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vestibulodynia

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https://www.readbyqxmd.com/read/28342741/treatment-of-secondary-vestibulodynia-with%C3%A2-conjugated-estrogen-cream-a-pilot-double-blind-randomized-placebo-controlled-trial
#1
Eve-Lyne Langlais, Jessica Lefebvre, Sarah Maheux-Lacroix, Emmanuel Bujold, Michel Fortier, Céline Bouchard
OBJECTIVE: To assess the efficacy of conjugated equine estrogen cream in reducing dyspareunia associated with secondary provoked vestibulodynia. METHODS: We conducted a randomized, double-blind, placebo-controlled trial that included women with secondary provoked vestibulodynia. Participants were randomly allocated to daily application of conjugated equine estrogen cream on the vulvar vestibule (estrogen group) or daily application of a similar placebo cream (placebo group)...
March 22, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28325536/self-reported-neuropathic-pain-characteristics-of-women-with-provoked-vulvar-pain-a-preliminary-investigation
#2
Emma Dargie, Ian Gilron, Caroline F Pukall
BACKGROUND: Provoked vestibulodynia (PVD) is a common chronic genital pain condition affecting approximately 12% of premenopausal women. Although parallels have been drawn between PVD and neuropathic pain (NP), no studies have examined self-reported NP characteristics in PVD. AIM: To explore pain symptoms that resemble NP reported by those with PVD and compare responses with those with an established NP condition. METHODS: Women with provoked vulvar pain (PVP; n = 65) completed online questionnaires designed to assess characteristics of NP...
March 15, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28302387/efficacy-of-transcranial-direct-current-stimulation-in-women-with-provoked-vestibulodynia
#3
Annie Morin, Guillaume Léonard, Véronique Gougeon, Marie-Pierre Cyr, Guy Waddell, Yves-André Bureau, Isabelle Girard, Mélanie Morin
BACKGROUND: Provoked vestibulodynia is a highly prevalent condition characterized by acute recurrent pain located at the vaginal entrance in response to pressure application or attempted vaginal penetration. Despite a wide variety of treatments offered to women with provoked vestibulodynia, a high proportion of women are refractory to conventional treatment. Transcranial direct-current stimulation is a noninvasive brain stimulation technique that has been shown effective for improving various chronic pain conditions...
March 14, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28238679/how-does-paying-attention-improve-sexual-functioning-in-women-a%C3%A2-review-of-mechanisms
#4
REVIEW
Nikita Arora, Lori A Brotto
INTRODUCTION: Female sexual dysfunction (FSD), consisting of a constellation of distressing sexual symptoms, is highly prevalent worldwide. Given the central role played by psychological factors in the development of FSD, psychologically and in particular mindfulness-based interventions have arisen as potential treatment options for women. Although mindfulness-based interventions have been evaluated in samples of women with gynecologic cancer; a history of sexual abuse; multiple sclerosis; and spinal cord injury; and provoked vestibulodynia, the mechanisms by which mindfulness leads to improvements in sexual functioning are largely unstudied...
February 23, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28178074/a-common-pro-nociceptive-pain-modulation-profile-typifying-subgroups-of-chronic-pelvic-pain-syndromes-is-interrelated-with-enhanced-clinical-pain
#5
Grinberg Keren, Granot Michal, Lowenstein Lior, Abramov Liora, Weissman-Fogel Irit
Provoked vestibulodynia (PVD) and painful bladder syndrome (PBS), subgroups of chronic pelvic pain syndromes (CPPS), are considered to share common bio-physiological peripheral mechanisms. In addition, indications of a pro-nociceptive pain profile co-existing with psychological vulnerability suggests common dysfunctional pain processing and pain modulation in these two subgroups of CPPS. We therefore aimed at comparing the pain profile and psychological traits of PVD and PBS patients to see whether the pain profile contributes to inter-subject variability of clinical pain symptoms...
February 7, 2017: Pain
https://www.readbyqxmd.com/read/28118257/provoked-vestibulodynia-a-comparative-examination-of-mental-health-sleep-sexual-functioning-and-relationship-adjustment
#6
Emma Dargie, Ian Gilron, Caroline Pukall
OBJECTIVES: Provoked vestibulodynia (PVD) is an idiopathic vulvar pain condition characterized by burning pain at the vaginal opening in response to contact or pressure. Previous research has established some of the psychosocial difficulties experienced by these patients, but direct comparisons with other pain conditions are needed. The purpose of this study was to compare women with PVD to those with post-herpetic neuralgia and pain-free control participants. METHODS: Participants were invited to complete an anonymous online survey consisting of sociodemographic questions and a range of validated measures...
