne. La morbidité et la mortalité de la maladie sont liées à l'hypertension artérielle et à l'hypokaliémie. Les objectifs de ce travail étaient de comparer l'évolution de l'HTA et de la kaliémie des patients ayant un hyperaldostéronisme primaire selon le type de traitement choisi. MéTHODES: Étude rétrospective portant sur 50 patients ayant un hyperaldostéronisme primaire avec un suivi minimum de 6 mois après traitement...
December 2015: Annales de Cardiologie et D'angéiologie
M Vallet, A Martin, E Huyghe, J Kantambadouno, J Amar, B Chamontin, I Tack, B Bouhanick
BACKGROUND: Aldosterone-producing adenoma is classically treated by unilateral adrenalectomy. Severe hyperkalemia, related to adrenal insufficiency, have been already reported after surgery. We describe here 4 male patients who, despite subnormal kalemia, developed a failure of the renin-aldosterone (RA) axis, resulting in a decrease in extracellular fluid volume (ECFV) following surgery METHODS: PA diagnosis was established according to French recommendations. Unilateral adrenalectomy was performed in all...
December 2015: Annales de Cardiologie et D'angéiologie
Maria-Christina Zennaro, Sheerazed Boulkroun, Fabio Fernandes-Rosa
Aldosterone plays an essential role in the maintenance of fluid and electrolyte homeostasis in the distal nephron. Monogenic forms of mineralocorticoid hypertension result from genetic defects leading to excessive production of aldosterone (or other mineralocorticoids) from the adrenal cortex or to illegitimate mineralocorticoid effects in the kidney. They are characterized in the majority of cases by early onset, severe or resistant hypertension and associated with suppressed renin levels. Depending on their causes, these diseases are distinguished at the clinical and biochemical level and differently affect aldosterone levels and kalemia...
August 2015: Best Practice & Research. Clinical Endocrinology & Metabolism
Luis Nogueira-Silva, Anne Blanchard, Emmanuel Curis, Aurélien Lorthioir, Valentina Zhygalina, Damien Bergerot, Stéphanie Baron, Laurence Amar, Guillaume Bobrie, Pierre-François Plouin, Joël Ménard, Michel Azizi
CONTEXT: The role of vasopressin (AVP) in the pathophysiology of primary aldosteronism (PA) remains unclear. OBJECTIVES: The primary aim of this study was to investigate AVP secretion in PA by measuring the plasma concentration of copeptin (PCop), the C-terminal portion of provasopressin. The secondary aim was to assess renal sensitivity to AVP. DESIGN AND SETTING: This was a cross-sectional study in a tertiary-care hospital. PROTOCOL: We recruited 115 patients with PA, 48 patients with essential hypertension (EH), and 108 normotensive healthy subjects (HS)...
September 2015: Journal of Clinical Endocrinology and Metabolism
Nieves Martell-Claros, María Abad-Cardiel, Beatriz Alvarez-Alvarez, José A García-Donaire, Cristina Fernández Pérez
BACKGROUND: Primary aldosteronism is the most frequent endocrine cause of secondary hypertension. Aldosterone excess damages the cardiovascular system. OBJECTIVES: We compared biochemical; morphological, and cardiovascular risk differences among hypokalemic and normokalemic primary aldosteronism. We evaluated either both presentations correspond to two different entities or a unique disease in different evolutive stage. MATERIAL AND METHODS: This is a retrospective study including 157 patients with primary aldosteronism divided into two groups: typical presentation (serum potassium < 3...
June 2015: Journal of Hypertension
Olivier Hanon, Clemence Boully, Laure Caillard, Florian Labourée, Sophie Cochiello, Edouard Chaussade
BACKGROUND: Combination treatments for hypertension most often include a renin-angiotensin-aldosterone system (RAAS) inhibitor. However, systolic blood pressure (SBP) remains difficult to control. Non-RAAS-inhibiting strategies such as calcium channel blocker/thiazide-like diuretic combinations may offer effective alternatives. METHODS: Hypertensive diabetic patients with microalbuminuria were included in this retrospective, post-hoc analysis of the Natrilix SR Versus Enalapril Study in Hypertensive Type 2 Diabetics With MicrOalbuminuRia (NESTOR) trial if they were uncontrolled on monotherapy (indapamide slow release (SR) 1...
August 2015: American Journal of Hypertension
Marilisa Citton, Giovanni Viel, Gian Paolo Rossi, Franco Mantero, Donato Nitti, Maurizio Iacobone
PURPOSE: The aim of this retrospective study was to analyze the early and long-term outcomes of the surgical treatment of primary aldosteronism (PA), the most common surgically correctable cause of endocrine hypertension. METHODS: Serum Potassium levels, blood pressure values, and aldosterone/renin ratio (ARR) were assessed in 128 patients undergoing unilateral adrenalectomy for PA, before and after surgery. The role of lateralizing techniques and the relationship between outcome and histopathology findings were also evaluated...
April 2015: Langenbeck's Archives of Surgery
Mirza Faisal Ahmed Rafiq, Noor Ahmed, Adil Aziz Khan
BACKGROUND: Electrolyte derangements are common sequel of traumatic brain injury. Use of intravenous fluids, diuretics, syndrome of inappropriate ADH secretion and cerebral salt washing are some of the factors responsible for this. Proper in time detection followed by appropriate treatment not only improves neurological status but also decrease morbidity and mortality. This study was conducted to know serum derangements of different electrolytes in patients with traumatic brain injury...
January 2013: Journal of Ayub Medical College, Abbottabad: JAMC
Catherine L Stables, Hassan Musa, Aditi Mitra, Sandesh Bhushal, Makarand Deo, Guadalupe Guerrero-Serna, Sergey Mironov, Manuel Zarzoso, Karen L Vikstrom, William Cawthorn, Sandeep V Pandit
Diabetes is associated with an increased risk of sudden cardiac death, but the underlying mechanisms remain unclear. Our goal was to investigate changes occurring in the action potential duration (APD) and conduction velocity (CV) in the diabetic rabbit ventricle, and delineate the principal ionic determinants. A rabbit model of alloxan-induced diabetes was utilized. Optical imaging was used to record electrical activity in isolated Langendorff-perfused hearts in normo-, hypo- and hyper-kalemia ([K(+)]o=4, 2, 12 mM respectively)...
April 2014: Journal of Molecular and Cellular Cardiology
S Feloni, L Radermacher, C Remy, J Jousten, V Corman
Mrs. A, a 62 year old patient with a history of hypertension, polyuria and polydipsia is hospitalized after a malaise. A severe hypokalemia, which is the cause of the polyuria and polydipsia, is discovered. The presence of hypertension and hypokalemia arises suspicion of a primary hyperaldosteronism and the plasma levels of renin and aldosterone are measured. Elevated aldosterone levels are combined with high plasma renin concentrations which permits to rule out primary hyperaldosteronism. Further explorations reveal a subocclusive ostial stenosis of the right renal artery...
July 2013: Revue Médicale de Liège
Grégoire Ficheur, Emmanuel Chazard, Béatrice Merlin, Laurie Ferret, Michel Luyckx, Régis Beuscart
Hospitals have at their disposal large databases that may be considered for reuse. The objective of this work is to evaluate the impact of a drug on a specific laboratory result by analyzing these data. This analysis first involves building a record of temporal patterns, including medical context, of drug prescriptions. Changes in outcome due to these patterns of drug prescription are assessed using short phases of the inpatient stay compared to monotonous changes in the laboratory result. To illustrate this technique, we investigated potassium chloride supplementation and its impact on kalemia...
2013: Studies in Health Technology and Informatics
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