January 21, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28062309/a-local-inflammatory-renin-angiotensin-system-drives-sensory-axon-sprouting-in-provoked-vestibulodynia
#7
Zhaohui Liao, Anuradha Chakrabarty, Ying Mu, Aritra Bhattacherjee, Martha Goestch, Catherine M Leclair, Peter G Smith
Vestibulodynia is a form of provoked vulvodynia characterized by profound tenderness, hyperinnervation, and frequently inflammation within well-defined areas of the human vestibule. Previous experiments in animal models show that inflammatory hypersensitivity and hyperinnervation occur in concert with establishment of a local renin-angiotensin system (RAS). Moreover, mechanical hypersensitivity and sensory axon sprouting are prevented by blocking effects of angiotensin II on angiotensin II receptor type 2 (AT2) receptors...
January 3, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28028667/interpersonal-goals-and-well-being-in-couples-coping-with-genito-pelvic-pain
#8
Natalie O Rosen, Marieke Dewitte, Kathleen Merwin, Sophie Bergeron
In the context of genito-pelvic pain, consideration of interpersonal goals is particularly relevant given that couples' distress is often predicated upon the relational setting. However, relationship goals have not been examined in this population. We investigated (1) the associations between relationship goals and women's pain during intercourse as well as the sexual, relational, and psychological well-being of women with provoked vestibulodynia (PVD) and their partners and (2) the moderating role of sexual goals in these associations...
December 27, 2016: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/27984345/vulvodynia-what-we-know-and-where-we-should-be-going
#9
Logan M Havemann, David R Cool, Pascal Gagneux, Michael P Markey, Jerome L Yaklic, Rose A Maxwell, Ashvin Iyer, Steven R Lindheim
OBJECTIVE: The aim of the study was to review the current nomenclature and literature examining microbiome cytokine, genomic, proteomic, and glycomic molecular biomarkers in identifying markers related to the understanding of the pathophysiology and diagnosis of vulvodynia (VVD). MATERIALS AND METHODS: Computerized searches of MEDLINE and PubMed were conducted focused on terminology, classification, and "omics" variations of VVD. Specific MESH terms used were VVD, vestibulodynia, metagenomics, vaginal fungi, cytokines, gene, protein, inflammation, glycomic, proteomic, secretomic, and genomic from 2001 to 2016...
December 15, 2016: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/27892829/understanding-the-sexual-satisfaction-of-women-with-provoked-vestibulodynia-and-their-partners-comparison-with-matched-controls
#10
Natalie O Rosen, Pablo Santos-Iglesias, E Sandra Byers
Provoked vestibulodynia (PVD)-a recurrent, localized vulvar pain-interferes with couples' sexual relationships as evidenced by lower sexual satisfaction compared to controls. Little is known about what components of sexual satisfaction contribute to this lower satisfaction. Using the Interpersonal Exchange Model of Sexual Satisfaction (IEMSS), we compared the sexual exchanges (sexual rewards and costs, relative sexual rewards and costs, balance of sexual rewards and costs, balance of relative sexual rewards and costs, equality of sexual rewards and costs) and sexual satisfaction of 50 women with PVD and their male partners to 50 matched-control couples...
November 28, 2016: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/27872003/primary-and-secondary-provoked-vestibulodynia-a-review-of-overlapping-and-distinct-factors
#11
REVIEW
Caroline F Pukall
INTRODUCTION: A common subtype of vulvodynia is provoked vestibulodynia (PVD), characterized by severe pain upon contact to the vaginal entrance. Some researchers have further delineated the PVD group based on pain onset (primary vs secondary PVD, referred to as PVD1 and PVD2, respectively). AIM: This study aims to review available evidence regarding sociodemographic variables, pain characteristics, medical history and examination findings, quantitative sensory testing, genetic markers, psychosocial/sexual/relationship function, treatment outcome, and brain imaging in women with PVD1 and PVD2...
January 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27864031/fractional-co2-laser-treatment-of-the-vestibule-for-patients-with-vestibulodynia-and-genitourinary-syndrome-of-menopause-a-pilot-study
#12
Filippo Murina, Mickey Karram, Stefano Salvatore, Raffaele Felice
INTRODUCTION: Chronic vulvar pain and burning remains one of the most perplexing problems faced by practicing gynecologists. AIM: To evaluate the effectiveness and safety of the application of micro-ablative fractional CO2 laser to the vulvar vestibule in the management of patients with vulvar pain from vestibulodynia or genitourinary syndrome of menopause. METHODS: Patients (N = 70) underwent fractional micro-ablative CO2 laser treatment for vestibular pain plus vestibulodynia (n = 37) or genitourinary syndrome of menopause (n = 33)...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27853523/recent-advances-in-understanding-provoked-vestibulodynia
#13
REVIEW
Ahinoam Lev-Sagie, Steven S Witkin
Vulvodynia refers to pain in the vulva of at least 3 months' duration in the absence of a recognized underlying cause. Provoked, localized vestibulodynia is the term used to describe superficial pain confined to the vulvar vestibule, provoked by touch. This review will focus on provoked vestibulodynia with regard to its suggested causative factors and will discuss the role of inflammation, vulvovaginal infections, mucosal nerve fiber proliferation, hormonal associations, central pain mechanisms, pelvic floor muscle dysfunction, and genetic factors...
2016: F1000Research
https://www.readbyqxmd.com/read/27678862/vestibulectomy-with-vaginal-advancement-for-treatment-of-vestibulodynia
#14
S Vilasagar, J F Carrillo, D C Foster
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27620322/maintaining-affection-despite-pain-daily-associations-between-physical-affection-and-sexual-and-relationship-well-being-in-women-with-genito-pelvic-pain
#15
Sarah A Vannier, Natalie O Rosen, Sean P Mackinnon, Sophie Bergeron
Provoked vestibulodynia (PVD) is a recurrent, genito-pelvic pain condition that affects 8-12 % of women and has negative implications for sexual and relationship functioning. Many women with PVD report avoiding physical affection because they are concerned that affectionate behavior will lead to painful sexual activity. In community samples, physical affection is associated with improved sexual and relational well-being; however, no research has assessed the influence of physical affection on well-being in women with PVD...
September 12, 2016: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/27586889/sexual-assertiveness-mediates-the-associations-between-partner-facilitative-responses-and-sexual-outcomes-in-women-with-provoked-vestibulodynia
#16
Gabrielle McNicoll, Serena Corsini-Munt, Natalie O Rosen, Pierre McDuff, Sophie Bergeron
Provoked vestibulodynia (PVD) is a recurrent idiopathic vulvo-vaginal pain associated with negative sexual and psychological consequences. Facilitative partner responses to pain are currently receiving empirical attention because they are positively associated with women's sexual outcomes. However, the mechanisms through which facilitative responses to pain are associated with these outcomes have not been examined. One potential mechanism is sexual assertiveness, which has been found to be associated with better sexual function and satisfaction in women with PVD...
September 1, 2016: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/27508984/is-the-dsm-v-leading-to-the-nondiagnosis-of-vulvodynia
#17
Pedro Vieira-Baptista, Joana Lima-Silva
No abstract text is available yet for this article.
October 2016: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/27457118/immune-activation-enhances-epithelial-nerve-growth-in-provoked-vestibulodynia
#18
Päivi Tommola, Leila Unkila-Kallio, Anders Paetau, Seppo Meri, Eija Kalso, Jorma Paavonen
BACKGROUND: Provoked vestibulodynia manifests as allodynia of the vulvar vestibular mucosa. The exact mechanisms that result in altered pain sensation are unknown. Recently, we demonstrated the presence of secondary lymphoid tissue, which is the vestibule-associated lymphoid tissue in the vestibular mucosa, and showed that this tissue becomes activated in provoked vestibulodynia. OBJECTIVE: The purpose of this study was to examine whether expression of intraepithelial nerve fibers and nerve growth factor are related to immune activation in provoked vestibulodynia...
December 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27424374/vestibulodynia-a-multifactorial-syndrome-a-case-report
#19
Julia Geynisman-Tan, William J Ledger
BACKGROUND: Vulvodynia is a difficult-to-treat, chronic, multifactorial malady that drastically lowers the quality of life of afflicted patients. CASE: A 68-year-old woman, who had been treated successfully for vulvodynia years before with medication, returned with a recurrence of vulvodynia symptoms that this time did not respond to treatment. She now had biopsy-confirmed lichen sclerosis and was found to have markedly elevated serum testosterone levels. An imaging study detected an ovarian lesion that, on removal, proved to be afibrothecoma...
May 2016: Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/27400010/local-and-systemic-inflammation-in-localized-provoked-vestibulodynia-a-systematic-review
#20
K Jane Chalmers, Victoria J Madden, Mark R Hutchinson, G Lorimer Moseley
OBJECTIVE: To synthesize and critically evaluate all available evidence investigating whether localized, provoked vestibulodynia is associated with a specific inflammatory profile at both a local and a systemic level. DATA SOURCES: Comprehensive electronic searches were performed in MEDLINE, EMBASE, Scopus, PubMed, Web of Science, Cumulative Index to Nursing and Allied Health Literature, the Cochrane Collaboration databases, and ClinicalTrials.gov. The search strategy was developed using MeSH terms related to localized, provoked vestibulodynia, and inflammatory markers...
August 2016: Obstetrics and Gynecology
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